Bambang Budi Siswanto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, University Of Indonesia, And National Cardiovascular Center Harapan Kita, Jakarta

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Effect of beta blocker therapy on survival in severe heart failure Sanjaya, William; Siswanto, Bambang B.
Medical Journal of Indonesia Vol 11, No 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.516 KB) | DOI: 10.13181/mji.v11i3.63

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Beta-blocking agents have been shown to reduce the risk of hospitalization and death in patients with mild to moderate heart failure, but little is known about the efficacy or safety of these agents in severe heart failure. A case of beta blocker administration in severe heart failure with ejection fraction less than 25% is reported. The reported benefits of beta blockers with regard to morbidity and mortality in patients with mild to moderate heart failure were also found in the patient with severe heart failure as reported in this case. (Med J Indones 2002; 11: 174-5) Keywords: beta-blocking agents, heart failure, ejection fraction
A randomized comparative trial of first-dose response to Angiotensin- Converting Enzyme Perindopril and Captopril in Indonesian heart failure patients Makmun, Lukman H.; Abdurachman, Nurhay; Alwi, Idrus; Afandi, Dedi; Siswanto, Bambang B.; Andriantoro, Hananto; Ratnaningsih, Endang; Utomo, Hari
Medical Journal of Indonesia Vol 11, No 1 (2002): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.88 KB) | DOI: 10.13181/mji.v11i1.45

Abstract

Several large placebo-controlled trials have confirmed that angiotensin converting enzyme (ACE) inhibitors significantly reduce mortality aid morbidity in all functional grades of congestive heart failure (CHF), nevertheless only a proportion of patients who may benefit from treatment are priscribed an ACE inhibitor. One of the perceived difficulties is the occurrence of first-dose hypotension in susceptible patients. A double-blind, randomised, single-dose therapy, parallel-group study was conducted with the aim to compare the first-dose responses to low dose ACE inhibitors captopril and perindopril in patients with stable chronic heart failure. Seventy patients (New York Heart Association class I-IV) were included. Blood pressure was recorded every 15 minutes 2 hours before starting treatment. The mean of these readings was taken as the baseline blood pressure. Patients were randomised to receive a single-dose of captopril 6.25 mg or perindopril 2 mg. After taking the drug, blood pressure was monitored every 15 minutes for 2 hours, every 30 minutes during 5 hours then hourly after 2 hours. The maximum mean arterial pressure fall from baseline of perindopril was 0.85 mmHg compared to captopril 4.60 mmHg. The maximum mean systolic fall from baseline of perindopril was 3 31 mmHg compared to captopril 6.76 mmHg while the maximum mean diastolic fall from baseline of perindopril was 1.08 mmHg compared to captopril 2.63 mmHg. The hypotensive effect of the captopril group started soon after dosing and reached its maximum after 1 to 2 hours while perindopril showed slight reduction of systolic after 1 hour and slight reduction of diastolic after 4 hours. Compared to captopril, perindopril seemed to be less likely to cause first-dose hypotension in patients with heart failure. (Med J Indones 2002; 11: 19-23)Keywords: first dose hypotension, perindopril, captopril, chronic heart failure
Cardiocerebral resuscitation: advances in cardiac arrest resuscitation Mulia, Erwin; Siswanto, Bambang B.
Medical Journal of Indonesia Vol 20, No 4 (2011): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (696.281 KB) | DOI: 10.13181/mji.v20i4.466

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Cardiac arrest remains a leading cause of death in the world. Although advances in emergency cardiac care has been achieved, the survival rate of those non hospitalized hospital cardiac arrest remains low. Update in guidelines for CPR and emergency cardiovascular, their approach to out of hospital cardiac arrest is far from optimal. This provides an opportunity to advocate cardiocerebral resuscitation as an alternative to  traditional cardiopulmonary resuscitation for non hospitalized cardiac arrest. Because cardiocerebral resuscitation results in improved survival and cerebral function in patients with witnessed cardiac arrest and a shockable rhythm whom have greatest chance of survival, it should replace CPR especially for non hospitalized cardiac arrest.(Med J Indones 2011; 20:306-9)Keywords: cardiocerebral resuscitation, cardiac arrest,  cardiopulmonary resuscitation
The role of copeptin as a novel cardiovascular biomarker Kristyagita, Andy; Siswanto, Bambang B.
Medical Journal of Indonesia Vol 24, No 1 (2015): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.723 KB) | DOI: 10.13181/mji.v24i1.1208

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Copeptin is a provasopressin-derived peptide, the precursor for arginine vasopressin (AVP), which is an antidiuretic hormone from the hypothalamus. Copeptin is secreted together with AVP equally as a response of AVP stimulation. While AVP’s main function is water and blood volume regulation and maintaining electrolyte homeostasis, copeptin’s function is still not fully understood. AVP, copeptin, and other vasopressinergic neuropeptides’ levels are elevated in acute stress caused by pathological conditions. Clinical use of AVP levels has many weaknesses. Copeptin can act as a replacement because of its molecular stability, easier testing methods, and faster results. For example, combination of copeptin and cardiac troponins can eliminate myocardial infarction (MI) diagnosis faster, while combined with brain-type natriuretic peptide (BNP) or its precursor can predict heart failure (HF) outcome. In cardiovascular shock, copeptin levels are elevated. As such, copeptin is a potential biomarker for MI diagnosis and predictor for HF mortality and morbidity. 
Chronic thromboembolic pulmonary hypertension in young woman with history of caesarian section Asbarinsyah, Nitia A.; Soerarso, Rarsari S.; Hersunarti, Nani; Siswanto, Bambang B.
Medical Journal of Indonesia Vol 23, No 4 (2014): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.569 KB) | DOI: 10.13181/mji.v23i4.1067

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Chronic thromboembolic pulmonary hypertension (CTEPH) is one of subgroups of pulmonary hypertension. This is a serious medical condition that severely under diagnosed. CTEPH is commonly underdiagnosed due to non specific symptoms and lack of diagnostic tools. The aim of this presentation is to discuss the etiology, risk factors, diagnosis and management of CTEPH. A 36-year-old woman presented with easily fatigue and dyspneu on effort since two years ago. The symptom occured about three months after she gave birth with caesarian section due to preeclampsia. Further history taking, physical examination, electrocardiography (ECG) and echocardiography were highly suggestive of pulmonary hypertension. No deep vein thrombosis (DVT) was found on vascular femoral sonography. It was found after the lung perfusion scintigraphy performed that she actually had CTEPH. This patient was categorized as inoperable because CT pulmonary angiography showed no thrombus. The patient got pulmonary vasodilator and oral anticoagulant for lifelong.
Accurate diagnoses, evidence based drugs, and new devices (3 Ds) in heart failure Siswanto, Bambang B.
Medical Journal of Indonesia Vol 21, No 1 (2012): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (537.188 KB) | DOI: 10.13181/mji.v21i1.478

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Heart failure becomes main problem in cardiology because of increasing of heart failure patients, rehospitalization rate, morbidity, and mortality rate. The main causes of increasing heart failure problems are: (1) Successful treatment of acute myocardial infarction can be life saving, but its sequelae can cause heart failure. (2) Increasing life expectancy rate grows along with incidences of ageing related heart failure. (3) High prevalence of infection in Indonesia can cause rheumatic heart disease post Streptococcal beta hemolyticus infection, viral myocarditis, infective endocartitis, and tuberculoid pericarditis. (4) Many risk factors for coronary heart disease are often found in heart failure patients, for examples smoking, diabetes, hypercholesterolemia, hypertension, and obesity. Indonesia joined international multicentered registry in 2006. Acute Decompensated HEart failure REgistry is a web based international registry to record patient with acute decompensated heart failure treated in emergency room. It was found that heart failure patients in 5 big hospitals in Java and Bali island that joined this registry are younger, sicker and late to seek treatment. The median hospital length of stay was 7 days and in hospital mortality rate was 6.7%. The aim of this article is to give summary about essential things in diagnosing and treating heart failure patients. 3D (accurate diagnoses, evidence based drugs, and new devices) are the most important but what to do and what not to do in dealing with heart failure is also useful for your daily practice. (Med J Indones 2012;21:52-8)Keywords: Devices, diagnostic, drugs, heart failure
Case report of secondary hypertension due to renal artery stenosis in young patient Saragih, Wendy M.; Sulistiowati, Siska; Haryono, Nur; Siswanto, Bambang B.; Hersunarti, Nani; Soesanto, Amiliana M.
Medical Journal of Indonesia Vol 23, No 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (792.088 KB) | DOI: 10.13181/mji.v23i2.666

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Secondary hypertension is rare to occur, but should become suspicion in young age. Secondary hypertension must be appropriately diagnosed and treated. Renal artery stenosis is one of many causes of secondary hypertension. The aim of this case report is to describe diagnosis, pathophysiology and management of secondary hypertension due to renal artery stenosis in young patient. A 17 year old man with symptom of shortness of breath was diagnosed with hypertension stage 3 on his medical examination at Pasar Rebo Hospital, Jakarta. Abdominal CT scan examination revealed bilateral renal artery stenosis. Percutaneous transluminal angiography (PTA) of left renal artery was performed at National Cardiovascular Centre Harapan Kita. Stent was placed succesfully and the blood pressure was normalized.
Challenges on management of heart failure in Indonesia: a general practitioner’s perspective Rizki, Rizki; Siswanto, Bambang B.
Medical Journal of Indonesia Vol 23, No 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.193 KB) | DOI: 10.13181/mji.v23i1.691

Abstract

Heart failure has become a public health problem with increasing incidence and prevalence. Many patients first came to the primary care and managed by general practitioner. Accurate diagnosis is essential to provide good management of heart failure. However, symptoms and signs alone are often neither sufficient nor specific to confirm the diagnosis. Some studies show that heart failure patients are still incorrectly diagnosed and inadequately treated, despite the availability of current guidelines. Inadequacy of facilities is the main obstacle in diagnosing and managing heart failure, especially in developing countries like Indonesia. The medications recommended for treating heart failure are still under-prescribed. This review discuss about the challenges of diagnosis and management of heart failure in primary care.Keywords: heart failure, general practice, primary care
Comparison of Roles between Alcohol Ablation and Surgical Myectomy in Hypertrophic Cardiomyopathy Kusuma, Nico; Pranata, Raymond; Vania, Rachel; Siswanto, Bambang Budi
Indonesian Journal of Cardiology Vol. 38, No. 2 April-June 2017
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.30701/ijc.v38i2.733

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Hypertrophic cardiomyopathy is a genetic myocardial disease that may extend to leftventricular outflow tract obstruction. Alcohol septal ablation (ASA) is preferred for itsnon-surgical, agreed as the safest way for advanced aged, or those with high risk for surgicalprocedure or comorbidities. On the other hand, surgical myectomy (SM) remainsas gold standard, established to be the most consistent to achieve optimal hemodynamicand spare longevity, regardless selective use. This article reviews the advantages anddisadvantages between SM and ASA ablation from its outcome, mortality, pre- and postprocedural,and patient’s profile selection.
Exercise training in heart failure: role, prescription and program Pranata, Raymond; Yonas, Emir; Siswanto, Bambang B.; Purwowiyoto, Budhi S.
Indonesian Journal of Cardiology Vol 38 No 4 (2017): October - December 2017
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.30701/ijc.v38i4.788

Abstract

Heart failure is one of the most common cardiovascular diseases and is a final pathway of various cardiac pathologies. Exercise intolerance and dyspnea accompanied by dete­riorating quality of life are common issues in those suffering from heart failure and may persist despite optimal medical therapy. Exercise training in heart failure theoretically helps to slow down the deterioration of the heart by antagonizing excess neurohormonal activity in heart failure, which translated into better functional capacity and quality of life. Exercise prescription is a mean of assessing and interpreting clinical information and applying the principles of training to develop an appropriate regimen and should be tailored to patient’s clinical condition. Resistance training improves peak VO2, exercise capacity and quality of life in heart failure patients. Both continuous and interval exercise training are linked to better quality of life despite ambiguous results in mortality. The aim of this article is to discuss the benefits of exercise in patients with congestive heart failure, exercise prescription, and exercise program including high-intensity interval training, continuous training and resistance exercise.   Abstrak Gagal jantung adalah salah satu penyakit kardiovaskular yang paling sering ditemui dan merupakan akhir daripada banyak jenis patologi jantung. Intoleransi olahraga dan sesak nafas disertai dengan memburuknya kualitas hidup merupakan beberapa masalah yang sering dihadapi oleh pasien gagal jantung, meskipun telah diberikan pengobatan yang optimal. Latihan olahraga pada gagal jantung secara teoritis dapat memperlambat menurunnya fungsi jantung dengan melawan aktivitas neurohormonal yang meningkat pada kondisi gagal jantung yang dicerminkan dengan kapasitas fungsional dan kualitas hidup yang lebih baik. Preskripsi olahraga meliputi pemeriksaan dan interpretasi dari informasi klinis dan aplikasi dari prinsip latihan untuk membentuk regimen yang sesuai dan harus di sesuaikan dengan keadaan klinis pasien. Latihan beban memperbaiki fungsi VO2 puncak, kapasitas olahraga dan kualitas hidup pada pasien dengan gagal jantung. Kedua metode olahraga baik secara kontinu ataupun interval dihubungkan dengan kualitas hidup yang lebih baik meskipun masih ambigu dalam hal mortalitas. Tujuan artikel ini adalah membahas manfaat latihan fisik pada pasien dengan gagal jantung kongestif, cara peresepan serta membahas program high intensity interval training, continuous training serta latihan beban.
Co-Authors Achir Yani S. Hamid Adi, Andi Wahjono Ambari, Ade Meidian Amiliana M Soesanto Amiliana M. Soesanto Andi Mahavira Andy Kristyagita Anna Ulfah Rahajoe Anwar Santoso Aria Kekalih Asrory, Virna Dwi Oktariana Astari Pranindya Sari Basuni Radi BRM Ario S. Kuncoro Budhi Antariksa Budhi S. Purwowiyoto Dedi Afandi Desandri, Dwita Rian Dewi H Suprobo Dewi H Suprobo DEWI IRAWATI Dewi Irawati Dewi Irawati Diana Septiyanti Doni Firman Dwiputra, Bambang Emir Yonas Endang Ratnaningsih Erwin Mulia Fatoni, Mukhamad Ganesja M Harimurti Ganesja M Harimurti Gipta Galih Widodo Hadrian Deka Hananto Andriantoro Harahap, Alida R. Harahap, Alida Rosita Hari Utomo Hariadi Hariawan Harmani Kalim Herliana , Rini Huda , Khoirul I Made Putra Swi Antara Idrus Alwi Ikhda Ulya Ikhda Ulya, Ikhda Indarto, Malik Jantra Indriwanto Sakidjan Januar W Martha Junaiti Sahar Jusup Endang Juzni Alkatiri Katsukawa, Hajime Kusuma, Nico Listyaningsih, Erlin Lukman H. Makmun Muhammad Munawar Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nico Kusuma Nico Kusuma Nitia A. Asbarinsyah Nur Haryono Nurhay Abdurachman Nusanti, Synthia Pius Almindu Leki Berek Poppy S Roebiono Pranata, Raymond Pratama, Erlan Anugrah Prima Almazini Prima Almazini Prima Almazini Prima Almazini Purwowiyoto, Budhi S. Rachel Vania Rachel Vania Radityo Prakoso Raja Adil C Siregar Rarsari S. Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Raymond Pranata Retna Dewayani Rizki Rizki Rony Mario Candrasatria, S Taofan Sadikaningtya, Lirasati Seskoati Prayitnaningsih Siska Sulistiowati Sri Yona Sri Yona Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Teuku Heriansyah, Teuku Tony Suharsono Tony Suharsono, Tony Triangto, Kevin Vania, Rachel Vidya Gilang Rejeki Wahju Aniwidyaningsih Wendy M. Saragih William Sanjaya Wisnu Jatmiko Yoga Yuniadi Yonas, Emir