Positive Disintegration

In this article, the author undertakes to analyse three passages of the Fourth Gospel (John 3:1-21; 7:45-53; 19:38-42), mentioning Nicodemus, who belonged to the party of the Pharisees and is mainly known for his encounter with Jesus in the secrecy of the night. Based on these three passages, in which the behaviour and utterances of the biblical protagonist can be observed, an attempt is made to determine the level of Nicodemus' development as well as to trace the path of his personal growth in the context of the assumptions of the theory of positive disintegration, created by the Polish psychiatrist and psychologist Kazimierz Dąbrowski.

In this article, the author undertakes to analyse three passages of the Fourth Gospel (John 3:1-21; 7:45-53; 19:38-42), mentioning Nicodemus, who belonged to the party of the Pharisees and is mainly known for his encounter with Jesus in the secrecy of the night. Based on these three passages, in which the behaviour and utterances of the biblical protagonist can be observed, an attempt is made to determine the level of Nicodemus' development as well as to trace the path of his personal growth in the context of the assumptions of the theory of positive disintegration, created by the Polish psychiatrist and psychologist Kazimierz Dąbrowski.

This presentation is a keynote address from 2018 Dabrowski Congress in Naperville, IL. It delineates the process of development through positive disintegration as that of inner transformation from ego (individuality) to personality reaching and expressing our True Self, the divine part within us.

Thunbergia laurifolia Lindl. is a medicinal plant that belongs to the family of Acanthaceae. It possesses several biological and pharmacological activities. According to the Thai National List of Essential Medicines, T. laurifolia leaves are used for the treatment of fever. This work sought to optimize microwave-assisted drying of Thunbergia laurifolia Lindl. leaf granules to shorten the granule drying process by the 32 full factorial design. Power was varied from 300, 450 and 600 W for 5, 10 and 15 min, to minimize moisture content and maximize rosmarinic acid content. Results showed that the optimal microwave-assisted drying condition within the design space and control space was the power of 450 W for 13 min. This condition gave the moisture content of 4.77 ± 0.24 % and rosmarinic acid content of 0.0566 ± 0.0075 %. The HPLC method was validated; it showed good linearity, specificity, precision, and accuracy. Furthermore, the system suitability was achieved. The T. laurifolia leaf...

Tomato (Solanum lycopersicum L.) is one of the most important crops in the world for its fruit production. Many critical characteristics related to the quality and quantity of tomatoes have been developed using cutting-edge techniques. Recently, genetic techniques such as gene transformation and gene editing have emerged as powerful tools to promptly generate new plant varieties with superior traits. In this study, we successfully induced parthenocarpy traits in a population of elite tomato (ET) lines. The ET lines were screened for their adaptability to new genetic techniques to determine the lines that performed best by applying ANT1 gene transformation and IAA9 knock-out using the CRISPR/Cas9 system. ET5 and ET8 emerged as excellent materials for these techniques due to their high efficiency in applying those modern techniques. Phenotypes of knock-out iaa9 were clearly shown in T-0 and T-1 plants, in which simple leaves and parthenocarpic fruits were observed. We generated T-DNA-...

This article is about formation of a new paradigm in present pedagogic. I claim that
present old paradigm in pedagogic don’t have enough to offer for student in modern
school. I’m also showing, that in the theory of positive disintegration many aspects
can be integral part of a new paradigm. In TDP perspective mental illness gives big
potential for accelerated development. Neurosis and psychoneurosis have the most
powerful correlation with reaching a new level of perception of reality in TDP. Old
paradigm reaches critical point and no longer supports scientific research in right way.
Children, that are in positive disintegration process must have appropriate care and
education because they also have outstanding abilities that are very needed in society
and culture. In this article I represent point of view of acrobatic philosophy of training,
which believes that all activities, also scientific, are only part of training systems that
give people necessary existential support and vertical tension in their lives. Such
science like pedagogics or psychiatry are only certain logic systems of exercises that
in right moment should transform in permanent scientific revolution to keep progress
in science.

Kazimierz Dąbrowski's five-level theory of personality development, the Theory of Positive Disintegration, is one in which the experience of all emotions is essential for the process of individual growth toward the personality ideal. In this article, we synthesize Dąbrowski's conception of syntony and the development of empathy. We discuss the genesis of empathy within the lower levels of human personality development and visually demonstrate the multilevelness of the development of empathy through a diagrammatic representation of syntonic and empathic responses with examples of these traits mapped to the varying levels of development within Dąbrowski's Theory of Positive Disintegration.

In my dissertation, I analyze Kazimierz Dabrowski's theory of positive disintegration with a particular focus on its pedagogical implications for contemporary social sciences. This concept has found recognition in the scientific world, but despite this, its reception is mainly undertaken outside
our country. It deals with the process of ontogenetic development of the
man. Compared to other such theories, it stands out because it comprehends in a positive way a large part of mental disorders, especially neuroses and psychoneuroses. Consequently, it also defines mental
health and mental illness in a different way. In short, it believes that some of the mental disorders that disintegrate a person's psyche are crucial to his accelerated development. This line of reasoning is also
transferred by the theory to the field of educational issues, and especially to the problem of gifted students and related educational interactions. This gives extensive pedagogical implications. The background of the considerations of the present in the work is the ideology of neoliberalism as a socio-political-educational context, making it possible to
show the theory of positive disintegration against the background of the changes experienced in the modern world.
The main purpose of this work is to present the original concept of a prominent Polish researcher in an educational context. I seek an answer to the question of whether its application in pedagogy and education is beneficial, or whether it is an outdated concept, no longer applicable.
The research method I use in this work is a hermeneutic analysis of Dabrowski's treatises, which involves interpreting and understanding the objectified cultural sources that are his texts. Thus, I analyze the works of the author of the theory of positive disintegration and extract from them those contents that give me insight into how he understood educational and social issues and how they fit into social science and educational practice today.

Sensitive, non-invasive biomarkers that facilitate Parkinson's disease (PD) detection and stage assignment are currently unavailable. The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD. Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients. Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls. The four serum miRNAs may represent novel biomarkers for the early detection of PD.

Cashew gum collected from Ejura cashew plantation in Ghana was evaluated for some physicochemical and binding properties in metronidazole tablet formulations. The moisture content and insoluble matter in crude cashew gum (CCG) and purified cashew gum (PCG) was (11.2 %, 0.35 %) and (10.4 %, 0.28 %), respectively. The gum contains divalent metal ions with the rank order: Ca 2+ > Mg 2+ > Fe 2+ > Zn 2+ , and trace amounts (< 0. 1 mg/kg) of the monovalent ions K + and Na +. The amount of each of the metal ions in CCG was higher than in PCG. The pH of CCG or PCG mucilage was more stable when refrigerated than on storage at 25 °C and 50 °C. The pH of PCG mucilage was less stable than CCG on storage. Addition of a preservative had little influence on the pH of cashew gum mucilage when stored. The viscosity of PCG increased with increase in gum concentration and decreased with increase in temperature. Granules comprising of metronidazole (25.7 % w/w), lactose (63.8 % w/w), maize starch (8.2 % w/w), talc (2.0 % w/w) and magnesium stearate (0.3 % w/w) were prepared by wet granulation using 2-8 % w/w PCG mucilage as binder. All the granules possessed good flow properties with Hausner ratio of 1.10-1.30 and Carr's index of 9.0-23.0 %. Tablets prepared with 4-8 % w/w PCG had hardness ≥ 4 kg while tablets prepared with 6-8 % w/w PCG had friability of < 1 %, comparable to that prepared with 4 % w/w acacia. The disintegration time of the tablets was < 15 min and increased with increase in PCG concentration. The tablets had fast dissolution in aqueous media with > 94 % drug dissolution in 45 min. This study shows that PCG can be used as a binder in conventional release tablet formulations.

Phytomedicines based on principles of Ayurveda are need of the hour and is more feasible than allopathic drugs which is not only more expensive in terms of "leads" but is also associated with many unwanted effects. Ethnopharmacological usage and the literature review revealed that the Alangium salvifolium seeds (Ankola) have significant antidiabetic activity. After the detailed study of powder of ethanolic extract of seeds of Alangium salvifolium Linn., a formulation using the plant material was prepared, to made the formulation more acceptable and justified for diabetics, an excipient having nutraceutical value like soy was also incorporated, the formulation was evaluated and standardized as per the pharmacopoeial standards. The results of preformulation studies revealed that all the values were within acceptable limit. Formulation showed appreciable hardness characteristics (3.25±0.57), which facilitates its fast disintegration. The friability (0.29±0.03) of formulation indicated that the tablets were mechanically stable. As the average weight of tablets was 340 mg, the acceptable weight variation range is ±7%. Hence the entire formulated tablet passed the weight variation test. The disintegration time of formulations was more than 1 minute. Thus the claims made by the traditional Indian systems of medicine regarding the use of this plant in the treatment of diabetes stands confirmed. The final conclusion drawn from the above mentioned data is that the possible use of these economical and relatively non toxic, non-hazardous natural remedies of plant origin may further be explored as they are devoid of major side effects associated with synthetic agents.

Cashew gum collected from Ejura cashew plantation in Ghana was evaluated for some physicochemical and binding properties in metronidazole tablet formulations. The moisture content and insoluble matter in crude cashew gum (CCG) and purified cashew gum (PCG) was (11.2 %, 0.35 %) and (10.4 %, 0.28 %), respectively. The gum contains divalent metal ions with the rank order: Ca2+ &gt; Mg2+ &gt; Fe2+ &gt; Zn2+, and trace amounts (&lt; 0. 1 mg/kg) of the monovalent ions K+ and Na+. The amount of each of the metal ions in CCG was higher than in PCG. The pH of CCG or PCG mucilage was more stable when refrigerated than on storage at 25 °C and 50 °C. The pH of PCG mucilage was less stable than CCG on storage. Addition of a preservative had little influence on the pH of cashew gum mucilage when stored. The viscosity of PCG increased with increase in gum concentration and decreased with increase in temperature. Granules comprising of metronidazole (25.7 % w/w), lactose (63.8 % w/w), maize starch ...

Cashew tree Anacardium occidentale is a spreading ever green perennial tree. The plant is naturalized and cultivated in the warmer parts of Sri Lanka. This study focused on evaluating purified cashew gum as an effective binding agent in tablet formulation using a range of binder solution strengths and different tablet formulations. A difficult to formulate "all starches filler tablet" was attempted as a challenge for the binding strength of the purified cashew gum. Method: Crude cashew gum was collected from the main trunk and purified by dialysis. The aqueous solution containing higher molecular mass fraction obtained from dialysis was then lyophilized. Placebo, pyridoxine hydrochloride 2 mg and carbamazepine 100 mg tablets were prepared using the high molecular mass fraction known as purified cashew gum. The physico-chemical properties of the purified gum were investigated. Physical properties of the tablets prepared with four binders, purified cashew gum, gum xanthan, hydroxypropyl methylcellulose and maize starch were studied and compared with respect to diameter, thickness, hardness, friability, weight variation and disintegration time. Results: The purified cashew gum was of a light amber color, glistening pieces and was odorless. It was found that the gum resembles the properties of gum acacia with parameters well within those of British Pharmacopeia specifications. A unique all starches filler tablets were a success. Tablets prepared with all four binders exhibited similar physical properties. Conclusion: It was possible to purify the gum to a specified quality similar to that of gum acacia. Tablets made with the cashew gum met the tested British Pharmacopeia specifications similar to the conventional binders indicating the potential for the use of purified cashew gum as a pharmaceutical binding agent.

Cashew tree Anacardium occidentale is a spreading ever green perennial tree. The plant is naturalized and cultivated in the warmer parts of Sri Lanka. This study focused on evaluating purified cashew gum as an effective binding agent in tablet formulation using a range of binder solution strengths and different tablet formulations. A difficult to formulate "all starches filler tablet" was attempted as a challenge for the binding strength of the purified cashew gum. Method: Crude cashew gum was collected from the main trunk and purified by dialysis. The aqueous solution containing higher molecular mass fraction obtained from dialysis was then lyophilized. Placebo, pyridoxine hydrochloride 2 mg and carbamazepine 100 mg tablets were prepared using the high molecular mass fraction known as purified cashew gum. The physico-chemical properties of the purified gum were investigated. Physical properties of the tablets prepared with four binders, purified cashew gum, gum xanthan, hydroxypropyl methylcellulose and maize starch were studied and compared with respect to diameter, thickness, hardness, friability, weight variation and disintegration time. Results: The purified cashew gum was of a light amber color, glistening pieces and was odorless. It was found that the gum resembles the properties of gum acacia with parameters well within those of British Pharmacopeia specifications. A unique all starches filler tablets were a success. Tablets prepared with all four binders exhibited similar physical properties. Conclusion: It was possible to purify the gum to a specified quality similar to that of gum acacia. Tablets made with the cashew gum met the tested British Pharmacopeia specifications similar to the conventional binders indicating the potential for the use of purified cashew gum as a pharmaceutical binding agent.

Cashew tree Anacardium occidentale is a spreading ever green perennial tree. The plant is naturalized and cultivated in the warmer parts of Sri Lanka. This study focused on evaluating purified cashew gum as an effective binding agent in tablet formulation using a range of binder solution strengths and different tablet formulations. A difficult to formulate "all starches filler tablet" was attempted as a challenge for the binding strength of the purified cashew gum. Method: Crude cashew gum was collected from the main trunk and purified by dialysis. The aqueous solution containing higher molecular mass fraction obtained from dialysis was then lyophilized. Placebo, pyridoxine hydrochloride 2 mg and carbamazepine 100 mg tablets were prepared using the high molecular mass fraction known as purified cashew gum. The physico-chemical properties of the purified gum were investigated. Physical properties of the tablets prepared with four binders, purified cashew gum, gum xanthan, hydroxypropyl methylcellulose and maize starch were studied and compared with respect to diameter, thickness, hardness, friability, weight variation and disintegration time. Results: The purified cashew gum was of a light amber color, glistening pieces and was odorless. It was found that the gum resembles the properties of gum acacia with parameters well within those of British Pharmacopeia specifications. A unique all starches filler tablets were a success. Tablets prepared with all four binders exhibited similar physical properties. Conclusion: It was possible to purify the gum to a specified quality similar to that of gum acacia. Tablets made with the cashew gum met the tested British Pharmacopeia specifications similar to the conventional binders indicating the potential for the use of purified cashew gum as a pharmaceutical binding agent.

W książce autor analizuje teorię dezintegracji pozytywnej Kazimierza Dąbrowskiego ze szczególnym uwzględnieniem jej pedagogicznych implikacji dla współczesnych nauk społecznych. Koncepcja ta znalazła uznanie w świecie naukowym, ale pomimo tego jej recepcja podejmowana jest głównie poza granicami naszego kraju. Zajmuje się ona procesem ontogenetycznego rozwoju człowieka. Na tle innych tego typu teorii wyróżnia się tym, że w pozytywny sposób pojmuje dużą część zaburzeń psychicznych, zwłaszcza nerwice i psychonerwice. W inny sposób definiuje też zdrowie psychiczne i chorobę psychiczną. Zgodnie z nią część zaburzeń psychicznych dezintegrujących psychikę człowieka ma kluczowe znaczenie dla jego przyspieszonego rozwoju. Ten tok rozumowania teoria ta przenosi również na obszar zagadnień związanych z edukacją, zwłaszcza na problematykę uczniów zdolnych i związanych z nimi oddziaływań wychowawczych. Daje to rozległe pedagogiczne implikacje.

Głównym celem publikacji jest przedstawienie oryginalnej koncepcji wybitnego polskiego badacza w kontekście edukacyjnym. Autor poszukuje odpowiedzi na pytanie, czy jej aplikacja w pedagogice i edukacji jest korzystna, czy też jest to koncepcja przestarzała, nieznajdująca już zastosowania.

Zastosowaną metodą badawczą, jest hermeneutyczna analiza rozpraw Dąbrowskiego, która polega na interpretacji i rozumieniu zobiektywizowanych źródeł kulturowych, jakimi są jego teksty. Analizowane są zatem prace autora teorii dezintegracji pozytywnej i wydobywane z nich te treści, które dają możliwość wglądu w to, w jaki sposób rozumiał on kwestie edukacyjne i społeczne oraz jak wpisują się one dzisiaj w nauki społeczne i praktykę oświatową.

Annona reticulata is a tropical tree found widely in India. Seeds of plant contain glucomannose hence attempt made to evaluate the seeds for suitability as tablet binder is considered. The present investigation hearsay the isolation of mucilage of Annona reticulata seeds. Physiochemical characteristics of mucilage, such as solubility, swelling index, loss on drying, viscosity, hydration capacity, powder porosity, and pH were studied. The mucilage was evaluated for its granulating and binding properties in compressed tablet, using Diclofenac sodium as model drug. Mucilage was used in four different concentration i.e. 0.25, 0.5, 0.75 and 1.00% w/v. Granules were prepared by wet granulation process. The prepared granules were evaluated for percentage of fines, average particle size, compressibility index and flow properties. The properties were compared with HPMC E5, which was used as standard binder at 1% w/v concentration. The tablet were prepared and evaluated for content uniformity, hardness, friability, disintegration time nd in vitro dissolution profile. The tablets had good physiochemical properties, and the drug release was more than 85% within 3 hrs. It was observed that increasing the concentration of mucilage increases hardness, decreases the disintegration time. All the formulations (F1, F2, F3, F4 and F5) were subjected to stability studies for three months at room temperature, 25°C/60% RH, 30°C/65% RH and 40°C/75% RH as per ICH guidelines, only F1 and F2 showed stability with respect to release pattern and other parameters.

Out of death comes life.  It is the death of the old that brings birth of the new.  This theme occurs countless times and in varying forms throughout mythology, religion, literature, science, psychology, education, and in our daily lives.  This article describes how the death and rebirth experiences of the Buddha are reflected in our own spiritual, intellectual, creative, psychological, and emotional growth experiences.

Cashew gum collected from Ejura cashew plantation in Ghana was evaluated for some physicochemical and binding properties in metronidazole tablet formulations. The moisture content and insoluble matter in crude cashew gum (CCG) and purified cashew gum (PCG) was (11.2 %, 0.35 %) and (10.4 %, 0.28 %), respectively. The gum contains divalent metal ions with the rank order: Ca 2+ > Mg 2+ > Fe 2+ > Zn 2+ , and trace amounts (< 0. 1 mg/kg) of the monovalent ions K + and Na + . The amount of each of the metal ions in CCG was higher than in PCG. The pH of CCG or PCG mucilage was more stable when refrigerated than on storage at 25 °C and 50 °C. The pH of PCG mucilage was less stable than CCG on storage. Addition of a preservative had little influence on the pH of cashew gum mucilage when stored. The viscosity of PCG increased with increase in gum concentration and decreased with increase in temperature. Granules comprising of metronidazole (25.7 % w/w), lactose (63.8 % w/w), maize starch (8.2 % w/w), talc (2.0 % w/w) and magnesium stearate (0.3 % w/w) were prepared by wet granulation using 2 -8 % w/w PCG mucilage as binder. All the granules possessed good flow properties with Hausner ratio of 1.10 -1.30 and Carr's index of 9.0 -23.0 %. Tablets prepared with 4 -8 % w/w PCG had hardness ≥ 4 kg while tablets prepared with 6 -8 % w/w PCG had friability of < 1 %, comparable to that prepared with 4 % w/w acacia. The disintegration time of the tablets was < 15 min and increased with increase in PCG concentration. The tablets had fast dissolution in aqueous media with > 94 % drug dissolution in 45 min. This study shows that PCG can be used as a binder in conventional release tablet formulations.

Cashew gum collected from Ejura cashew plantation in Ghana was evaluated for some physicochemical and binding properties in metronidazole tablet formulations. The moisture content and insoluble matter in crude cashew gum (CCG) and purified cashew gum (PCG) was (11.2 %, 0.35 %) and (10.4 %, 0.28 %), respectively. The gum contains divalent metal ions with the rank order: Ca 2+ > Mg 2+ > Fe 2+ > Zn 2+ , and trace amounts (< 0. 1 mg/kg) of the monovalent ions K + and Na + . The amount of each of the metal ions in CCG was higher than in PCG. The pH of CCG or PCG mucilage was more stable when refrigerated than on storage at 25 °C and 50 °C. The pH of PCG mucilage was less stable than CCG on storage. Addition of a preservative had little influence on the pH of cashew gum mucilage when stored. The viscosity of PCG increased with increase in gum concentration and decreased with increase in temperature. Granules comprising of metronidazole (25.7 % w/w), lactose (63.8 % w/w), maize starch (8.2 % w/w), talc (2.0 % w/w) and magnesium stearate (0.3 % w/w) were prepared by wet granulation using 2 -8 % w/w PCG mucilage as binder. All the granules possessed good flow properties with Hausner ratio of 1.10 -1.30 and Carr's index of 9.0 -23.0 %. Tablets prepared with 4 -8 % w/w PCG had hardness ≥ 4 kg while tablets prepared with 6 -8 % w/w PCG had friability of < 1 %, comparable to that prepared with 4 % w/w acacia. The disintegration time of the tablets was < 15 min and increased with increase in PCG concentration. The tablets had fast dissolution in aqueous media with > 94 % drug dissolution in 45 min. This study shows that PCG can be used as a binder in conventional release tablet formulations.

Cashew gum collected from Ejura cashew plantation in Ghana was evaluated for some physicochemical and binding properties in metronidazole tablet formulations. The moisture content and insoluble matter in crude cashew gum (CCG) and purified cashew gum (PCG) was (11.2 %, 0.35 %) and (10.4 %, 0.28 %), respectively. The gum contains divalent metal ions with the rank order: Ca 2+ > Mg 2+ > Fe 2+ > Zn 2+ , and trace amounts (< 0. 1 mg/kg) of the monovalent ions K + and Na + . The amount of each of the metal ions in CCG was higher than in PCG. The pH of CCG or PCG mucilage was more stable when refrigerated than on storage at 25 °C and 50 °C. The pH of PCG mucilage was less stable than CCG on storage. Addition of a preservative had little influence on the pH of cashew gum mucilage when stored. The viscosity of PCG increased with increase in gum concentration and decreased with increase in temperature. Granules comprising of metronidazole (25.7 % w/w), lactose (63.8 % w/w), maize starch (8.2 % w/w), talc (2.0 % w/w) and magnesium stearate (0.3 % w/w) were prepared by wet granulation using 2 -8 % w/w PCG mucilage as binder. All the granules possessed good flow properties with Hausner ratio of 1.10 -1.30 and Carr's index of 9.0 -23.0 %. Tablets prepared with 4 -8 % w/w PCG had hardness ≥ 4 kg while tablets prepared with 6 -8 % w/w PCG had friability of < 1 %, comparable to that prepared with 4 % w/w acacia. The disintegration time of the tablets was < 15 min and increased with increase in PCG concentration. The tablets had fast dissolution in aqueous media with > 94 % drug dissolution in 45 min. This study shows that PCG can be used as a binder in conventional release tablet formulations.

Plant gums and mucilage’s are being used due to their abundance in nature, safety and economy. So in the present study an attempt was made to know the efficacy of Alstonia scholaris gum as a binder in paracetamol tablets by comparing with starch. In majority of tablets and capsules binders are used as important additives and in the present study gum isolated from trunk of Alstonia scholaris was studied at different concentrations and conditions. The paracetamol granules were prepared with different concentration of gum as binder by wet granulation method and evaluated for moisture content, angle of
repose, bulk and tapped densities. The tablets were evaluated for thickness, weight variation, hardness, friability, and disintegration time and in vitro release profiles. Studies showed that increase in binding concentration of Alstonia scholaris gum, increases the hardness, as well as the disintegration time, decreases the percentage friability and decreases percentage cumulative release. Results obtained indicated that Alstonia scholaris gum performed as good binder at lower percentage.

The study was designed to evaluate the antidiabetic potential of formulation of hydro-alcoholic extract of Luffa acutangula and Madhuca longifolia. The formulation was evaluated in the alloxan monohydrate induced diabetic model. Graded doses of the "hydroalcholic extract" were administered to "normal" and "experimental" diabetic rats for 10 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animal. The formulation treated diabetic rats were compared with diabetic control and normal animals. Positive results were obtained in the observed parameters, thereby favouring the use of the plant in the "indigenous system" of medicine. The extract were designed in solid dosage form (Tablet) and standardized as per the pharmacopoeial standards. Antidiabetic potential of formulation of hydro-alcoholic extract (Luffa acutangula and Madhuca longifolia), evaluated. Appreciable hardness characteristics (3.24±0.58), shown by formulation "which facilitates its fast disintegration". The friability of formulated tablets were (0.28±0.02) indicated that the tablets were mechanically stable. The average weight of tablets were [340 mg], and the acceptable weight variation range was (±7%). Hence the entire formulated tablet passed the weight variation test. The disintegration time of formulations was more than (3.01±1.3) minute. Phytomedicines offer greater advantage over synthetic drugs as they are cheaper and show no side effects.

Anacardiumgum  derived  from  the  edible  seeds  of
Anacardiumoccidantale(family  Anacardiaceae) was evaluated for its binding  properties  at  a  concentration  of  5  %  w/w  and  10%  w/w  in Ibuprofen  tablets  with  official  starch  as  a  control.  A  comparative analysis showed that the granules bound with  Anacardiumgum were relatively  bigger and harder than the ones obtained with starch gum. The hardness,  disintegration time and dissolution rate increased with increase  in  concentration  of  Anacardiumgum.  Tablets  containing
10% w/w of  Anacardiumgum had a binding  capacity approximately twice that of starch with a dissolution rate of 58.5% after 30  min. The results obtained suggest that Anacardiumgum possesses potential as a commercial binding agent.