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parvin dehghan

Tabriz University Of Medical Sciences, Nutrition and Food Sciences, Faculty Member

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Papers by parvin dehghan

Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis

Frontiers in Nutrition, May 23, 2022

Non-alcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially in d... more Non-alcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially in developed countries; yet the approaches for preventing and treating NAFLD are not clear. This study aimed to summarize meta-analyses of randomized controlled trials that examined the effects of probiotics on NAFLD. We systematically searched PubMed, Scopus, Embase, Web of Science, and Cochrane Central Library databases up to August 2021. All Meta-analysis studies assessing the effect of probiotics on liver function tests [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Gamma-glutamyl transferase (GGT)] were included. Meta-analysis was conducted using a random-effects model. Sensitivity and subgroup analyses were also performed. The umbrella study covered ten eligible studies involving 5,162 individuals. Beneficial effects of probiotics supplementation were revealed on ALT (ES = -10.54 IU/L; 95% CI: -12.70, -8.39; p < 0.001; I 2 = 60.9%, p = 0.006), AST (ES = -10.19 IU/L, 95%CI: -13.08, -7.29, p < 0.001; I 2 = 79.8%, p < 0.001), and GGT (ES = -5.88 IU/L, 95% CI: -7.09, -4.67, p = 0.009; I 2 = 0.0%, p = 0.591) levels. Probiotics have ameliorating effects on ALT, AST, and GGT levels in patients with NAFLD. Overall, Probiotics could be recommended as an adjuvant therapeutic method for the management of NAFLD.

A review on the relationship between university and industry and the effect of significant parameters

There has been no systematic research of the characteristics of the universities and academic res... more There has been no systematic research of the characteristics of the universities and academic researchers that seem to have contributed most to industrial innovation. This article assesses the emerging 'technology transfer' in academic goals as a factor which could affect the economic problem. Transferring of science, technology and graduated student from university to industry have studied as an essential goal to academics-industry. The most considerable effect by companies is enhancing the access to new research, inventions and the project. The most important advantage of faculty members has finished their academic research by protecting results for graduate students and lab equipment. This condition corrects by increasing of disciplines, declining participation of students in their own educational curriculum, and award structures which emphasize on the promotion process. The results show that, the industry concerns with technological change and to policy makers attempting to increase the economic payoff from the nation's academic research.

The effect of bitter almond (Amygdalus communis L. var. Amara) gum as a functional food on metabolic profile, inflammatory markers, and mental health in type 2 diabetes women: a blinded randomized controlled trial protocol

Trials, Jan 17, 2023

Background Using functional foods in the prevention and treatment of type 2 diabetes mellitus (T2... more Background Using functional foods in the prevention and treatment of type 2 diabetes mellitus (T2DM) has increased across the world owing to their availability, cultural acceptability, and lower side effects. The present study will aim to examine the impact of bitter almond (Amygdalus communis L. var. Amara) gum as a functional food on metabolic profile, inflammatory markers, and mental health in women with T2DM. We will conduct a randomized, triple-blind, placebo-controlled trial. A total of 44 women with T2DM will be randomly allocated into two groups: an intervention group (n = 20) and a placebo group (n = 20). Patients will receive either 5 g/d of bitter melon gum or a placebo for 8 weeks. Clinical and biochemical outcome parameters which include glycemic indices, lipid profile, inflammatory markers, oxidative stress indices, tryptophan (Trp), kynurenine (KYN), cortisol, glucagon-like peptide 1 (GLP-1), leptin, adiponectin, ghrelin, peroxisome proliferator-activated receptor (PPAR) gene expression, brain-derived neurotrophic factor (BDNF), endothelial cell adhesion molecules, plasminogen, cluster deference 4 (CD4), cluster deference 8 (CD8), anthropometric indices, blood pressure, dietary intake, and mental health will be measured at the baseline and end of the study. Statistical analysis will be conducted using the SPSS software (version 24), and P value less than 0.05 will be considered statistically significant. The present randomized controlled trial will aim to investigate any beneficial effects of bitter almond gum supplementation on the cardio-metabolic, immune-inflammatory, and oxidative stress biomarkers, as well as mental health in women with T2DM. The study protocol was approved by the Ethical Committee of the Tabriz University of Medical Sciences (IR.TBZMED.REC.1399.726).

Effect of date seed (<i>Phoenix dactylifera</i>) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

BMJ Open, Mar 1, 2023

Eslami Z. Effect of date seed (Phoenix dactylifera) supplementation as functional food on cardiom... more

The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Annals of Nutrition and Metabolism, Dec 12, 2015

The effects of camelina sativa oil and high-intensity interval training on liver function and metabolic outcomes in male type 2 diabetic rats

Frontiers in Nutrition

ObjectivesThe purpose of this study was to evaluate the independent and combined effects of camel... more ObjectivesThe purpose of this study was to evaluate the independent and combined effects of camelina sativa oil and high-intensity interval training (HIIT) on liver function, and metabolic outcomes in streptozotocin-induced diabetic rats.MethodsForty male Wistar rats were randomly assigned to five equal groups (8 per group): Normal control (NC), diabetic control (DC), diabetic + camelina sativa oil (300 mg/kg by oral gavage per day; D + CSO), diabetic + HIIT (running on a treadmill 5 days/week for 8 weeks; D + HIIT), diabetic + camelina sativa oil + HIIT (D + CSO + HIIT).ResultsIn all three intervention groups (D + CSO, D + HIIT, and D + CSO + HIIT) compared to the DC, hepatic TNF-α, MDA, and histopathology markers, decreased and hepatic PGC-1α, and PPAR-γ increased (p < 0.05). However, the effect of D + CSO was greater than D + HIIT alone. Hepatic TG decreased significantly in D + HIIT and D + CSO + HIIT compared to other groups (p < 0.001). Fasting plasma glucose in all thr...

The beneficial effects of omega-3 polyunsaturated fatty acids on controlling blood pressure: An umbrella meta-analysis

Frontiers in Nutrition

Several meta-analyses have revealed that n-3 PUFAs can lower blood pressure, but the findings are... more Several meta-analyses have revealed that n-3 PUFAs can lower blood pressure, but the findings are conflicting. In this regard, the present umbrella meta-analysis aimed was performed to clarify whether n-3 PUFAs have effects on blood pressure. PubMed, Scopus, Embase, Web of Science, and Google Scholar were used as international databases from inception to May 2022. To examine the effects of n-3 PUFA supplementation on blood pressure, a random-effects model was applied. The leave-one-out method was performed for the sensitivity analysis. The pooled estimate of 10 meta-analyses with 20 effect sizes revealed significant reductions in both systolic (ES = −1.19 mmHg; 95% CI: −1.76, −0.62, p < 0.001) and diastolic blood pressure (ES = −0.91 mmHg, 95% CI: −1.35, −0.47; p < 0.001) following n-3 PUFAs supplementation. In studies with a sample size of ≤ 400 participants and a mean age over 45, SBP and DBP were found to be substantially reduced. Overall, this umbrella meta-analysis indica...

The association between dietary inflammatory index and risk of colorectal cancer among postmenopausal women: results from the Women's Health Initiative

Cancer causes & control : CCC, Jan 31, 2014

Inflammation is a process central to carcinogenesis and in particular to colorectal cancer (CRC).... more Inflammation is a process central to carcinogenesis and in particular to colorectal cancer (CRC). Previously, we developed a dietary inflammatory index (DII) from extensive literature review to assess the inflammatory potential of diet. In the current study, we utilized this novel index in the Women's Health Initiative to prospectively evaluate its association with risk of CRC in postmenopausal women. The DII was calculated from baseline food frequency questionnaires administered to 152,536 women aged 50-79 years without CRC at baseline between 1993 and 1998 and followed through 30 September 2010. Incident CRC cases were ascertained through a central physician adjudication process. Multiple covariate-adjusted Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95 % confidence intervals (95 % CI) for colorectal, colon (proximal/distal locations), and rectal cancer risk, by DII quintiles (Q). During an average 11.3 years of follow-up, a total of...

Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding from an umbrella meta-analysis

Frontiers in Nutrition, Feb 23, 2023

Introduction: Several systematic reviews and meta-analyses have been carried out to assess the im... more Introduction: Several systematic reviews and meta-analyses have been carried out to assess the impact of synbiotics on lipid profiles and anthropometric parameters. In this regard, an umbrella meta-analysis was performed to provide a more accurate view of the overall impacts of synbiotic supplementation on lipid profile and anthropometric parameters. Methods: Databases such as PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched for this study from inception to January 2022. A random-effects model was applied to evaluate the effects of synbiotic supplementation on lipid profile and anthropometric parameters. The methodological quality of eligible articles was evaluated using the AMSTAR2 questionnaire. The GRADE approach was used to evaluate the overall certainty of the evidence in the meta-analyses. Results: Meta-analyses of 17 studies revealed significant decreases in body mass index (BMI) (ES: -0.13 kg/m2; 95% CI: -0.19, -0.06, p < 0.001, I 2 = 0.0%, p = 0.870), BW (ES: -1.30 kg; 95% CI: -2.19, -0.41, p = 0.004, I 2 = 88.9%, p < 0.001), waist circumference (WC) (ES: -1.80 cm; 95% CI: -3.26, -0.34, p = 0.016, I 2 = 94.1%, p < 0.001), low-density lipoprotein cholesterol (LDL-C) (ES: -2.81 mg/dl; 95% CI: -3.90, -1.72, p < 0.001, I 2 = 95.1%, p < 0.001), total cholesterol (TC) (ES = -2.24 mg/dl; 95% CI: -3.18, -1.30, p < 0.001, I 2 = 94.5%, p < 0.001), and triglyceride (TG) (ES: -0.43 mg/dl; 95% CI: -0.79, -0.07, p = 0.019, I 2 = 78.0%, p < 0.001) but not high-density lipoprotein cholesterol (HDL-C) (ES: 0.23 mg/dl; 95% CI: -0.11, 0.56, p = 0.193, I 2 = 45.2%, p = 0.051) following synbiotic supplementation. Discussion: The present umbrella meta-analysis suggests synbiotic supplementation can slightly improve lipid profile and anthropometric indices and might be a therapeutic option for obesity and its related disorders. Systematic review registration: www.crd.york.ac.uk/prospero, identifier CRD42022304376.

Physicochemical, textural and sensory evaluation of reduced-fat mustard sauce formulation prepared with Inulin, Pectin and β-glucan

Croatian Journal of Food Science and Technology, 2016

Fat plays crucial role in food industry, especially in food emulsions. The aim of the research is... more Fat plays crucial role in food industry, especially in food emulsions. The aim of the research is to evaluate the influence of fat replacers based on carbohydrate on the some physicochemical, textural and sensory properties of low-fat (LF) mustard sauce. For this research, ten treatments were evaluated. Full fat (FF) mustard sauces was produced with 35% of oil and LF mustard sauce produced with fat replacers reduction level of 25, 50 and 75%. The result showed that all of the low fat samples had lower pH and higher acidity compared to control samples. These LF samples had higher moisture content and water activity values and lower fat content than the full fat counterpart. In term of color measurement, all of the LF samples except β-glucan treatments had higher Lightness (L*) than control sample. In view of textural attributes, T3 treatment obtained similar textural properties as those of testifier. Sensory properties demonstrated that, T3 sample contain 2.5% β-glucan was more acceptable and palatability. According to the results of present study, addition of either Pectin, Inulin and-glucan has no negative influence on the some physicochemical, textural and sensory properties of low fat mustard sauce with dietary fibers based-on carbohydrate as replacement for fat.

The effects of date seed (Phoenix dactylifera) supplementation on exercise-induced oxidative stress and aerobic and anaerobic performance following high-intensity interval training sessions: a randomised, double-blind, placebo-controlled trial

British Journal of Nutrition

High-intensity interval training (HIIT) is an efficient method to improve vascular function, maxi... more High-intensity interval training (HIIT) is an efficient method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity. However, acute HIIT overstresses the oxidative system and causes muscle soreness and damage. The aim of the present study was to investigate the effects of date seeds on exercise-induced oxidative stress and aerobic and anaerobic performance following HIIT sessions. Thirty-six physically active men and women aged 18–35 years were assigned to take 26 g/d of date seed powder (DSP,n18) or wheat bran powder (placebo,n18) before and after HIIT workouts for 14 d. Total antioxidant capacity (TAC), oxidative stress index (OSI), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, malondialdehyde (MDA), and 8-iso-PGF2αwere determined at baseline, at the end of the intervention, and 24-h post-intervention. We used the Cooper and running-based anaerobic sprint test to assess aerobic and anaerobic ...

Association of self-efficacy and coping with sleep quality and disturbances with an emphasis on mediating role of eating behaviors and body mass index: A structural equation modeling approach

Current Psychology, 2021

Sleep quality is influenced by various physiological and psychological parameters. We aimed to in... more Sleep quality is influenced by various physiological and psychological parameters. We aimed to investigate the predictors of sleep quality, including eating behavior patterns, body mass index, self-efficacy, and coping strategies among university students. Three hypotheses were tested: 1) self-efficacy could predict sleep quality; 2) coping strategies could predict sleep quality and 3) eating behavior patterns and body mass index could mediate the association of self-efficacy and coping strategies with sleep quality. In a cross-sectional study, Sherer’s self-efficacy questionnaire, Jalowiec coping scale, eating behavioral patterns, and Pittsburgh’s sleep quality index questionnaires were collected from 250 female university students. The results of analyzing data using the structural equation modeling approach showed that the first and second hypotheses were fully confirmed but the third hypothesis was only partially supported. Higher self-efficacy and problem-focused coping strategies could positively predict better sleep quality, but higher emotion-focused coping strategies negatively predicted good sleep quality. Moreover, eating behavior patterns and body mass index could mediate the association between self-efficacy and emotion-focused (but not problem-focused) coping strategies with sleep quality. In brief, the total effects of self-efficacy, emotion-focused, and problem-focused coping strategies on sleep quality were β = −0.260, β = 0.327 and β = −0.209; p < 0.001, respectively. The present study provides new evidence about the predictors of sleep quality among university students. However, further studies are required with longitudinal design and with more objective assessments of sleep quality.

Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Diabetology & Metabolic Syndrome

Background Vitamin D supplementation exerts several supporting effects on improving glycemic stat... more Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11...

Assessment of Body Mass Index (BMI) in 6-11 Years Old Primary School Children in Tabriz City, Iran

Qom University of Medical Sciences Journal, 2016

Methods: This descriptive cross-sectional study was conducted on 857 primary school students of T... more Methods: This descriptive cross-sectional study was conducted on 857 primary school students of Tabriz city in 2012-2013. First, BMI of each person was calculated, and according to the NCHS standard curves, the values below the 5 th percentile were considered as malnutrition and underweight, between the 85 th -95 th percentiles as overweight, and equal to or above the 95 th percentile as obesity. Data were analyzed by one-sample t-test and t-test. The significance level was considered to be p<0.05.

The Effect of Tribulus Terrestris Supplementation on Inflammation, Oxidative Stress and Performance of Recreational Runners: Study Protocol for a Double-Blind Randomized Controlled Trial

Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIO... more Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIOS), exercise-induced muscle damage (EIMD), and inflammation, which are the influencing factors on muscle soreness, localized swelling, and sport performance. Therefore, the purpose of this study is to determine the effectiveness of Tribulus terrestris (TT) as an herbal supplement with antioxidant and anti-inflammatory properties on the nutritional, oxidative stress, and anti/inflammatory status, as well as the sport performance of recreational runners.Methods/design: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners of Tabriz stadiums, Iran. Thirty-four recreational runners will be selected, and participants will be assigned randomly to two groups: to receive 500 mg TT supplement or placebo capsules twice daily for two weeks. Both groups will do the high-intensity interval training (HIIT) workouts during the study. Base...

Co-supplementation of camelina oil and a prebiotic is more effective for in improving cardiometabolic risk factors and mental health in patients with NAFLD: a randomized clinical trial

Food & Function, 2021

The effects of co-supplementing Camelina oil and a prebiotic as modulators of the gut microbiota ... more

Spectroscopic, thermodynamic and molecular docking studies of bovine serum albumin interaction with ascorbyl palmitate food additive

BioImpacts, 2017

Introduction: Ascorbyl palmitate (AP) is an example of natural secondary food antioxidant, which ... more Introduction: Ascorbyl palmitate (AP) is an example of natural secondary food antioxidant, which has been used for oxidative rancidity prevention in food industry. In this study, the interaction of AP with bovine serum albumin (BSA) was investigated. Methods: The mechanism of BSA interaction with AP was investigated using spectroscopic methods (UV-Vis, fluorescence). The thermodynamic parameters including enthalpy change (ΔH), entropy change (ΔS), and Gibb's free energy (ΔG) were calculated using Van't Hoff equation at different temperatures. Results: The experimental results showed that UV-Vis absorption spectra of BSA decreased upon increasing AP concentration, indicating that the AP can bind to BSA. Formation of the AP-BSA complex was approved by quenching of fluorescence and the quenching mechanism was found to be resultant from dynamic procedure. The positive values of both ΔH and ΔS showed that hydrophobic forces were the major binding forces. The negative value of ΔG demonstrated that AP interacts with BSA spontaneously. Molecular docking results confirmed that AP binds to BSA through hydrophobic forces. Conclusion: The attained results showed that AP can bind to BSA and effectively distributed into the bloodstream.

Is there any place for resistant starch, as alimentary prebiotic, for patients with type 2 diabetes?

Complementary Therapies in Medicine, 2015

The aim of the present study was to determine effects of Resistant Starch (RS2) on metabolic para... more The aim of the present study was to determine effects of Resistant Starch (RS2) on metabolic parameters and inflammation in women with type 2 diabetes (T2DM). Methods: In this randomized controlled clinical trial, 60 females with T2DM were divided into intervention (n = 28) and placebo groups (n = 32). They received 10 g/d RS2 or placebo for 8 weeks, respectively. Fasting blood sugar (FBS), glycated hemoglobin (HbA1c), lipid profile, high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-␣) were measured at baseline and at the end of the trial. Paired t test, unpaired t-test and ANCOVA were used to compare the quantitative variables. The data were analyzed using SPSS software version 13.0. Results: RS2 decreased HbA1c (−0.3%, −3.6%), TNF-␣ (−3.4 pg/mL, −18.9%), triglyceride (−33.4 mg/dL, −15.4%), and it increased HDL-c (+9.4 mg/dL, +24.6%) significantly compared with the placebo group (p < 0.05). Changes in FBS, total cholesterol, low-density lipoprotein, hs-CRP and IL-6 were not significant in the RS2 group compared with the control group. RS2 can improve glycemic status, inflammatory markers and lipid profile in women with T2DM. Conclusions: Although findings of the present study indicated positive effects of RS2 on inflammation and metabolic parameters, more studies are needed to confirm efficacy of RS2 as an adjunct therapy in diabetes.

Effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes

Background: The purpose of this study was to evaluate the effects of high performance inulin supp... more Background: The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes. Methods: In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index<35 kg/m 2) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study. Results: At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups. Conclusion: Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.

Knowledge and attitude towards health and food safety among students of Tabriz University of Medical Sciences, Tabriz, Iran

Journal of Analytical Research in Clinical Medicine, 2017