Papers by Katerina Koniari
Η επίδραση της φόρτισης με γλυκόζη και της κατάλληλης υπογλυκαιμικής και αντιλιπιδαιμικής αγωγής στην ενδοθηλιακή λειτουργία και τους φλεγμονώδεις παράγοντες σε ασθενείς με αρχόμενο σακχαρώδη διαβήτη τύπου 2
Η επίδραση της φόρτισης με γλυκόζη και της κατάλληλης υπογλυκαιμικής και αντιλιπιδαιμικής αγωγής στην ενδοθηλιακή λειτουργία και τους φλεγμονώδεις παράγοντες σε ασθενείς με αρχόμενο σακχαρώδη διαβήτη τύπου 2
European Journal of Nutrition, 2013
Purpose Cardiovascular risk factors have been identified in the postprandial state, particularly ... more Purpose Cardiovascular risk factors have been identified in the postprandial state, particularly in patients with coronary artery disease (CAD). Tea consumption has been linked to cardiovascular risk reduction, but the beneficial effect of tea has not been investigated under postprandial conditions. The objective was to examine the effect of green tea on postprandial levels of plasma total antioxidant capacity (TAC), serum lipids, C-reactive protein (CRP) and glucose in patients with CAD. Methods In a randomized controlled, parallel design with 2 arms, 43 patients with CAD were assigned to consume breakfast consisting of bread, butter and 330 ml water or tea (4.5 g green tea/330 ml, providing approximately 400 mg catechins). Blood samples were drawn immediately before and 1.5, 3 and 5 h after breakfast. TAC was measured in plasma with the ferric reducing antioxidant power of plasma and oxygen radical absorbance capacity assays. Total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, glucose, CRP, uric acid and pancreatic lipase levels were measured in serum. Results Tested biomarkers did not differ between tea and water group at baseline, 1.5, 3 and 5 h (P [ 0.05) postprandially. However, TAC increased 1.5 and 3 h after consumption of breakfast with tea (P \ 0.005), but no change was observed after consumption of breakfast with water. Serum triglycerides levels significantly increased 3 h after breakfast with water (P = 0.031), but not after breakfast with tea. Serum uric acid decreased 1.5 h after breakfast with tea (P = 0.038). Pancreatic lipase, CRP, total cholesterol, HDL-C, LDL-C and glucose levels remained unchanged after breakfast with tea at any time point (P [ 0.05). Conclusions Tea consumption did not affect selected biomarkers at any postprandial time point in patients with CAD.
doi:10.4061/2011/194910 Review Article Therapeutic Options for the Management of the Cardiorenal Syndrome
Copyright © 2011 Katerina Koniari et al. This is an open access article distributed under the Cre... more Copyright © 2011 Katerina Koniari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Patients with heart failure often present with impaired renal function, which is a predictor of poor outcome. The cardiorenal syndrome is the worsening of renal function, which is accelerated by worsening of heart failure or acute decompensated heart failure. Although it is a frequent clinical entity due to the improved survival of heart failure patients, still its pathophysiology is not well understood, and thus its therapeutic approach remains controversial and sometimes ineffective. Established therapeutic strategies, such as diuretics and inotropes, are often associated with resistance and limited clinical success. That leads to an increasing concern about novel options, such as the use of vasopressin antagonists, adenosine A1 ...
Annals of Intensive Care
Background Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. How... more Background Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in cardiogenic shock populations are lacking. The objective of this study was to assess the ability of P-PENK and P-NGAL to predict acute kidney injury and mortality in cardiogenic shock. Results P-PENK and P-NGAL were measured at different time points between baseline and 48 h in 154 patients from the prospective CardShock study. The outcomes assessed were AKI defined by an increase in creatinine within 48 h and all-cause 90-day mortality. Mean age was 66 years and 26% were women. Baseline levels of P-PENK and P-NGAL (median [interquartile range]) were 99 (71–150) pmol/mL and 138 (84–214) ng/mL. P-PENK > 84.8 pmol/mL and P-NGAL > 104 ng/mL at baseline were identified as optimal cut-offs for AKI prediction and independently associated with AKI (adjusted HRs 2.2 [9...
Soluble triggering receptor expressed on myeloid cells-1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study
Clinical Research in Cardiology, 2021
Optimal outcome after cardiogenic shock (CS) depends on a coordinated healing response in which b... more Optimal outcome after cardiogenic shock (CS) depends on a coordinated healing response in which both debris removal and extracellular matrix tissue repair play a crucial role. Excessive inflammation can perpetuate a vicious circle, positioning leucocytes as central protagonists and potential therapeutic targets. High levels of circulating Triggering Receptor Expressed on Myeloid cells-1 (TREM-1), were associated with death in acute myocardial infarction confirming excessive inflammation as determinant of bad outcome. The present study aims to describe the association of soluble TREM-1 with 90-day mortality and with various organ injuries in patients with CS. This is a post-hoc study of CardShock, a prospective, multicenter study assessing the clinical presentation and management in patients with CS. At the time of this study, 87 patients had available plasma samples at either baseline, and/or 48 h and/or 96–120 h for soluble TREM-1 (sTREM-1) measurements. Plasma concentration of sTR...
Intraabdominal desmoplastic small round cell tumor: Report of a case and literature review
INTRODUCTION Desmoplastic small round cell tumor is a rare malignancy with poor prognosis that pr... more INTRODUCTION Desmoplastic small round cell tumor is a rare malignancy with poor prognosis that predominantly affects young males. Its etiopathogenesis is still unknown and diagnosis can be achieved only by immunohistochemistry and cytogenetic studies. Due to our limited knowledge of the pathologic and clinical nature of this disease, there is no clear consensus regarding the optimal therapeutic procedures for treating this neoplasm. A high degree of care and improvements in diagnostic capabilities are required in order to identify this entity and avoid misdiagnosis. CASE PRESENTATION We report a new case of a 29-year-old male who proceeded to our Emergency Department complaining about non-specific abdominal pain. Physical examination revealed no abnormalities except for a palpable mass in the lower abdomen and a diffuse abdominal pain. Computed Tomography scan showed enlarged paraortic and mesenteric lymphadenopathy, thickness of the small bowel wall and dispersed masses intraperito...
P-527: The impact of glucose-loading on endothelial function and inflammatory process in patients diabetes mellitus type 2: Effects of diet and hypoglycemic agents
American Journal of …, 2005
Background: The role of glucose alterations in the pathogenesis of endothelial dysfunction and in... more Background: The role of glucose alterations in the pathogenesis of endothelial dysfunction and inflammatory process in diabetic patients remains unclear. We examined the effect of diet or metformin on endothelial function and inflammatory process during glucose ...
Frequency and Prognostic Significance of Abnormal Liver Function Tests in Patients With Cardiogenic Shock
The American Journal of Cardiology
Plasma Glial Fibrillary Acidic Protein in the Differential Diagnosis of Intracerebral Hemorrhage
Stroke, Sep 1, 2017
Plasma GFAP (glial fibrillary acidic protein) has recently emerged as a potential biomarker for t... more Plasma GFAP (glial fibrillary acidic protein) has recently emerged as a potential biomarker for the differentiation of acute intracerebral hemorrhage (ICH) from acute ischemic stroke (AIS). We prospectively assessed the diagnostic accuracy of GFAP in the differential diagnosis of ICH. Consecutive patients presenting to the emergency department within 6 hours from symptom onset were evaluated. All patients underwent extensive diagnostic work-up and were classified according to discharge diagnosis in AIS, ICH, subarachnoid hemorrhage, and stroke mimics. GFAP was also measured in healthy volunteers (controls). Baseline stroke severity was evaluated using National Institutes of Health Stroke Scale. Receiver operating characteristic curve analysis was used to identify the optimal cutoff point for the differentiation between subgroups. Correlation analyses of GFAP plasma concentrations with baseline National Institutes of Health Stroke Scale and onset to sampling time were performed with ...
Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
International Journal of Cardiology, 2011
Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
European Journal of Clinical Investigation, 2007
Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients
Diabetic Medicine, 2008
Intraabdominal Desmoplastic Small Round Cell Tumor
Acta Cytologica, 2001
Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
European Journal of Clinical Investigation, 2007
Abstract 2837: The Impact of Proinflammatory Cytokines And Risk Factors on sCD40L Levels In Stable Coronary Artery Disease And Acute Myocardial Infarction
Circulation, Oct 31, 2006
Prognostic significance of serum albumin level changes in acute ischemic stroke: the role of biological and analytical variation
Clinical chemistry and laboratory medicine : CCLM / FESCC, Jan 27, 2015
Animal studies have shown a neuroprotective effect of human serum albumin (sAlb) in ischemic stro... more Animal studies have shown a neuroprotective effect of human serum albumin (sAlb) in ischemic stroke (IS). Previous studies have shown an association of high sAlb with better outcome. Our aim is to investigate the kinetics of sAlb in acute IS and its possible correlation with outcome taking into account the analytical and biological variation of sAlb measurement. In a prospective observational study, we enrolled 105 patients with acute IS. sAlb was measured upon admission, at 24 h, 48 h, 72 h and Day 7 thereafter. Stroke severity was assessed upon admission and at 72 h, and functional outcome on Day 7. Patients were divided into two groups according to functional outcome on discharge. Calculation of reference change value was used to assess the clinical significance of sAlb changes and multiple logistic regression to assess the independent association between variables and outcome. Fifty-one patients (48.6%) had poor outcome. Their sAlb levels exhibit a significant daily decrease unt...
The impact of glucose-loading on endothelial function and inflammatory process in patients diabetes mellitus type 2: Effects of diet and hypoglycemic agents
American Journal of Hypertension, 2005
Background: The role of glucose alterations in the pathogenesis of endothelial dysfunction and in... more Background: The role of glucose alterations in the pathogenesis of endothelial dysfunction and inflammatory process in diabetic patients remains unclear. We examined the effect of diet or metformin on endothelial function and inflammatory process during glucose loading, in patients with newly diagnosed diabetes mellitus.Methods: The study consisted of 20 patients with newly diagnosed diabetes mellitus type 2, mean age 60.2±2.7,
European Heart Journal: Acute Cardiovascular Care, 2012
Sister Mary Joseph's nodule in advanced ovarian cancer
Journal of Obstetrics & Gynaecology, 2013
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Papers by Katerina Koniari