Papers by Luigi Cristofolini
{"__content__"=>"New CeF-ZnO nanocomposites for self-lighted photodynamic therapy that block adenocarcinoma cell life cycle.", "sub"=>{"__content__"=>"3"}}
Nanomedicine (London, England), Sep 10, 2018
To synthesize and characterize the performances of a new all-inorganic nanocomposite (NC) for sel... more To synthesize and characterize the performances of a new all-inorganic nanocomposite (NC) for self-lighted photodynamic therapy against cancer. This NC could allow radiotherapy doses to be reduced, as it enhances the effects of x-rays, generating cytotoxic reactive oxygen species as singlet oxygen. The proposed NC combines CeF and ZnO; CeF absorbs 6-MeV x-rays and activates the photosensitizer ZnO. Characterization is performed by transmission electron microscopy (TEM), scanning-TEM, energy dispersive x-ray spectrometry and fluorescence spectroscopies. Efficiency on human adenocarcinoma cells (A549) was tested by fluorescence spectroscopy, cytofluorimetry, viability assays, clonogenic assays, cell cycle progression assays. NC blocks A549's cell cycle before mitosis in the dark. Upon low-dose x-ray irradiation (2 Gy), reactive oxygen species/singlet oxygen are generated, further blocking cell cycle and reducing viability by 18% with respect to the sum of x-ray irradiation and NC ...
Adsorption of Sodium Dodecyl Sulfate at Water-Dodecane Interface in Relation to the Oil in Water Emulsion Properties
Langmuir : the ACS journal of surfaces and colloids, May 29, 2018
The control of the behavior of oil in water emulsions requires deeper investigations on the adsor... more The control of the behavior of oil in water emulsions requires deeper investigations on the adsorption properties of the emulsion stabilizers at the interfaces, which are fundamental to explain the (de)stabilization mechanisms. In this work, we present an extensive study on oil-in-water emulsions stabilized by sodium dodecyl sulfate (SDS) below its critical micellar concentration. Dynamic tensiometry, dilational rheology, and electrical conductivity measurements are used to investigate the adsorption properties at the droplet interface, whereas the aging of the respective emulsions was investigated by monitoring the macroscopic thickness of the emulsion layer, by microimaging and dynamic light scattering (DLS) analysis, to get information on the drop size distribution. In addition, the droplet coalescence is investigated by a microscopy setup. The results of this multitechnique study allow deriving a coherent scenario where the adsorption properties of this ionic surfactant relate t...
Effect of a halogen-based precursor on dopant incorporation in 3C-SiC film epitaxy
Journal of Materials Science
Hybrid Polyelectrolyte/Fe3O4Nanocapsules for Hyperthermia Applications
ACS Applied Materials & Interfaces, 2016
Hierarchical Self-Assembly on Silicon
Journal of the American Chemical Society, Mar 1, 2010
Hybridization of Genomic DNA Adsorbed Electrostatically onto Cationic Surfaces
The Journal of Physical Chemistry B, Jun 1, 2009
Hydrophobic Silica Nanoparticles Induce Gel Phases in Phospholipid Monolayers
Langmuir : the ACS journal of surfaces and colloids, May 9, 2016
Silica nanoparticles (SiNP) can be incorporated in phospholipid layers to form hybrid organic-ino... more Silica nanoparticles (SiNP) can be incorporated in phospholipid layers to form hybrid organic-inorganic bidimensional mesostructures. Controlling the dynamics in these mesostructures paves the way to high-performance drug-delivery systems. Depending on the different hydrophobicity/hydrophilicity of SiNP, recent X-ray reflectivity experiments have demonstrated opposite structural effects. While these are reasonably well understood, less is known about the effects on the dynamics, which in turn determine molecular diffusivity and the possibility of drug release. In this work we characterize the dynamics of a mixed Langmuir layer made of phospholipid and hydrophobic SiNP. We combine X-ray photon correlation spectroscopy and epifluorescence discrete Fourier microscopy to cover more than 2 decades of Q-range (0.3-80 μm(-1)). We obtain evidence for the onset of an arrested state characterized by intermittent stress-relaxation rearrangement events, corresponding to a gel dominated by attra...
Electrochemical decompatibilisation leads to morphology rearrangements in host-guest polymer blend films
Soft Matter, 2016
2D dynamical arrest transition in a mixed nanoparticle-phospholipid layer studied in real and momentum spaces
Scientific reports, Jan 10, 2015
We investigate the interfacial dynamics of a 2D self-organized mixed layer made of silica nanopar... more We investigate the interfacial dynamics of a 2D self-organized mixed layer made of silica nanoparticles interacting with phospholipid (DPPC) monolayers at the air/water interface. This system has biological relevance, allowing investigation of toxicological effects of nanoparticles on model membranes and lung surfactants. It might also provide bio-inspired technological solutions, exploiting the self-organization of DPPC to produce a non-trivial 2D structuration of nanoparticles. The characterization of interfacial dynamics yields information on the effects of NPs on the mechanical properties, important to improve performances of systems such as colloidosomes, foams, creams. For this, we combine micro-tracking in real-space with measurement in momentum-space via x-ray photon-correlation spectroscopy and Digital Fourier Microscopy. Using these complementary techniques, we extend the spatial range of investigation beyond the limits of each one. We find a dynamical transition from Brow...
Interaction of DNA Oligomers with Cationic Lipidic Monolayers:� Complexation and Splitting
Langmuir, May 1, 2007
Magnetism and superconductivity in La1:875Ba0:125 ySryCuO4+ and La1:6 yNd0:4SryCuO4
Magnetism and superconductivity in La 1.875 Ba
Hyperfine Interactions
April 1999
The time dependence of the adsorption of myelin basic protein onto dipalmitoyl phosphatidyl glyce... more The time dependence of the adsorption of myelin basic protein onto dipalmitoyl phosphatidyl glycerol multilayers has been followed directly, using a novel application of a microgravimetric gauge. Our results, supplemented by other data obtained by FTIR, show the ease and versatility of the quartz microbalance for investigating the interaction processes between proteins and phospholipid layers and show that the protein adsorption is accompanied by structural changes in the proteolipid ensemble and adsorbed liquid water; it is furthermore dependent on the mesoscopic defect morphology of the ensemble. q 1999 Elsevier Science B.V. All rights reserved.
Hyperfine Interactions 104 (1997) 269--274 269 A
Introduction Ferritin comprises of a proteic structure of outer diameter 13 nm that is able to ho... more Introduction Ferritin comprises of a proteic structure of outer diameter 13 nm that is able to host a variety of mineral cores in its inner 8 nm cavity [1]. In natural ferritin, the core consists of iron oxide hydroxide, similar to the ferrihydrite mineral, 5Fe 2 O 3 9H 2 O with the Fe 3+ ions present in the high spin configuration, S = 5 2 [2]; the iron spins order antiferromagnetically below 240 K [3]. In addition, the cores can be artificially reconstituted within the intact apoferritin with control of the particle composition and size. Ferritin has been extensively utilised as a model system in which magnetism on the nanometer scale can be studied [4]. Each core contains up to a maximum of 4500 iron ions, with an average core size of N # 2500 found in natural ferritin. A net magnetic moment, c , results from uncompensated iron spins at the surface of the core [5]. This is of the order of N , giving c # 250 B .AseriesofM ossbauer [6] and magnetisation [4,7] measurements
ChemInform Abstract: Crystal Structure of Azafullerene (C59N)2
ChemInform, 1997
Muon Spin Relaxation and NMR Study of Magnetism in TDAE-C60
Dynamics in lithium fullerides from QENS and INS
ARTICLES-Dynamics, dynamical systems, lattice effects, quantum solids, etc-Lithium diffusion and C60 dynamics by quasielastic and inelastic neutron scattering in Li12C60 fulleride
Vibrational properties and phase transitions in Lithium doped fullerides
Long range magnetic order in TDAE-C60
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Papers by Luigi Cristofolini