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Outline

A Fuzzy-Membrane-Immune Algorithm For Breast Cancer Diagnosis

2012

Abstract

The automatic diagnosis of breast cancer is an important medical problem. This paper hybridizes metaphors from cells membranes and intercommunication between compartments with clonal selection principle together with fuzzy logic to produce a fuzzy rule system in order to be used in diagnosis. The fuzzy-membrane-immune algorithm suggested were implemented and tested on the Wisconsin breast cancer diagnosis (WBCD) problem. The developed solution scheme is compared with five previous works based on neural networks and genetic algorithms. The algorithm surpasses all of them. There are two motivations for using fuzzy rules with the membrane-immune algorithm in the underline problem. The first is attaining high classification performance. The second is the possibility of attributing a confidence measure (degree of benignity or malignancy) to the output diagnosis, beside the simplicity of the diagnosis system, which means that the system is human interpretable.

References (20)

  1. C. A. Pena-Reyes, M. sipper, A fuzzy-genetic approach to breast cancer diagnosis. Arti- ficial Intelligence in Medicine, 17(2): 131-155, October 1999.
  2. C. A. Pena-Reyes, M. Sipper, Evolving fuzzy rules for breast cancer diagnosis, Pro- ceedings of 1998 International Symposium on Nonlinear Theory and Applications (NOLTA'98), Vol. 2. Lausanne: Presses Polytechniques ET Universitaires Romandes, 369-372, 1998.
  3. C. J. Merz, P.M. Murphy, UCI repository of machine learning databases. http://www.ics.uci.edu/ mlearn/MLRepository.html, 1996.
  4. D. Dasgupta, N. Attoh-Okine, Immunity-Based Systems:A Survey, In the proceedings of the IEEE International Conference on Systems, Man, and Cybernetics, Orlando,1997.
  5. G. Paun, Computing with membranes ,TUCS Report 208, Turku Center for Computer Science, 1998.
  6. H. Zhang, D. Liu, Fuzzy Modeling and Fuzzy Control, Birkhauser, 2006.
  7. Taha, J. Ghosh, Evaluation and ordering of rules extracted from feed forward networks, Proceedings of the IEEE International Conference on Neural Networks, pp. 221-226, 1997.
  8. J.J. Espinosa, J. Vandewalle, Constructing fuzzy models with linguistic integrity, IEEE Transactions on Fuzzy Systems, 1999.
  9. L. N. De Castro, F. J. Zuben, Artificial Immune Systems: Part I -Basic Theory and Applications, Technical Report -RT DCA, pp. 89, 1999.
  10. L. N. de Castro,J. Timmis, H. Knidel, F. Von Zuben, Artificial Immune Systems: struc- ture, function, diversity and an application to biclustering, Natural Computing, vol. 9, no. 3, 2010.
  11. L. N. De Castro, F. J. Zuben, Learning and optimization using the clonal selection principle, IEEE transactions on evolutionary computation, 2002.
  12. L. N. De Castro, F. J. Zuben, The Clonal Selection Algorithm with Engineering Appli- cations, proceedings of the genetic and evolutionary computation conference, workshop on artificial immune systems and their applications; pp. 36-37, 2000.
  13. L. N. De Castro, Fundamentals of natural computing: basic concepts, algorithms, and applications. CRC Press LLC; 2007.
  14. L. N. De Castro, J. Timmis, Artificial Immune Systems A new computational approach, Springer, 2002.
  15. L. N. De Castro, Natural computing, Encyclopedia of information science and technol- ogy, vol. IV. Idea Group Inc, 2005.
  16. R. Setiono, Extracting rules from pruned neural networks for breast cancer diagnosis, Artificial Intelligence in Medicine, vol. 8, no. 1,pp. 37-51, 1996.
  17. R. Setiono, H. Liu, Symbolic representation of neural networks. IEEE Computer, vol. 29, no.3, pp.71-77, 1996.
  18. R.R. Yager, L.A. Zadeh, Fuzzy Sets, Neural Networks, and Soft Computing, New York, Van Nos-trand Reinhold, 1994.
  19. S. Forrest, S. A. Hofmeyrt, A. Somayajit, Computer Immunology, University of New Mexico Albuquerque, NM 87131-1386, March 21, 1996.
  20. T. Back, D. Fogel and Z. Mechalewicz, Evolutionary computation, basic algorithms and operators, institute of physics publishing, 2000.