Ehsan Mohajeri

Kerman University of Medical Sciences, Pharmacy, Faculty Member

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Papers by Ehsan Mohajeri

Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial

Turkish journal of emergency medicine, 2020

OBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one ... more OBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one of the most important factors that should be considered in pediatric emergencies. The aim of this study was to compare the efficacy of oral versus intranasal midazolam in sedation during radiologic imaging in the largest province of Iran, Kerman. MATERIALS AND METHODS: Eighty children were enrolled in this single-blind clinical trial based on convenience sampling and were divided into two groups receiving 0.5 mg/kg midazolam in oral route administration and 0.2 mg/kg midazolam in intranasal route administration. Finally, 75 patients remained for evaluating medication acceptability, sedation level, onset time of sedation, additional sedative dose, adverse effects of sedation, and provider satisfaction. RESULTS: Children in the intranasal group accepted medication more easily (89.8% vs. 36.9%; P ≤ 0.001), while these children received a lower sedation dose, but the sedation level in both methods was similar (P = 0.72). Our findings showed that children in the intranasal sedation group had a faster onset of sedation compared to the oral group (17.94 ± 8.99 vs. 34.50 ± 11.45; P ≤ 0.001). The frequency of midazolam side effects had no difference between the groups (29.7% vs. 15.8%; P = 0.15). CONCLUSION: Intranasal midazolam with a lower sedation dose induces a faster onset and better acceptance. Intranasal midazolam can be used as an effective sedative method for pediatric patients, especially in emergency wards.

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Preparation and Evaluation of Physicochemical Properties of the Doxepin Mucoadhesive Gel

Jundishapur Journal of Natural Pharmaceutical Products, Dec 20, 2020

Background: Oral mucositis is a common debilitating complication of cancer chemotherapy and radio... more Background: Oral mucositis is a common debilitating complication of cancer chemotherapy and radiotherapy that can reduce the quality of patient's lives. Hence, treating this condition plays an important role in increasing the patient's tolerance. Objectives: Doxepin mucoadhesive gel is useful for treating oral mucosa inflammation caused by long-term effects of chemotherapy, which has low adverse effects. Methods: Doxepin gel's formulation was prepared with various concentrations of poloxamer 407 and hydroxypropyl methylcellulose in deionized water. The prepared gels were evaluated for pH, appearance, viscosity, spreadability, stability, and drug release. Results: After providing gels containing doxepin, formulations 1, 2, 8, and 9 had low quality and, thus, were removed from the study. Based on qualitative evaluations, formulations 3 and 4 did not meet the criteria for mucoadhesive gel and were removed from the study. The best formulation contained 17% w/w poloxamer 407, 10% w/w hydroxypropyl methylcellulose, and 5% w/w doxepin. Conclusions: Suitable physicochemical properties of prepared doxepin mucoadhesive gel enable it to well cover inflamed and damaged oral mucosa. On the other hand, doxepin's slow release from formulation (8 hours) can increase therapeutic effects and reduce side effects, which can heal and soothe inflammations of the oral mucosa and be useful in cancer patient's treatment.

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A Thermodynamic Micellization and Hemolysis Evaluation of Polysorbate Surfactants in Combination with Short-Chain Alcohols

Journal of Cluster Science, 2021

Surface active agents have been used in many pharmaceutical formulations for different purposes a... more Surface active agents have been used in many pharmaceutical formulations for different purposes as penetration enhancers. In this study, the penetration enhancement activity of four nonionic surfactants from polyoxyethylene sorbitan fatty acid esters alone and in combination with some short-chain alcohols on red blood cells were investigated. Hemolysis at different concentrations of each nonionic surfactant (0.1, 0.2, 0.5, 1, and 2%) and ethanol, isopropyl alcohol, glycerol, and propylene glycol (0.5, 1, 2, 5, and 10% w/v) were investigated. Critical micelle concentration (CMC) and micellization thermodynamic parameters of tween 80 in presence of ethanol and glycerol at different concentrations were determined. The influence of the ethanol and glycerol on nonionic surfactant micelle formation was evaluated by determining CMC and micellization thermodynamic parameters of tween80 at different concentrations of alcohol-tween mixtures. The mixture of Tween 20 and glycerol have the lowest hemolytic activity while tween 80-ethanol mixture has the highest hemolysis activity. The self-aggregation of surfactant monomers was affected by short-chain alcohols. The structure breaking ability of alcohol and their interactions with the hydrophilic-hydrophobic groups of surfactants might be the main factors for changing the micelle formation. The CMCs of tween 80 was incremented by increasing the concentration of alcohol. The results indicated that by adding and increasing short chain alcohols the CMCs increased also the CMCs were increasing through raising the temperature (while in the presents of surfactants alone the CMCs decreased by raising temperature).

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Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial

Turkish Journal of Emergency Medicine, 2020

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Preparação e avaliação das propriedades físico-químicas de membranas de quitosana para uso biomédico e farmacêutico

Sumário ii 3-Material e Métodos 29 3.1-Extração da quitina 30 3.2-Obtenção da quitosana 3.3-Deter... more Sumário ii 3-Material e Métodos 29 3.1-Extração da quitina 30 3.2-Obtenção da quitosana 3.3-Determinação do grau de desacetilação das amostras de quitosana 33 3.3.1-Método colori métrico da ninhidrina 3.3.2-Método da titulação do sal de Br-quitosana 33 3.3.3-Por infra-vermelho (IV) 3.4-Grau de higroscopia 34 3.5-Preparo das membranas 3.5.1-Preparo das soluções 3.5.1.1-Preparo da solução de ácido acético 3.5.1.2-Preparo da solução de polivinilpirrolidona (PVP) 3.5.1.3-Preparo das soluções de quitosana 1%,2%, 3% e 6% 3.5.1.4-Preparo da solução de quitosana-PVP com glutaraldeído e glioxal 3.5.1.5-Preparo da solução de quitosana e colágeno 3.5.1.6-Preparo da solução de quitosana e fibroína de seda 3.5.1.7-Preparo da solução de quitosana e cinamaldeído 3.5.1.8-Preparo da solução de quitosana e papaína 3.5.2-Preparo das membranas 3.6-Absorção de líquidos 3.7-Microscopia eletrônica de varredura 4-Resultados e Discussão 4.1-Síntese da quitosana 4.2-Determinação do grau de desacetilação das amostras de quitosana pelo método colorimétrico da ninhidrina, titulação do sal de Brquitosana e por infra-vermelho (IV) 4.3-Grau de higroscopia 4.4-Preparação das membranas de quitosana 4.4.1-Membranas preparadas em diferentes concentrações, secas em estufa e associadas a PVP e glutaraldeído 4.4.2-Membranas preparadas em diferentes concentrações, secas em estufa e associadas a PVP e glioxal Sumário iii 4.4.3-Membranas preparadas em diferentes concentrações, secas por liofilização e associadas à PVP e glutaraldeído 4.4.4-Membranas preparadas em diferentes concentrações, secas por liofilização e associadas à PvP e glioxal 4.4.5-Membranas preparadas em diferentes concentrações, secas por e~ufu 4.4.6-Membranas de quitosana a 3%, secas por liofilização e incorporadas a diferentes tipos de suportes mecânicos 51 4.4.7-Membranas de quitosana a 2% e a 1%, liofilizadas e incorporadas a diferentes tipos de suportes mecânicos 4.4.8-Membranas de quitosana associadas a diferentes substâncias, liofilizadas e incorporadas a diferentes tipos de suportes mecânicos 4.4.9-Membranas de quitosana secas por liofilização, sem suporte mecânico 4.5-Absorção de líquidos 4.6-Microscopia eletrônica de varredura das membranas de quitosana 61 4.7-Preços 5-Conclusões 71 6-Referências Bibliográficas Agradecimentos IV A Deus, pelo fato de estar sempre me acompanhando, dando-me forças para lutar e, principalmente, para vencer. Ao meu marido, e aos meus pais, por estarem presentes nos momentos mais difíceis e estarem sempre prontos para estenderem as mãos quando, por um momento de fraqueza, eu arquejava.

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Effect of temperature on critical micelle concentration and thermodynamic potentials of micellization of anionic ammonium dodecyl sulfate and cationic octadecyl trimethyl ammonium chloride

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2001

Abstract The critical micelle concentrations (CMCs) of anionic ammonium dodecyl sulfate (ADS) and... more Abstract The critical micelle concentrations (CMCs) of anionic ammonium dodecyl sulfate (ADS) and cationic octadecyltrimethylammonium chloride (OTAC) were determined at various temperatures using a du Nouy ring tensiometer. The CMC decreased to a certain minimum and then increased with the temperature, displaying a U-shaped behavior. This behavior was analyzed using a power-law equation on the basis of reduced variables. The exponents of the power-law equation were found to be 1.05 for ADS and 1.12 for OTAC. These values were different from previous literature values of 1.74 for ionics, 3.54 for commercial ionics, and 5.80 for commercial amphoterics. Also, the U-shaped behavior is explained in terms of hydrophobic forces, as described by the thermodynamic potentials and parameters in the pseudo-phase separation model.

Medicinal plants as surface activity modifiers

JOURNAL OF MEDICINAL PLANTS RESEARCH, May 3, 2009

The Plant's saponins are naturally occurring triterpene or steroid glycosides that possess a... more The Plant's saponins are naturally occurring triterpene or steroid glycosides that possess a number of biological and pharmacological activities. Saponins are found in a number of medicinal plants and are secondary metabolites of the plants. They contain either a steroidal or a triterpenoid aglycone to which one or more glycoside chains are attached. The glycoside subunits usually include glucose, galactose, glucuronic acid, xylose or rhamnose. They exhibit a range of biological properties, both beneficial and deleterious. The main ...

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Population Pharmacokinetics of Imatinib and its application to the therapeutic drug monitoring: Middle East CML population

The Gulf journal of oncology, 2016

Despite the outstanding results generally obtained with Imatinib in the treatment of chronic myel... more Despite the outstanding results generally obtained with Imatinib in the treatment of chronic myeloid leukemia, some patients show sub-optimal or no response. To evaluate the relationship between steady-state through plasma concentration and clinical response in CML patients. The objectives of this study were to assess the variability in Imatinib pharmacokinetics and to explore the effects of several demographic and biological covariates on the disposition of Imatinib. A population pharmacokinetic analysis was performed on 170 plasma samples from 74 adult Iranian chronic myeloid leukemia patients. A population pharmacokinetics model was developed to evaluate the influence of covariates on clearance and volume of distribution. A one-compartment model with first-order absorption appropriately described the data, giving a mean (±SEM) clearance of 14.3l (±1.0) and a volume of distribution of 347 l (±62). Clearance was influenced by body weight, age and gender. By considering these covari...

Comparative pharmacokinetic evaluation and bioequivalence study of three different formulations of Imatinib Mesylate in CML patients

International journal of hematology-oncology and stem cell research, 2015

Imatinib is known as the drug of choice for treatment of chronic myeloid leukemia (CML). For adul... more Imatinib is known as the drug of choice for treatment of chronic myeloid leukemia (CML). For adults the recommended daily dosage of 400 mg requires simultaneous intake of up to four capsules or tablets each 100 mg. A new 400 mg film coated tablet developed due to the need to swallow multiple capsules or tablets per dose and that was a negative impact on treatment adherence. A group of 36 patients were randomly assigned to receive Imatinib as 4×100 mg capsules, 4×100 mg tablets and 1×400 mg tablet. Blood sampling was performed for up to 48 h after first dosing. After that, subjects were monitored to assess drug related adverse events. Pharmacokinetic parameters were assessed using concentration-time curves for plasma Imatinib and its metabolite. Mean area under the curve (AUC (0-∞)) values were 27011, 25811 and 25699 ng/ml for 4×100 mg capsules, 4×100 mg tablets and 1×400 mg tablets, respectively. Cmax values were 1548, 1605 and 1622 ng/ml and t1/2 values were 15.7, 15.8 and 15.6 h. ...

Controlled Release Imatinib Mesylate Tablet Formulation: Using Hydrophilic Matrix System

Pharmaceutical Sciences, 2015

Background: Imatinib mesylat as an oral anticancer agent need a controlled released formulation t... more Background: Imatinib mesylat as an oral anticancer agent need a controlled released formulation to get steady and stable plasma concentration. The aim of the present study was to develop controlled release matrix tablet formulations of Imatinib using hydroxy propyl methyl Cellulose as a hydrophilic release retardant polymer and to study the effects of different formulation features like polymer viscosity grade, ratio of the polymer, compression force, and release medium on the in vitro release properties. Methods: The in vitro release studies were performed using US Pharmacopoeia type I apparatus. The release kinetics was analyzed by Korsmeyer-Peppas model and were also analyzed using statistical method and f 2 metric values. The release profiles look like Higuchi's square root kinetics model irrespective of the viscosity grade and polymer proportion. Results: The results showed that the release rate of the drug is greatly affected by the drug/polymer ratio and viscosity grade. Also, the effect of release medium and compression force was showed to be significant on the release profiles. The release mechanism was found to be anomalous non-Fickian diffusion in all formulations. Conclusions: The formulations were found to be reproducible and stable. Controlled release formulations were developed with different release rates and profiles so that these formulations could be evaluated for more in vivo studies.

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Formulation of herbal conditioner shampoo by using extract of fenugreek seeds and evaluation of its physicochemical parameters

by Ehsan Mohajeri and p khazaeli

African Journal of Pharmacy and Pharmacology, 2011

Nowadays, people are interested in hair preparations and conditioner materials, such as shampoos.... more Nowadays, people are interested in hair preparations and conditioner materials, such as shampoos. Hair tonic and conditioner formulations containing herbal extracts, such as fenugreek, can prevent hair loss and retain hair conditioning. First of all, the proved seeds of fenugreek were extracted with 50% ethanol by maceration method, and then were freeze dried and stored in the fridge. After preparing the formulation, some physicochemical properties such as pH, foam formation, viscosity, conditioning and wettability were ...

Evaluation of Insulin Stability in the Presence of Nonionic Surface Active Agents (Polysorbate Groups) by Circular Dichroism and Fluorescence Spectroscopy

Asian Journal of Biochemistry, 2015

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Effect of temperature on critical micelle concentration and thermodynamic behavior of dodecyldimethylethylammonium bromide and dodecyltrimethylammonium chloride in aqueous media

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2005

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