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All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Journal of Nutrition College Psikohumaniora: Jurnal Penelitian Psikologi Holistic Nursing and Health Science Medica Hospitalia Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Penyakit Dalam Indonesia International Journal of Cell and Biomedical Science
Muchlis Achsan Udji Sofro
2Staf Pengajar Bagian Ilmu Penyakit Dalam FK UNDIP/RSUP Dr. Kariadi Semarang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Kadar seng dan kadar malondialdehyde pada penderita multi drug resistant tuberculosis dan tuberkulosis sensitif Suparno, Suparno; Suhartono, Suhartono; Sofro, Muchlis Achsan Udji; Sulchan, Mohammad; Tjahjono, Kusmiyati
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 7, No 1 (2018)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.743 KB) | DOI: 10.14710/jgi.7.1.8-14

Abstract

Background: Zinc is the main constituent element of Superoxide Dismutase (SOD) which acts to protect cells from inflammation and the toxic effects of Reactive Oxygen Species (ROS). High ROS production induces fat peroxidation, and forms malondialdehyde (MDA) which causes oxidative stress.Objectives: This study aimed to analyze the difference of zinc and malondialdehyde levels among Multi Drug Resistant Tuberculosis and sensitive Tuberculosis.Methods: Crossectional study with 55 subjects consisted of 32 MDR-TB subjects and 23 subjects TB sensitive. Selection of subjects using consecutive sampling. Zinc and MDA serum was obtained from venous blood. Zinc and MDA concentration were assessed by quantitative colometric and Thiobarbituric Acid Reactive Substances (TBARS) respectively. Data were analized statistic by independent t-test and Mann Whitney test.Results: Zinc level of MDR-TB and TB sensitive were 74.85 (64 - 97) μg/dl and 73.03 (63 - 97) μg/dl respectively, while MDA of MDR-TB and sensitive TB were 2.262±1.055 nmol/mL and 2.66±0.992 nmol/mL. There was no significantly different in zinc level between MDR-TB and sensitive TB (p=1.000). Furthermore, there was not significantly different of MDA level between MDR-TB and sensitive Tuberculosis (p=0,147).Conclusion: There are no differences in zinc and MDA levels in patient between MDR-TB and sensitive TB.
Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar Ariani, Ariani; Anjani, Gemala; Sofro, Muchlis Achsan Udji; Djamiatun, Kis
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 6, No 2 (2018)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.96 KB) | DOI: 10.14710/jgi.6.2.131-138

Abstract

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation  NO level at mice  who received standard antimalarial therapy  Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.Results : The mean  NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was  proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.
Antiretroviral Side Effects on Adherence in People Living with HIV/AIDS Arisudhana, Gede Arya Bagus; Sofro, Muchlis Achsan Udji; Sujianto, Untung
Nurse Media Journal of Nursing Vol 8, No 2 (2018): (DECEMBER 2018)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.199 KB) | DOI: 10.14710/nmjn.v8i2.20742

Abstract

Background: Antiretroviral therapy is a lifelong treatment in people living with HIV/AIDS (PLWHA). Adherence is the key to the effectiveness of antiretroviral therapy. The administration of antiretroviral has some side effects that may affect patient adherence.Purpose: This study aimed to examine the impacts of antiretroviral side effects on adherence in PLWHA.Methods: This study used a correlational research design. The samples were 78 patients receiving antiretroviral therapy at the tropical disease and infection polyclinic in a hospital in Semarang. Purposive sampling was used to recruit the samples. Data on side effects of antiretroviral were obtained based on the patients’ reports, while data on adherence of pill consumption were obtained through the calculation of pills using pill count adherence rate. The collected data were analyzed using the Fisher’s exact test.Results: Results showed that the side effects of antiretroviral therapy influenced the antiretroviral adherence (p<0.001). Most of the side effects of antiretroviral reported by participants were nausea and dizziness. Some participants also reported weakness, difficult to concentrate, and diarrhea.Conclusion: The side effects of antiretroviral had negative impacts on patients’ antiretroviral therapy adherence. Therefore, nurses and health care providers of PLWHA should be able to recognize and give concern on antiretroviral side effect management.
PENGARUH SUPPLEMENTASI PROBIOTIK DAN SELENIUM TERHADAP RESPON IMUN NLR (NEUTROPHIL LYMPHOCYTE COUNT RATIO) , HAEMOGLOBIN DAN ALBUMIN PADA TIKUS WISTAR YANG DIINDUKSI MYCOBAKTERIUM TUBERCULOSIS Widiastuti, Yuliati; S.S, Darmono; Sofro, Muchlis Achsan Udji
Journal of Nutrition College Vol 8, No 1 (2019): Januari
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.066 KB) | DOI: 10.14710/jnc.v8i1.23811

Abstract

Latar belakang : Penyakit    tuberkulosis  (TBC)  paru   merupakan masalah   kesehatan masyarakat global termasuk   Indonesia. Penyakit tuberkulosis paru pada umumnya terjadi malnutrisi akibat efek samping obat anti tuberculosis, yang menyebabkan gangguan saluran cerna dan respon imunitas. Probiotik dan Selenium diduga memiliki efek menguntungkan respon imunitas dan status gizi pada pasien terinfeksi tuberculosisTujuan : Untuk menganalisis pengaruh pemberian suplementasi probiotik dan selenium  terhadap NLR ( Neutrophill Ratio Lymphocyte ), Hemoglobin dan Albumin pada tikus wistar yang diinduksi Mycobacterium tuberculosis.Metode : Penelitian eksperimen dengan rancangan Randomized Post test Control Group Design. Dua puluh delapan tikus Wistar dibagi 4 kelompok, kelompok 1 : kelompok kontrol hanya diberikan OAT, kelompok 2 : probiotik + OAT, kelompok 3 : selenium + OAT serta kelompok 4 : probiotik dan selenium + OAT. Setelah diinduksi 14 hari, hewan diberikan perlakuan selama 28 hari. Analisis data menggunakan Anova, Post Hoc atau Kruskal Wallis, Mann Whitney pada tingkat kemaknaan p<0.05. Hasil : Terjadi penurunan kadar NLR, peningkatan kadar Hemoglobin dan Albumin  pada tikus kelompok 1 (p<0.05), kelompok 2 (p<0.05) serta kelompok 3 (p<0.05). Efektifitas pemberian probiotik dan selenium paling kuat terdapat pada NLR, Hemoglobin dan AlbuminSimpulan : Suplementasi probiotik dan selenium selama 28 hari mampu meningkatkan sistem imunitas ( NRL ), Hemoglobin dan Albumin  pada kelompok perlakuan lebih baik dibanding kelompok kontrol.  
Effect of zinc on milkfish nastar-cookies to albumin and hemoglobin levels in HIV/AIDS patients Hindaryani, Nurul; Sofro, Muchlis Achsan Udji; Agustini, Tri Winarni
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 2 (2020)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.62 KB) | DOI: 10.14710/jgi.8.2.149-153

Abstract

Background: Human Immunodeficiency Virus (HIV) destroys the antibody system, which causes faster protein breakdown resulting in lower albumin concentration. Zinc supplementation when added to protein in milkfish flour may increase albumin and zinc levels that associated with activity of the aminolevulinic acid dehydrase (ALAD) that synthesizes heme. Objectives: This study aimed to prove the effect of zinc and milkfish flour addition on albumin and hemoglobin levels in HIV/AIDS patients.Methods: An experimental study with randomized pre and post-test with the control group design using control subjects (n=17) and treatment (n=21). The administration of milkfish nastar with zinc to treatment group was 100 g/day for 60 days, while the control group was given milkfish nastar without zinc 100 g/day for 60 days. The measurement of albumin level used auto photometric with enzymatic color test methods and reticulated method for hemoglobin level measurement conducted before and after treatments. Data were analyzed using Shapiro-Wilk, paired t-test, and independent t-test with a significance value at p<0.05. Results: The means of albumin level in the treatment group increased by 7.03%, while the control group increased by 4.33% (p>0.05). Means of hemoglobin level in the treatment group increased by 12.0%, while the control group increased by 7.9% (p<0.05). Conclusion: Albumin and hemoglobin levels increased after milkfish nastar administration with zinc addition in HIV/AIDS patients.
Proportion of Depression Symptoms and Its Relationship with ARV Therapy: A Study at the VCT Clinic, Dr. Kariadi General Hospital Sofro, Muchlis Achsan Udji; Raharja, Tommy; Haidati, Titis; Sari, Linda Kartika; Jusup, Innawati
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Indonesia has the second largest HIV burden in Asia. The prevalence of depression in HIV/AIDS is 2-10 times higher than the general population, influenced by biological, environmental, psychological, and demographic factors. Data on the proportion of depression symptoms in HIV/AIDS patients and their relationship to biological factors are still limited, which needed for better treatment of HIV/AIDS. This study aimed to determine the prevalence of depression and its relationship to the biologic factors of ARV therapy (ART) in HIV/AIDS patients.Methods. Cross-sectional study was conducted among 142 HIV/AIDS patients undergoing ARV treatment at RSUP. Dr. Kariadi in January – March 2021. Demographic data, ART, ART type, side effects, ARV use duration, viral load, and CD4 cell count were obtained from medical records. The incidence of depression was assessed by the Beck Depression Inventory II (BDI-II).Results. The proportion of depression symptoms was 48.6%, consisting of mild depression (26.1%), moderate depression (17.6%), and severe depression (4.9%). Multivariate analysis resulted a significant relationship between the incidence of depression and biological factors, consisting of ART side effects, ART use duration, and CD4 cell count. Meanwhile, there was no significant relationship between the incidence of depression with the ART type and viral load. Conclusion. The proportion of depression symptoms in HIV patients undergoing ART is 48.6%. It is concluded that biological factors can affect the proportion of depression in patients with ART.
The Distinction in Level of Stress, Anxiety, and Depression between Efavirenz with Nevirapine Therapies (Study on HIV/AIDS-infected patients at VCT-CST clinic Dr.Kariadi Hospital Semarang) Muflihatunnaimah, Muflihatunnaimah; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Pemberian Antibiotik Dini Berpengaruh terhadap Mortalitas COVID-19? Sofro, Muchlis Achsan Udji
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

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Coronavirus disease 2019 (COVID-19) merupakan infeksi saluran napas yang diakibatkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data di seluruh dunia sampai akhir Juni 2022 menunjukkan bahwa COVID-19 telah menyebabkan 6,2 juta kematian dengan jumlah 530 juta kasus.
The Differences of Marital Satisfaction of ODHA Couples with and without Depression Symptoms Salahudin, Muhammad Ismail; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji; Julianti, Hari Peni
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. HIV/AIDS disease has caused physical, social, and emotional problems to infected individuals and their spouses. ODHA couples have a prevalence of depression symptoms with physical complaints, which amounted to 12.7%. There is a relationship between love, communication, and physical intimacy to satisfaction in marriage. Depression in ODHA couples is correlated with marital satisfaction. This study aimed to analyze the differences of marital satisfaction of ODHA HIV negative couples who experience depression symptoms with ODHA who do not experience depression symptoms Methods. The research design was cross-sectional. The samples were 52 official couples of ODHA aged 18-60 years who had outpatient treatment in Poly of Infection Tropical RSUP. Dr. Kariadi Semarang and met the criteria of research inclusion. Sampling technique was conducted with consecutive sampling method. Depression status was measured by the beck depression inventory (BDI) instrument and marital satisfaction was measured by ENRICH marital satisfaction scale (EMS). Processing and data analysis using SPSS program. The relationship analysis test using chi-square test. Results. Subjects who did not experience depression 78.8% and those with depression 21.2% consisted of mild 9.6%, moderate 11.6%, and severe 0%. No subjects were found to be unsatisfied with their marriage, 55.8% were very satisfied and 44.2% were satisfied. There was no significant difference between marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms (p = 0,595). There was a significant difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms in communication (p = 0.021), conflict resolution (p = 0.025), use of leisure activities (p = 0.025), and sexual activities (p = 0.007) Conclusion. There was no difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms. There was a significant difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms in communication, conflict resolution, the use of leisure activities, and sex activities.
Association between Stigma, ARV Therapy and Complications ofPsychiatric Disorders iIn HIV / AIDS Patients Wicaksono, Yamaji Adi; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji; Peni, Hari
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Stigma and discrimination among HIV/AIDS patients cause varrious problems such as physical, psychological, and social. Therefore, its management requires comprehensive intervention. Antiretroviral therapy improves the patient’s clinical course, but may lead to neuropsychiatric complications especially anxiety disorders, depression, and psychotic disorders. This study aimed to know the associationbetween stigma,ARV therapy and complications of psychiatric disorders of HIV patients. Methods. A cross-sectional study was conducted among HIV/AIDS patients undergoing antiretroviral therapy in VCT-CST RSUP dr. Kariadi and RSUD RAA Soewondo Pati. Subjects were recruited using consecutive sampling method. Asessment of disorders and stigma was conducted using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and Questionnaire scale perception of PLWHA on community HIV/AIDS stigma. Analysis was performed using SPSS program. Correlation test analyzed with chi square test. Results. Total of 102 subjects were included in this study. The majority of subjects was male (51%) and the age mean value was 35.88 (SD 8.24) years. The most common type of antiretroviral drugs bas lamividine+zidovudine) + nevirapine (52.9%). The highest stigma scale of PLHIV was 95.1% positive stigma. Characteristics of psychiatric disorders consisted of 89.2% experienced psychiatric disorders, most depression 30.4%, and 6.9% psychotic disorders. Analysis showed that there was a statistically significant association between type of ARV therapy and psychiatric disorder. There was no statistically significant association between stigma and psychiatric disorders. Conclusions. There is an association between type of ARV therapy andpsychiatric disorders, but no association found between stigma and psychiatric disorders
Co-Authors Alifiati Fitrikasari Anak Agung Gede Sugianthara Anindita, Yohana Prima Ceria Anisah, Retno Lusmiati Anjani, Gemala Ardani, Yanuar Ari Suwondo Ariani Ariani Arifah, Meika Rahmawati Chairunnisa, Andita Darmono Dessy Triana Ema Hidayanti Franzeska Anna Dewi Mursita Widinartasari, Franzeska Anna Dewi Mursita Gede Arya Bagus Arisudhana Gunasari, Lala Foresta Valentine Haidati, Titis Hari Peni Julianti Hindaryani, Nurul Ilham Uddin Innawati Jusup Joyeti Darni K. Heri Nugroho HS, K. Heri Kis Djamiatun Kusmiyati Tjahjono Linda Kartika Sari Martini Martini Megah Andriany Minuljo, Tania Tedjo Mochamad Arif Nugroho Mohammad Sulchan Muflihatunnaimah, Muflihatunnaimah Muhammad Ali Sodiq, Muhammad Ali Peni, Hari Piriyasart, Jitlada Pratama, Yanuar Surya Raharja, Tommy S.S, Darmono Salahudin, Muhammad Ismail Sammy, Alwi Suparno Suparno Tjokorda Gde Dalem Pemayun Tri Nur Kristina Tri Winarni Agustini Udin Bahrudin, Udin Untung Sujianto Wicaksono, Yamaji Adi Widiastuti, Yuliati