Oral Dispersible Tablets

Difficulty in swallowing (dysphagia) is common among all age groups, especially for geriatric and pediatric patients. Oral dispersible tablets (ODT) constitute an innovative dosage form that overcome the problems of swallowing and provides a quick onset of action. The aim of the present research was to prepare taste masked oral dispersible tablets by sublimation method and investigate the effects of super disintegrant (Kollidon CL) on the disintegration time as well as the percent release of a model drug from Kollidon 30, Ispaghula husk and Guar Gum based formulations. Domperidone, an anti-emetic drug was taken as the model drug for the study. A high porosity was achieved using camphor as volatilizing agent which allowed easy penetration of dissolution media followed by rapid release of drug. The granules and tablets were evaluated and found to be acceptable according to standard limits. In vitro release studies were performed using USP apparatus-II (paddle method) in 900ml of 0.1N HCl (pH 1.2) at 50rpm. The release mechanisms were explored and explained with different kinetic model. Kollidon CL was found to cause a rapid disintegration of ODTs within 24 to 39 seconds. The highest drug release was obtained from F-6 (88.19%) containing Ispaghula husk. Finally, the overall study indicate a proper balance between the rate retarding polymers and disintegrant having a drug release profile of ODT under the presence of a volatilizing agent showed an acceptable disintegration time with a percent of drug release.

The objective of the present study is to develop a pharmaceutically
stable,  cost  effective  and  quality  improved  robust  formulation  of
Valsartan Immediate Release tablets. The aim of work is related to
the  formulation  and  evaluation  of  10mg  of  dispersible  tablet.
Valsartan  belongs  to  a  class  of  antihypertensive  agents  called
angiotensin II receptor blockers (ARBs). Total nine formulations
were  prepared  by  direct  compression  method  in  which  the
concentration of the superdisintegrants is varied to evaluate the effect
on the disintegration time of valsartan mouth dissolving tablets. The
superdisintegrants,  involved  in  preparation  are  Sodium  starch
glycolate, Avicel PH 102, Low HPC. The prepared batches of tablets
were  evaluated  for  micromeritic  parameters,  weight  variation,
hardness,  friability,  wetting  time,  In  vitro  dispersion  time,  drug
content and In vitro dissolution studies. In Formulations F1, F2, F3,
releases 89.83%, 91.10%, 96.20%, respectively, Formulation F4, F5,
and F6, which release 85.11%, 88.71% and 90.44% respectively and.
Formulation  F7,  F8,  F9,  releases  78.26%,  82.26%,  85.31%,
respectively,  at  end  of  15  minutes.  Amongst  all  the  developed
formulations, valsartan mouth dissolving tablets formulated by using
sodium starch glycolate as superdisintegrants, having hardness (3.7
Kg/cm
2
), Friability (0.1356 %), Drug Content (9.9250.067 mg). and
it  is  fulfilling  all  the  parameters.  It  has  shown  good  In  vitro
disintegration time (8.00  1.023 sec), In vitro dispersion time (14.33
 1.24 sec), compared to other superdisintegrants. The optimized
formulation  (F3)  containing  Sodium  starch  glycolate,  as
superdisintegrant  is  producing  best  results  compared  to  other
formulations.

Anacardiumgum  derived  from  the  edible  seeds  of
Anacardiumoccidantale(family  Anacardiaceae) was evaluated for its binding  properties  at  a  concentration  of  5  %  w/w  and  10%  w/w  in Ibuprofen  tablets  with  official  starch  as  a  control.  A  comparative analysis showed that the granules bound with  Anacardiumgum were relatively  bigger and harder than the ones obtained with starch gum. The hardness,  disintegration time and dissolution rate increased with increase  in  concentration  of  Anacardiumgum.  Tablets  containing
10% w/w of  Anacardiumgum had a binding  capacity approximately twice that of starch with a dissolution rate of 58.5% after 30  min. The results obtained suggest that Anacardiumgum possesses potential as a commercial binding agent.

The present study was aimed to formulate and evaluate fast
dissolving oral films of Zolmitriptan using sodium alginate, xanthan
gum and sodium starch glycolate, guar gum. The suitable plasticizer
and its concentration were selected on the basis of flexibility, tensile
strength and stickiness of the film. The films are prepared by solvent
casting method and characterized by UV, FTIR studies. The films
were evaluated for disintegration time, Folding endurance, Tensile
Strength, Mouth dissolving time, Thickness, content uniformity and
In-vitro dissolution studies. The F5 formulation has given 98.5% drug
release within 6 minutes and has a tensile strength of 1.80 MPa.

Formulation research is oriented towards safety, efficacy and quick onset of action of existing drug molecule through novel concepts of drug delivery. Orally disintegrating tablets of sumatriptan succinate were prepared by direct compression method to provide faster relief from pain to migraine sufferers. About twelve formulations for the present study were carried out based on 2 level 2 factor full factorial design for each set of superdisintegrants. Croscarmellose sodium, Crospovidone and Sodium starch glycolate (SSG) were used as superdisintegrants, while microcrystalline cellulose was used as diluent. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of Croscarmellose sodium and Sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 8 seconds. It also showed a higher water absorption ratio and 99.58% of drug is released within 2 minutes.

The current study was aimed to develop the meclizine hydrochloride
sublimated fast dissolving tablets using different sublimated agents to
enhance the dissolution rate. The prepared fast dissolving tablets
were subjected to pre-compression properties and characterized for
hardness, weight variation, friability, wetting time, water absorption
ratio, and disintegration time. From In vitro dissolution studies, the
formulation F3 containing camphor (10%w/w) as the sublimating
agent showed rapid dissolution of about 98.61% in 30 min, and
disintegration time 43 sec when compared with other sublimating
agents. The percent drug release in 30 min (Q30) and initial
dissolution rate for formulation F3 was 98.61±0.25%, 3.29%/min.
These were very much higher compared to marketed tablets
(65.43±0.57%, 2.18%/min). The dissolution efficiency was found to
be 63.37 and it is increased by 1.4 fold with F3 FDT tablets
compared to marketed tablets. Differential scanning calorimetry and
Fourier transform infrared spectroscopy studies revealed that there
was no possibility of interactions. In conclusion, development of
meclizine hydrochloride fast dissolving tablets by sublimation
method is an appropriate method to enhance the dissolution rate.

http://www.researchmoz.us/global-combo-chip-for-tablet-market-2014-2018-report.html

Global Combo-chip for Tablet market  to grow at a CAGR of 41.3 percent over the period 2014-2018. One of the key factors contributing to this market growth is the increasing sales of tablets worldwide. The Global Combo-chip market for Tablets has also been witnessing technological convergence. However, the high cost of integration could pose a challenge to the growth of this market.Global Combo-chip Market for Tablets 2014-2018, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the Americas, and the APAC and EMEA regions; it also covers the Global Combo-chip market landscape and its growth prospects in the coming years. The report also includes a discussion of the key vendors operating in this market.