Papers by Muhammad Fayez Aziz
Scientific Reports, 2016
The formation of protein structural domains requires that biochemical functions, defined by conse... more The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop sequences and domain structures defined at the fold superfamily level of SCOP classification. The resulting 'elementary functionome' network and its loop motif and structural domain graph projections create evolutionary 'waterfalls' describing the emergence of primordial functions. Waterfalls reveal how ancient loops are shared by domain structures in two initial waves of functional innovation that involve founder 'p-loop' and 'winged helix' domain structures. They also uncover a dynamics of modular motif embedding in domain structures that is ongoing, which transfers 'preferential' cooption properties of ancient loops to emerging domains. Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and power law behavior in network evolution as the network of motifs and structures expand metabolic pathways and translation.
Information Technology Journal, 2004
Information Technology Journal 3 (1): 69-73, 2004 ISSN 1682-6027 © 2004 Asian Network for Scienti... more Information Technology Journal 3 (1): 69-73, 2004 ISSN 1682-6027 © 2004 Asian Network for Scientific Information Converting Standard HTML Input Controls to Urdu Muhammad Zaheer Aziz, Muhammad Fayez Aziz and Khalid Rashid Department of Computer Science, ...
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Papers by Muhammad Fayez Aziz