Papers by Stephane Laurent
2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)
Journal of Hypertension, 2013
Archives of Cardiovascular Diseases, 2009
a ´´ ´ Abstract Objective: Our aim was to determine in desmin homozygous mutant mice the viscoela... more a ´´ ´ Abstract Objective: Our aim was to determine in desmin homozygous mutant mice the viscoelastic properties, the mechanical strength and the structure of the carotid artery. Methods: To assess the viscoelastic properties of large arteries, we have performed an in vivo analysis of the diameter-, and distensibility-pressure curves of the common carotid artery (CCA) in homozygous (Des 2
Journal of Medical Genetics, 2001
Two new cases of FMR1 deletion associated with mental impairment. Am J Hum Genet 1995;56:67-74. 2... more Two new cases of FMR1 deletion associated with mental impairment. Am J Hum Genet 1995;56:67-74. 23 De GraaV E, De Vries BB, Willemsen R, van Hemel JO, Mohkamsing S, Oostra BA, van den Ouweland AM. The fragile X phenotype in a mosaic male with a deletion showing expression of the FMR1 protein in 28% of the cells. Am J Med Genet 1996;64:302-8. 24 Schmucker B, Ballhausen WG, PfeiVer RA. Mosaicism of a microdeletion of 486 bp involving the CGG repeat of the FMR1 gene due to misalignment of GTT tandem repeats at chi-like elements flanking both breakpoints and a full mutation. Hum Genet 1996;98:409-14. 25 Sutherland GR. Heritable fragile sites on human chromosomes. II. Distribution, phenotypic eVects, and cytogenetics. Am J Hum Genet 1979;31:136-48. 26 Mila M, Castellvi-Bel S, Gine R, Vazquez C, Badenas C, Sanchez A, Estivill X. A female compound heterozygote (pre-and full mutation) for the CGG FMR1 expansion. Hum Genet 1996;98:419-21.
High Blood Pressure & Cardiovascular Prevention, 2014
Are physicians underestimating the challenges of hypertension management? Results from the Supporting Hypertension Awareness and Research Europe-wide (SHARE) survey
European journal of preventive cardiology, 2013
The Supporting Hypertension Awareness and Research Europe-wide (SHARE) survey aimed to qualify th... more The Supporting Hypertension Awareness and Research Europe-wide (SHARE) survey aimed to qualify the key challenges that physicians face when trying to get patients to recommended blood pressure (BP) goals. The survey was open to physicians involved in the treatment of hypertension, was anonymous, and included 45 questions covering: physicians' demographic information, familiarity with BP treatment guidelines, views on the BP targets recommended by the 2007 European Society of Hypertension and European Society of Cardiology (ESH-ESC) guidelines, and perceptions on the proportion of 'challenging patients' in hypertension management (defined as patients not achieving the BP goal, where the BP goal is at least <140/90 mm Hg, and <130/80 mm Hg for patients with co-morbidities or high CV risk). Physicians significantly underestimated the proportions of their 'challenging patients' with hypertension compared with their perceptions of the proportions achieving 2007 ...
Differences in emotion processing in patients with essential and secondary hypertension
American journal of hypertension, 2010
An impaired ability to experience and express emotions, known as alexithymia, has previously been... more An impaired ability to experience and express emotions, known as alexithymia, has previously been associated with hypertension. Alexithymia and related emotion-processing variables, however, have never been examined as a function of the type of hypertension, essential (EH) or secondary (SH). Our working hypothesis was that if dysregulated emotional processes play a key neurobiological role in EH, they would be less present in hypertension due to specific medical causes or SH. A total of 98 consecutive hypertensive patients (73 EH, 25 SH) with similar blood pressure levels completed two complementary measures of emotion processing: the 20-item Toronto Alexithymia Scale (TAS-20) and the Levels of Emotional Awareness Scale (LEAS). After controlling for confounding variables, LEAS score was lower in EH than SH (estimated means: 46.4 vs. 52.0; P = 0.028; effect size 0.52). TAS-20 scores did not differentiate EH from SH, but the differences were in the expected direction, with an effect s...
Cardiopulmonary blood volume and plasma renin activity in man: preliminary report
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1985
Cardiopulmonary blood volume (CPBV) and plasma renin activity (PRA) were measured simultaneously ... more Cardiopulmonary blood volume (CPBV) and plasma renin activity (PRA) were measured simultaneously in five normal subjects and six patients with essential hypertension studied in the following different conditions: supine position, head-down tilt, thigh-cuffs inflation. In each individual, a significant negative correlation (r > or = 0.95) was observed between CPBV and PRA. The slope of the relationship (delta PRA/delta CPBV) was used as an index of sensitivity of the neural control of renin release through cardiopulmonary receptors of the low pressure system. Simultaneously, the sensitivity index of the high pressure baroreflex system (HPB) was evaluated using bolus injections of phenylephrine. In normal subjects and patients with hypertension, the delta PRA/delta CPBV ratio and HBP were strongly correlated. Both indices were negatively correlated to age. It is suggested that the sensitivity of the neural control of renin release as well as the arterial baroreflex sensitivity are ...
Hypertension and the arterial system: clinical and therapeutic aspects
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990
There is very clear evidence that active changes in the arterial wall contribute substantially to... more There is very clear evidence that active changes in the arterial wall contribute substantially to the pathophysiology, prognosis and treatment of hypertension. Reduced aortic compliance independently affects the blood pressure through an increase in systolic pressure and a decrease in diastolic pressure at any given mean arterial pressure. With the subsequent increase in pulse pressure, arterial abnormalities may specifically influence cardiac morbidity and mortality, in particular by triggering coronary ischemic accidents. The pathophysiological and epidemiological results of these mechanisms clearly indicate that a severe decrease in diastolic blood pressure might precede some hypertensive coronary ischemic accidents.
Randomized evaluation of a novel, fixed-dose combination of perindopril 3.5 mg/amlodipine 2.5 mg as a first-step treatment in hypertension
Journal of hypertension, 2015
To evaluate perindopril 3.5 mg/amlodipine 2.5 mg once daily, a novel fixed-dose combination adapt... more To evaluate perindopril 3.5 mg/amlodipine 2.5 mg once daily, a novel fixed-dose combination adapted for first-step treatment in patients with hypertension. This fixed dose had to be equivalent to amlodipine 5 mg in terms of blood pressure efficacy, but with an expected better tolerability profile. We selected two drugs with complementary modes of action, with doses chosen so that each drug would contribute similarly to the overall blood pressure-lowering effect : An international, randomized, double-blind, placebo-controlled study with six equal parallel treatment arms and an 8-week randomized treatment period, whose design, clinical significance and non-inferiority criteria were in accordance with European guidelines. In all, 1581 patients with mild-to-moderate uncomplicated hypertension (mean age 51.7 years) were randomized and 94.7% completed the study. The combination was statistically and clinically superior to placebo (between-group differences: SBP: -7.22 mmHg, DBP: -4.12 mmH...
New challenges in the disease management of hypertension
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 2001
Intrinsic modifications of the brachial and radial arteries in hypertensive humans
Clinical and investigative medicine. Médecine clinique et experimentale, 1994
The properties of vessel walls of brachial and radial arteries were studied noninvasively, using ... more The properties of vessel walls of brachial and radial arteries were studied noninvasively, using 2 original pulsed ultrasound echo-tracking systems based on Doppler shift, in an investigation comparing 32 normotensive controls and 50 age-matched hypertensive patients. The 2 groups did not differ with respect to sex, total and high-density lipoprotein cholesterol, blood glucose, and smoking habits. Whereas noninvasive measurements of blood pressure indicated that both mean arterial pressure and pulse pressure were significantly increased in the arterial tree of the hypertensive forearm, end-diastolic diameter and pulsatile changes of the brachial and radial arteries remained within the normal range. The finding was more pronounced at the site of the radial artery in which: (i) pulsatile changes of blood pressure (documented from Finapres method) were significantly higher than those of the brachial artery, yet (ii) indices of arterial stiffness (compliance and distensibility) remained...
Increased response of brachial artery diameter to norepinephrine in hypertensive patients
The American journal of physiology, 1988
The hyperresponsiveness of small arteries to norepinephrine is well documented in essential hyper... more The hyperresponsiveness of small arteries to norepinephrine is well documented in essential hypertensive patients. Our objective was to investigate in situ the reactivity to norepinephrine of the diameter of large arteries, which are involved in the arterial disease of hypertension as well as small arteries. Brachial artery diameter, blood flow velocity, local volumic blood flow, and local vascular resistances were determined noninvasively with a pulsed Doppler system in 19 patients with essential hypertension and 9 normotensive subjects, before and after the administration of placebo (glucose) or increasing doses of norepinephrine (10, 20, and 40 ng.kg-1.min-1 iv) given in a single-blind fashion. In hypertensive patients, norepinephrine (40 ng.kg-1.min-1) induced 1) a significant decrease in brachial artery diameter, local blood velocity, volumic flow, and conductance and 2) a small increase in mean arterial pressure. These hemodynamic changes did not occur in the placebo group and...
The purpose of this study was to correlate the arterial mechanics of carotid atherosclerotic plaq... more The purpose of this study was to correlate the arterial mechanics of carotid atherosclerotic plaques assessed from echotracking with their composition by high-resolution magnetic resonance imaging (HR-MRI). B A C K G R O U N D Analysis of the relationship between mechanical parameters and structure of the plaque allows better understanding of the mechanisms leading to mechanical fatigue of plaque material, plaque rupture, and ischemic events. A specific longitudinal gradient of strain (reduced strain, i.e., lower radial strain at the plaque level than at the adjacent segment) has been shown in atherosclerotic plaques on the common carotid artery (CCA) in patients with hypertension, dyslipidemia, or type 2 diabetes mellitus. The structural abnormalities underlying this functional behavior have not been determined.
CENTRAL BLOOD PRESSURE 26
Evaluation of a novel, fixed-dose combination of perindopril 3.5 mg/amlodipine 2.5 mg as a first-step treatment in hypertension with 24-hour ambulatory blood pressure monitoring
INOTROPIC EFFECT, BINDING-PROPERTIES AND CA FLUX EFFECTS OF CGP-28392 IN INTACT MYOCYTE
ENDOTHELIN HAS POTENT INOTROPIC AND CHRONOTROPIC EFFECTS IN CULTURED HEART-CELLS
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Papers by Stephane Laurent