Key research themes
1. How can silk fibroin be processed into multiscale formats to tailor its structural and biomedical properties?
This research theme investigates the methodologies to fabricate and manipulate silk fibroin constructs across multiple scales—from nano- to macroscale—in order to achieve tunable physicochemical and biological properties optimized for diverse biomedical applications. Understanding and controlling silk fibroin processing parameters allow modulation of mechanical strength, degradation rate, and cellular interactions, which are crucial for applications in drug delivery, tissue engineering, and bioelectronics.
2. What is the influence of molecular and nanoscale structural features on the mechanical properties and toughness of silkworm silk fibers and composites?
This research area focuses on elucidating how amino acid sequences, secondary structures (especially β-sheets), and micro- to nano-fibrillar architectures within silk fibers underpin their intrinsic tensile strength, extensibility, and toughness. It also investigates how these natural properties translate to enhanced mechanical performance in silk fiber-reinforced polymer composites, informing material design principles for engineering and biomedical applications.
3. How do processing conditions and environmental factors affect the mechanical performance and durability of silk-based materials?
This theme addresses the impact of degumming techniques, spinning parameters, hydration, and aging on the mechanical and structural integrity of silk fibers and their composites. Investigating these factors provides actionable insights for optimizing silk fiber fabrication, storage, and application environments to maximize material performance and longevity, especially critical for biomedical and textile uses.