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Key research themes
1. How do electrostatic interactions govern the direct electron transfer and orientation of enzymes on electrode surfaces in biomolecular electrochemistry?
This research area focuses on the fundamental role of electrostatic forces in modulating enzyme adsorption, orientation, and direct electron transfer (DET) efficiency on electrode surfaces, which are crucial for the design of effective bioelectrocatalysts and biosensors. Understanding how electric double layers and surface charges affect enzyme behaviour enables improved electrode functionalization strategies and enhanced enzyme-electrode coupling, fundamental to biomolecular electrochemistry applications.
Key finding: The paper emphasizes the theoretical significance of nanoscale electrode architectures and the impact of diffuse layer electrical fields on electron transfer kinetics and enzyme adsorption in single molecule electrochemistry.... Read more
Key finding: The study outlines that the electronic coupling between redox metalloproteins and electrodes is strongly influenced by electrostatic interactions governed by the surface functional groups of self-assembled monolayers (SAMs).... Read more
2. What advances in electrode and reactor design have improved bioelectrochemical system performance for bioelectrocatalysis and microbial electrochemical applications?
This theme explores engineering innovations in electrochemical cell assemblies and reactor configurations that optimize enzyme or microbial electrode interfaces, enhance electron transfer efficiency, and facilitate scalability and control in bioelectrochemical systems (BES). These advances address challenges of electrode surface area, mass transport, and system stability critical for translating biomolecular electrochemistry principles into practical applications such as biosynthesis, energy conversion, and environmental remediation.
Key finding: This tutorial review presents an accessible overview of synthetic electrochemistry setups, including continuous flow electrochemical reactors. It highlights how simplified designs and continuous flow approaches facilitate... Read more
Key finding: The review introduces novel electrochemical biotechnologies like electro-fermentation and indirect electro-stimulation that require significantly fewer electrodes by manipulating intracellular and extracellular redox states... Read more
Key finding: The study provides an analytical framework to interpret complex impedance spectra of bio-photovoltaic cells employing photosynthetic reaction centers. It develops normalized equivalent circuit models that capture transitions... Read more
3. How is molecular and enzymatic electrochemistry employed to understand redox mechanisms and enhance biosensing and bioelectrocatalysis performance?
This theme addresses the application of molecular electrochemical techniques, including protein-film voltammetry and enzyme bioelectrochemistry, to elucidate redox enzyme mechanisms, electron transfer kinetics, and enzyme-electrode interface behavior. These insights fuel the rational design of enzymatic biosensors, biofuel cells, and electrocatalytic systems with improved sensitivity, selectivity, and operational stability, bridging fundamental electrochemistry with biomedical and biotechnological applications.
Key finding: Theoretical modeling revealed distinct square-wave voltammetry features caused by reversible follow-up chemical reactions coupled to enzymatic electrode processes, particularly at high electron transfer kinetics. Notably,... Read more
Key finding: This work extends theoretical understanding of complex protein-film voltammetry by modeling reactions coupled with follow-up, preceding, or regenerative chemical steps under square-wave conditions. It identifies... Read more
Key finding: This review synthesizes advances in enzyme electrochemistry, highlighting direct and mediated electron transfer mechanisms, immobilization techniques to enhance enzyme stability and electron transfer rates, and design... Read more
Key finding: The review emphasizes the central role of quinone electrochemistry in understanding biological redox processes relevant to medicine. It details electrochemical pathways involving quinones linked to oxidative stress and redox... Read more
Key finding: The article reviews how enzyme electrochemistry combined with nanomaterials, particularly carbon-based nanostructures, enhances biosensor sensitivity and selectivity by improving enzyme immobilization and electron transfer at... Read more