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Tobacco Extract

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Tobacco extract refers to the concentrated liquid derived from the leaves of the tobacco plant, containing various chemical compounds, including nicotine, alkaloids, and other phytochemicals. It is used in research to study the biological effects of tobacco constituents and their potential health impacts.
lightbulbAbout this topic
Tobacco extract refers to the concentrated liquid derived from the leaves of the tobacco plant, containing various chemical compounds, including nicotine, alkaloids, and other phytochemicals. It is used in research to study the biological effects of tobacco constituents and their potential health impacts.

Key research themes

1. How do the chemical constituents and extraction methods affect the composition and potential biological activities of tobacco extracts?

This research theme investigates the phytochemical complexity of tobacco extracts, focusing on identifying active compounds such as nicotine, alkaloids, terpenoids, flavonoids, and other bioactives. It also explores diverse extraction and analytical techniques, including solvent extraction, ultrasonic and microwave-assisted extraction, and chromatographic methods, to optimize compound yield and characterize chemical profiles. Understanding these factors is critical for evaluating tobacco's pharmacological potential and toxicological risks.

Key finding: Although focused on cannabis, the paper demonstrates the concept that herbal extracts contain multiple active ingredients where secondary compounds (e.g., terpenoids, flavonoids) synergize or mitigate effects of primaries... Read more
Key finding: Optimized ultrasonic and microwave-assisted extraction methods improved nicotine and minor alkaloid yields compared to conventional Soxhlet and AOAC-modified procedures. Use of response surface methodology allowed precise... Read more
Key finding: From tobacco leaves separated from cigarettes, nicotine was successfully extracted using liquid-liquid solvent extraction with ether under alkaline conditions, achieving a 0.6% yield. Physical properties and IR analysis... Read more
Key finding: Nicotine content varied significantly among seven Syrian Nicotiana tabacum varieties, ranging from less than 3% to 6.7% dry weight. Quantification by LC-MS/MS under validated protocols revealed Virginia variety as having the... Read more
Key finding: Tobacco plants contain thousands of metabolites, including pyridine alkaloids, flavonoids, diterpenes, and polyphenols with potential anti-inflammatory, antibacterial, antitumor, and antioxidant activities. The review... Read more

2. What are the toxicological profiles and health implications of tobacco-derived products, including novel delivery systems such as heated tobacco products and smokeless tobacco?

This area concentrates on analysis of harmful and potentially harmful constituents (HPHCs) in various tobacco-based and tobacco-free products, the toxicity associated with their use, and health outcomes related to exposure. It covers chemical characterization of traditional tobacco products, heated tobacco products, and smokeless tobacco, alongside biomarkers of exposure and potential for harm reduction. Understanding the toxicant profile informs regulatory assessment and public health strategies.

Key finding: Heated tobacco products (HTPs) heat tobacco at lower temperatures to reduce combustion-related toxins, resulting in overall lower toxic chemicals than conventional cigarette smoke; however, some harmful and potentially... Read more
Key finding: Extensive chemical profiling using WHO-validated SOPs showed high nicotine content, bioavailability modulated by pH and moisture, and substantial levels of flavors such as menthol in various smokeless tobacco (SLT) products.... Read more
Key finding: Analysis of South Asian smokeless tobacco products revealed high variation in nicotine forms, tobacco-specific nitrosamines, and an array of flavor compounds. Elevated free-base nicotine levels indicate higher addictive... Read more
Key finding: Novel tobacco-free nicotine pouches (e.g., ZYN) contain lower or undetectable levels of many HPHCs compared with traditional smokeless tobacco products, aligning them closer to pharmaceutical nicotine replacement therapies in... Read more
Key finding: Sub-acute oral exposure to aqueous tobacco leaf extract in rats caused alterations in liver and kidney serum markers (ALT, AST, ALP, urea, creatinine) and disturbed lipid profiles. Findings suggest that tobacco extract... Read more

3. Can tobacco plant extracts exhibit antimicrobial properties and be useful for agricultural or biomedical applications?

Research here explores the bioactivity of tobacco-derived compounds beyond toxicity, focusing on antimicrobial efficacy against phytopathogens or contamination in vitro. Tobacco leaf-surface extracts rich in diterpenes and other metabolites are investigated for antifungal activity and potential as natural alternatives to synthetic agrochemicals, highlighting tobacco's multifunctional phytochemical roles with practical implications.

Key finding: Ethanol extracts from leaf surfaces of Nicotiana tabacum accessions, containing diterpenes like cis-abienol and α-CBT diol, demonstrated significant in vitro antifungal activity against key phytopathogens (e.g., Rhizoctonia... Read more
Key finding: Cigarette aqueous extracts stimulated growth and biofilm formation of Streptococcus mutans in vitro in a dose-dependent manner, suggesting tobacco additives and altered oral environments favor cariogenic bacteria... Read more

All papers in Tobacco Extract

Objective: Tobacco use in the smoking or smokeless form is the most common form of substance abuse recorded in the world. Not only does tobacco influence carcinogenesis but also modifies the oral microflora. The aim of our study was to... more
Nowdays, the number of resident building and public facilities project is increasing rapidly. So, the demand of building materials is increasing too. One of building materials is brick. Then, there are some efforts to find other building... more
Tujuan dari penelitian ini adalah untuk mengetahui perbedaan kekuatan kekuatan batu bata tanah liat terhadap posisi terbakar pada kotak api. Penelitian ini dilakukan di Laboratorium Struktur, Jurusan Teknik Sipil, Fakultas Teknik,... more
Concrete Is a function of constituting materials consisting of hydraulic cement materials, coarse aggregate, fine aggregate, water, and additional materials. In research, there are two kinds of fine aggregate used i.e. Lumajang Sand and... more
Concrete Is a function of constituting materials consisting of hydraulic cement materials, coarse aggregate, fine aggregate, water, and additional materials. In research, there are two kinds of fine aggregate used i.e. Lumajang Sand and... more
ABSTRAK Dalam setiap proses produksi atau proses pekerjaan konstruksi, selalu dijumpai hasil produk atau sisa bahan bangunan yang tidak digunakan lagi dan dibuang sebagai limbah. Jika limbah ini dibuang secara sembarangan tentunya akan... more
It suggested exploiting local materials and waste such as the roof tile fraction as aggregate, known as substitution concrete of roof tile fraction (SPG concrete). This research makes use aggregate of roof tile fraction (APG) from Godean... more
Peneliti di sebuah pabrik pembuatan genteng bermaksud mencari bahan dan suhu pemanasan optimal dalam produksi gentengnya. Untuk mendapatkan jawaban itu, mereka melakukan percobaan dengan mencoba beberapa kombinasi antara bahan dan suhu... more
Timber supply is diminishing in addition to the trend to lower quality but higher cost of wood production manufacturing. However, because the demand of this material continues, an alternative or substitution on the use of timber, such as... more
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