Key research themes
1. How does enteric nervous system dysfunction contribute to bowel motility disorders and neurological disease associations?
This research theme investigates the role of the enteric nervous system (ENS) in regulating gastrointestinal motility and its dysfunction in bowel disorders such as constipation, with a focus on how ENS abnormalities also relate to neurological diseases. Understanding ENS pathophysiology is vital because it operates semi-autonomously to coordinate bowel movements, and its impairment, through structural or neurochemical changes, leads to motility disorders and may serve as a conduit for neurodegenerative disease spread.
2. What are the current clinical methods and challenges in assessing gastrointestinal and colonic transit relevant to bowel movement disorders?
This theme focuses on the clinical measurement techniques for gastrointestinal motility and transit, their methodological developments, diagnostic utility, and limitations in functional bowel disorders such as constipation. Accurately measuring GI transit is critical for diagnosis, targeted treatment, and understanding disease mechanisms. Challenges remain in standardizing methodology, correlating transit times with symptoms, and implementing advanced technologies in clinical settings.
3. How do biomechanical properties and sensory mechanisms regulate normal and disordered defecation dynamics?
This theme explores the biomechanical and sensory underpinnings of defecation, focusing on novel analytic techniques to quantify forces, pressures, and neural sensory feedback during stool passage. Understanding these mechanophysiological aspects is critical for elucidating the etiology of defecatory disorders such as constipation and for developing improved diagnostic tools and therapeutic approaches that integrate motility with sensory processing in the anorectal region.