580 California St., Suite 400
San Francisco, CA, 94104
Key research themes
1. How does timing and surgical protocol influence implant placement success in tooth extraction sites?
This research theme investigates the evolution and impact of various implant placement protocols post-tooth extraction, focusing on immediate, early, and late implant placement. It is significant because the timing of implant insertion affects alveolar ridge preservation, osseointegration success, esthetic outcomes, and patient morbidity. The theme synthesizes clinical decision-making informed by biological understanding of bone healing and dimensional changes post-extraction.
Key finding: This paper provides a comprehensive historical analysis of implant placement timing post-extraction, highlighting that immediate implant placement has evolved with guided bone regeneration techniques to mitigate ridge... Read more
Key finding: This retrospective study reports a high survival rate (95.7%) over three years for immediate implants placed in fresh extraction sites after dental trauma in the anterior maxilla, without additional bone augmentation. It... Read more
Key finding: Through a case report illustrating atraumatic extraction, immediate implant placement, and temporization without flap reflection, this study demonstrates preservation of hard and soft tissues at the implant site alongside... Read more
Key finding: This clinical report shows successful immediate tooth autotransplantation combined with autografting partially demineralized dentin/cementum matrix during surgery with root canal filling, underscoring that simultaneous... Read more
Key finding: This paper elucidates how decoronation of ankylosed teeth followed by immediate or late dental implant placement preserves bone volume vertically and horizontally. It reveals that the remodelling process following ankylosis... Read more
2. What preclinical and methodological advances improve the modeling and evaluation of implant osseointegration and the implant-soft tissue interface?
This theme focuses on innovations in preclinical models and histological methods for assessing osseointegration and the biologic seal of peri-implant soft tissues, critical for implant success. Improved models account for the complex oral environment, including bone quality, soft tissue attachment, and host responses. Such methodological advancements enable translational research that better predicts clinical implant outcomes and helps design implants with optimized surface characteristics.
Key finding: This study introduces an innovative rabbit maxilla model for dental implant osseointegration assessment, implanting in the extraction sockets of secondary incisors to mimic clinical oral conditions including surrounding... Read more
Key finding: This comprehensive review categorizes and critiques histological sample preparation methods for analyzing the implant-soft tissue interface, emphasizing the challenges posed by metal-tissue specimens. It highlights the... Read more
Key finding: This study develops a three-dimensional, tissue-engineered oral mucosal model comprising human oral keratinocytes and fibroblasts to replicate in vivo peri-implant soft tissue architecture for in vitro analysis. This... Read more
Key finding: Utilizing transmission electron microscopy with electropolishing preparation techniques, this study reveals hemidesmosome-like structures indicating epithelial attachment at the interface between titanium implant surfaces and... Read more
3. Which patient-related and procedural factors contribute to dental implant failure and how can implant stability be optimized surgically?
This theme addresses clinically relevant risk factors influencing failure rates of dental implants and investigates surgical variables affecting initial implant stability, a crucial determinant of osseointegration. By identifying patient conditions (age, bone quality, smoking), anatomic considerations, and procedural techniques (implant insertion torque, insertion approach), this research informs evidence-based protocols to maximize implant survival and long-term success.
Key finding: This large retrospective cohort study of 4,680 implants in 1,140 patients identifies increasing patient age and smoking as significant factors elevating implant failure risk, while comorbidities such as diabetes,... Read more
Key finding: This experimental study compares continuous rotation insertion (CRI) versus combined continuous and intermittent rotation insertion (IRI) in artificial bones differing by quality, showing that insertion technique affects... Read more
Key finding: This article proposes that mini-implant failures are frequently attributable to improper site selection, inappropriate implant size relative to alveolar bone dimensions, inadequate pre-placement orthodontic tooth uprighting... Read more
Key finding: This case report highlights an early implant failure occurring within 10 days post-placement attributed to inadequate pre-surgical bone assessment and failure to recognize large buccal cortical plate defects, resulting in... Read more
Key finding: Besides maintaining bone volume, this study elucidates that implants placed post-decoronation in ankylosed teeth undergoing replacement root resorption demonstrate successful osseointegration without failure. The paper... Read more