articles by Sukanth Kumar
Springer Nature, 2024
regions around the world. There are four known henipavirus species that infect humans: Nipah heni... more regions around the world. There are four known henipavirus species that infect humans: Nipah henipavirus, Hendra henipavirus, Cedar henipavirus, and Langya henipavirus. Henipaviruses are classified under the family Paramyxoviridae and belong to the genus Henipavirus. The deadliest strains, with fatality rates of 60% and 90% in humans, are
SARS-CoV-2 and its repercussive effect on reproductive health: recent trends
An invited commentary article on SARS-COV-2 and its impact on male and female fertility.
Journal of Biomolecular Structure and Dynamics, 2020
SARS-CoV-2 a virus which caused the global pandemic the Coronavirus Disease- 2019 (COVID-2019) ha... more SARS-CoV-2 a virus which caused the global pandemic the Coronavirus Disease- 2019 (COVID-2019) has infected about 1,203,959 patients and brought forth death rate about 64,788 among 206 countries as mentioned by WHO in the month of April 2020. The clinical trials are underway for Remdesivir, an investigational anti-viral drug from Gilead Sciences. Antimalarial drugs such as Chloroquine and Hydroxychloroquine derivatives are being used in emergency cases; however, they are not suitable for patients with conditions like diabetes, hypertension and cardiac issues. The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. This paper evaluates the compound Andrographolide from Andrographis paniculata as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction. Andrographolide was docked successfully in the binding site of SARS-CoV-2 Mpro. Computational approaches also predicts that this molecule to have good solubility, pharmacodynamics property and target accuracy. This molecule also obeys Lipinski’s rule, which makes it a promising compound to pursue further in biochemical and cell based assays to explore its potential for use against COVID-19.
Papers by Sukanth Kumar
Journal of Biomolecular Structure and Dynamics, 2020
SARS-CoV-2 virus which caused the global pandemic the Coronavirus Disease-2019 (COVID-2019) has i... more SARS-CoV-2 virus which caused the global pandemic the Coronavirus Disease-2019 (COVID-2019) has infected about 1,203,959 patients and brought forth death rate about 64,788 among 206 countries as mentioned by WHO in the month of April 2020. The clinical trials are underway for Remdesivir, an investigational anti-viral drug from Gilead Sciences. Antimalarial drugs such as Chloroquine and Hydroxychloroquine derivatives are being used in emergency cases; however, they are not suitable for patients with conditions like diabetes, hypertension and cardiac issues. The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. This paper evaluates the compound Andrographolide from Andrographis paniculata as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction. Andrographolide was docked successfully in the binding site of SARS-CoV-2 Mpro. Computational approaches also predicts this molecule to have good solubility, pharmacodynamics property and target accuracy. This molecule also obeys Lipinski's rule, which makes it a promising compound to pursue further biochemical and cell based assays to explore its potential for use against COVID-19.
Future Virology
Large-scale studies on both male and female reproductive systems should be conducted to elucidate... more Large-scale studies on both male and female reproductive systems should be conducted to elucidate the underlying mechanisms and investigate the effect of SARS-CoV-2 infection during and after infection. "
Future Virology
Large-scale studies on both male and female reproductive systems should be conducted to elucidate... more Large-scale studies on both male and female reproductive systems should be conducted to elucidate the underlying mechanisms and investigate the effect of SARS-CoV-2 infection during and after infection. "
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articles by Sukanth Kumar
Papers by Sukanth Kumar