Key research themes
1. How do circadian rhythms and chronotype govern the timing and regulation of wake-up behavior in humans?
This research area investigates the endogenous circadian mechanisms underlying sleep-wake cycles, focusing on how individual differences in chronotype (morningness-eveningness) influence the timing of wake-up and sleep episodes. Understanding these relationships is critical for elucidating physiological variability in wake timing, phase angle differences between sleep-wake schedules and circadian markers, and how circadian misalignment may manifest in disorders.
2. What are the effects of split versus consolidated sleep-wake schedules on wakefulness, sleepiness, and neurobehavioral performance?
This theme addresses how dividing sleep and wake periods into multiple shorter episodes (split schedules) compared to a consolidated single sleep episode impacts subjective sleepiness, sleep architecture, and objective neurobehavioral performance. This is significant for operational settings requiring continuous wakefulness, as scheduling manipulations may mitigate circadian and homeostatic sleep pressure-driven impairments in wake-up timing and alertness.
3. How can mathematical models predict human wake-up timing, alertness, and neurobehavioral performance under varying sleep schedules and sleep deprivation?
This research stream focuses on developing and validating mathematical and computational models integrating circadian and homeostatic processes to predict performance, sleepiness, and wake timing. Such models are foundational for understanding sleep-wake regulation and optimizing wake-up scheduling in operational and clinical contexts.