黑素皮质素受体1

MC1R 基因
标识符
代号	MC1R
扩展标识	OMIM：155555；MGI：99456；HomoloGene：1789；GeneCards：MC1R；OMA：MC1R - orthologs
基因位置（人类）
染色体	16號染色體
终止	89,920,973 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	124,137,483 bp
RNA表达模式
	Top expressed in
	right uterine tube; ; left testis; ; right hemisphere of cerebellum; ; right testis; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; left ovary;
	Top expressed in
	Ileal epithelium; ; neural layer of retina; ; epithelium of lens; ; skin of abdomen;
	查阅更多表达数据
	无数据
基因本體
分子功能	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; signal transducer activity; melanocyte-stimulating hormone receptor activity; 血浆蛋白结合; melanocortin receptor activity; 泛素蛋白连接酶结合;
細胞組分	integral component of membrane; 膜; 细胞膜; integral component of plasma membrane; 胞內;
生物學過程	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; multicellular organism development; UV protection; 腫瘤壞死因子產生的負調控; UV-damage excision repair; 訊息傳遞; positive regulation of protein kinase A signaling; intracellular signal transduction; 色素沉着; positive regulation of transcription by RNA polymerase II; positive regulation of protein kinase B signaling; positive regulation of protein kinase C signaling; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; 痛覺; melanin biosynthetic process;
	来源：Amigo / QuickGO
直系同源
	4157
	17199
	ENSG00000258839
	ENSMUSG00000074037
	Q01726
	Q01727
	NM_002386
	NM_008559
	NP_002377
	NP_032585
	维基数据
檢視/編輯人類	檢視/編輯小鼠

黑素皮质素受体1 (MC1R)是一种G蛋白耦合受体，长度约为310个氨基酸左右，其基因序列只有一个外显子, 有7个跨膜结构域, 是最小的G蛋白耦合受体^[5]。

MC1R是参与调节动物皮肤和毛发颜色的关键蛋白质之一。 MC1R基因的变异可引起动物黑色素形成的变化及毛色的变异。^[6]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000258839 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000074037 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ren, Gang; Li, En; Zhao, Shiye; Jiang, Yanqiong; Wang, Shasha; Tang, Sixian; Hu, Huijian. Correlation between color polymorphism and the MC1R gene of Lanius schach. Biodiversity Science. 2020-06-20, 28 (6): 688. doi:10.17520/biods.2019307.
^ 董飚; 秦豪荣,徐琪,李晓鸣,纪荣超,王健. 番鸭MC1R基因多态性与羽毛相关性分析. 江苏农业科学. 2017, 45 (10): 24–27 [2020-12-15].

外部链接

Melanocortin Receptors: MC₁. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2020-12-16]. （原始内容存档于2021-01-28）.
醫學主題詞表（MeSH）：Melanocortin+Receptor+1

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000258839 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000074037 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ren, Gang; Li, En; Zhao, Shiye; Jiang, Yanqiong; Wang, Shasha; Tang, Sixian; Hu, Huijian. Correlation between color polymorphism and the MC1R gene of Lanius schach. Biodiversity Science. 2020-06-20, 28 (6): 688. doi:10.17520/biods.2019307.

[6] 董飚; 秦豪荣,徐琪,李晓鸣,纪荣超,王健. 番鸭MC1R基因多态性与羽毛相关性分析. 江苏农业科学. 2017, 45 (10): 24–27 [2020-12-15].

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