Papers by mohammad amin karimi
Research Square (Research Square), Jan 30, 2024
Sodium-glucose cotransporter two inhibitors could reduce cardiovascular events by modulating the ... more Sodium-glucose cotransporter two inhibitors could reduce cardiovascular events by modulating the lipid pro le in patients with heart failure, irrespective of diabetes status. In this study, we aimed to assess the effect of SGLT-2 inhibitors on heart failure patients' lipid pro les via a meta-analysis. PubMed, Scopus, Web of Science, and Google Scholar databases were searched up to 2023 to retrieve relevant articles' titles, abstracts, and full text. STATA software was used to conduct the meta-analysis. Forest plot of fasting blood sugar levels in patients receiving SGLT2 differed signi cantly compared to control groups (mean difference =-0.08, 95%CI [-0.13, -0.02], p < 0.05). Analysis of lipid pro le items, including total cholesterol, triglyceride, HDL, and LDL in HF patients receiving SGLT2, did not show a notable difference from the control group (p > 0.005). However, the mean difference was towards reduction for LDL, cholesterol, and triglycerides and showed an increase in HDL levels. Egger's test for publication bias revealed some publication bias (p < 0.05). Our topic analysis did not suggest notable lipid pro le alterations. In order to come to a more rm agreement, more research on heart failure subjects is necessary because there is currently insu cient evidence.
Annals of Military and Health Sciences Research
Background: During the Iran-Iraq war (1980 - 1988), Iran was subjected to chemical attacks for ov... more Background: During the Iran-Iraq war (1980 - 1988), Iran was subjected to chemical attacks for over five years. These attacks left many mental injuries, especially for the veterans exposed to chemical weapons. Objectives: This case-control study compared mental disorder symptoms and brain executive functions of veterans exposed to chemical weapons with healthy individuals. Methods: The present study was conducted on veterans exposed to chemical weapons during the war. The control group comprised healthy individuals matched to the cases based on age, gender, occupation, level of education, and place of residence. One hundred seventy participants were included in the study, with 85 individuals in each group. The Symptom Checklist-90-Revised (SCL-90-R) and Nejati questionnaire were used to collect data on the symptoms of mental disorders and brain executive functions. Multivariate analysis of variance was used for data analysis. Results: The findings revealed that the total effect of t...
Frontiers in Aging Neuroscience
Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzhei... more Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to...
Frontiers in Psychology
BackgroundInflammatory Bowel Disease (IBD) affects the quality of life. Patient education and sup... more BackgroundInflammatory Bowel Disease (IBD) affects the quality of life. Patient education and support needs are crucial components of comprehensive chronic illness care. The main purposes of this review were to (i) explore the informational and supportive needs of these patients to improve the quality of life in the existing literature and (ii) identify the gaps related to the needs of the patients in articles.MethodsThe scoping review is based on the Daudt methodological framework, a modified version of Arksey and O'Malley. Electronic databases were extensively searched from January 01, 2000 to April 30, 2022. Four electronic databases (PubMed/Medline, CINAHL, APA PsycInfo, Psychology and Behavioral Sciences Collection, APA PsycArticles, and ProQuest) were searched using controlled vocabulary, and specific keywords. The searched terms were matched to each database. We manually searched two key journals, namely the Journal of Inflammatory Bowel Disease and the Journal of Crohn&#...
Background and aims: The current systematic review aimed to elucidate the effects of lipid variab... more Background and aims: The current systematic review aimed to elucidate the effects of lipid variability on microvascular complication risk in diabetic patients. The lipid components studied were as follows: LDL, HDL, TG, Total Cholesterol, and Remnant Cholesterol. Method: We carried out a systematic search in multiple databases, including PubMed, Google Scholar, and Scopus, up to September 2022. Finally, after omitting the duplicates, 2724 studies were left, 104 related articles were extracted from the databases, and five articles were included in the study after screening the title, abstract and full text. Result: Five studies (4 cohorts and one cross-sectional) with a total population of 138664 were reviewed. These studies were done in China, Japan, Hong Kong, Taiwan, and Italy. The average age of the patients varied from 45 to 84 years. The follow-up duration of cohort studies ranged from 4 to 7 years. These studies have shown that higher LDL, HDL, and TG variability adversely aff...
Frontiers in Pharmacology, Jan 10, 2023
Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules co... more Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses. The most flavonoid's critical subclasses with improved health properties are the catechins or flavonols (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavanones (e.g., naringenin from citrus), the flavanols (e.g., quercetin glycosides from berries, onion, and apples), the isoflavones (e.g., genistein from soya beans) and the anthocyanins (e.g., cyanidin-3-O-glucoside from berries). Scientific data conclusively demonstrates that frequent intake of efficient amounts of dietary flavonoids decreases chronic inflammation and the chance of oxidative stress expressing the pathogenesis of human diseases like cardiovascular diseases (CVDs). The endoplasmic reticulum (ER) is a critical organelle that plays a role in protein folding, post-transcriptional conversion, and transportation, which plays a critical part in maintaining cell homeostasis. Various stimuli can lead to the creation of unfolded or misfolded proteins in the endoplasmic reticulum and then arise in endoplasmic reticulum stress. Constant endoplasmic reticulum stress triggers unfolded protein response (UPR), which ultimately causes apoptosis. Research has shown that endoplasmic reticulum stress plays a critical part in the pathogenesis of several cardiovascular diseases, including diabetic cardiomyopathy, ischemic heart disease, heart failure, aortic aneurysm, and hypertension. Endoplasmic reticulum stress could be one of the crucial points in treating multiple cardiovascular diseases. In this review, we summarized findings on flavonoids' effects on the endoplasmic reticulum and their role in the prevention and treatment of cardiovascular diseases.
Application of a nanocomposite based on modified salep glucomannan for monitoring controlled release of tetracycline as a model drug
Journal of Polymer Research, 2022
Carbohydrates (polysaccharides) such as chitosan, alginate, carrageenan or salep are suitable can... more Carbohydrates (polysaccharides) such as chitosan, alginate, carrageenan or salep are suitable candidates to make hydrogels for drug delivery applications. Generally, salep is obtained from tubers of Orchis. It is a rich source of glucomannan carbohydrate. In this regard, magnetic multi-walled carbon nanotubes (MMWCNT) hydrogel nanocomposite based on poly(acrylic acid) grafted onto salep carbohydrate can act as a potential carrier for novel drug delivery systems. The MMWCNT / hydrogel nanocomposite was prepared via conventional radical polymerization using salep as a natural carbohydrate. Following characterization of salep hydrogel nanocomposite, diffusion coefficients and the mechanism of release of Tetracycline hydrochloride (TCH) from the carbohydrate hydrogel was investigated. According to our findings, diffusion exponent ‘n’ has 0.46 and 0.26 values for TCH release from hydrogel without MMWCNTs and with MMWCNTs, indicating non-Fickian transport and Fickian transport, respective...
Fluorometric detection of phytase enzyme activity and phosphate ion based on gelatin supported silver nanoclusters
Food Chemistry
Frontiers in Neuroscience
Hundreds of millions of people around the world suffer from neurological disorders or have experi... more Hundreds of millions of people around the world suffer from neurological disorders or have experienced them intermittently, which has significantly reduced their quality of life. The common treatments for neurological disorders are relatively expensive and may lead to a wide variety of side effects including sleep attacks, gastrointestinal side effects, blood pressure changes, etc. On the other hand, several herbal medications have attracted colossal popularity worldwide in the recent years due to their availability, affordable prices, and few side effects. Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia), and rosemary (Salvia Rosmarinus) have already shown anxiolytics, anti-inflammatory, antioxidant, and neuroprotective effects. They have also shown potential in treating common neurological disorders, including Alzheimer's disease, Parkinson's disease, migraine, and cognitive disorders. This review summarizes the data on the neuroprotective pote...
Simulation of hydrological and land surface variables over Iran – a new 24/7 operational system based on the coupled WRF-SEBAL model
&amp;lt;p&amp;gt;Water scarcity is regarded as one of the most important issues in many d... more &amp;lt;p&amp;gt;Water scarcity is regarded as one of the most important issues in many dry climates, with serious impacts on the food security and national development. Since agriculture irrigation accounts for the most of water use worldwide, providing a water management system is of paramount importance to cope with water stress and its challenges. Agricultural water management is an interdisciplinary task including meteorological and environmental factors. In this work, we have established a 24/7 system to simulate those land surface variables, associated with evapotranspiration, biomass growth, and water deficit, using the Surface Energy Balance Algorithm for Land (SEBAL). SEBAL simulates the energy balance, using satellite data for shortwave and thermal bands, as well as soil and meteorological data (such as wind speed and humidity).&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;This system consists of 3 interconnected units: WRF model, Python implementation of the SEBAL model (pySEBAL), and a web-based management panel for the visualization, reanalysis, and publishing the results. The WRF model is run in a daily basis for 36 hours, starting from 12:00 UTC, to provide the meteorological data for the next day. At the next stage, the simulated WRF data after some required processing (converting formats and units of files and variables, etc.)&amp;amp;#160; will be incorporated as input data into the SEBAL model. The key data for the SEBAL model is the &amp;amp;#8220;Visible Infrared Imaging Radiometer Suite&amp;amp;#8221; (VIIRS) real-time data over the Suomi satellite, which is received automatically after tracking the satellite and picking the appropriate data files for download. SEBAL outputs include some of the variables with key role in agricultural water management, such as actual and potential evapotranspiration, biomass production and deficit, albedo, NDVI, etc, with a resolution of 375m over Iran.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;The third part of operational system is a web-based panel, consisting of an open-source server to share and edit the SEBAL outputs. An open-source database management system for the client-based analysis of the SEBAL outputs, and an open-source JavaScript library for displaying the maps of the SEBAL outputs in web browsers.&amp;lt;/p&amp;gt;
The Supporting Information file provides a short theoretic background on elastomer adhesion and f... more The Supporting Information file provides a short theoretic background on elastomer adhesion and friction, and attempts to model friction of SGAs, results of the additional experiments performed to evaluate cycling loading effect to the friction strength and friction profile type and other figures to support information provided in the main text.
The Effect of a Novel Combination of Vitamin D and Probiotic on Clinical Symptoms, Biomarkers of Oxidative Stress and Cardio-Metabolic Risk in Patients with Chronic Schizophrenia: A Randomized, Double-Blinded, Placebo-Controlled Trial
SSRN Electronic Journal, 2018
Cable-Driven Jamming of a Boundary Constrained Soft Robot
2020 3rd IEEE International Conference on Soft Robotics (RoboSoft), 2020
Soft robots employ flexible and compliant materials to perform adaptive tasks and navigate uncert... more Soft robots employ flexible and compliant materials to perform adaptive tasks and navigate uncertain environments. However, soft robots are often unable to achieve forces and precision on the order of rigid-bodied robots. In this paper, we propose a new class of mobile soft robots that can reversibly transition between compliant and stiff states without reconfiguration. The robot can passively conform or actively control its shape, stiffen in its current configuration to function as a rigid-bodied robot, then return to its flexible form. The robotic structure consists of passive granular material surrounded by an active membrane. The membrane is composed of interconnected robotic sub-units that can control the packing density of the granular material and exploit jamming behaviors by varying the length of the interconnecting cables. Each robotic sub-unit uses a differential drive system to achieve locomotion and self-reconfigurability. We present the robot design and perform a set of locomotion and object manipulation experiments to characterize the robot’s performance in soft and rigid states. We also introduce a simulation framework in which we model the jamming soft robot design and study the scalability of this class of robots. The proposed concept demonstrates the properties of both soft and rigid robots, and has the potential to bridge the gap between the two.
A Boundary-Constrained Swarm Robot with Granular Jamming
2020 3rd IEEE International Conference on Soft Robotics (RoboSoft), 2020
This paper describes a new type of compliant and configurable soft robot, a boundary-constrained ... more This paper describes a new type of compliant and configurable soft robot, a boundary-constrained swarm. The robot consists of a sealed flexible membrane that constrains both a number of mobile robotic subunits and passive granular material. The robot can change the volume fraction of the sealed membrane by applying a vacuum, which gives the robot the ability to operate in two distinct states: compliant and jammed. The compliant state allows the robot to surround and conform to objects or pass through narrow corridors. Jamming allows the robot to form a desired shape; grasp, (a) manipulate, and exert relatively high forces on external objects; and achieve relatively higher locomotion speeds. Locomotion is achieved with a combination of whegs (wheeled legs) and vibration motors that are located on the robotic subunits. The paper describes the mechanical design of the robot, the control methodology, and its object handling capability.
Background: Because of the high prevalence of cardiovascular diseases and their urgent treatment ... more Background: Because of the high prevalence of cardiovascular diseases and their urgent treatment in a way that have minimal side effects and maximum benefits, this study aims to compare the mortality rate, re-hospitalization, and ejection fraction of smoker patients undergone P-PCI (primary percutaneous coronary intervention) with those who received thrombolytic therapy in autumn 2018.Methods: This cross-sectional study was done in Ayatollah Taleghani and Labbafinejad hospitals of Tehran City, Iran. The study group consisted of 42 smoker patients referred to the hospitals with the diagnosis of ST-Elevation Myocardial Infarction (STEMI) and have undergone P-PCI or thrombolytic therapy from September 2018 to December 2018. Complications such as death and re-hospitalization were noted, and the ejection fraction of each patient was also recorded. Statistical analyses were performed using SPSS version 25. Statistical significance was considered at P< 0.05.Results: The Independent Samp...
Comparison of behavioral activation subscales of Gray’s original reinforcement sensitivity theory in opioid and methamphetamine dependent patients
Introduction: The relationship of behavioral activation subsystems with methamphetamine and opioi... more Introduction: The relationship of behavioral activation subsystems with methamphetamine and opioids dependency, which are the most commonly used illicit substances in Iran, is still unclear. The purpose of this study was to compare the behavioral activation subsystems and behavioral inhibition system of opioid and methamphetamine dependents with those of healthy subjects. Materials and Methods: In this case-control study, two groups of methamphetamine and opioids dependents (25 cases on each group) were selected through purposeful method from patients admitted to substance rehabilitation centers of Mashhad, Iran, during March to September 2012. A group of 25 healthy cases (non-addict) were also matched as the control group. Data was collected using Carver and White’s BAS/BIS scales and analyzed using Chi-square test, one-way analysis of variance, and multivariate analysis of variance. Results: The methamphetamine-dependents group had a higher BAS-DR subscale score than the opioid de...
Supplementary material from "Understanding the influence of silicone elastomer properties on wedge-shaped microstructured dry adhesives loaded in shear
Anisotropic, gecko-inspired, microstructured adhesives are one of the most promising solutions fo... more Anisotropic, gecko-inspired, microstructured adhesives are one of the most promising solutions for many applications in robotics and biomedical applications that require controllable adhesives to grip flat surfaces. In such adhesives, normal adhesion is negligible when loaded solely in the normal direction, but becomes available when the adhesive is loaded in shear first. However, much remains to be learned regarding the friction and failure mechanisms of microstructures loaded in shear. In response, we analysed the load–displacement profiles of wedge-shaped microstructured adhesives comprised of nine different silicone elastomers and their mixtures loaded in shear. The results show that the friction profile depends on at least three factors related to material properties: interfacial adhesion strength in the normal direction (work of separation), elastic modulus and the sample's imperfections (e.g. contamination, misalignment and moulding errors). Moreover, the work of separation influences the maximum friction load such that for materials with the same elastic modulus, the strongest interfacial adhesion yields the lowest friction force. To explain this, we suggest that strongly adhering materials will lead to a macroscopic frictional sliding of the array rather than previously reported stick-slip behaviour.
A Self-Reconfigurable Variable-Stiffness Soft Robot Based on Boundary-Constrained Modular Units
IEEE Transactions on Robotics, 2021
This article describes a soft robot based onboundary constrained modular subunits. The loop-shape... more This article describes a soft robot based onboundary constrained modular subunits. The loop-shaped robot consists of a granule-filled elastic toroidal membrane with a series of modular subunit robots attached to its exterior. The robot can operate both as a soft robot to conform to external objects or navigate through narrow corridors and as a rigid robot by jamming its internal granules using a vacuum. The jammed state is useful for exerting forces on the environment in object manipulation or locomotion tasks. This article describes the robot’s design, object handling capabilities, locomotion, shape formation, and ability to navigate narrow corridors. We also present computationally efficient control methodologies used for self-reconfiguration and target tracking, which enable scaling the number of subunits to create larger systems. The robot’s scalability and the control methodologies are verified through simulation with ProjectChrono, a multibody dynamic simulation platform. All other results are obtained experimentally.
International Journal of Structural Engineering, 2018
In previous works in the field of topology optimisation of discrete structures, the starting poin... more In previous works in the field of topology optimisation of discrete structures, the starting point of the algorithm in the most cases is a structure that consists of all members (ground structure). In this case, too much computing is needed to obtain optimum topology of the structure. In order to overcome this disadvantage of the structural topology optimisation, the minimum growing ground structure method (MGGSM) was proposed. The method consists of three phases. In the first phase, the minimum stable structure is constructed. In the second phase, this structure, by applying the growth idea becomes a feasible and acceptable structure, and in the third phase, a meta-heuristic optimisation method is used to obtain the optimal topology of the structure. The comparison between the results obtained by the MGGSM and other methods for standard examples shows the efficiency of the MGGSM algorithm to obtain the optimum state.
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Papers by mohammad amin karimi