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All Journal HAYATI Journal of Biosciences INDONESIAN JOURNAL OF PHARMACY FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceuticals and Natural Sciences Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan

Fadlina Chany Saputri

Fakultas Farmasi, Universitas Indonesia, Depok, Indonesia

Author-ID : 3685220

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Synthesis and Preliminary In Vitro Anti-inflammatory Evaluation of Mannich Bases Derivatives of 4’-Methoxy-substituted of Asymmetrical Cyclovalone Analogs Rahmawati, Nur; Hariyanti, Hariyanti; Saputri, Fadlina Chany; Hayun, Hayun
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp35

Two of Mannich bases derivatives of 4’-methoxy-substituted of asymmetrical cyclovalone analog (ACA) (2a and 2b) were synthesized. The synthesized compounds and the other two Mannich bases derivatives of 4'-methoxy-substituted ACA (2c and 2d) were evaluated for their in-vitro anti-inflammatory activity preliminary by protein denaturation inhibition method using a final concentration of 1.57 μM. The study found that all the Mannich bases exhibited anti-inflammatory potential with inhibition ranging from 33.17- 42.47%. The activity of 2b (42,47%) and 2d (41.90%) was higher than that of diclofenac sodium (35.27%) and the parent compound 1 (38.16%). As a conclusion, 2b and 2d have a prospect as a potential candidate for an anti-inflammatory agent. Further study should be done using more specific methods.

Formulasi Serum sebagai Penyembuh Luka Bakar Berbahan Baku Utama Serbuk Konsentrat Ikan Gabus (Channa striatus) SITI MARDIYANTI; EFFIONORA ANWAR; FADLINA CHANY SAPUTRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Ikan gabus (Channa striatus) diketahui dapat menyembuhkan luka karena mengandung kadar tinggi protein, asam amino esensial dan asam lemak yang berperan dalam proses penyembuhan luka. Tujuan dari penelitian ini adalah membuat serum sebagai penyembuh luka bakar yang mengandung serbuk konsentrat ikan gabus (Channa striatus) yang telah dibuat gelasi ionik dengan kitosan dan natrium tripolifosfat sebagai zat aktif. Serbuk konsentrat ikan gabus dengan kosentrasi 7,5% (formula 1), 10% (formula 2) dan 12,5% (formula 3). Selanjutnya dibuat menjadi serum dengan menggunakan kolagen dan gelatin sebagai bahan pengental. Sediaan serum yang dihasilkan dikarakterisasi in vitro dan dievaluasi secara in vivo penyembuhan luka bakar derajat dua (deep partial thickness) pada kelinci. Suspensi dan serum yang dihasilkan dikarakterisasi secara fisik maupun kimia. Hasil pengukuran suspensi formula 1, 2 dan 3 adalah sebagai berikut: ukuran partikel berturut–turut 42,67-204,23 nm, 70,81-257,11 nm, 128,86-323,68 nm; nilai potensial zeta (+)16,9 mV, (+)18,3 mV, (+)8,4 mV; ketiga formula memiliki partikel berbentuk sferis. Dari hasil uji in vivo dan analisa histologi sediaan serum serbuk konsentrat ikan gabus-kitosan tripolifosfat dapat digunakan sebagai penyembuh luka bakar derajat dua dalam.

Pengaruh Metode Ekstraksi Terhadap Kandungan Senyawa Polifenol dan Aktivitas Antioksidan pada Rubus fraxinifolius Yesi Desmiaty; Berna Elya; Fadlina Chany Saputri; Iis Irawatty Dewi; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Rubus fraxinifolius can be founded in the mountainous regions of West Java. Previous studies have shown that this plant has potent antioxidant activity. The content of polyphenol compounds in this species contributes substantially to antioxidant activity, and the extraction method will affect the content of the compound. In this study an evaluation of the extraction method effect on leaves, young fruits and stems of R. fraxinifolius on the content of polyphenols and their antioxidant activity, have been done. Method: The leaves, fruits, and stems of R. fraxinifolius were extracted by maceration, reflux, and soxhlet using methanol as a solvent. Each extract was determined the total polyphenol content using Folin-Ciocalteu reagent and antioxidant activity test using DPPH reduction method. Result: The highest extract yield was R. fraxinifolius leaf reflux extract (30.20%). The highest total polyphenol content was given by the Soxhlet extract of leaf R. fraxinifolius (48.79 mg GAE / g extract). The highest antioxidant activity was leaf Soxhlet extract of R. fraxinifolius (98.29% at 100 ppm). Conclusion: From this study it was shown that the methanol extract of R. fraxinifolius leaves extracted by Soxhlet gave the highest polyphenol content and antioxidant activity.

Pengembangan Metode Induksi Tukak Lambung Saputri, Fadlina Chany; Sari, Santi Purna; Munim, Abdul
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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Scientific evaluation on pharmacological activity of medicinal herbs required repro-ducible and valid method-induced ulcer models in animal. In this study, the method of antiulcerogenic effect was investigated using several inducers. The male white Sprague-Dawley rats divided into five groups which were orally administrated water, indomethacin (48 mg/kg bw), aspirin-HCl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. The result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer index. Histological examination of the stomach showed abnormality of mucosa cells on the aspirin-HCl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.

Removal of Mimosine from Leucaena leucocephala (Lam.) de Wit Seeds to Increase Their Benefits as Nutraceuticals Wardatun, Sri; Harahap, Yahdiana; Mun'im, Abdul; Saputri, Fadlina Chany, Dr.; Sutandyo, Noorwati
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

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The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value. The extraction yields show the number of compounds that have been extracted by solvent. However, Leucaena leucocephala (Lam.) de Wit seeds also contain mimosine, which can cause hair loss. The present study investigated the process of removing mimosine from the seeds. Three treatments were applied to these seeds: treatment without soaking, soaking with distilled water for 24 hours, and splitting the seeds in half and then soaking with distilled water for 24 hours. The seeds were dried, ground, and then extracted with different concentrations of ethanol solvent. The mimosine levels of the extracts were measured with a JascoV-730 spectrophotometer using ferry chloride as a reagent. The results showed that the soaking process and the concentration of ethanol had significant effects on the extract yields and mimosine levels. The unsoaked seeds, extracted with 70% ethanol, produced the highest ratio of extract yield to mimosine level. Therefore, 70% ethanol can be used as a solvent to utilize unsoaked seeds as nutraceuticals.

Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum americanum L.) pada Tikus Putih Jantan yang Diinduksi Karagenan Saputri, Fadlina Chany; Zahara, Rita
Pharmaceutical Sciences and Research Vol. 3, No. 3
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is an aromatic plant that contains citral and known as anti-inflammatory agents. The aim of this study was to determine the anti-inflammatory activity of the essential oil kemangi leaves on carrageenan-induced rat. The male rats were divided into six groups, each consisting of four rats. Group I as negative control was given 0.5% CMC solution, group II as positive control was given diclofenac sodium, group III was given sitral, groups IV, V and VI were given 40 mg/200 g BW, 80 mg/200 g BW, and 160 mg/200 g BW essential oil of Ocimum americanum L., emulsified in 0.5% CMC solution. After 30 minutes of test substance administration, left paw of rats injected by 0.2 mL of carrageenan to induce edema. Edema volume was measured using pletismometer every hour for six hours. The result showed that at dose 160 mg/200 g BW gives the best effect in inhibited the inflamation response 44,83%. There was significant difference (p < 0.05) at dose 160 mg/200 g BB to negative control. From this study can be concluded that essential oil kemangi leaves has anti-inflammatory activity.

Pengaruh Pemberian Minyak Atsiri Daun Kemangi (Ocimum americanum L.) Terhadap ~ Motilitas Usus Mencit Putih Jantan Sriyani, Dewi; Saputri, Fadlina Chany
Pharmaceutical Sciences and Research Vol. 3, No. 1
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is a well known plant that contains essential oils with citral as a major compound. Citral is reported to have beneficial effect on intestinal motility. In the present study, we investigated the effect of essential oil of kemangi leaves (Ocimum americanum L.) on male DDY mices intestinal motility. Thirty mices were divided into six groups and each group was pretreated with 0,2 ml of 0,5% CMC (negative control), 1 mg/kg BW of atropine sulfate (positive control), 5 mg/kg BW of citral (comparative control), and three dose variation of volatile oil of kemangi leaves (25 mg/kg BW; 50 mg/kg BW; 100 mg/kg BW) orally. All mices were given charcoal meal suspension 0,2 ml orally, and the animals were sacrificed. The percentage ratio and inhibition were analysed by measure the intestinal transit of charcoal. The results showed that the essential oil of kemangi leaves dose 100 mg/kg BW significantly (p < 0.05) reduced intestinal transit in mice with the percentage ihibition value of 59,79%. This value is not significant different (p > 0.05) compared with citral and atropine sulfate. It is concluded that the essential oil of kemangi leaves has potential effect as antispasmodic agent.

Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats Imam Syafi'i; Fadlina Chany Saputri; Berna Elya
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5975

High blood pressure can be caused by excess salt intake Dexamethasone is a potent anti-inflammatory drug, but the long-term administration can cause hypertension. This study aims to determine the accurate time and dose that cause hypertension in rat models by administration of a combination of dexamethasone and 5% NaCl solution. The control group was administrated with aquadest orally, 3 test groups were administrated with dexamethasone at a doses of 0.02mg/kg BW, 0.03mg/kg BW, and 0.5mg/kg BW intraperitonially (i.p) for 28 days. A 5% NaCl solution were administrated instead of drinking water to the test group. Blood pressure and body weight were measured weekly for 28 days. Results of the study show that Dexamethasone at a dose of 0.02mg/kg BW caused hypertension on day-28 where the rats blood pressure increase to 148mmHg/103mmHg (±1.9/±3.1) (P0.05) compared to control rats and the weight decline by 90 grams. Dexamethasone 0.03mg/kg BW caused hypertension on day-21, with the increase of rats blood pressure at144mmHg/101mmHg (±2,6/±3.2) (P0.05) compared to control and the weight decrease by 83 grams. Dexamethasone 0.5mg/kg BW caused hypertension on day-7, the rats blood pressure rise to 146mmHg/103mmHg (±1.6/1.9) (P0.05) compared to control and the weight decrease by 69 grams. As conclusion, Dexamethasone at dose of 0.5mg/kg BW and NaCl 5% cause hypertension faster on day 14 compared to dexamethasone at dose of 0.02mg/kg BW and NaCl 5% which cause hypertension slower after 28 days of administration.

Metabolic Syndrome Induced by Hipercalory Diet in Wistar Rats: impact on diabetic risk, dyslipidemia and hypertension complication Dimas Thoriq Muhammad Iqbal; Fadlina Chany Saputri; Abdul Mun’im; Vicko Suswidiantoro
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No S1: Supplement
Publisher : Universitas Aisyah Pringsewu

Objective: Metabolic syndrome is a group of metabolic disorders that are usually found in individuals with a high risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Comparison of diet composition, especially macronutrients, over a certainperiode in both humans and experimental animals can allegedly increase the risk of metabolic syndrome. This study aims to determine the use of a hypercaloric diet that can cause metabolic syndrome in male Wistar rats. Methods: The hypercaloric diet was administered orally in pellets and oral solution to rats for 16 weeks. Analysis of the condition of the metabolic syndrome was carried out by looking at the increase in serum levels of total cholesterol, triglycerides and decreased HDL levels. Fasting blood sugar and fasting insulin levels were also seen to increase and blood pressure testing was carried out to see an increase in blood pressure after 16 weeks of giving a hypercaloric diet. Results: Administration of a hypercaloric diet showed an increased risk of metabolic syndrome in rats. Administration for 16 weeks showed a significant difference in the improvementofs conditions of dyslipidemia, insulin resistance and hypertension. Conclusion: Based on the results, a hypercaloric diet for 16 weeks can cause metabolic syndrome in rats. Abstrak: Objektif: Sindrom metabolik adalah sekelompok kelainan metabolik yang biasanya ditemukan pada individu dengan risiko tinggi diabetes militus tipe 2 (T2DM) dan penyakit kardiovaskular. Perbandingan komposisi diet khususnya makronutrien, dalam jangka waktu tertentu baik pada manusia maupun hewan coba disinyalir dapat meningkatkan resiko dari sindroma metabolik. Penelitian ini bertujuan untuk menentukan penggunaan diet hipercalori yang dapat menyebabkan kondisi sindrome metabolikpada tikus Wistar jantan. Metode:diet hiperkalori diberikan secara oral dalam bentuk pelet dan larutan oral pada tikus selama 16 minggu. Analisis terhadap kondisi syndrome metabolic dilakukan dengan melihat peningkatan kadar serum kolesterol total, trigliserida dan penurunan kadar HDL. Kadar gula darah puasa dan insulin puasa juga dilihat peningkatannya serta dilakukan pengujian tekanan darah untuk melihat terjadinya peningkatan tekanan darah setelah 16 minggu pemberian diet hiperkalori. Hasil: Pemberian diet hiperkalori menunjukkan adanya peningkatan risiko sindrom metabolic pada tikus. Pemberian selama 16 minggu menujukkan adanya perbedaan signifikan pada peningkatan kearah kondisi dyslipidemia, resistensi insulin dan hipertensi. Kesimpulan: Berdasarkan hasil, pemberian diet hiperkalori selama 16 minggu dapat menyebabkan terjadinya kondisi sindrom metabolic pada tikus

Memory Loss induced by Aspartame in Albino Rats: Study on neurobehavioral changes Suswidiantoro, Vicko; Saputri, Fadlina Chany; Mun'im, Abdul
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 2: June 2021
Publisher : Universitas Aisyah Pringsewu

Objective: Aspartame (ASP) consumption in various food and beverage products has generated a lot of controversy on safety. Many reports, ASP caused deterioration of health condition likes diabetes, psychiatric disorders, memory loss, etc. This study aimed to investigate the optimization duration of ASP to induce memory loss in Sprague Dawley rats. Methods: The ASP was administered 40 mg/kg BW orally for 28 days in rats. Analysis of memory loss by neurobehavioural changes including latency time, length of track, per cent time and frequency target quadrant using Morris Water Maze (MWM) at day 14, 21, 28, and 24 hours after the last treatment. Results: The administration of ASP showed the time-dependent changes for each indicator of neurobehavioural. The results demonstrated during 28 days of induction showed a significant decrease in latency time, length of track, per cent time and frequency target quadrant. Conclusion: From the results, it can be concluded administration of ASP during 28 days induce neurobehavioural changes related to memory loss in rats. Abstrak: Objektif: Penggunaan aspartame (ASP) sebagai pemanis buatan yang banyak terdapat pada makanan, dan minuman menimbulkan berbagai kontroversi dalam hal keamanan. Berbagai data menunjukkan ASP dapat menyebabkan gangguan kesehatan seperti diabetes, gangguan psikiatrik, penurunan fungsi memori, dll. Penelitian ini bertujuan untuk menentukan waktu durasi penggunaan ASP yang dapat menyebabkan gangguan fungsi memori pada tikus Sprague Dawley. Metode:ASP diberikan secara oral pada tikus dengan dosis 40 mg/kg BB selama 28 hari. Analisis terhadap fungsi memori dilakukan dengan adanya perubahan perilaku pada hewan, meliputi waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran menggunakan Morris Water Maze (MWM) setelah 24 jam setelah pemberian pada hari ke 14,21, 28. Hasil: Pemberian ASP menunjukkan adanya perbedaan waktu pada setiap indicator perilaku. Pemberian selama 28 hari menujukkan adanya perbedaan signifikan pada penurunan waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran. Kesimpulan: Berdasarkan hasil, pemberian ASP selama 28 hari dapat menyebabkan adanya perubahan perilaku yang berkaitan dengan fungsi memori pada tikus.

Co-Authors Abdul Malik Abdul Mun'ím Abdul Mun'im Abdul Munim Abdul Mun’im Ahmad, Aktsar Roskiana Arry Yanuar Asriani Suhaenah Bayu Putra, Bayu Bayu, Asep Berna Elya Chianese, Giuseppina Dewi Sriyani Dewi Sriyani, Dewi Dimas Thoriq Muhammad Iqbal Effionora Anwar Effionora Anwar Fahleni Fahleni Hariyanti Hariyanti Hayati Hayati Hayun, Hayun Iis Irawatty Dewi Imam Syafi'i Mahdi Jufri Muhammad Hanafi Mun'im, Abdul Ni Putu Ermi Hikmawanti Noorwati Sutandyo Nur Rahmawati Putra, Masteria Yunovilsa Raditya Iswandana Rahmawati, Siti Irma Ratih Asmana Ningrum Rita Zahara Rita Zahara, Rita Rizqi Nur Azizah Santi Purna Sari Santi Purna Sari Silvia Surini SITI MARDIYANTI Sri Wardatun Suswidiantoro, Vicko Tri Nofi Yani Wahda Fitria Widiani Batubara, Risa Yahdiana Harahap Yani, Tri Nofi Yesi Desmiaty, Yesi Yunas, Ranum Wanudya

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