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Endogenous cannabinoids acting at CB 1 receptors stimulate appetite, and CB 1 antagonists show promise in the treatment of obesity. CB 1 -/mice are resistant to diet-induced obesity even though their caloric intake is similar to that of... more
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      PharmacologyPharmacyMolecular BiologyToxicology
The endocannabinoid system has recently emerged as an important regulator of energy homeostasis, involved in the control of both appetite and peripheral fat metabolism. We briefly review current understanding of the possible sites of... more
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    •   3  
      PharmacologyNeurosciencePharmacy
The enzyme fatty acid amide hydrolase (FAAH) catalyzes the in vivo degradation of the endocannabinoid anandamide, thus controlling its action at receptors. A novel FAAH inhibitor, AM3506, normalizes the elevated blood pressure and cardiac... more
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    •   5  
      BiochemistryEndocrinology & MetabolismCancer cachexiaEvolutionary medicine
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    •   2  
      Cell communicationClinical Trials as Topic
Objective-To determine the physiologic importance of endocannabinoids and mitochondrial function in the long-term outcome using a rat model of Roux-en-Y gastric bypass (RYGB) surgery.
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    •   3  
      Skeletal muscle biologyMedicineGastric Bypass
The novel endocannabinoid-like lipid N-arachidonoyl L-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations... more
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    •   2  
      PharmacologyPatch-clamp and imaging techniques
The endocannabinoid system has recently emerged as an important regulator of energy homeostasis, involved in the control of both appetite and peripheral fat metabolism. We briefly review current understanding of the possible sites of... more
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    •   2  
      EducationFatty Acid Synthesis
Cannabinoids, including the bioactive constituents of the marijuana plant, their synthetic analogs, and endogenous lipids with cannabinoid-like activity, produce their biological effects by interacting with specific receptors. To date,... more
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    •   5  
      PharmacologyNOPresynaptic InhibitionCB 1 receptor
Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, because mice... more
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    • CB 1 receptor
Hepatic ischemia-reperfusion (I/R) injury continues to be a fatal complication that can follow liver surgery or transplantation. We have investigated the involvement of the endocannabinoid system in hepatic I/R injury using an in vivo... more
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      PhysiologyMedical PhysiologyCB 1 receptorBiochemistry and cell biology
Obesity and its metabolic consequences are a major public health concern worldwide. Obesity is associated with overactivity of the endocannabinoid system, which is involved in the regulation of appetite, lipogenesis, and insulin... more
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dala, the bed nucleus of the stria terminalis and the nucleus accumbens, and treatment of FAAH -/mice with rimonabant, 3 mg/kg/day for 7 days, increased CART levels toward those seen in FAAH +/+ wild-type controls. In contrast, no... more
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    •   5  
      Brain ChemistryNerve EndingsCannabinoid ReceptorFood Deprivation
Endogenous cannabinoids acting at CB 1 receptors stimulate appetite, and CB 1 antagonists show promise in the treatment of obesity. CB 1 -/mice are resistant to diet-induced obesity even though their caloric intake is similar to that of... more
    • by 
    •   7  
      PharmacologyPharmacyMolecular BiologyToxicology
Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that the steatosis induced in mice by a low-fat, liquid ethanol... more
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    • Biochemistry and cell biology
profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. The endocannabinoid anandamide exerts neurobehavioral, cardiovascular, and immune-regulatory effects through cannabinoid... more
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      PhysiologyMedical Physiology
In this study, we have investigated the role of the cannabinoid CB 2 (CB 2 ) receptor in an in vivo mouse model of hepatic ischemia/reperfusion (I/R) injury. In addition, we have assessed the role of the CB 2 receptor in TNF-␣-induced... more
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      ImmunologyCB 1 receptorAlanine Transaminase
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released ''on demand'' by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has... more
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    • Protein tyrosine phosphatase
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    • Public health systems and services research
Endocannabinoids, endogenous lipid ligands of cannabinoid receptors, mediate a variety of effects similar to those of marijuana. Cannabinoid CB 1 receptors are highly abundant in the brain and mediate psychotropic effects, which limits... more
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    • Cannabinoid Receptor
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