Sanjay Mistry

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Papers by Sanjay Mistry

Real-time experiments in neural identification and control of disturbance

American Control Conference, 1995

Designs have been proposed for neural identification and control of dynamic systems with unknown ... more Designs have been proposed for neural identification and control of dynamic systems with unknown disturbance. These neural designs have been implemented in real-time experiments using a DC motor system with friction as the plant and additive disturbance at the input. The experimental results reveal the capability of neural networks to identify bounded, unknown, periodic disturbance. It also shows the improved

Experimental studies in neural network control

Conference on Decision and Control, 1992

Control algorithms are designed using neural networks and experimentally implemented on an electr... more Control algorithms are designed using neural networks and experimentally implemented on an electromechanical system. Such algorithms require very little knowledge about the systems which, together with their capability of learning, make them attractive for the control of nonlinear partially known dynamic systems. Issues pertaining to such algorithms are investigated, and preliminary results are presented. The controllers perform well compared to

Mechatronic Designs for a Computer Controlled All-Terrain Vehicle

SAE Technical Paper Series, 1996

Experimental Implementation of Neural Control Architectures for a Class of Nonlinear Dynamic Systems

Membrane Technology, 1993

A novel neural network controller architecture is explored for the speed control of a DC motor-dr... more A novel neural network controller architecture is explored for the speed control of a DC motor-driven four bar linkage system which represents a class of time-varying nonlinear systems. Simulation and experimental implementation show the viability and effectiveness of this promising tool for nonlinear systems. Identification and control, as well as real-time implementation issues are considered. Comparative studies with two other

Infinitely Variable Transmission (IVT) of John Deere 7000 TEN Series Tractors

Fluid Power Systems and Technology, 2002

Analysis of the symptoms of depression — a neural network approach

Psychiatry Research, 1999

The purpose of this study is to determine the individual contribution, or importance number, of t... more The purpose of this study is to determine the individual contribution, or importance number, of the symptoms to an analysis of depression, utilizing a neural network model. In addition, the presence of hopelessness and somatic complaints was examined, to determine their relevance to depression. Using Wave 1 data from Duke University’s contribution in the Epidemiological Catchment Area (ECA) study, we

The Use of a Neural Factory to Investigate the Effect of Product Line Width on Manufacturing Performance

by Sanjay Mistry and Paul Swamidass

Management Science, 1999

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Effectiveness of stages of change and adinazolam SR in panic disorder: A neural network analysis

Journal of Anxiety Disorders, 1996

We ascertained the relationship of stages of change (SOC) and adinazolam SR on panic disorder in ... more We ascertained the relationship of stages of change (SOC) and adinazolam SR on panic disorder in a randomized double-blind study. Outpatients (n = 133) with panic disorder and agoraphobia were assessed for readiness to change and then were randomly assigned to adinazolam SR or to placebo in a 4-week double-blind trial. The active drug was significantly more effective than the placebo. After 4 weeks, patients on the drug treatment had significantly lower anxiety on two of the measures. Two neural networks were trained with gender, history of depression, agoraphobia, readiness to change, and five anxiety measures at baseline data as inputs, and the five anxiety measures 4 weeks later as outputs.

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Indirect control of a class of nonlinear dynamic systems

IEEE Transactions on Neural Networks, 1996

Identification and control designs are considered using neural networks for a class of nonlinear ... more Identification and control designs are considered using neural networks for a class of nonlinear partially known dynamic systems. Real-time implementation of two designs, a neural identifier and a proposed neural controller, using an experimental system, comparisons with two other neural networks as well as conventional schemes, and an implementation architecture are reported. The proposed control design facilitates incorporation of available knowledge about the structure of the system. The study also illustrates the inherent capability of neural networks to handle nonlinearities and perform control effectively for a real world system, based on minimal system information.

Identification and control experiments using neural designs

IEEE Control Systems, 2000

Page 1. Identification and Control Experiments Using Neural Designs Sanjay I. Mistry and Satish S... more

Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor

by Sanjay Mistry and Anthony Hollander

Stem cells (Dayton, Ohio), 2007

Conventional methods for regulating the differentiation of stem cells are largely based on the us... more Conventional methods for regulating the differentiation of stem cells are largely based on the use of biological agents such as growth factors. We hypothesize that stem cell differentiation could be driven by specific synthetic molecules. If true, this would offer the possibility of screening chemical libraries to develop pharmacological agents with improved efficacy. To test our hypothesis, we have determined which, if any, of the nuclear receptor superfamily might be involved in chondrogenesis. We used fluorescence-activated cell sorting, as well as quantitative polymerase chain reaction, to study expression of a range of nuclear receptors in the undifferentiated mesenchymal population and after growth factor-driven differentiation of these cells to chondrocytes. In this way, we identified retinoic acid receptor beta (RAR beta) as a potential pharmacological target. A low molecular weight synthetic inhibitor of the RAR alpha and RAR beta receptors was able to induce chondrogenic d...

Growth performance of thai pangus (pangasius hypophthalmus) in polyculture system using different supplementary feeds

Thai pangus polyculture with carps has been increasing for its high potential, however very few a... more Thai pangus polyculture with carps has been increasing for its high potential, however very few attempts were made to compare its growth using different types of feed. A research was undertaken to assess the effect of three types of feed on growth of Thai pangus (Pangasius hypophthalmus) and rohu (Labeo rohita) in polyculture system for 11 months from 15 May

International Patents

Intrauterine Hyperglycemia Increases Insulin Binding Sites but Not Glucose Transporter Expression in Discrete Brain Areas in Term Rat Fetuses

Pediatric Research, 2004

Diabetic pregnancy results in several metabolic and hormonal disorders, both in the embryo and th... more Diabetic pregnancy results in several metabolic and hormonal disorders, both in the embryo and the fetus of different species, including humans. Insulin is a potent modulator of brain development and is suggested to promote the differentiation and maturation of hypothalamic or related extrahypothalamic structures, which are directly involved in neural inputs to the pancreas. Because these structures are known to be specifically responsive both to insulin and glucose, we examined the effects of 48-h hyperglycemic clamps in unrestrained pregnant rats on insulin binding and glucose transporter expression in hypothalamic and extrahypothalamic-related areas of their fetal offspring. The main result was an increase in insulin binding in the ventromedial hypothalamic nucleus (VMH), the arcuate nucleus (AN), and the lateral hypothalamus (LH), and in the nucleus of the tractus solitarius (NTS) for extrahypothalamic areas (ϩ30% in the VMH, ϩ37% in the AN, ϩ25.8% in the LH, and ϩ37.3% in the NTS). The deleterious effect of brain hyperinsulinism during the late gestational stage does not seem to act through glucose transporter (GLUT) expression, inasmuch as no relation-ship between GLUT level and hyperinsulinism in brain areas could be observed. The specific increase in insulin binding in areas involved in the nervous control of metabolism could be a factor in the increased glucose intolerance and impairment of insulin secretion that was previously observed in the adult rats from hyperglycemic mothers. Pediatr Res 56: 263-267, 2004) Abbreviations GLUT, glucose transporter VMH, ventromedial hypothalamic nucleus AN, arcuate nucleus LH, lateral hypothalamus NTS, nucleus of the tractus solitarius ANS, autonomic nervous system PVN, paraventricular nucleus qcRT-PCR, quantitative competitive reverse transcription polymerase chain reaction TH, tyrosine hydroxylase HI-HG, hyperinsulinemic-hyperglycemic ABSTRACT 263

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Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus

American journal of physiology. Gastrointestinal and liver physiology, 2002

Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a potentially i... more Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a potentially important mechanism for regulating the biological effects of agmatine in mammalian cells but also represents an alternative to ornithine decarboxylase for polyamine biosynthesis. We have isolated a full-length cDNA encoding human agmatinase whose function was confirmed by complementation in yeast. The single-copy human agmatinase gene located on chromosome 1 encodes a 352-residue protein with a putative mitochondrial targeting sequence at the NH(3)-terminus. Human agmatinase has about 30% identity to bacterial agmatinases and <20% identity to mammalian arginases. Residues required for binding of Mn(2+) at the active site in bacterial agmatinase and other members of the arginase superfamily are fully conserved in human agmatinase. Agmatinase mRNA is most abundant in human liver and kidney but also is expressed in several other tissues, including skeletal muscle and brain. Its expression...

Trauma increases extrahepatic arginase activity☆☆☆

Surgery, 2000

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Probing Erectile Function: S -(2-Boronoethyl)- l Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile Corpus Cavernosum † , ‡

Biochemistry, 2001

The boronic acid-based arginine analogue S-(2-boronoethyl)-L-cysteine (BEC) has been synthesized ... more The boronic acid-based arginine analogue S-(2-boronoethyl)-L-cysteine (BEC) has been synthesized and assayed as a slow-binding competitive inhibitor of the binuclear manganese metalloenzyme arginase. Kinetic measurements indicate a K I value of 0.4-0.6 µM, which is in reasonable agreement with the dissociation constant of 2.22 µM measured by isothermal titration calorimetry. The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 Å resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction. Accordingly, the binding mode of BEC is consistent with the structure-based mechanism proposed for arginase as outlined in Cox et al.

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Induction of arginases I and II in cornea during herpes simplex virus infection

Virus Research, 2001

Induction of inducible nitric oxide synthase (iNOS) following corneal infection with herpes simpl... more Induction of inducible nitric oxide synthase (iNOS) following corneal infection with herpes simplex virus type-1 (HSV-1) generates nitric oxide (NO), an important player in the defense against viral infection. Changes in arginine metabolism during infection are not limited to effects of iNOS but can also involve arginases, which can modulate NO synthesis and produce ornithine for the generation of polyamines and proline. The latter are important molecules involved in tissue damage and repair during inflammation. In this study we determined the responses of arginase I and II in a murine model of HSV-1-induced stromal keratitis (HSK). In the cornea iNOS and arginase II mRNA were co-induced as the initial inflammation developed at 2 days postinfection (p.i.). As stromal keratitis progressed (days 8-15 p.i.) arginase I mRNA was induced tenfold, in contrast to a moderate decrease in arginase II and a loss of iNOS expression. These results suggest that elevated expression of arginase I and II in the cornea at late stages of ocular HSV-1 infection may play a role in lesion expression in HSK.

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Evidence for Atrial Natriuretic Factor Induced Natriuretic Peptide Receptor Subtype Switching in Rat Proximal Tubular Cells during Culture

Nephron Experimental Nephrology, 1998

Culture and natriuretic peptide dependent changes in the expression of the natriuretic peptides a... more Culture and natriuretic peptide dependent changes in the expression of the natriuretic peptides atrial natriuretic factor (ANF), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) and the natriuretic peptide receptors A, B, and C in primary cultures of rat proximal tubular cells were demonstrated using polymerase chain reaction analysis and cyclic guanosine monophosphate response to ANF and CNP. Freshly isolated cells expressed mRNA coding for the natriuretic peptide receptor C only, with no expression of the natriuretic peptides or the natriuretic peptide receptors A or B. At confluence natriuretic peptide receptor C expression was lost, while mRNA transcripts for both ANF and BNP and the A and B receptors became apparent. The appearance of mRNA transcripts for the natriuretic peptide receptors A and B during cell growth correspond with a significant increase in the cyclic guanosine monophosphate response to both ANF and CNP, confirming the presence of functionally active guanylate cyclase linked A and B natriuretic peptide receptors. The observed changes in peptide receptor expression during culture were preceded by changes in natriuretic peptide mRNA expression, suggesting the possibility that natriuretic peptide receptor subtype switching may be under the control of endogenous peptide release. Incubation of freshly isolated proximal tubular cells with ANF, BNP, or CNP for 3 h induced similar changes in receptor expression. Incubation with ANF induced expression of the natriuretic peptide receptor B and CNP while inhibiting natriuretic peptide receptor C. Incubation with BNP induced expression of the natriuretic peptide receptor B and CNP. Incubation with CNP induced expression of the natriuretic peptide receptors A and B and CNP. These results suggest that primary cultures of rat proximal tubular cells may experience natriuretic peptide and natriuretic peptide receptor subtype switching as they approach confluence under the control of endogenously expressed natriuretic peptides.

The Expression of Connexin 43 in Human Kidney and Cultured Renal Cells

Nephron, 1997

Gap junctions enable intercellular communication and play an important role in a variety of vital... more Gap junctions enable intercellular communication and play an important role in a variety of vital cellular functions including differentiation and the control of growth. These junctions are formed by a hexameric of proteins known as connexins. We investigated the distribution of the connexin 43 (Cx43) gap junction protein in renal cells and human kidney using the alkaline phosphatase anti-alkaline phosphatase immunohistochemical technique with a monoclonal antibody directed against the cytoplasmic domain of this antigen. Strong staining was demonstrated on the vascular endothelium, the smooth muscle of larger vessels and on glomerular epithelial cells. In addition, Cx43 was expressed on proximal tubular cells, glomerular endothelial cells and occasional cells infiltrating the interstitium. In areas of tubular atrophy there was increased staining for Cx43. Using reverse transcription-polymerase chain reaction we have also demonstrated that cultured human and rat mesangial cells and human proximal tubular cells express Cx43 messenger RNA. In summary, we have described for the first time the distribution of Cx43 in human kidney and cultured renal cells.

Sanjay Mistry

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