Naim Gafor

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Papers by Naim Gafor

Hemodynamic assessment and long term results of femorofemoral bypass grafting

Japanese Journal of Cardiovascular Surgery, 1991

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Discusión y comentarios finales

Discusión y comentarios finales * Mariana Garzón Rogé: Bueno, muchísimas gracias a les cuatro por... more Discusión y comentarios finales * Mariana Garzón Rogé: Bueno, muchísimas gracias a les cuatro por comentarios tan sugerentes. No es mi intención responder, porque no soy les autores. Sí sé por qué los elegí y ciertas maneras de responder a muchas cosas que surgieron aunque, por supuesto, no a todas. De * Discusión final del conversatorio sobre Historia pragmática, una perspectiva sobre la acción, el contexto y las fuentes,

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Kinetische bestimmung der konsekutiven komplexitätskonstanten von Cer(IV)-komplexen mit glycin

Collection of Czechoslovak Chemical Communications, 1964

Synthesis of chitin–bentonite clay based polyurethane bio-nanocomposites

International Journal of Biological Macromolecules, 2010

Chitin based polyurethane bio-nanocomposites (PUBNC) were prepared by emulsion polymerization. A ... more Chitin based polyurethane bio-nanocomposites (PUBNC) were prepared by emulsion polymerization. A mixture of polymer and bentonite clay enriched in montmorillonite (MMT) was formed in emulsion polymerization, in which MMT dispersed differently depending on interaction of MMT with polymer chains. Cation exchange capacity (CEC) of bentonite clay enriched in montmorillonite was found 74 meq/100 g. The existence of the intercalated clay by PU in the hybrid was confirmed using optical microscope (OM) technique. Optical microscope (OM) photographs verified the well dispersed ordered intercalated assembles layers of bentonite in PU matrix.

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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

SUMMARYBackgroundREGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and imdevimab... more SUMMARYBackgroundREGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of REGEN-COV in patients admitted to hospital with COVID-19.MethodsIn this randomised, controlled, open-label platform trial, several possible treatments were compared with usual care in patients hospitalised with COVID-19. Eligible and consenting patients were randomly allocated (1:1) to either usual standard of care alone (usual care group) or usual care plus a single dose of REGEN-COV 8g (casirivimab 4g and imdevimab 4g) by intravenous infusion (REGEN-COV group). The primary outcome was 28-day mortality assessed first among patients without detectable antibodies to SARS-CoV-2 at randomisation (seronegative) and then in the overall population. The trial is registered with ISRCTN (50189673) and clinicaltrials.gov (NCT04381936).FindingsBetween 18...

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The Complex X-ray Properties of 2MASS, Red AGN

ABSTRACT

Evaluation of Hybrid Ventilation Efficiency to Improve the Indoor Air Quality for Patients’ Rooms in Hospitals of Aswan City

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Efeito Da Escovacao Com Dentrificios Clareadores Na Rugosidade Superficial Do Esmalte e Da Dentina

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Wheat bran extracts: a potent source of natural antioxidants for the stabilization of canola oil

Grasas y Aceites, 2011

in a linoleic acid system, total phenolic contents (TPC) and bleachability of -carotene in the l... more in a linoleic acid system, total phenolic contents (TPC) and bleachability of -carotene in the linoleic acid system. Additionally, the canola oil samples were stabilized with crude concentrated extracts and subjected to ambient aging (6 months). The extent of oxidative deterioration was followed by the measurement of peroxide-, p-anisidine-, conjugated dienes-, and trienes-values. The results of ambient stored samples revealed a significant improvement in these oxidation parameters. The overall order of antioxidant activity of the extracts as determined by various antioxidant assays was determined to be; 80% methanolic extract . 100% methanolic extract . 80% acetone extracts . 100% acetone extract. The results of the present comprehensive analysis demonstrate that extracts of the wheat bran indigenous to Pakistan are a viable source of natural antioxidants and might be exploited for commercial and neutraceutical applications.

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Noncoding Mutations of HGF Are Associated with Nonsyndromic Hearing Loss, DFNB39

by Naim Gafor and Kwanghyuk Lee

The American Journal of Human Genetics, 2009

A gene causing autosomal-recessive, nonsyndromic hearing loss, DFNB39, was previously mapped to a... more A gene causing autosomal-recessive, nonsyndromic hearing loss, DFNB39, was previously mapped to an 18 Mb interval on chromosome 7q11.22-q21.12. We mapped an additional 40 consanguineous families segregating nonsyndromic hearing loss to the DFNB39 locus and refined the obligate interval to 1.2 Mb. The coding regions of all genes in this interval were sequenced, and no missense, nonsense, or frameshift mutations were found. We sequenced the noncoding sequences of genes, as well as noncoding genes, and found three mutations clustered in intron 4 and exon 5 in the hepatocyte growth factor gene (HGF). Two intron 4 deletions occur in a highly conserved sequence that is part of the 3 0 untranslated region of a previously undescribed short isoform of HGF. The third mutation is a silent substitution, and we demonstrate that it affects splicing in vitro. HGF is involved in a wide variety of signaling pathways in many different tissues, yet these putative regulatory mutations cause a surprisingly specific phenotype, which is nonsydromic hearing loss. Two mouse models of Hgf dysregulation, one in which an Hgf transgene is ubiquitously overexpressed and the other a conditional knockout that deletes Hgf from a limited number of tissues, including the cochlea, result in deafness. Overexpression of HGF is associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deletion of Hgf is associated with more general dysplasia.

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The oral candiasis in diabetic patients

Asian journal of multidisciplinary studies, 2018

Background: this study was done in order to find of the frequency of oral fungal infection associ... more Background: this study was done in order to find of the frequency of oral fungal infection associated with diabetes type 2 and its correlation with the age, gender, glycemic control, timespan of illness and kind of therapy. METHODS: This study was a cross sectional one, carried out at the medical unit 1, Benazir Bhutto hospital, Rawalpindi over the periods of 3months. This study included 305 diabetic patients admitted in the ward. Detail history of these patients was taken which included the age, family history, duration of illness, type of therapy and history of other comorbid. Oral examination of these patients was carried out to rule out candidiasis and grams staining were done from buccal mucosa scrapings to analyze fungal hyphae. RESULTS: Out of 305 patients examined, 71 patients had oral candidiasis. 58.64% patients with and 57.50% patients without oral fungal infection were male (p value > 0.05). Mean age of patients with and without oral candidiasis was 58.4 ± 5.76 and 53...

Wheat bran extracts: a potent source of natural antioxidants for the stabilization of canola oil

Grasas y Aceites

In the present work, the antioxidant activity of different solvent extracts of wheat (var. Inqala... more

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Intragenic deletions in the dystrophin gene in 211 Pakistani Duchenne muscular dystrophy patients

Pediatrics International, 2008

Deletions of single or multiple exonic regions within the dystrophin gene can be detected using c... more Deletions of single or multiple exonic regions within the dystrophin gene can be detected using current molecular methods in approximately 65% of the patients with X-linked recessive neuromuscular disorder, Duchenne/Becker muscular dystrophy (DMD/BMD). Population-based variations in frequency and distribution of dystrophin gene deletions have been reported in DMD/BMD patients. In the present study, the first in the Pakistani population, frequency and distribution of deletions of 18 exons clustered in two hot spots within the dystrophin gene in 211 unrelated DMD patients were analyzed. A total of 211 patients suffering from DMD were ascertained, and intragenic deletions within the dystrophin gene were detected on polymerase chain reaction amplification of the genomic DNA using 18 primer sets clustered within two major deletion hot spots. lovd v.1.1.0 software from the Leiden Muscular Dystrophy website has been used to predict in-frame and out-of-frame deletions. Intragenic deletions were detected in 86 patients (40.75%): 35 patients (40.69%) had deletions within the proximal hot spot, and 51 patients (59.30%) had deletions confined to the distal deletion hot spot of the dystrophin gene. The most frequently deleted exons were 50, 6, 47, 13 and 52 with deletion frequencies of 15.11%, 12.79%, 10.46%, 8.13%, and 4.65%, respectively. lovd v.1.1.0 predicted out-of-frame deletions in 67 DMD patients and in-frame deletions in 19 DMD patients. The observed proportion of intragenic deletions in the Pakistani population is relatively low, which is comparable with most of the Asian data. Also, deletions in 67 patients (77.9%) are in agreement with the frame-shift rule.

TRG: Trading rate for good-put in wireless multimedia sensor networks

2011 Eighth International Conference on Wireless and Optical Communications Networks, 2011

Abstract Wireless sensor networks pose strict bandwidth and power constraints. In multimedia Sen... more

Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: novel sequence variants in ASPM gene

Neurogenetics, 2006

Human autosomal recessive primary microcephaly (MCPH) is a rare genetic disorder in which affecte... more Human autosomal recessive primary microcephaly (MCPH) is a rare genetic disorder in which affected individuals are born with reduced brain size. MCPH is genetically heterogeneous, with six loci and four genes reported to date. Mutations in the ASPM gene at the MCPH5 locus appear to be the most common cause of MCPH. For this study, 33 Pakistani families with primary microcephaly were enrolled. Genotyping using microsatellite markers linked to the six known MCPH loci showed the linkage of 18 families to the MCPH5 locus, two to the MCPH2 locus, two to the MCPH4 locus, and one to the MCPH6 locus. The remaining ten families were not linked to any of the known loci. Families linked to the MCPH5 locus were further subjected to screening of the ASPM gene with direct DNA sequencing. Two previously reported variants, 3978G>A (W1326X) and 9557C>G (S3186X), were observed in five Pakistani families. Four novel nonsynonymous sequence variants, 9118insCATT, 9238A>T (L3080X), 9539A>C (Q3180P), and 1260delT-CAAGTC, were found to segregate within four families, but were not observed in 200 Pakistani control chromosomes. One of the variants, 9539A>C (Q3180P), occurred in the IQ 79 domain, but its functional significance awaits definition.

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A novel deletion mutation in CENPJ gene in a Pakistani family with autosomal recessive primary microcephaly

Journal of Human Genetics, 2006

Autosomal recessive primary microcephaly (MCPH) is a rare human genetic disorder in which the hea... more Autosomal recessive primary microcephaly (MCPH) is a rare human genetic disorder in which the head circumference is reduced because of abnormality in fetal brain growth. To date, six loci and four genes have been identified for this condition. Our study of primary MCPH led to the identification of 33 Pakistani families with different ethnic backgrounds. Most of these families showed linkage to MCPH5 locus on chromosome 1q31. Only one family with Pashtoon origin from a remote region in Pakistan linked to MCPH6 locus on chromosome 13q12.12-q12.13. Sequence analysis of exon 11 of CENPJ gene, located at MCPH6 locus, revealed a novel four base pair deletion mutation, which is predicted to be protein truncating.

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Environmental impact assessment on water quality deterioration caused by the decreased Ganges outflow and saline water intrusion in south-western Bangladesh

Environmental Geology, 2000

This paper deals with an environmental impact assessment of low water flow in the river Ganges du... more This paper deals with an environmental impact assessment of low water flow in the river Ganges during a dry period at the Khulna and Mongla port areas in southwestern Bangladesh. Large-scale surface water withdrawal in India after commissioning the Farakka Barrage causes a drastic fall in the Ganges low-flow condition within the Bangladesh territory during every dry period. The average lowest discharge in the Ganges is 552 m 3 /s, which is about 73% less than that in the pre-Farakka time. This has caused the deterioration of both surface and groundwater quality of the study area. Salinity is the principal cause of water quality degradation in the area. Present observation shows that the surface water of the area is sulphate-chloride dominated, which signifies high salinity whereas the groundwater is categorized as of medium to high salinity. To maintain the Rupsa River's maximum salinity below 1000 mS/cm the discharge in the Ganges should be F1500 m 3 /s, whereas that at Garai basin is F10 m 3 /s. If this present situation continues it will be a crippling blow to the environment of the area in the long term. An integrated multidisciplinary approach to hydrogeological research is urgently required to salvage the area from further deterioration.

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Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly

BMC Neurology, 2011

Background Autosomal recessive primary microcephaly is a disorder of neurogenic mitosis that caus... more Background Autosomal recessive primary microcephaly is a disorder of neurogenic mitosis that causes reduction in brain size. It is a rare heterogeneous condition with seven causative genes reported to date. Mutations in WD repeat protein 62 are associated with autosomal recessive primary microcephaly with cortical malformations. This study was initiated to screen WDR62 mutations in four consanguineous Pakistani families with autosomal recessive primary microcephaly. Methods As part of a large study to detect the genetic basis of primary microcephaly in Pakistan, homozygosity mapping and DNA sequencing was used to explore the genetic basis of autosomal recessive primary microcephaly in four families. Results Four out of 100 families recruited in the study revealed linkage to the MCPH2 locus on chromosome 19, which harbor WDR62 gene. DNA sequencing in these MCPH2 linked families result in the identification of a novel nonsense mutation (p.Q648X) and three previously known mutations. C...

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Hematotoxicity in patients with snake bites

Asian journal of multidisciplinary studies, 2018

Background : This study was carried out in order to check the frequency of hematotoxicity in pati... more Background : This study was carried out in order to check the frequency of hematotoxicity in patients presented to hospital with complaint of snake bite. Methods: This is the descriptive study in which the patient with the history of snake bite were asked about the detailed history, accessed clinically along with the evaluation of laboratory parameters in order to rule any sign of hematoxcity. Results: The majority of patients included in this studies were male (74%) and the affected patient mostly belong to the age group 23-29years. Overall, hemotoxicity was observed in 66% patient while neurotoxicity was observed in case of 4.2% of patient with snake bite. In patient with hemotoxicity, the deranged PT and APTT were more commonly observed (79.4%) followed by hematuria 29.3% , thrombocytopenia 22.6%, Hematemesis 7.8%, bleeding from injection site 5.8% and bleeding from musclocutenous site 8.3%. Conclusion : Snake bite is the serious health related problem more common in villages. He...

Assessment of Oxidative Deterioration of Soybean Oil at Ambient and Sunlight Storage

Grasas y Aceites, 2007

Se lleva a cabo un estudio para conocer las diferencias en la oxidación del aceite de soja conser... more

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