Papers by Jose luis Gonzalez-Mora
Chemosensors
This work proposes an outstanding screening magneto-bioassay for the early identification of bovi... more This work proposes an outstanding screening magneto-bioassay for the early identification of bovine subclinical mastitis. Haptoglobin (Hp) was used as a promising biomarker for the diagnosis of subclinical mastitis. To this end, novel chitosan-modified magnetic particles, coated with haemoglobin-modified polyaniline (MNPs@Chi/PANI-Hb), have been integrated in a sensitive electrochemical Hp bioassay. Haemoglobin was used as bioreceptor due to its high affinity against Hp. The appropriateness of their synthesis and their modifications were demonstrated by XRD, FT-IR spectroscopy, thermogravimetry and N2 adsorption–desorption analyses. After the optimization of the experimental parameters the main analytical features were obtained showing excellent performance. The electrochemical biosensor in milk matrix presented a dynamic range of 0.001 to 0.32 μg mL−1 with a detection limit of 0.031 μg mL−1, a value much lower than the normal Hp values in bovine milk, making it highly suitable for ...
Enzyme Kinetics of N-Acetyl-Aspartyl-Glutamate in the Cingulated Cortices in Asd: A 1 H-MRS Model
Autism-Spectrum Quotient (AQ): a preliminary Study of its Diagnostic Validity in a Clinical Spanish sample, more than a psychometric test?
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World Scientific and Engineering Academy and Society (WSEAS), Feb 1, 2010
This paper describes in detail the development and applications of a Virtual Reality Simulator fo... more This paper describes in detail the development and applications of a Virtual Reality Simulator for Visually Impaired People. It makes an auditory representation of the virtual environment, rendering the virtual world entirely through the hearing. The simulator has these main purposes: validation of auditory representation techniques, 3d sensor emulation for environment recognition and hardware integration, training of visually impaired users with these new auditory representation, and acoustic perception experiments aimed to improve the auditory rendering. The interaction with the simulator is made by a 3d tracking system to locate user's head orientation and position. This means the user interaction is as natural as possible, all performed by just "walking through" the environment, and at the same time, the user perceives the environment through acoustic information.
Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms, 2013
From the clinical diagnosis point of view in vivo nuclear magnetic resonance (NMR) spectroscopy h... more From the clinical diagnosis point of view in vivo nuclear magnetic resonance (NMR) spectroscopy has proven to be a valuable tool for performing non-invasive quantitative assessments of brain tumour glucose metabolism. Brain tumours are considered fast-growth tumours because of their high rate of proliferation. Therefore, there is strong interest from the clinical investigator's point of view in the development of early tumour detection techniques. Unfortunately, current diagnosis techniques ignore the dynamic aspects of these signals. It is largely believed that temporal variations of NMR spectra are simply due to noise or do not carry enough information to be exploited by any reliable diagnosis procedure. Thus, current diagnosis procedures are mainly based on empirical observations extracted from single averaged spectra. In this paper, a machine learning framework for the analysis of NMR spectroscopy signals is introduced. The proposed framework is characterized by a set of structural parameters that are shown to be very sensitive to metabolic changes as those exhibited by tumour cells. Furthermore, they are able to cope not only with highdimensional characteristics of NMR data but also with the dynamic aspects of these signals.
This study utilizes voxel-based morphometry to examine the neural basis of developmental changes ... more This study utilizes voxel-based morphometry to examine the neural basis of developmental changes in transitive reasoning in parietal regions. Two groups of participants (young adolescents and adults) performed a transitive reasoning task, subsequent to undergoing anatomical MRI brain scans. Behaviorally, adults performed better on the transitive reasoning task than the young adolescents. Grey matter analysis of their brains showed the expected thinning/pruning of grey matter in BA 7 and a significantly greater correlation between the performance of the adults and grey matter density than the performance of adolescents and grey matter density in this area. These results support the idea that developmental anatomical changes in parietal cortex facilitate developmental changes in transitive reasoning.
Constitutive NOS isoforms account for gastric mucosal NO overproduction in uremic rats
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1997
To study whether renal failure enhances gastric mucosal nitric oxide (NO) formation in the rat, w... more To study whether renal failure enhances gastric mucosal nitric oxide (NO) formation in the rat, we measured 1) in vivo NO concentration and 2) NO synthase (NOS) activity, content, and mRNA expression in gastric mucosal homogenates of uremic and sham-operated anesthetized rats. Gastric mucosal NO release was measured by an electrochemical technique. NOS content was analyzed by Western immunoblots, using specific monoclonal antibodies. Constitutive (Ca2+ dependent; cNOS) and inducible (Ca2+ independent; iNOS) NOS activities were assayed by following the conversion of L-[U-14C]arginine to [U-14C]citrulline. mRNA expression for the constitutive neuronal (ncNOS), endothelial (ecNOS), and iNOS isoforms was determined by reverse transcription-polymerase chain reaction. Under basal conditions, gastric mucosal NO concentration was significantly greater in uremic compared with control rats. This was accompanied by significantly greater gastric mucosal cNOS activity in uremic rats than in cont...
Journal of Rehabilitation and Assistive Technologies Engineering, 2019
Introduction Action observation neurorehabilitation systems are usually based on the observation ... more Introduction Action observation neurorehabilitation systems are usually based on the observation of a virtual limb performing different kinds of actions. In this way, the activity in the frontoparietal Mirror Neuron System is enhanced, which can be helpful to rehabilitate stroke patients. However, the presence of limbs in such systems might not be necessary to produce mirror activity, for example, frontoparietal mirror activity can be produced just by the observation of virtual tool movements. The objective of this work was to explore to what point the presence of a virtual limb impacts the Mirror Neuron System activity in neurorehabilitation systems. Methods The study was conducted by using an action observation neurorehabilitation task during a functional magnetic resonance imaging (fMRI) experiment with healthy volunteers and comparing two action observation conditions that: 1 – included or 2 – did not include a virtual limb. Results It was found that activity in the Mirror Neuro...
Neurophotonics, 2017
Diffuse optical tomography (DOT) measures concentration changes in both oxy-and deoxyhemoglobin p... more Diffuse optical tomography (DOT) measures concentration changes in both oxy-and deoxyhemoglobin providing three-dimensional images of local brain activations. A pilot study, which compares both DOT and functional magnetic resonance imaging (fMRI) volumes through t-maps given by canonical statistical parametric mapping (SPM) processing for both data modalities, is presented. The DOT series were processed using a method that is based on a Bayesian filter application on raw DOT data to remove physiological changes and minimum description length application index to select a number of singular values, which reduce the data dimensionality during image reconstruction and adaptation of DOT volume series to normalized standard space. Therefore, statistical analysis is performed with canonical SPM software in the same way as fMRI analysis is done, accepting DOT volumes as if they were fMRI volumes. The results show the reproducibility and ruggedness of the method to process DOT series on group analysis using cognitive paradigms on the prefrontal cortex. Difficulties such as the fact that scalp-brain distances vary between subjects or cerebral activations are difficult to reproduce due to strategies used by the subjects to solve arithmetic problems are considered. T-images given by fMRI and DOT volume series analyzed in SPM show that at the functional level, both DOT and fMRI measures detect the same areas, although DOT provides complementary information to fMRI signals about cerebral activity.
Simultaneous real-time measurements of dopamine and serotonin levels:New methodological developments
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Numerical separation of monoamine mixtures: analysis of FCV data
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In vivo monitoring of NO release from the gastric mucosa by a porphyrinic-based microsensor
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Anomalous correlation between regional distribution of nitric oxide synthase activity and extracellular concentration of nitric oxide in brain tissues
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Interest of thermal-annealed Naflon films for electrochemical detection of serotonin in vivo
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Dynamic changes in cerebral oxygenation coupled to neuronal activity measured by near infrared spectroscopy and in vivo voltammetry
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Espacio Acústico Virtual de Aplicación Médica
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Analizador Bioelectroquímico Computerizado
Neuropsychological Evaluation of Visuospatial Abilities in Blind People by Haptic Tasks
A new approach to analyze the in vivo visible reflectance pectroscopy signal
In vivo visible reflectance spectroscopy (VRS) has been widely used for estimating changes in hae... more In vivo visible reflectance spectroscopy (VRS) has been widely used for estimating changes in haemodynamic parameters. Deoxyhaemoglobin, oxyhaemoglobin, methaemoglobin and blood volume have been monitorized by recording changes in reflected light intensity from living tissues and by using multicomponent analyses based on modified Beer-Lambert law in order to give relative increments or decrements of these parameters1'2”’’4. However, this approach has several limitations. Firstly, it is not able to measure absolute concentration unless phase shift or time of flight are known (difficult to implement in the visible range). In addition, monitoring of reliable percentage changes of haemodynamic parameters requires knowing the pathlength wavelength dependence, which is unknown and affected by concentration changes of endogenous chromophore and scatterer concentrations and other parameters such as optical geometry. As a consequence of the latter factors, increases in the VRS signal are...
System on Chip (SoC) Devices in Telemedicine from LABoC to High Resolution Images
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Papers by Jose luis Gonzalez-Mora