Papers by Hossein Bannazadeh Baghi
Iranian journal of public health, Jun 15, 2020
Iranian journal of public health, Jul 6, 2020
Immune-checkpoint expression in antigen-presenting cells (APCs) of cytomegaloviruses infection after transplantation: as a diagnostic biomarker
Archives of Microbiology, Jul 10, 2023
Molecular Biology Reports, May 7, 2020
Cervical cancer is one of the most common disorders in females all around the world. Similar to o... more Cervical cancer is one of the most common disorders in females all around the world. Similar to other types of cancer, several signaling pathways are demonstrated to be involved in the progression of this cancer including ERK/MAPK, PI3K/ AKT, apoptotic signaling pathways, Wnt, and epidermal growth factor receptor (EGFR). Various microRNAs (miRNAs) and their target genes involved in cervical cancer have been extracted from the kinds of literature of Scopus, Pubmed and Google scholar databases. Regarding the targets, some of them were found to belong in EGFR signaling pathways. The regulation patterns of these miRNA are different in cervical cancer; however, their main aim is to trigger EGFR signaling to proceed with cancer. Moreover, several predicted miRNAs were found to have some interactions with the differentially expressed genes of cervical cancer which are the members of the EGFR signaling pathway by using miRWalk 3.0 (https :// mirwa lk.umm.uni-heide lberg .de/) and TargetScan 7.1 (https ://www.targe tscan .org/vert_71/). Also, the microarray data were obtained from the NCBI-Gene Expression Omnibus (GEO) datasets of cervical cancer. In the present review, we highlight the miRNAs involved in cervical cancer and the role of their targets in the EGFR signaling pathway. Furthermore, some predicted miRNAs were the candidate to target EGFR signaling pathway members differentially expressed in cervical cancer samples compared to normal samples.
Cluster of differentiation frequency on antigen presenting-cells: The next step to cervical cancer prognosis?
International Immunopharmacology, Jul 1, 2022
Immunoanalysis, Dec 25, 2022
Background: The purpose of this investigation was to specify the genotypes and subtypes of hepati... more Background: The purpose of this investigation was to specify the genotypes and subtypes of hepatitis B virus (HBV) by phylogenetic analysis and to investigate the mutations in the S gene region in chronic patients with hepatitis B surface antigen (HBsAg)-positive. Methods: In the present study, Serum sample of 95 patients with chronic HBV infection were subjected. Nested polymerase chain reaction was used for detection of HBV DNA. The S gene region of the DNA isolates was subjected to direct sequencing and phylogenetic analysis. Results: Genotype D was present in all isolates, and the predominant subtype was ayw2 (94.7%), followed by three isolates, ayw3 (3.1%), and two isolates, ayw4 (2.1%). There were totally 169 nucleotide changes. Eighty-one (47.92%) were missense, while 88 (52.07%) were silent. None of the nucleotide or amino acid changes were seen in 31 (32.6%) patients. Eight (8.4%) of the 95 samples had at least one mutation in the HBsAg "a" determinant region. Fifty-eight (71.6%) of the 81 amino acid changes in the surface protein occurred in immunological epitopes, with 16 (27.5%) occurring in B cell epitopes, 17 (29.3%) in T helper epitopes, and 25 (43.1%) in internal cytotoxic T lymphocyte epitopes. Conclusion: This investigation demonstrated that the genotype D is the prevalent genotype in Eastern Azerbaijan province, similar to other Iranian areas and Mediterranean nations. Furthermore, the highest rate of mutation of antigenic epitopes occurred in the T lymphocyte epitopes of our patients.
Pharmaceutical Sciences, Jul 28, 2021
The coronavirus disease 2019 (COVID-19) outbreak has caused a public health crisis worldwide. How... more The coronavirus disease 2019 (COVID-19) outbreak has caused a public health crisis worldwide. However, data regarding the protective factors of the disease is limited. Consequently, preventive health measures that can decrease the risk of infection, progression, and severity are dreadfully required. It is well-documented that people with immunodeficiency, such as the elderly, people who already have comorbidities (e.g., diabetes mellitus, hypertension, respiratory and cardiovascular disorders), and underrepresented minorities, are placed in a group with a higher risk of getting infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A diet rich in vitamins, minerals, and antioxidants plays an essential role in strengthening the immune system and fighting against invading pathogens. The present comprehensive review has discussed published literature regarding the potential role of vitamins in strengthening the immune system and managing viral infections, particularly SARS-CoV-2 infection. Although there are controversial data regarding the plasma level of vitamin D and the severity of the disease, according to the limited evidence, vitamin D may lower the mortality rate. Moreover, vitamin C could reduce the development of inflammatory response; however, the results of ongoing clinical trials are required to confirm these primary findings.
Lancet Infectious Diseases, Nov 1, 2019
Tavoschi L, O'Moore É, Hedrich D. Challenges and opportunities for the management of infectious d... more Tavoschi L, O'Moore É, Hedrich D. Challenges and opportunities for the management of infectious diseases in Europes' prisons: evidence-based guidance.
Canadian Journal of Gastroenterology & Hepatology, Dec 8, 2022
Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs... more Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs such as the lungs, kidneys, liver, heart, and brain have been identifed as priority organs. Liver diseases are considered a risk factor for high mortality from the COVID-19 pandemic. Besides, liver damage has been demonstrated in a substantial proportion of patients with COVID-19, especially those with severe clinical symptoms. Furthermore, antiviral medications, immunosuppressive drugs after liver transplantation, pre-existing hepatic diseases, and chronic liver diseases such as cirrhosis have also been implicated in SARS-CoV-2-induced liver injury. As a result, some precautions have been taken to prevent, monitor the virus, and avoid immunocompromised and susceptible individuals, such as liver and kidney transplant recipients, from being infected with SARS-CoV-2, thereby avoiding an increase in mortality. Te purpose of this review was to examine the impairment caused by SARS-CoV-2 infection and the impact of drugs used during the pandemic on the mortality range and therefore the possibility of preventive measures in patients with liver disease.
Pathology Research and Practice, May 1, 2022
Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recen... more Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the so-called "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARS-CoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.
Iranian journal of public health, Jul 5, 2020
Virology Journal, Jan 7, 2023
After the first reporting of the index case of Severe Acute Respiratory Syndrome (SARS)-CoV-2-ass... more After the first reporting of the index case of Severe Acute Respiratory Syndrome (SARS)-CoV-2-associated disease at the end of December 2019, the virus spread quickly throughout the world, prompting the WHO on 11 March 2020 to declare the disease a global pandemic. The coronavirus disease 2019 (COVID-19) pandemic, raises concerns for all people, mainly for susceptible population. People with pre-existing diseases, especially individuals with autoimmune disorders, are more at the risk of SARS-CoV-2 infection because of compromised immune system due to frequent use of immunosuppressive drugs and steroids. Patients with autoimmune diseases and their physicians have concerns about these patients' healthcare, since they are at a higher risk for COVID-19 infection, may show severe complications of COVID-19, and may experience probable flares of their pre-existing disease. Even though there have been several studies discussing the relation between COVID-19 and various types of autoimmune diseases, it cannot be ascertained that all patients with autoimmune diseases experience more severe complications of COVID-19 and have more hospitalization or mortality rate. The situation depends on each patient's condition, such as the type and the severity of the underlying autoimmune disease and the kind of treatment they receive. In the present review, we have discussed the effects of COVID-19 pandemic on patients with different autoimmune diseases and their relative concerns about their treatments. As a result, we have reviewed further considerations that should be taken into account for these patients during the pandemic or when they are infected with COVID-19.
Cervical cancer is known as one of the most important cancers in women worldwide. Chemotherapy is... more Cervical cancer is known as one of the most important cancers in women worldwide. Chemotherapy is a standard treatment for advanced/recurrent cervical cancer in which the prognosis of the disease is really poor and the 1-year survival chance in these patients is maximally 20%. However, resistance to anticancer drugs is a major problem in treating cancer. Cervical cancer stem cells are considered as a fundamental cause of chemo and radioresistance and also relapse after primary successful treatment. Signaling pathways include a wide range of molecular mechanisms contribute to drug resistance. Recently, microRNAs (miRNAs) are announced as a group of molecular biomarkers involving in response to chemotherapy in cancer patients. As the miRNAs, there are some long non-coding RNAs (LncRNAs) which their aberrant expression is considered as a biomarker for monitoring chemoresistance. In this review, we summarized current reports about the involvement of signaling pathways during chemoresistance in cervical cancer. Then, genes that have been demonstrated their involvement during drug resistance in cervical cancer were tabulated. Further, miRNAs that have been reported as biomarkers during treatment are listed. By bioinformatic analysis, we predictedmiR-335-5p and miR-16-5p as the most potential biomarkers for monitoring resistance to chemotherapy. Finally, long non-coding RNAs that have been introduced in recent studies as novel biomarkers during the response to chemotherapy were mentioned.
Comparative Immunology Microbiology and Infectious Diseases, Dec 1, 2014
The mucosal surfaces are important sites of entry for a majority of pathogens, and viruses in par... more The mucosal surfaces are important sites of entry for a majority of pathogens, and viruses in particular. The migration of antigen presenting cells (APCs) from the apical side of the mucosal epithelium to the lymph node is a key event in the development of mucosal immunity during viral infections. However, the mechanism by which viruses utilize the transmigration of these cells to invade the mucosa is largely unexplored. Here, we establish an ex vivo explant model of monocytic cell transmigration across the nasal mucosal epithelium and lamina propria. Equine nasal mucosal CD172a + cells (nmCD172a + cells), blood-derived monocytes and monocyte-derived DCs (moDCs) were labeled with a fluorescent dye and transferred to the apical part of a polarized mucosal explant. Confocal imaging was used to monitor the migration patterns of monocytic cells and the effect of equine herpesvirus type 1 (EHV-1) on their transmigration. We observed that 16-26% of mock-inoculated nmCD172a + cells and moDCs moved into the nasal epithelia, and 1-7% moved further in the lamina propria. The migration of EHV-1 inoculated monocytic cells was not increased in these tissues compared to the mock-inoculated monocytic cells. Immediate early protein positive (IEP +) cells were observed beneath the basement membrane (BM) 48 hours post addition (hpa) of moDCs and nmCD172a + cells, but not blood-derived monocytes. Together, our finding demonstrate that monocytic cells may become infected with EHV-1 in the respiratory mucosa and transport the virus from the apical side of the epithelium to the lamina propria en route to the lymph and blood circulation.
The Lancet, Oct 1, 2016
Fighting rabies in Eastern Europe, the Middle East and Central Asia-experts call for a regional i... more Fighting rabies in Eastern Europe, the Middle East and Central Asia-experts call for a regional initiative for rabies elimination.
Iranian Journal of Medical Microbiology, 2023
Background and Aim: Gastric cancer (GC) is a major health problem worldwide. Several studies have... more Background and Aim: Gastric cancer (GC) is a major health problem worldwide. Several studies have shown the virus's role in cancer pathogenesis. Therefore, the aim of this study was to evaluate the presence of human papillomavirus (HPV) in GC by immunohistochemistry (IHC) and polymerase chain reaction (PCR) in hospitals in the East Azerbaijan province, Iran. Materials and Methods: In this descriptive cross-sectional study, 100 tissue samples of paraffin-embedded, including GC (50 samples), benign gastric hyperplasia (25 samples), and a control group (25 samples) were collected from the archives of laboratories in East Azerbaijan province from April to October 2021. The IHC and PCR were used to detect the HPV virus. SPSS software version 22 and t-test and Chi-Square statistical tests were used for data analysis. Results: 8 out of 50 cancer samples were HPV positive by IHC and PCR. HPV-positive samples had a mean age of 62.87 ± 9.67. Men had the highest number of HPV-positive samples compared to women (5 samples vs. 3 samples). However, no viral genomes were observed in non-malignant and control samples. There was a significant relationship between HPV infection and GC (P=0.03). Conclusion: According to the present study's findings, the presence of HPV infection in GC plays an important role in the development of GC in the hospitals of East Azerbaijan province. Also, the results showed that PCR and IHC are both more sensitive and reliable in detecting HPV because the results of both IHC and PCR were the same. Hence IHC method can be used as an alternative to the PCR method to detect HPV oncoproteins.
Ecology of the Human Gastrointestinal Trac
BENTHAM SCIENCE PUBLISHERS eBooks, Jun 2, 2021
Main Methods for the Preparation of Postbiotics
BENTHAM SCIENCE PUBLISHERS eBooks, Jun 2, 2021
Alphaherpesviruses Infection in the Upper Respiratory Tract
Applied microbiology: open access, Aug 29, 2017
Journal of Infection in Developing Countries, Mar 31, 2023
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Papers by Hossein Bannazadeh Baghi