Papers by Theodoros Arvanitis
Studies in Health Technology and Informatics
The Tommy’s National Centre for Miscarriage Research aims to support the diagnosis and treatment ... more The Tommy’s National Centre for Miscarriage Research aims to support the diagnosis and treatment for couples suffering from recurrent miscarriage. Tommy’s Net is an electronic data gathering tool, collecting miscarriage data and links with hospital Clinical Information System databases. The gathering of patient reported data is an important aspect, especially as data relating to pregnancy and miscarriage events are often left unreported. Methods: Both traditional paper-based and electronic patient reported outcome (ePRO) solutions have been explored to improve response rates, minimize data redundancy and reduce burden on staff. Popular ePRO survey solutions have been compared, including REDCap, SurveyMonkey, Qualtrics and LimeSurvey. Results: LimeSurvey was selected as the most appropriate solution as it provided self-hosting capability, SMS integration and ease of use. Conclusion: We have implemented a LimeSurvey based ePRO system for collection of baseline and follow-up data for p...
Studies in Health Technology and Informatics
Modern healthcare providers rely upon Electronic Healthcare Records (EHR) systems to record patie... more Modern healthcare providers rely upon Electronic Healthcare Records (EHR) systems to record patient data inside their own organization. Some healthcare providers share this data to facilitate patient care with other providers. Medical devices and healthcare providers can use differing standards of recording healthcare information. The Structural and Semantic Mapper Proxy API solution offers a practical way to tackles the issues of Structural and Semantic mapping of Application Programing Interfaces (API) in a healthcare context to enable connection of all existing systems to a healthcare providers EHR creating a single source of truth regarding the treatment of patients and enabling healthcare providers to bridge the gap between external EHR systems.
Journal of biomechanics, Feb 29, 2016
Left-ventricular (LV) remodelling, associated with diastolic heart failure, is driven by an incre... more Left-ventricular (LV) remodelling, associated with diastolic heart failure, is driven by an increase in myocardial stress. Therefore, normalisation of LV wall stress is the cornerstone of many therapeutic treatments. However, information regarding such regional stress-strain for human LV is still limited. Thus, the objectives of our study were to determine local diastolic stress-strain field in healthy LVs, and consequently, to identify the regional variations amongst them due to geometric heterogeneity. Effects of LV base movement on diastolic model predictions, which were ignored in the literature, were further explored. Personalised finite-element modelling of five normal human bi-ventricles was carried out using subject-specific myocardium properties. Model prediction was validated individually through comparison with end-diastolic volume and a new shape-volume based measurement of LV cavity, extracted from magnetic resonance imaging. Results indicated that incorporation of LV b...
E-health and learning project methodology and design
ABSTRACT
Journal of Clinical Bioinformatics, 2015
NeuroImage, Jan 17, 2015
Information flow between the thalamus and cerebral cortex is a crucial component of adaptive brai... more Information flow between the thalamus and cerebral cortex is a crucial component of adaptive brain function, but the details of thalamocortical interactions in human subjects remain unclear. The principal aim of this study was to evaluate the agreement between functional thalamic network patterns, derived using seed-based connectivity analysis and independent component analysis (ICA) applied separately to resting state functional MRI (fMRI) data from 21 healthy participants. For the seed-based analysis, functional thalamic parcellation was achieved by computing functional connectivity (FC) between thalamic voxels and a set of pre-defined cortical regions. Thalamus-constrained ICA provided an alternative parcellation. Both FC analyses demonstrated plausible and comparable group-level thalamic subdivisions, in agreement with previous work. Quantitative assessment of the spatial overlap between FC thalamic segmentations, and comparison of each to a histological "gold-standard"...
Large-scale behaviour of packet-switched networks: theoretical analysis framework
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2005
We present a possible way to study large-size packet-switched networks capable of accounting for ... more We present a possible way to study large-size packet-switched networks capable of accounting for interactions between adjacent queues. The interaction between queues arises, because of the influence of the routing protocol on each switching decision, and the stochastic nature of packet lengths and inter-arrival times.Both the methodology and the analysis tools are adaptations of methods of statistical mechanics. The justification for their use lies in recent experimental evidence indicating that aggregate, core-network IP traffic, exhibits quasi-Markovian properties when the network is heavily loaded.In this paper, we present a general methodology and introduce approximations that greatly simplify the analysis. These approximations, are owing to the quasi-Markovian nature of the traffic and the large size of the network.
European Journal of Emergency Medicine, 1998
The digital classification of ancient near eastern cuneiform data
Información del artículo The digital classification of ancient near eastern cuneiform data.
Advanced Science Letters, 2011
Link to publication on Research at Birmingham portal General rights Unless a licence is specified... more Link to publication on Research at Birmingham portal General rights Unless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law. • Users may freely distribute the URL that is used to identify this publication. • Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. • User may use extracts from the document in line with the concept of 'fair dealing' under the Copyright, Designs and Patents Act 1988 (?) • Users may not further distribute the material nor use it for the purposes of commercial gain. Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.
ObjectiveRemote or mobile consulting (mConsulting) is being promoted to strengthen health systems... more ObjectiveRemote or mobile consulting (mConsulting) is being promoted to strengthen health systems, deliver universal health coverage and facilitate safe clinical communication during COVID-19 and beyond. We explored whether mConsulting is a viable option for communities with minimal resources in low- and middle-income countries (LMICs).MethodsWe reviewed evidence published since 2018 about mConsulting in LMICs and undertook a scoping study (pre-COVID) in two rural settings (Pakistan, Tanzania) and five urban slums (Kenya, Nigeria, Bangladesh), using policy/document review, secondary analysis of survey data (from the urban sites), and thematic analysis of interviews/workshops with community members, healthcare workers, digital/telecommunications experts, mConsulting providers, local and national decision-makers. Project advisory groups guided the study in each country.ResultsWe reviewed five empirical studies and seven reviews, analysed data from 5,219 urban slum households and engag...
Studies in Health Technology and Informatics
CAREPATH project is focusing on providing an integrated solution for sustainable care for multimo... more CAREPATH project is focusing on providing an integrated solution for sustainable care for multimorbid elderly patients with dementia or mild cognitive impairment. The project has a digitally enhanced integrated patient-centered care approach clinical decision and associated intelligent tools with the aim to increase patients’ independence, quality of life and intrinsic capacity. In this paper, the conceptual aspects of the CAREPATH project, in terms of technical and clinical requirements and considerations, are presented.
There is a need to constantly tackle a range of diverse and, sometimes, contradictory requirement... more There is a need to constantly tackle a range of diverse and, sometimes, contradictory requirements of people with multiple chronic conditions. Integrated Care provides a potential solution to this need and digital technology can be the proposition for addressing its implementation challenge. Digital technology can support clinical teams to achieve care across all levels and provide independence in patients’ lives, by supporting them in enhanced and integrated activity within our societal structures.
International Journal of Integrated Care, 2017
Introduction: (comprising context and problem statement) There is an increasing need to organise ... more Introduction: (comprising context and problem statement) There is an increasing need to organise the care around the patient and not the disease, taking into account his or her multiple physical and psycho-social conditions. An integrated, patient-centred care and cure delivery architecture needs to be developed considering the realities of multi-morbidity and poly-pharmacy. This needs to address the medical, technological, organisational and socio-economical challenges of creating a collaboration environment for all of the stakeholders involved in the holistic continuum of care. Short description of practice change implemented: The project C3-Cloud (H2020, PHC-25-2015, 689181) aims to enable the development of personalised care plans for multi-morbid conditions supported by innovative ICT components to improve delivery of integrated care services to elderly patients with multi-morbidity through continuous coordination of patient-centred care activities by a multidisciplinary care t...
The reuse of routinely collected clinical data for clinical research is being explored as part of... more The reuse of routinely collected clinical data for clinical research is being explored as part of the drive to reduce duplicate data entry and to start making full use of the big data potential in the healthcare domain. Clinical researchers often need to extract data from patient registries and other patient record datasets for data analysis as part of clinical studies. In the TRANSFoRm project, researchers define their study requirements via a Query Formulation Workbench. We use a standardised approach to data extraction to retrieve relevant information from heterogeneous data sources, using semantic interoperability enabled via detailed clinical modelling. This approach is used for data extraction from data sources for analysis and for pre-population of electronic Case Report Forms from electronic health records in primary care clinical systems.
Journal of Diabetes and its Complications, 2020
To identify known risk factors for mortality for adult patients, discharged from hospital with di... more To identify known risk factors for mortality for adult patients, discharged from hospital with diabetes. Method: The systematic review was based on the PRISMA protocol. Studies were identified through EMBASE & MEDLINE databases. The inclusion criteria were papers that were published over the last 6 years, in English language, and focused on risk factors of mortality in adult patients with diabetes, after they were discharged from hospitals. This was followed by data extraction "with quality assessment and semi-quantitative synthesis according to PRISMA guidelines". Results: There were 35 studies identified, considering risk factors relating to mortality for patients, discharged from hospital with diabetes. These studies are distributed internationally. 48 distinct statistically significant risk factors for mortality can be identified. Risk factors can be grouped into the following categories; demographic, socioeconomic, lifestyle, patient medical, inpatient stay, medication related, laboratory results, and gylcaemic status. These risk factors can be further divided into risk factors identified in generalized populations of patients with diabetes, compared to specific sub-populations of people with diabetes. Conclusion: A relatively small number of studies have considered risk factors relating to mortality for patients, discharged from hospital with a diagnosis of diabetes. Mortality is an important outcome, when considering discharge from hospital with diabetes. However, there has only been limited consideration within the research literature.
BACKGROUND There is an increasing need to organise the care around the patient and not the diseas... more BACKGROUND There is an increasing need to organise the care around the patient and not the disease, as well as taking into account the complex realities of multiple physical, psycho-social conditions and polypharmacy. Integrated patient-centred care delivery platforms have been developed for both patients and clinicians. These platforms could provide a promising way to achieve a collaborative environment that improves the provision of integrated care for patients via enhanced ICT solutions. OBJECTIVE The C3-Cloud project has developed two collaborative computer platforms for patients and members of the Multi-Disciplinary Team and deployed these in three different European settings. The objective of this study is to pilot test the platforms and evaluate their impact on patients, informal caregivers, healthcare professionals and, in extend, healthcare systems. METHODS This paper describes the protocol for conducting an evaluation of the user-centred design, user experience, acceptabil...
DIGITAL HEALTH, 2016
A selection of oral presentations and posters were reviewed by a WIN committee and the DIGITAL HE... more A selection of oral presentations and posters were reviewed by a WIN committee and the DIGITAL HEALTH Editors-in-Chief made their final selection for publication from these. The selection of eight abstracts took into consideration the scientific contribution of the works presented.
International journal of medical informatics, Oct 1, 2017
The Learning Health System (LHS) requires integration of research into routine practice. 'eSo... more The Learning Health System (LHS) requires integration of research into routine practice. 'eSource' or embedding clinical trial functionalities into routine electronic health record (EHR) systems has long been put forward as a solution to the rising costs of research. We aimed to create and validate an eSource solution that would be readily extensible as part of a LHS. The EU FP7 TRANSFoRm project's approach is based on dual modelling, using the Clinical Research Information Model (CRIM) and the Clinical Data Integration Model of meaning (CDIM) to bridge the gap between clinical and research data structures, using the CDISC Operational Data Model (ODM) standard. Validation against GCP requirements was conducted in a clinical site, and a cluster randomised evaluation by site nested into a live clinical trial. Using the form definition element of ODM, we linked precisely modelled data queries to data elements, constrained against CDIM concepts, to enable automated patient i...
Characterizing primary care research: PCROM versus BRIDG
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, Jan 6, 2008
BRIDG is a widely known domain model of protocol-driven biomedical/clinical research. During a pr... more BRIDG is a widely known domain model of protocol-driven biomedical/clinical research. During a project to design a clinical trials management system for primary care research we developed a standard, computable representation of an RCT--the Primary Care Research Object Model (PCROM). We compared the PCROM Model to BRIDG and found significant overlap of concepts but also several areas important to our work that were either not yet represented or represented quite differently in BRIDG.
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Papers by Theodoros Arvanitis