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Stem Cell Travel

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lightbulbAbout this topic
Stem cell travel refers to the practice of individuals traveling to other countries to receive stem cell therapies or treatments that may not be available or approved in their home countries. This phenomenon raises ethical, legal, and medical concerns regarding the safety, efficacy, and regulation of such therapies.
lightbulbAbout this topic
Stem cell travel refers to the practice of individuals traveling to other countries to receive stem cell therapies or treatments that may not be available or approved in their home countries. This phenomenon raises ethical, legal, and medical concerns regarding the safety, efficacy, and regulation of such therapies.

Key research themes

1. How do ethical, legal, and regulatory frameworks shape patient access and the practice of international stem cell treatments?

This research theme explores the complex interplay of ethics, law, and regulation governing access to stem cell therapies across national borders. It is critical because divergent regulations and varying ethical standards internationally create gaps that spawn stem cell tourism and challenge consistent patient protections. The theme focuses on patients' rights, informed consent, governmental oversight, and the tension between rapid therapy availability and safeguarding efficacy and safety.

Key finding: The Costa Rican Supreme Court ruling established a legal precedent allowing patients receiving experimental stem cell therapy to continue treatment despite initial regulatory prohibition, underscoring tensions between patient... Read more
Key finding: This study identifies critical policy and regulatory challenges posed by unproven stem cell interventions marketed domestically and internationally, emphasizing inadequate patient protections, lack of consistent follow-up,... Read more
Key finding: This paper critiques the framing of unproven stem cell treatment travel as mere tourism and highlights the regulatory voids and transnational governance challenges, such as ensuring product quality, safeguarding informed... Read more

2. What biological and cellular factors influence the migration, homing, and therapeutic efficacy of stem cells in regenerative applications?

Understanding the mechanisms that regulate stem cell migration, homing to injury sites, and survival is fundamental to improving the delivery and success of cell-based regenerative therapies. This theme synthesizes research identifying intrinsic heterogeneity in migration potential within stem cell populations, the role of microenvironmental cues, and how administration routes and cellular subpopulations affect targeted delivery and therapeutic outcomes.

Key finding: The study isolates highly migrating subpopulations within mesenchymal and neural stem cells, demonstrating that enhanced migratory capacity directly correlates with superior lesion-targeted homing and improved therapeutic... Read more
Key finding: This review identifies discrepancies between in vivo and in vitro data on homing mechanisms of intrathecal stem cell delivery to the central nervous system and underscores the need for advanced bioengineering and... Read more
Key finding: This comprehensive methodological resource emphasizes the importance of sophisticated in vivo imaging and identification techniques to analyze the spatiotemporal dynamics of diverse stem cell migration processes, thereby... Read more

3. How can advanced stem cell technologies and methodologies enhance regenerative medicine effectiveness and patient safety?

This theme addresses technological innovations and methodological advances that improve stem cell production, differentiation, cultivation, and quality control, which are essential to overcoming current limitations in therapy scalability, safety, and clinical efficacy. Emphasis is placed on induced pluripotent stem cell (iPSC) technology, 3D culturing methods, cryopreservation, and automated assays for functional characterization.

Key finding: This paper elucidates how iPSCs, generated by reprogramming mature somatic cells, combined with automated patch clamp electrophysiology, provide scalable, physiologically relevant human cell models that enable precise... Read more
Key finding: The adoption of three-dimensional culture systems, such as spheroids and organoids, overcomes limitations of traditional 2D cultures by better mimicking in vivo microenvironmental interactions, improving extracellular matrix... Read more
Key finding: This review underscores the clinical utility of umbilical cord blood as a rich source of hematopoietic stem cells, detailing optimized methodologies for collection and cryopreservation that support widespread banking and... Read more

All papers in Stem Cell Travel

This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission-Directorate General Home Affairs. Timothy Caulfield led the group's discussion, wrote the first draft of the... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission -Directorate General Home Affairs. The HOTT project has been funded with the support of the European... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission -Directorate General Home Affairs. The HOTT project has been funded with the support of the European... more
The article aims to discuss the intricacies of the fertility industry in India through Raj Mehta’s directorial debut, Good Newws (2019). The movie serves as a social commentary by building upon the tragic switching of sperms between two... more
Physicians and other health care professionals seem well placed to play a role in the monitoring and, perhaps, in the curtailment of the trafficking in human beings for the purpose of organ removal. They serve as important sources of... more
Physicians and other health care professionals seem well placed to play a role in the monitoring and, perhaps, in the curtailment of the trafficking in human beings for the purpose of organ removal. They serve as important sources of... more
Kidney trade has been on the rise despite the domestic and international law enforcement aiming to protect the vulnerable population from potential exploitation. Regional hubs are emerging in several parts of the world including South... more
Physicians and other health care professionals seem well placed to play a role in the monitoring and, perhaps, in the curtailment of the trafficking in human beings for the purpose of organ removal. They serve as important sources of... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission-Directorate General Home Affairs. The HOTT project has been funded with the support of the European Commission.... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission-Directorate General Home Affairs. The HOTT project has been funded with the support of the European Commission.... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission -Directorate General Home Affairs. The HOTT project has been funded with the support of the European... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission-Directorate General Home Affairs. The HOTT project has been funded with the support of the European Commission.... more
This report is published with the financial support of the Prevention of and Fight against Crime Programme European Commission-Directorate General Home Affairs. The HOTT project has been funded with the support of the European Commission.... more
The increasing demand for human egg cells has led to reproductive tourism and a transnational egg trade. The activity flourishes due to poverty and criminality, as well as medical needs (infertility) and cultural needs (the dream of... more
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