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Low risk pregnancy

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Low risk pregnancy refers to a gestational condition characterized by the absence of significant medical, obstetric, or psychosocial complications that could adversely affect the health of the mother or fetus. It typically involves normal physiological processes and allows for standard prenatal care without heightened monitoring or intervention.
lightbulbAbout this topic
Low risk pregnancy refers to a gestational condition characterized by the absence of significant medical, obstetric, or psychosocial complications that could adversely affect the health of the mother or fetus. It typically involves normal physiological processes and allows for standard prenatal care without heightened monitoring or intervention.

Key research themes

1. How do metabolic and cardiovascular risk factors shape adverse outcomes and screening needs in low-risk pregnancy?

This research area investigates the influence of metabolic syndrome, hypertensive disorders, obesity, gestational diabetes, and related cardiovascular conditions on adverse pregnancy outcomes in apparently low-risk or nulliparous pregnancies. Understanding how these risk factors contribute to complications such as preeclampsia, gestational diabetes, preterm birth, and low birth weight informs improved screening, risk stratification, and preventive strategies during pregnancy.

Key finding: In a prospective international cohort of 5,530 low-risk nulliparous women, metabolic syndrome (MetS) defined by adult criteria at 15 ± 1 weeks' gestation was associated with a 1.63-fold increased risk of preeclampsia and a... Read more
Key finding: Among a large Medicaid-insured cohort from three US states, pregnancy-related cardiometabolic conditions, including hypertensive disorders and gestational diabetes, showed rising incidence and were associated with increased... Read more
Key finding: A multivariable risk prediction model developed and validated in a Medicaid cohort incorporated social determinants (e.g., history of childhood abuse, substance use), clinical factors (prior preterm birth, comorbid... Read more

2. What are the key maternal and sociodemographic risk factors influencing low birth weight and adverse neonatal outcomes in low-risk pregnancies across diverse populations?

This theme addresses identifiable maternal characteristics, socioeconomic factors, obstetric complications, and behavioral risk factors that contribute to low birth weight (LBW), prematurity, and neonatal complications within ostensibly low-risk pregnancy populations. The findings inform prevention strategies and targeted maternal care even among otherwise healthy and literate women, with attention to disparities in rural, urban, and marginalized populations worldwide.

Key finding: In a population-based cross-sectional study among women in tribal and non-tribal blocks of Nashik District, India, multiple health and behavioral risk factors—such as parental consanguinity, heavy work in late pregnancy,... Read more
Key finding: In a hospital-based case-control study among healthy, literate mothers of middle socioeconomic status in India, parity (primiparity), premature rupture of membranes, pregnancy-induced hypertension, prematurity, and... Read more
Key finding: Analysis of over 150,000 singleton births in St. Louis, USA revealed that Black race, advanced maternal age, primiparity, and gestational hypertension were significant predictors of very low birth weight (VLBW) regardless of... Read more
Key finding: In a retrospective cohort comparing singleton pregnancies, women with a low fetal fraction (<4%) on noninvasive prenatal testing (NIPT) exhibited higher rates of adverse perinatal outcomes including miscarriage, fetal demise,... Read more

3. How do perinatal and long-term reproductive outcomes relate to adverse pregnancy conditions and birth weight among low-risk populations?

This theme investigates the reproductive trajectory and offspring health outcomes of individuals born with adverse early-life conditions such as very low birth weight (VLBW) or exposure to late-term pregnancy, as well as maternal metabolic indicators related to glycemia and hypertensive pregnancy disorders. These studies inform risks spanning generations and optimize prenatal care timing and metabolic monitoring in low-risk women.

Key finding: A retrospective cohort linkage study of 618 adults born at VLBW (<1500g) in Israel demonstrated that male and female VLBW survivors had approximately half the reproductive rate relative to those born at normal birth weight,... Read more
Key finding: A retrospective study of 7,619 singleton pregnancies in Iran found that late-term pregnancy (41 0/7 to 41 6/7 weeks) constituted 4.1% of deliveries and was associated with increased rates of macrosomia, meconium-stained... Read more
Key finding: Among 1,841 pregnant women classified as normal glucose tolerant using OGTT screening, those with low glycemia (<3.9 mmol/L) during fasting, 1-hour, or 2-hour measurements had significantly higher odds (adjusted OR 3.41) of... Read more

All papers in Low risk pregnancy

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial... more
To establish longitudinal reference intervals for pulsatility index (PI) and systolic velocity (SV) of the fetal renal artery, and to evaluate their correlation with the amniotic fluid index (AFI). Methods: A prospective longitudinal... more
Background and objectives There has been a steady annual increase in the number of deliveries performed at Chris Hani Baragwanath Hospital in recent years. A 2004 audit found that approximately one third of deliveries conducted at the... more
The aim of this scoping review is to map the available evidence on the nature, extent, and range of antenatal care policies for low-risk pregnant women in high-income countries with a health system founded on the Beveridge Model.... more
South Africa's healthcare system is based on the primary care model in which women with lowrisk pregnancies are encouraged to deliver in clinics, community health centres and district hospitals while women with high-risk pregnancies are... more
Amaç: Doğuştan kalp hastalıkları için yüksek ve düşük risk taşıyan gebelerde intrauterin kalp hastalığı sıklığını belirlemek ve karşılaştırmak. Yöntemler: Üniversitemiz Tıp Fakültesi Pediatrik Kardiyoloji Ünitesinde fetal ekokardiyografi... more
Background. Pregnancy risk perception affects a pregnant woman's decision about health care services such as prenatal care, place of birth, choices about medical interventions, adherence to medical procedures, and recommendations.... more
Randomized retrospective study of the rise in cesarean surgery among low risk women between 1990 and 2000 at Hadassah Ein Kerem Labor and Delivery Unit in Jerusalem. The CS rate in low risk women increased from 4% to 10.5%. Approximately... more
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