Key research themes
1. How do the chemical constituents and extraction methods affect the composition and potential biological activities of tobacco extracts?
This research theme investigates the phytochemical complexity of tobacco extracts, focusing on identifying active compounds such as nicotine, alkaloids, terpenoids, flavonoids, and other bioactives. It also explores diverse extraction and analytical techniques, including solvent extraction, ultrasonic and microwave-assisted extraction, and chromatographic methods, to optimize compound yield and characterize chemical profiles. Understanding these factors is critical for evaluating tobacco's pharmacological potential and toxicological risks.
2. What are the toxicological profiles and health implications of tobacco-derived products, including novel delivery systems such as heated tobacco products and smokeless tobacco?
This area concentrates on analysis of harmful and potentially harmful constituents (HPHCs) in various tobacco-based and tobacco-free products, the toxicity associated with their use, and health outcomes related to exposure. It covers chemical characterization of traditional tobacco products, heated tobacco products, and smokeless tobacco, alongside biomarkers of exposure and potential for harm reduction. Understanding the toxicant profile informs regulatory assessment and public health strategies.
3. Can tobacco plant extracts exhibit antimicrobial properties and be useful for agricultural or biomedical applications?
Research here explores the bioactivity of tobacco-derived compounds beyond toxicity, focusing on antimicrobial efficacy against phytopathogens or contamination in vitro. Tobacco leaf-surface extracts rich in diterpenes and other metabolites are investigated for antifungal activity and potential as natural alternatives to synthetic agrochemicals, highlighting tobacco's multifunctional phytochemical roles with practical implications.