Dietary Fermented Rice Bran Is an Effective Modulator of Ulcerative Colitis in Experimental Animal
IntechOpen eBooks, Nov 23, 2022
Ulcerative colitis (UC) is an inflammatory disorder with colon and rectum, characterized by recur... more Ulcerative colitis (UC) is an inflammatory disorder with colon and rectum, characterized by recurring bloody diarrhea due to microbial dysfunction and some autoimmune response. Scientists have linked microbial disruption in the gut to several chronic conditions such as UC and other types of inflammatory bowel disease (IBD). Surprisingly, our gastrointestinal tract contains more than 100 trillion microbial cells. Some microbes in the gut microbiome are friendly bacteria that can help to treat UC by influencing metabolism, nutrition, immune function, and more in the gut. The conventional medical treatment of UC relies on the use of amino-salicylates, corticosteroids, immunosuppressive drugs, glucocorticoids, and antibiotics. Multiple new mechanisms in the treatment of UC are being developed and many are showing promising results in ulcerative colitis. Still need scientific evidence to support the role of gut microbiota in the etiology of UC. The dietary fermented rice bran (DFRB) may include the active potential for the treatment of ulcerative colitis. The DFRB may attenuate intestinal inflammation by regulating gut permeability for cellular infiltration and maintenance of luminal safety with favorable efficacy in UC. In this chapter, we discussed and summarized the insight mechanism of DFRB’s modulatory activities for the management or treatment of ulcerative colitis.
Perspective Chapter: Exercise-Eating Pattern and Social Inclusion (EES) is an Effective Modulator of Pathophysiological Hallmarks of Alzheimer’s Disease
Hospital pharmacy and graduate pharmacists are part and parcel of a proper healthcare system. Thi... more Hospital pharmacy and graduate pharmacists are part and parcel of a proper healthcare system. This study aims to assess Bangladesh's current hospital pharmacy practice and drug management system. A face-to-face interview-based survey was designed, and 15 hospitals of Khulna Division of Bangladesh were subjected to evaluation by a close-ended questionnaire containing 17 questions regarding hospital pharmacy practice and drug management system. Among 15 hospitals, 67% had hospital pharmacy services, whereas 47% had “C” grade pharmacists, and 53% of hospitals had no narcotic drug locker. Surprisingly, 87% of hospitals had no PTC (pharmacy and therapeutic committee), and 40% had no control over drug abuse. Besides, only 6.67% of hospitals had graduate pharmacists (A grade pharmacists), and 33% had no pharmacists. Furthermore, 67% of hospitals provided drug-using information, and 60% of hospitals provided no dosing information to their patients. Moreover, 40% did not maintain the rec...
Comparative Phytochemical and Antimicrobial Study of Ultrasound-Assisted Aqueous Extract from Fresh Plants of Bryophyllum pinnatum with Conventional Extraction Method
Bryophyllum pinnatum is a potential medicinal plant widely used in different tribes in Bangladesh... more Bryophyllum pinnatum is a potential medicinal plant widely used in different tribes in Bangladesh. The leaves of B. pinnatum were used in the present study for the compatibility assessment of a proposed ultrasound-assisted green extraction method with the conventional extraction method. An aqueous Ultrasound-Assisted Extraction (UAE) by using both fresh and dried leaves of B. pinnatum was proposed in the present study and successively compared with the traditional methanolic and aqueous (decoction) extraction method. The promising extraction yield was found through the proposed extraction method which was much better than decoction and almost similar to the methanolic extraction method. Phytochemical contents were also observed similar to the methanolic extract. Both methanolic and UAE extracts obtained from B. pinnatum leaves showed favorable antimicrobial sensitivity against both grams positive (Staphylococcus aureus and Streptococcus pyogenes) and gram-negative (Escherichia coli and Salmonella typhi) bacteria. Extracts obtained from the decoction method showed slightly poor antimicrobial activities. The difference in efficiency and efficacy of aqueous UAE extract obtained from fresh and dried leaves was observed insignificant. This indicates there is no necessity to impart the drying stage before extraction normally practiced in the conventional extraction method. Drying of plant material is a common stage of the conventional extraction cycle which ultimately lengthy the process and impose cost due to energy consumption and labor. Ultrasound-assisted extraction may successfully decrease the overall extraction cycle and ultimately reduce the overall cost of extraction. This method also creates opportunities to replace the water instead of with hazardous organic solvent for phytochemical extraction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jun 10, 2016
Activation of inflammatory signaling pathways links obesity with metabolic disorders. TLR4-mediat... more Activation of inflammatory signaling pathways links obesity with metabolic disorders. TLR4-mediated activation of MAPKs and NF-κB are 2 such pathways implicated in obesity-induced inflammation. Apolipoprotein A-I (apoA-I) exerts anti-inflammatory effects on adipocytes by effluxing cholesterol from the cells via the ATP binding cassette transporter A1 (ABCA1). It is not known if these effects involve inhibition of inflammatory signaling pathways by apoA-I. This study asks if apoA-I inhibits activation of MAPKs and NF-κB in mouse 3T3-L1 adipocytes and whether this inhibition is ABCA1-dependent. Incubation of differentiated 3T3-L1 adipocytes with apoA-I decreased cell surface expression of TLR4 by 16 ± 2% and synthesis of the TLR4 adaptor protein, myeloid differentiation primary response 88, by 24 ± 4% in an ABCA1-dependent manner. ApoA-I also inhibited downstream activation of MAPKs, such as ERK, p38MAPK, and JNK, as well as expression of proinflammatory adipokines in bacterial LPS-st...
Urinary tract infections (UTIs) are broadly common in inpatient and outpatient males and females ... more Urinary tract infections (UTIs) are broadly common in inpatient and outpatient males and females of different ages and comprise 40% of the nosocomial infections that collectively cause 150 million deaths per year. The right care is obligatory if the patients do not want to die, but this is hard to do because the things that make people sick are getting better at resisting antibiotics (AMR). Collected specimens were examined microscopically and cultured on Cystine Lactose Electrolyte Deficient (CLED) agar to isolate the pathogens. Isolated pathogens were identified through colony morphology, microscopic studies, and biochemical indications. Lastly, antimicrobial responsiveness patterns of the pathogens were determined by the disc diffusion method to find possible antibiotics that could treat the disease well. Among 17.67% of positive cultures, 73.58% were females, and 26.42% were males, dominated by the age group ≥ 37 years (49.06%). E. coli (56.6%), Enterococcus faecalis (26.4%), Pseudomonas aeruginosa (7.5%), Staphylococcus aureus (3.8%), Acinetobacter baumannii (3.8%). Moreover, Serratia marcescens (1.9%) were the isolated pathogens, with 69.8% Gram-negative and 30.2% Gram-positive. The most effective antibiotics were amikacin (88.68%), levofloxacin (88.68%), ciprofloxacin (86.79%), gentamicin (84.91%), and imipenem (84.91%). The least effective antibiotics were mecillinam (50.94%), cefuroxime (37.74%), ceftazidime (37.74%), meropenem (35.85%), and cefotaxime (33.96%). To treat and suggest antimicrobials, routine and emphatic research about urogenital pathogens and their antibiotic susceptibilities is required. Patients should be prescribed appropriate antimicrobial therapies after completing a standard test of pathogen identification and antibiotic resistance pattern determination. This study would be of extensive importance to patients and physicians in picking appropriate antimicrobial therapies for empiric treatment.
Journal of Advances in Medical and Pharmaceutical Sciences, 2021
This work was carried out in collaboration among all authors. Author MEHM and MZA conceived and p... more This work was carried out in collaboration among all authors. Author MEHM and MZA conceived and planned the experiments. MIS, MAS, FY, and MA conducted the survey and performed the analysis. MZA and MEHM contributed to the interpretation of the results and took the lead in writing the manuscript. FAK, MEA, NEKF, MRK, MA, AA and MK supervised and reviewed the manuscript. All authors provided critical feedback and helped shape the research, analysis, and manuscript as a whole. All authors read and approved the final manuscript.
Background Crude ethanolic extracts of leaves and stem of Physalis minima (Solanaceae) were evalu... more Background Crude ethanolic extracts of leaves and stem of Physalis minima (Solanaceae) were evaluated for in vitro anthelmintic activity on the Bangladeshi mature parasitic flatworm Paramphistomum cervi (Trematoda) in cattle. To compare the test results, Albendazole was used as a standard drug. Methods A leaves and stem extract of the P. minima was prepared in a Soxhlet apparatus using ethanol as a solvent. After concentrating in a vacuum rotary evaporator, the extract was analyzed for phytochemical activities. In vitro anthelmintic activity was tested against the flat worm P. cervi. Results The results of anthelmintic activity of P. minima were evaluated by paralysis instead of taking as of the paralysis time and death time of the flatworm. The study concluded that the ethanolic leaves and stem extracts of P. minima had anthelmintic activity in a dose-dependent inhibition of spontaneous motility of flatworm. From the screening experiment, the crude extracts showed the best anthelmi...
Journal of Advances in Medical and Pharmaceutical Sciences, 2021
Antibiotics, alternatively known as antibacterial drugs, prevent or reduce the development of ger... more Antibiotics, alternatively known as antibacterial drugs, prevent or reduce the development of germs. A decade has been added to the life expectancy of human beings since the discovery of antibiotics. Antibiotic overuse can result in resistance to a wide spectrum of diseases and bacteria. Antibiotic utility is being jeopardized by the rise of resistance. There aren't enough innovative agents to deal with the problem of resistant strains. The current study targeted to highlight the current status of antibiotic use.The study was designed as a prescription-based survey where the medicines in prescriptions were checked containing antibiotics, whether the drugs were prescribed rationally or not. The study was conducted from February to July 2018 at Khwaja Yunus Ali Medical College and Hospital, Bangladesh. Patient’s data were collected through review of patient medical records and prepared questionnaires. 100 people were interviewed, and their prescriptions were captured as photos and...
ETHNOMEDICAL STUDY OF TRADITIONAL HEALER IN BELKUCHI AND CHAUHALI UPAZILA OF SIRAJGONJ DISTRICT OF BANGLADESH
KYAU journal, 2021
The primary goal of this research was the compilation of a list of medicinal plants in the Sirajg... more The primary goal of this research was the compilation of a list of medicinal plants in the Sirajganj district, utilized in the treatment of various diseases by folk practitioners. This was done by conducting a survey of the residents of different sandbars and banks along the river Jamuna. Most of the people who live on the sandbar are gipsy in nature and come from different regions of Bangladesh due to having lost their residence. Most of the people are poor and have very limited capacity to bear the expenses of the modern treatment facilities. They are mostly dependent on their traditional knowledge of medicine and use plant resources to combat the diseases. Sometimes people get suggestions from professional medicinal practitioners who are commonly known as kaviraj. Traditionally, it was observed that elderly people who lived on the sandbar or bank of the river had a rich knowledge of medicinal plants. Method: Both structured and open-ended questions were prepared both in English and Bengali. A list of practitioners was prepared and selected most renowned personnel from them for interview. A trained interviewer was asked the question among the selected practitioners and recorded accordingly. From the survey results, 31 plants from 24 families were identified. The local name was compared with the common name of the medicinal plants' database and identified their botanical nomenclature. It was observed that most of the plants were in the family of liliaceae, caesalpiniaceae, anacardiaceae, myrtaceae, and fabaceae. This survey study was a unique contribution to the treasury of the natural medicinal database of Bangladesh.
Keywords: Folk medicinal practitioner, Family names, Medicinal plants, Common Disease, Treatment
Diabetes mellitus is a metabolic disorder associated with chronic hyperglycemia caused by inherit... more Diabetes mellitus is a metabolic disorder associated with chronic hyperglycemia caused by inherited or acquired deficiency of insulin production or resistance to action of the produced insulin. In the present study fresh leaves extracts of Azadirachta indica, Bryophyllum pinnatum, Carica papayaand Mikania cordatawere selected on the basis of traditional behavior of local people for the treatment of diabetes in Bangladesh. Crude extracts prepared by aqueous UAE method was used in this study on hormone induced diabetic mice by FPG Test. Most of the plants showed marked anti-diabetic properties comparison to the standard antidiabetic drug Glibenclamide.
Background Crude ethanolic extracts of leaves and stem of Physalis minima (Solanaceae) were evalu... more Background Crude ethanolic extracts of leaves and stem of Physalis minima (Solanaceae) were evaluated for in vitro anthelmintic activity on the Bangladeshi mature parasitic flatworm Paramphistomum cervi ( Trematoda ) in cattle. To compare the test results, Albendazole was used as a standard drug. Methods A leaves and stem extract of the P. minima was prepared in a Soxhlet apparatus using ethanol as a solvent. After concentrating in a vacuum rotary evaporator, the extract was analyzed for phytochemical activities. In vitro anthelmintic activity was tested against the flat worm P. cervi. Results The results of anthelmintic activity of P. minima were evaluated by paralysis instead of taking as of the paralysis time and death time of the flatworm. The study concluded that the ethanolic leaves and stem extracts of P. minima had anthelmintic activity in a dose-dependent inhibition of spontaneous motility of flatworm. From the screening experiment, the crude extracts showed the best anthel...
Cancer and metabolic syndrome (MetS) are associated with genetic mutation and often seen as the r... more Cancer and metabolic syndrome (MetS) are associated with genetic mutation and often seen as the results of altered metabolic signals. Several nutraceuticals have been found to be effective in treating these diseases in clinical practice through the modulation of biochemical and clinical endpoints associated with the pathogenesis of cancer and MetS. In line with the availability of multiple interventions that could counteract the metabolic changes, there is mounting evidence for nutraceuticals as potential complementary medicine for these diseases on the foundation of their multi-factorial nature. Although cancer and MetS are the major contributors to deaths globally, the therapeutic effects of nutraceuticals and the role of nutritional genetics and nutritional genomics in the treatment of these diseases have not yet been explored in-depth. In recent years, many studies revealed that certain compounds are able to halt the progression of cancer and MetS and subsequently improve indivi...
Introduction A short flashback of the history of rice grown in the world, domesticated rice speci... more Introduction A short flashback of the history of rice grown in the world, domesticated rice species were grown worldwide among them Oryza sativa and Oryza glaberrima is called Asian rice and African rice respectively. Asian cultivars extensively cultivated Oryza sativa Japonica and Oryza sativa Indica is the history of about 13000 years ago 1. The species Oryza sativa Indica comes from the crosses between Oryza sativa Japonica and local wild rice. The genetic evolution, geographical diversity, land quality, different agronomic practices, and environmental conditions may cause nutritional variation among global rice. The composition of whole rice grain has been divided into several compartments such as edible part 70 , non-edible hull 20 , bran 7-8.5 , and rudiment 2-3 2. Rice bran oil RBO , extracted from rice bran, is gained popularity as a healthy cooking oil in Japan,
Empirical Research Press Ltd., London, United Kingdom, 2022
Bryophyllum pinnatum is a potential medicinal plant widely used in different tribes in Bangladesh... more Bryophyllum pinnatum is a potential medicinal plant widely used in different tribes in Bangladesh. The leaves of B. pinnatum were used in the present study for the compatibility assessment of a proposed ultrasound-assisted green extraction method with the conventional extraction method. An aqueous Ultrasound-Assisted Extraction (UAE) by using both fresh and dried leaves of B. pinnatum was proposed in the present study and successively compared with the traditional methanolic and aqueous (decoction) extraction method. The promising extraction yield was found through the proposed extraction method which was much better than decoction and almost similar to the methanolic extraction method. Phytochemical contents were also observed similar to the methanolic extract. Both methanolic and UAE extracts obtained from B. pinnatum leaves showed favorable antimicrobial sensitivity against both grams positive (Staphylococcus aureus and Streptococcus pyogenes) and gram-negative (Escherichia coli and Salmonella typhi) bacteria. Extracts obtained from the decoction method showed slightly poor antimicrobial activities. The difference in efficiency and efficacy of aqueous UAE extract obtained from fresh and dried leaves was observed insignificant. This indicates there is no necessity to impart the drying stage before extraction normally practiced in the conventional extraction method. Drying of plant material is a common stage of the conventional extraction cycle which ultimately lengthy the process and impose cost due to energy consumption and labor. Ultrasound-assisted extraction may successfully decrease the overall extraction cycle and ultimately reduce the overall cost of extraction. This method also creates opportunities to replace the water instead of with hazardous organic solvent for phytochemical extraction.
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Papers by Afroza Sultana
Keywords: Folk medicinal practitioner, Family names, Medicinal plants, Common Disease, Treatment