Papers by Sureshkumar Sivanpillai
On the Occurrence and DNA Barcoding of Darwin’s Slimehead, Gephyroberyx darwinii (Johnson, 1866) in the Laccadive Archipelago, Western Indian Ocean
Thalassas: an International Journal of Marine Sciences, Jun 2, 2023
Bioinformation, Aug 31, 2015
The present AChE inhibitors have been successful in the treatment of Alzheimer's Diseases however... more The present AChE inhibitors have been successful in the treatment of Alzheimer's Diseases however suffers serious side effects. Therefore in this view, the present study was sought to identify compounds with appreciable pharmacological profile targeting AChE. Analogue of Rivastigmine and Fluoxetine hybrid synthesized by Toda et al, 2003 (dataset1), and Coumarin-Tacrine hybrids synthesized by Qi Sun et al (dataset2) formed the test compounds for the present pharmacological evaluation. p-cholorophenyl substituted Rivastigmine and Fluoxetine hybrid compound (26d) from dataset 1 and-OCH3 substitute Coumarin-Tacrine hybrids (1h) from dataset 2 demonstrated superior pharmacological profile. 26 d showed superior pharmacological profile comparison to the entire compounds in either dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify still better compound with pharmacological profile than 26 d and 1h, virtual screening was performed. The best docked compound (PubCId: PubCid: 68874404) showed better affinity than its parent 26 d, however showed poor ADME profile and AMES toxicity. CHEMBL2391475 (PubCid: 71699632) similar to 1h had reduced affinity in comparison to its parent compound 1h. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer's disease.
Asian Pacific Journal of Cancer Prevention, 2016
Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibito... more Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.
Current neuropharmacology, Nov 13, 2016
Two different sets of AChE inhibitors, dataset-I (30 compounds) and dataset-II (20 compounds) wer... more Two different sets of AChE inhibitors, dataset-I (30 compounds) and dataset-II (20 compounds) were investigated through MLR aided linear and SVM aided non-linear QSAR models. The obtained QSAR models were found statistically fit, stable and predictive on validation scales. These QSAR models were further investigated for their common structure-activity relationship in terms of overlapping molecular descriptors selection. Atomic mass weighted 3D Morse descriptors (MATS5m) and Radial Distribution Function (RDF045m) descriptors were found in common SAR for both the datasets. Electronegativity weighted (MATS5e, HATSe, and Mor17e) descriptors have also been identified in regulative roles towards endpoint values of dataset-I and dataset-II. The common SAR identified in these linear and non-linear QSAR models could be utilized to design novel inhibitors of AChE with improved biological activity.
A new species of spiny eel of the genus Notacanthus Bloch 1788 (Notacanthiformes: Notacanthidae) from the Indian Ocean
Journal of Fish Biology
Extremely heavy rainfall has been occurred over Kerala, southwest coast of India, during mid-Augu... more Extremely heavy rainfall has been occurred over Kerala, southwest coast of India, during mid-August 2018. The meteorological conditions during this period are analysed, and it is found that a combination of many rain favouring conditions prevailed at that time. The positive phase of Madden Julian Oscillation coupled with a monsoon depression in the Bay of Bengal and a weak trough in the south-eastern Arabian Sea strengthened the Monsoon Low Level Jet bringing moisture-laden winds over Kerala. The rising limb of Walker and Hadley circulations was also found over Kerala, which gave favourable updraft for cloud formation. In addition, the core of the Tropical Easterly Jet was found over the Kerala and Karnataka region. The cyclonic circulation in the mid-troposphere observed around the monsoon depression extended up to the west coast of India. Simultaneous occurrences of all these could have contributed to the extreme rainfall events and severe floods over Kerala.
Aquaculture, 2020
Light is one of the most important structuring factors for life in aquactic biology. For zooplank... more Light is one of the most important structuring factors for life in aquactic biology. For zooplankton grazers, including copepods, light offers a behavioral dilemma that is potentially present at both small and large scales. We investigated the grazing rate, clearance rate, fecal pellet production rate, egg production rate, percertage of egg hatching and survival percentage of the freshwater copepod Thermocyclops deceipiens under different light intensities (0 lx, 500 lx, 1500 lx) over periods of 15 days. For the grazing experiment the fresh water microalgae Chlorella vulgaris was used at concentrations 2-6 × 10 6 cells/mL −1. The grazing rates of the copepod decreased at higher light intensities when compared to other treatments. Maximum grazing rate and the clearance rate occurred in the treatment with 500 lx (70,490 cells copepod −1 h −1 , 0.23 mL copepod −1 h −1). Egg production rate and hatching rate percentage (17.4 eggs female −1 day −1 , 99 ± 0.98%) were also higher at the algae fed with 500 lx light intensity. Copepods survived well and continuously produced fecal pellets on a 500 lx light intensity diet of Chlorella vulgaris. The results suggest that low light intensity influenced the grazing rate, fecundity and survival of copepod T.decipiens.
Journal of Marine Science and Engineering
Chitons (Polyplacophora) are marine molluscs that mostly inhabit rocky intertidal shores. Their b... more Chitons (Polyplacophora) are marine molluscs that mostly inhabit rocky intertidal shores. Their biological and phylogenetic studies are comparatively sparse in the western Indo-Pacific regions. In addition, chitons belonging to the subfamily Acanthopleurinae Dall, 1889, collected from the Andaman Sea of the northeastern Indian Ocean and the Jizan coast of Saudi Arabia were sequenced and analyzed to study the phylogenetic affinities. The analysis was carried out using a single locus dataset (cytochrome oxidase 1) generated during the present study and integrated with sequences retrieved from GenBank. Acanthopleura gemmata (Blainville, 1825) from India was linked to Acanthopleura vaillantii Rochebrune, 1882, from the Saudi Arabia coast. Squamopleura miles (Carpenter in Pilsbry, 1893) from the Indian coast forms a separate clade representing the genus. Furthermore, the results illustrate several significant instances of misplacement of several species under the wrong genus and the exis...
Aquaculture Research, 2019
Live feeds, including phytoplankton and zooplankton, are suitable starter feed for many aquacultu... more Live feeds, including phytoplankton and zooplankton, are suitable starter feed for many aquaculture species. It contains high nutritional components of macro-and micronutrients; hence, they are commonly known as 'living capsules of nutrition'. Live feed organisms being freely swimming in the water, and continuosly available to newly hatched fish larvae. Their mobility in water column stimulates a feeding response in larvae due to their jerking movements (Bengtson, 2007). Zooplanktons have recognized as an important natural basic diet for many fish and shrimps. Most fish and prawn species rely on zooplankton during some life stages, and some feed exclusively on zooplankton throughout their life. Live feed is particularly essential for the growth of larval forms in aquaculture, as they more easily ingested and digested (Kinne, 1997), they do not affect the water quality (Watanabe, Oowa, Kitajima, & Fujita, 1978) and contain essential growth factors such as fatty acids and amino acids. Conventional live feeds include rotifers (e.g. Brachionus sp.), copepods and freshwater cladocerans (e.g. Daphnia sp. and Moina sp.) all of which have a high reproductive potential, ability to attain a massive rate in short period and capability to survive in adverse conditions (Neelakantan, Naik, Prasad, & Kusuma, 1988). Most of the live feed species provide superior nutritional prey for many aquaculture species (
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Papers by Sureshkumar Sivanpillai