patients who died of COVID-19 in China demonstrated that there is evidence of the invasion of sev... more patients who died of COVID-19 in China demonstrated that there is evidence of the invasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into kidney tissue, along with significant acute tubular injury and endothelial damage, as well as glomerular and vascular changes indicative of underlying diabetic or hypertensive disease. 2 Moreover, Chung et al., 2021 found that the incidence of COVID-19 may be higher in people
COVID-19 mainly spreads through respiratory droplets with an incubation period between 1-14 days,... more COVID-19 mainly spreads through respiratory droplets with an incubation period between 1-14 days, generally 3-7 days. The clinical spectrum of COVID-19 varies from asymptomatic to symptomatic, with symptoms of fever, cough, shortness of breath, headache, sore throat, and rhinorrhea. Some patients may experience gastrointestinal manifestations such as nausea and diarrhea. Patients may experience severe clinical manifestations, including severe pneumonia, sepsis, septic shock, acute respiratory distress syndrome (ARDS), and multiple organ dysfunction syndrome (MODS). Patients who are over 65 years old, smoke, and have comorbid diseases such as hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, and
Leukemia is a type of cancer that occurs when the proliferation of blood cells is out of control ... more Leukemia is a type of cancer that occurs when the proliferation of blood cells is out of control and interferes with normal blood cell division. The incidence of leukemia, according to GLOBOCAN in 2020, found 14,979 cases of leukemia, with a percentage of 3.8% of the total cases. The number of new cases of leukemia in 2022 in America is 60,650 cases, with a death rate of 24,000 cases. 3 Nonetheless, the use of chemotherapy has resulted in remission of acute leukemia as much as 90%-100% compared to the previous 4 decades. 3 Based on the speed of proliferation, leukemia can be classified as acute or chronic, and based on the originating cells, it is classified as myeloid and lymphoid. The predominant subtypes are acute myeloid leukemia (AML) and chronic myeloid leukaemia (CML), which involve the myeloid chain,
Kidneys play an important role in potassium homeostasis. The important role of the kidneys in mai... more Kidneys play an important role in potassium homeostasis. The important role of the kidneys in maintaining potassium balance is reflected in the high level of potassium disturbances in patients with decreased kidney function, especially patients with severely decreased renal function and patients who have comorbidities, such as diabetes, hypertension, or heart failure. Chronic kidney disease is characterized by abnormalities of kidney structure or function that persist for more than 3 months, have many complex causes, and have a major impact on global health status. There are several methods to measure the amount of potassium intake consumed, including a food frequency questionnaire, dietary recall, temporary urine potassium examination, and 24-hour urine potassium examination. The standard gold measurement for evaluating urinary potassium excretion is through 24-hour urine collection. This literature review aims to describe the role of urinary potassium excretion in assessing the progression of chronic kidney disease.
Assessment of renal function is based on determination of serum creatinine and creatinine-based e... more Assessment of renal function is based on determination of serum creatinine and creatinine-based equations to assess GFR. However, this marker is not perfect or accurate, especially for longitudinal monitoring of kidney function in Chronic Kidney Disease (CKD patients). Decreased kidney function can be slowed or even anticipated with early detection, so as to avoid secondary complications. So it is important to find new biomarkers that can identify individuals at risk as early as possible. Plasma galectin-3 is a ?-galactoside-binding lectin expressed in monocytes, which plays an important role in inflammation, immunity, cancer, and is involved in the pathogenesis of atherosclerosis, diabetes, renal fibrosis and asthma. Higher galectin-3 levels were associated with reduced eGFR in a cross-sectional study. Galectin-3 is essential in various biological activities including cell growth, cell proliferation, differentiation, apoptosis, pre-mRNA splicing, transformation, angiogenesis, infla...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in ... more Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: There have been many studies that say Ramadan fasting has a positive effect on reduci... more Background: There have been many studies that say Ramadan fasting has a positive effect on reducing BMI, blood sugar, inflammatory factors, and DNA Repair. However, there are still no guidelines for fasting in patients with chronic kidney disease (CKD) both nationally and internationally. This study aimed to conduct a review to explore the effects of Ramadan fasting against chronic kidney disease, specifically on DNA repair, Immune System, Inflammation, and Cognitive Function in patients with chronic kidney disease. Methods: This study is a systematic literature review (SLR) with sources obtained from various reputable journal databases such as PubMed, Cochrane Library, EBSCO, and Elsevier using relevant keywords. The selected articles have passed the inclusion and exclusion criteria. A total of 39 articles that discuss fasting were obtained from Ramadan in chronic kidney disease patients on metabolic response and inflammatory markers in the body. Results: Ramadan fasting has a posi...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thro... more Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 pati...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Kidneys play an important role in potassium homeostasis. The important role of the kidneys in mai... more Kidneys play an important role in potassium homeostasis. The important role of the kidneys in maintaining potassium balance is reflected in the high level of potassium disturbances in patients with decreased kidney function, especially patients with severely decreased renal function and patients who have comorbidities, such as diabetes, hypertension, or heart failure. Chronic kidney disease is characterized by abnormalities of kidney structure or function that persist for more than 3 months, have many complex causes, and have a major impact on global health status. There are several methods to measure the amount of potassium intake consumed, including a food frequency questionnaire, dietary recall, temporary urine potassium examination, and 24-hour urine potassium examination. The standard gold measurement for evaluating urinary potassium excretion is through 24-hour urine collection. This literature review aims to describe the role of urinary potassium excretion in assessing the pr...
Sepsis didefinisikan sebagai infeksi bersama dengan manifestasi sistemik dari infeksi. Sepsis ber... more Sepsis didefinisikan sebagai infeksi bersama dengan manifestasi sistemik dari infeksi. Sepsis berat adalah penyebab 50% kasus acute kidney injury (AKI) pada pasien kritis. Patofisiologi cedera ginjal akut (AKI) pada sepsis disebabkan oleh respon inflamasi, toksin dan perubahan hemodinamik glomerulus. Tingkat keparahan disfungsi ginjal tergantung pada tingkat keparahan sepsis. Perubahan laju filtrasi glomerulus (GFR) adalah fenomena AKI yang terlambat. Diagnosis AKI dengan mengukur kreatinin serum. Sayangnya, kreatinin adalah indikator yang kurang dapat diandalkan selama perubahan akut pada fungsi ginjal. Munculnya penanda biologis baru dalam lingkup AKI sangat membantu bagi dokter untuk dapat mendiagnosa awal AKI. Penanda biologis AKI bisa menjadi komponen serum atau urin. Penanda biologis urin menjanjikan untuk mendeteksi awal AKI, sehingga dapat berguna untuk diagnosis dini.
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, lead... more Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, leading to the inability of the kidneys to perform their functions. Chronic kidney disease causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress associated with cognitive impairment. Age is a population group aged 60 years or more at risk of experiencing health problems and the consequences associated with CKD. One of the common comorbidities experienced by elderly patients with CKD is cognitive impairment. Current treatment options for CKD with cognitive impairment aimed at common risk factors, including angiotensin converting enzyme inhibitors (ACEI) and, angiotensin receptor blockers (ARBs), SGLT-2 inhibitors., GLP-1 RA, and DPP-4 inhibitors. Other interventions, such as erythropoietin (EPO) compensation and reduction of inflammation and oxidative stress, can help improve patients' clinical symptoms. This literature review ...
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Papers by Drajad Priyono