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Table 1. Performance characteristics of cobalt in quality control material. Seronorm™ trace element controls were used as internal controls. Exter- nal quality assurance data are presented from the 2018 rounds of the Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) and Quebec Multi-Element Quality Assurance Scheme (QMEQAS). Method accuracy is indicated by average bias. The coefficient of varia- tion (CV) and z’-score provide a measurement of method imprecision between the different cobalt measures were obtained (Table 2). For all statistical analyses, a P value of <0.05 was considered significant. Table 2. Correlation analysis of cobalt concentration between different sample matrices. Calculations performed on results from the 14 sample collection points for the 6 treatment horses As a horse’s overall level of hydration changes, homeostatic balance is maintained by regulating the amount of water excreted in the urine. To allow for variations in the water content and dilution of cobalt in urine, a creatinine adjustment was performed. Creatinine-adjusted urinary cobalt concentrations were calculated by dividing the total urinary cobalt concentration by the urine creatinine concentration.

Table 1 Performance characteristics of cobalt in quality control material. Seronorm™ trace element controls were used as internal controls. Exter- nal quality assurance data are presented from the 2018 rounds of the Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) and Quebec Multi-Element Quality Assurance Scheme (QMEQAS). Method accuracy is indicated by average bias. The coefficient of varia- tion (CV) and z’-score provide a measurement of method imprecision between the different cobalt measures were obtained (Table 2). For all statistical analyses, a P value of <0.05 was considered significant. Table 2. Correlation analysis of cobalt concentration between different sample matrices. Calculations performed on results from the 14 sample collection points for the 6 treatment horses As a horse’s overall level of hydration changes, homeostatic balance is maintained by regulating the amount of water excreted in the urine. To allow for variations in the water content and dilution of cobalt in urine, a creatinine adjustment was performed. Creatinine-adjusted urinary cobalt concentrations were calculated by dividing the total urinary cobalt concentration by the urine creatinine concentration.

Related Figures (7)

Whole blood cobalt - (Plasma cobalt x [1 - Haematocrit])
Whole blood cobalt - (Plasma cobalt x [1 - Haematocrit])
six horses with higher correlation coefficients (R’) demonstrating a marked decrease in the difference between urine and both blood and plasma cobalt concentrations following creatinine adjustment (Table 2).
six horses with higher correlation coefficients (R’) demonstrating a marked decrease in the difference between urine and both blood and plasma cobalt concentrations following creatinine adjustment (Table 2).
Predicted mean red cell cobalt concentrations (Figure 5) were calcu- lated from the plasma, whole blood and haematocrit results. The accumulated measurement uncertainties from these three analytes resulted in relatively large error bars, limiting the overall accuracy. Calculations were performed from the last day of treatment at day 42 as the red cells initially contained insufficient cobalt for accurate quantification. Measurement uncertainty prevented definitive separa- tion of the various treatment regimes. Graphically it is noted that
Predicted mean red cell cobalt concentrations (Figure 5) were calcu- lated from the plasma, whole blood and haematocrit results. The accumulated measurement uncertainties from these three analytes resulted in relatively large error bars, limiting the overall accuracy. Calculations were performed from the last day of treatment at day 42 as the red cells initially contained insufficient cobalt for accurate quantification. Measurement uncertainty prevented definitive separa- tion of the various treatment regimes. Graphically it is noted that
points plotted for red cell cobalt concentrations were highest in the group receiving 50 mg cobalt once per week compared with the group receiving a weekly total of 50 mg but given as two 25 mg doses.
points plotted for red cell cobalt concentrations were highest in the group receiving 50 mg cobalt once per week compared with the group receiving a weekly total of 50 mg but given as two 25 mg doses.
To account for differences between animals, each dosage level was administered to two horses that were sampled multiple times over 18 weeks. When graphing this data, the measurement uncertainty created a jagged line connecting the time points. By applying a statis- tical process to calculate the predicted measurement rather than plotting raw data, a smoothed line is generated while maintaining the same error bars to provide a graphical representation of the
To account for differences between animals, each dosage level was administered to two horses that were sampled multiple times over 18 weeks. When graphing this data, the measurement uncertainty created a jagged line connecting the time points. By applying a statis- tical process to calculate the predicted measurement rather than plotting raw data, a smoothed line is generated while maintaining the same error bars to provide a graphical representation of the
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ChemistryMedicineVeterinary SciencesCobalt chloride
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