Sayed Ali

Followers

Following

Public Views

Interests

Uploads

Papers by Sayed Ali

Water Purification in Atmospheric Water Generator

Port-Said Engineering Research Journal

Experimental Investigation on Asphaltene Deposition in Porous Media During Miscible Gas Injection

Iranian Journal of Chemistry & Chemical Engineering-international English Edition, Dec 1, 2007

In this work the likelihood of asphaltene deposition problems during dynamic displacement of oil ... more In this work the likelihood of asphaltene deposition problems during dynamic displacement of oil by natural gas in unconsolidated porous media is experimentally inspected. The two different rock materials, limestone and sandstone, are used as a representative of porous media. Dynamic flow experiments indicate that the increase of natural gas injection increases asphaltene deposition in the unconsolidated matrix. The results of the study show that increase in asphaltene deposition leads to pore plugging, porosity reduction and absolute permeability damage. Irreducible water measurements showed that natural gas-induced asphaltenes change the rock wettability to oil-wet.

Download

A Review: Tribological Study of Advanced Coating on Cast Iron

AIJR Abstracts, Feb 6, 2021

Hybrid Pointer Networks for Combinatorial Optimization Problems

In this work, a novel idea is presented for combinatorial optimization problems, a hybrid network... more In this work, a novel idea is presented for combinatorial optimization problems, a hybrid network, which results in a superior outcome. We applied this method to graph pointer networks [1] expanding its capabilities to a higher level. We proposed a hybrid pointer network (HPN) to solve the travelling salesman problem trained by reinforcement learning. Furthermore, HPN builds upon graph pointer networks which is an extension of pointer networks with an additional graph embedding layer. HPN outperforms the graph pointer network in solution quality due to the hybrid encoder, which provides our model with a verity encoding type, allowing our model to converge to a better policy. Our network significantly outperforms the original graph pointer network for small and large-scale problems increasing its performance for TSP50 from 5.959 to 5.706 without utilizing 2opt, Pointer networks, Attention model, and a wide range of models, producing results comparable to highly tuned and specialized algorithms. We make our data, models, and code publicly available https://github.com/AhmedStohy/Hybrid-PointerNetworks.

Marker Mining in Bambara Groundnut

Design of a compact triple band-notch flower-shaped hexagonal microstrip patch antenna

2016 International Conference on Information Technology (InCITe) - The Next Generation IT Summit on the Theme - Internet of Things: Connect your Worlds, 2016

In this paper, a compact triple band-notch Direct fed Flower-shaped Hexagonal Microstrip Patch An... more In this paper, a compact triple band-notch Direct fed Flower-shaped Hexagonal Microstrip Patch Antenna is presented for embedding in UWB (Ultra-Wide Band) systems. The antenna consists of two C-shape slot resonators in the patch and two parasitic strips parallel to microstrip feed line. The antenna is designed in Ansoft HFSS ver. 15. Three notched bands created are 3.3–4.2 GHz, 5.15–5.825 GHz and 8.025–8.4 GHz. These three notched-bands includes rejection characteristics for IEEE 802.16 i.e. WI-Max at 3.5/5.5 GHz (3.3 to 3.7 GHz and 5.25–5.85 GHz), IEEE 802.11a i.e. WLAN2 systems at 5.2/5.8 GHz (5.15–5.35 and 5.725–5.825 GHz), Satellite C Band at 4 GHz (3.7–4.2 GHz) and ITU Band at 8.2 GHz (8.025–8.4 GHz). Overall six standard bands are notched. All notches are controllable. The simulation results of antenna shows ultra-wide impedance matching, good gain and stable radiation patterns across operational bandwidth and is suitable for wireless UWB applications.

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Frontiers in Immunology, 2020

Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metas... more Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast cancer stem cells. Here we show that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients express higher levels of nLSD1p compared to responders, which is associated with co-expression of stem-like, mesenchymal genes. Targeting nLSD1p with selective nLSD1 inhibitors better inhibits the stem-like mesenchymal signature than traditional FAD-specific LSD1 catalytic inhibitors such as GSK2879552. We also demonstrate that nLSD1p is enriched in PD-1 + CD8 + T cells from resistant melanoma patients and 4T1 immunotherapy-resistant mice. Targeting the LSD1p nuclear axis induces IFN-γ/TNF-α-expressing CD8 + T cell infiltration into the tumors of 4T1 immunotherapy-resistant mice, which is further augmented by combined immunotherapy. Underpinning these observations, nLSD1p is regulated by the key T cell exhaustion transcription factor EOMES in dysfunctional CD8 + T cells. EOMES co-exists with nLSD1p in PD-1 + CD8 + T cells in resistant patients, and nLSD1p regulates EOMES nuclear dynamics via demethylation/acetylation switching of critical EOMES residues. Using novel antibodies to target these post-translational modifications, we show that EOMES demethylation/acetylation is reciprocally expressed in resistant and responder patients. Overall, we show for the first time that dual inhibition of metastatic cancer cells and re-invigoration of the immune system requires LSD1 inhibitors that target the nLSD1p axis.

Download

Repetitive Strain Injuries of the Upper Extremity: Imaging of Tendon Pathology and Compressive Neuropathies

Current Problems in Diagnostic Radiology, 2020

Repetitive strain injuries (RSIs) encompass a broad clinicopathologic spectrum which includes dis... more Repetitive strain injuries (RSIs) encompass a broad clinicopathologic spectrum which includes discrete patterns of tissue injury involving tendons, bursae and nerves although an element of subjective symptomatology may be contributory. Upper extremity RSIs include De Quervain's tenosynovitis, intersection syndromes, epicondylitis, ulnar, and median neuritis as well as other compressive neuropathies. It is estimated that RSIs cost the US economy over $60 billion annually and while detailed clinical examination remains the diagnostic mainstay, imaging can aid in diagnosis, guide management and reduce costs.

Prevalence and molecular characterization of some circulating strains of the peste-des-petits-ruminants virus in Saudi Arabia between 2014–2016

PeerJ, 2020

Background The peste-des-petits-ruminants virus (PPRV) is a highly devastating virus of small rum... more Background The peste-des-petits-ruminants virus (PPRV) is a highly devastating virus of small ruminants in many parts of the world, including the Kingdome of Saudi Arabia. Therefore, our objectives were (1) to conduct a molecular prevalence study of PPRV in sheep and goat across the KSA and (2) to isolate and identify currently circulating PPRV lineages. Swabs and tissue specimens were collected from 97 herds suspected to be infected with PPRV across the Kingdome of Saudi Arabia (KSA). Testing for the presence of the virus was done by the real-time PCR. Confirmation of the identity of the reactions was done by the gel-based-PCR then by sequencing of the partial PPRV genome. Results Our results revealed that 24.1% of the tested specimens were PPRV-positive. Isolation of PPRV was successful from samples using the Vero cell line. Sequence analysis of some partial PPRV genes (N, F, M, L, P, and H) revealed that these strains were belonging to lineage IV of the PPRV. Conclusions This is ...

Download

Acceleration of implicit schemes for large systems of nonlinear differential-algebraic equations

AIMS Mathematics, 2020

Implicit integration schemes for large systems of nonlinear ODEs require, at each integration ste... more Implicit integration schemes for large systems of nonlinear ODEs require, at each integration step, the solution of a large nonlinear system. Typically, the nonlinear systems are solved by an inexact Newton method that leads to a set of linear systems involving the Jacobian matrix of the ODE which are solved by Krylov subspace methods. The convergence of the whole process relies on the quality of initial solutions for both the inexact Newton iteration and the linear systems. To improve global convergence, line search and trust region algorithms are used to find effective initial solutions. The purpose of this paper is to construct subspaces of small dimension where descent directions for line search and trust region algorithms and initial solutions for each linear system are found. Only one subspace is required for each integration step. This approach can be seen as an improved predictor, leading to a significant saving in the total number of integration steps. Estimates are provided that relate the quality of the computed initial solutions to the step size of the discretization, the order of the implicit scheme and the dimension of the constructed subspaces. Numerical results are reported.

Download

$Research paper thumbnail of Vedolizumab in combined immune checkpoint therapy-induced infliximab-refractory colitis in a patient with metastatic melanoma: A case report$

Vedolizumab in combined immune checkpoint therapy-induced infliximab-refractory colitis in a patient with metastatic melanoma: A case report

World Journal of Clinical Oncology, 2019

-Access:This article is an open-access article which was selected by an in-house editor and fully... more

Download

Identify factors that effecting on wood and papers student’s entrepreneurial spirit (case study: college of agricultural and natural resources of Tehran university)

International Journal of Advanced Biological and Biomedical Research, 2016

The purpose of this study was to identify factors that effecting on wood and papers student's ent... more The purpose of this study was to identify factors that effecting on wood and papers student's entrepreneurial spirit. Statistical population of this research consisted of whole wood and paper students in college of agricultural and natural of Tehran University (N= 263). A stratified random sampling method was used to select 100 students applying Morgan's table. The main tool to collect data was a researcher made questionnaire that Content validity of the questionnaire was approved, by a panel of experts and Exploratory factor analysis and its reliability, was confirmed by calculating Cronbach's alpha coefficient (α= 0.71-0.79). Data was analyzed by SPSSWin20 software. Results of factor analysis showed that four factors: curriculum content, psychological, teaching method and management explained 60.87 percent of the variance of students' entrepreneurial spirit.

Download

A Civil Engineering Senior Design Research Effort to Ascertain Discharge Coefficients of Different Orifice Geometries

Journal of Civil Engineering and Architecture, 2019

The present researched topic was conceived from a senior design course for Civil Engineering stud... more The present researched topic was conceived from a senior design course for Civil Engineering students at CSUN (California State University), Northridge. In this work, experimental trials were performed and compared to establish theoretical values of the discharge coefficient. The discharge coefficient is a dimensionless number used to characterize the flow and pressure loss behavior of nozzles and orifices in fluid systems. A group of low-income undergraduate students with diverse backgrounds designed multiple 3D printed orifices where each 3D printed orifice had a specific shape. Utilizing the methods of technical problem solving, the undergraduates found experimental discharge coefficient values for the following orifices: borda, short-tubed, and sharp-edged. Implementing ethics of engineering practice and utilizing university resources, this study is a representation of the collaborative work of minorities and females that want to expand their knowledge within their respective discipline of Civil Engineering.

Download

Magnetostrictive Cold Spray Sensor Feasibility Assessment

Communication of Contrast in the Flexor Hallucis Longus Tendon with Other Pedal Tendons at the Master Knot of Henry

Journal of the American Podiatric Medical Association, 2017

It is important to have a full appreciation of lower-extremity anatomical relationships before un... more It is important to have a full appreciation of lower-extremity anatomical relationships before undertaking diabetic foot surgery. We sought to evaluate the potential for communication of the flexor hallucis longus (FHL) tendon with other pedal tendons and plantar foot compartments at the master knot of Henry and to provide cadaveric images and computed tomographic (CT) scans of such communications. Computed tomography and subsequent anatomical dissection were performed on embalmed cadaveric limbs. Initially, 5 to 10 mL (1:4 dilution) of iohexol and normal saline was injected into the FHL sheath as it coursed between the two hallux sesamoids. Subsequently, CT scans were obtained in the axial plane using a multidetector CT scanner with sagittal and coronal reformatted images. The limbs were then dissected for specific evaluation of the known variable intertendinous connections between the FHL and flexor digitorum longus (FDL) and quadratus plantae (QP) muscles. One cadaver demonstrate...

Investigation of Ultrasonic Calibration using Steel Standard Reference Blocks

Walailak Journal of Science and Technology (WJST), Mar 14, 2012

The equipment used in standardization must be adjusted in order that both the receiver amplifier ... more The equipment used in standardization must be adjusted in order that both the receiver amplifier and video display are linear over the range of distance and flaw size to be used. The failure to do that would result in different block-to-block response ratios because of the measurements depending on the scope reading or attenuator setting. In this paper, using two sets of steel reference blocks (area-amplitude and distance-amplitude) to modified method to verify the linearity of the system of instruments used in the ultrasonic inspection. This method depends on the response from reference blocks with different hole diameters at constant gain and ratio between the figures slope at different gains. The linearity of the ultrasonic instruments can be measured with high precision. The results can be used effectively for determining resolution and sensitivity capabilities.

Download

A pictorial review of reconstructive foot and ankle surgery: hallux abductovalgus

Journal of Radiology Case Reports, 2015

This pictorial review focuses on basic procedures performed within the field of podiatric surgery... more This pictorial review focuses on basic procedures performed within the field of podiatric surgery, specifically for the hallux abductovalgus or "bunion" deformity. Our goal is to define objective radiographic parameters that surgeons utilize to initially define deformity, lead to procedure selection and judge post-operative outcomes. We hope that radiologists will employ this information to improve their assessment of post-operative radiographs following reconstructive foot surgeries. First, relevant radiographic measurements are defined and their role in procedure selection explained. Second, the specific surgical procedures of the distal metatarsal, metatarsal shaft, metatarsal base, and phalangeal osteotomies are described in detail. Additional explanations of arthrodesis of the first metatarsal-phalangeal and metatarsal-cuneiform joints are also provided. Finally, specific plain film radiographic findings that judge post-operative outcomes for each procedure are ...

Download

Patterns of care and outcomes for elderly patients with metastatic colorectal cancer in Australia

Journal of geriatric oncology, Jan 17, 2015

The elderly accounts for a large proportion of patients with metastatic colorectal cancer (mCRC).... more The elderly accounts for a large proportion of patients with metastatic colorectal cancer (mCRC). This study reviews patterns of care and outcomes for elderly patients with mCRC in the community setting. Elderly patients (≥65years) with mCRC on the TRACC (Treatment of Recurrent and Advanced Colorectal Cancer) registry were identified. Treatment, bevacizumab-related adverse events, and overall survival (OS) were analysed by age cohorts, comparing those aged 65-74 vs. 75-84 vs. ≥85years and correlated with potential prognostic factors. Factors affecting chemotherapy and bevacizumab administration were analysed using logistic regression analysis. Of 1439 patients, 363, 352, and 106 were aged 65-74, 75-84, and ≥85years, respectively. 584 (71%) patients received first-line chemotherapy, with chemotherapy use declining with advancing age (84%, 69%, and 34% in 65-74-, 75-84- and ≥85-year-olds, respectively). Seven (10%) patients aged ≥85years were not treated with chemotherapy on the basis...

$Research paper thumbnail of Ultrasonography of occult fractures: a pictorial essay$

Ultrasonography of occult fractures: a pictorial essay

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 2001

Either your web browser doesn't support Javascript or it is currently turned off. In the lat... more

Comparison of the EBNA1 Proteins of Epstein–Barr Virus and Herpesvirus Papio in Sequence and Function

Virology, 1996

The EBNA1 protein of Epstein-Barr virus (EBV) supports replication and maintenance of the circula... more The EBNA1 protein of Epstein-Barr virus (EBV) supports replication and maintenance of the circularized viral chromosome in cells that are latently infected. We have isolated, sequenced, and functionally characterized the EBNA1 gene of herpesvirus papio (HVP), an EBV-like virus that infects baboons. The amino acid sequences of EBNA1 of HVP and EBV are 56% identical, if the difference in the length of the glycine and alanine containing repetitive region, which is much shorter for HVP EBNA1, is omitted for the calculation. The key structural features of the DNA-binding/dimerization domain (the carboxyl-terminal domain) appear to have been conserved, as have amino acids in the two regions thought to be most critical for DNA binding. Most of the salient features of the amino-terminal two-thirds of EBNA1 (the amino-terminal domain), including a dearth of sequences predictive of alpha-helical or beta-sheet structures, are shared by the two sequences, although numerous gaps in this region were needed for alignment of the sequences. The amino-terminal fifty amino acids of EBNA1 of both EBV and HVP weakly resemble the amino terminus of rat ribosomal protein S2. Plasmids carrying oriP of either virus replicated stably in mammalian cells and supported efficient outgrowth of colonies under selection when supported by EBNA1 from either virus, although with each oriP there was a noticeable preference for EBNA1 to be from the same virus. HVP EBNA1 was less effective than EBV EBNA1 at activating the enhancer function of EBV oriP and under certain conditions was less effective than EBV EBNA1 at supporting maintenance of plasmids carrying EBV oriP. Results obtained with hybrid EBNA1 molecules indicated that differences in the amino-terminal and carboxyl-terminal domains, respectively, are primarily responsible for the differences in transcriptional activation and plasmid maintenance, respectively. The results showed that changes within EBNA1 can differentially alter its transcriptional and replicational activities.

Download

Sayed Ali

Uploads

Papers by Sayed Ali

Log In