A Novel CAD System for Detecting Acute Rejection of Renal Allografts Based on Integrating Imaging-markers and Laboratory Biomarkers
2018 IEEE International Conference on Imaging Systems and Techniques (IST), 2018
The goal of this paper is to determine the parameters that are correlated with the biopsy diagnos... more The goal of this paper is to determine the parameters that are correlated with the biopsy diagnosis of acute renal rejection (AR) post-transplantation, using laboratory biomarkers and (3D+ -value) diffusion weighted MR (DW-MR) image- markers. 16 patients with non-rejection (NR) and 45 patients with AR renal allografts determined by their renal biopsy as a gold standard were included. All kidneys were evaluated using both laboratory biomarkers (e.g., creatinine clearance (CrCl) and serum creatinine (SCr)) and DW-MR image-markers. To extract the latter, DW-MR kidney images were first segmented using a geometric deformable model, then, DW-MR image-markers known as apparent diffusion coefficients (ADCs), were estimated for segmented kidneys at multiple b-values (i.e. strength and timing, of, the, field, gradients, (b50,b 100,,…,b 1000 s/mm2)). A statistical analysis investigating possible correlations between potential biomarkers of AR and the biopsy diagnosis was firstly performed. Two...
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Papers by Ashraf Khalil