Herbal medicines derived from plant extracts are being progressively more utilized to treat a var... more Herbal medicines derived from plant extracts are being progressively more utilized to treat a variety of clinical diseases, though relatively little knowledge about their mode of action is available. There is increasing interest in the health and wellness benefits of herbs and botanicals. This is with good reason as they might offer a natural safeguard against the development of certain conditions and be a putative treatment for some diseases. One such area may be the lowering of blood pressure in those where it is elevated. One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine. There are a growing number of studies purporting diuretic effects with traditional medicines. Any substance that tends to increase the flow of urine, which causes the body to get rid of excess water, is known as diuretic drugs. Substances that induce "diuresis," or the ...
In this case blood escapes the body and bleeding is clearly visible. It is further classified as:... more In this case blood escapes the body and bleeding is clearly visible. It is further classified as: Incised wound, laceration or tear wound, Abrasions or superficial wounds, Puncture wounds, Penetration wounds and gunshot wounds. 7 Closed wounds In closed wounds blood escapes the circulatory system but remains in the body. It includes Contusion or bruises, heamatomas or blood tumor, Crush injury etc. Acute wounds Acute wound is a tissue injury that normally precedes through an orderly and timely reparative process that result in sustained restoration of anatomic and functional integrity. Acute wounds are usually caused by cuts or surgical incisions and complete the wound healing process within the expected time frame. 8 Chronic wounds Chronic wounds are wounds that have failed to progress through the normal stages of healing and therefore enter a state of pathologic inflammation chronic wounds either require a prolonged time to heal or recur frequently. Local infection, hypoxia, trauma, foreign bodies and systemic problems such as diabetes mellitus, malnutrition, immunodeficiency or medications are the most frequent causes of chronic wounds. 9 WOUND HEALING MECHANISM Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with ABSTRACT A wound may be defined as a break in the epithelial integrity of the skin or may also be defined as a loss or contravention of cellular and anatomic or functional permanence of living tissue. Wound healing is the process of repair that follows injury to the skin and proper healing of wounds is crucial for the re-establishment of disrupted anatomical continuity and disturbed functional status of the skin. The phyto-medicines for wound healing are not only economical and inexpensive but are also supposedly safe as hyper sensitive reactions are rarely encountered with the use of these agents. Many plants have proved to possess momentous healing properties in poles apart from type of wounds. Nature has best owed on us a very rich botanical wealth and a large number of diverse types of plants grow in different parts of the country. This review examine about wound healing prospective of plants, its family, part used, extract used, model used and references which are supportive for researchers for expansion of novel wound healing formulation.
Herbal medicines derived from plant extracts are being progressively more utilized to treat a var... more Herbal medicines derived from plant extracts are being progressively more utilized to treat a variety of clinical diseases, though relatively little knowledge about their mode of action is available. There is increasing interest in the health and wellness benefits of herbs and botanicals. This is with good reason as they might offer a natural safeguard against the development of certain conditions and be a putative treatment for some diseases. One such area may be the lowering of blood pressure in those where it is elevated. One class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as well as the amount of sodium in urine. There are a growing number of studies purporting diuretic effects with traditional medicines. Any substance that tends to increase the flow of urine, which causes the body to get rid of excess water, is known as diuretic drugs. Substances that induce "diuresis," or the ...
The lipid metabolism is regulated in many different ways. Enzymes are major regulators of lipid m... more The lipid metabolism is regulated in many different ways. Enzymes are major regulators of lipid metabolism. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is one of the enzymes involved in cholesterol biosynthesis 1. Hyperlipidemia and Hyper-cholesterolemia are not only secondary metabolic dysregulations associated with diabetes but also represent increased risk factors for development of diabetes 2. Hyperlipidemia is a highly predictive risk factor for atherosclerosis coronary artery disease and cerebral vascular disease 3. There is a general consensus that these metabolic disorders share hyperinsulinemia and insulin resistance as a common link leading to both micro-and macro-angiopathies 4. Generally after a prolonged "silent" period atherogenesis may become clinically significant. The fatty streak and thickening of intima in blood vessels represent the initial lesion of atherosclerosis 5. Evidence from studies both in animals and humans indicates that progression can be Nyctaginaceae Roots Ethanolic Streptozotocin 12. Carica papaya Linn 23. Caricaceae Leaves Aqueous Alloxan
Sodium valproate and tomato extract have been studied in different experimental models of epileps... more Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These groups were treated with pentylenetetrazol (45 mg/kg on days 8, 10, and 12 and 70 mg/kg on day 14 day, i.p.); sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol; lycopene (2 mg/kg, p.o.) + sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol; and lycopene (4 mg/kg, p.o.) + sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol, for 14 days, respectively. After treatment, the animals were observed for 30 minutes for behavioral analysis. Subsequently, the animals were sacrificed, and their brain was removed for the biochemical estimations of thiobarbituric acid reactive substances, catalase, su...
The lipid metabolism is regulated in many different ways. Enzymes are major regulators of lipid m... more The lipid metabolism is regulated in many different ways. Enzymes are major regulators of lipid metabolism. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is one of the enzymes involved in cholesterol
Anti-inflammatory, Anti-arthritis, Asparagus racemosus, Liliaceae Correspondence to Author
ABSTRACT: In this research work we elucidated the anti-inflammatory and anti-arthritic activity o... more ABSTRACT: In this research work we elucidated the anti-inflammatory and anti-arthritic activity of hydroalcoholic extract of Asparagus racemosus roots (ARHE) in-vivo. Carrageenan induced paw edema methodology is used to induce inflammation and Diclofenac sodium is used as standard drug whereas Freund’s Complete adjuvant used to induce arthritis and Dexamethasone is used as standard drug. Asparagus racemosus roots were showed significant anti-inflammatory and antiarthritic activity at oral dose of (200mg/kg and 400mg/kg). E-mail:
International Journal of Research in Pharmaceutical Sciences
The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(co... more The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(covid-19), has spread quickly from the initially known cases in china in December 2019 to nations round the globe. On March 10,2020, the world health organization reported that there have been 113,702 affirmed instances of corona virus -19 round the globe, additionaly to 4,012 passing. Due to this worldwide well being emergency analysts are handling build up a corona virus immunization. Protected and compelling immunizations are going to be a game changer: yet for years to return we should always wearing covers, genuinely separating and staying faraway from swarms. Being inoculated doesn't imply that we will laugh in the face of any potential risk and put ourselves as well as other people in danger, especially in light of the very fact that it is as yet not satisfactory what proportions the antibodies can ensure against sickness also as against contamination and transmission. Vaccine f...
A Comprehensive Review on Anti-Diabetic Agents of Herbal Origin
Diabetes mellitus is one of the oldest diseases known to mankind and yet with the tremendous scie... more Diabetes mellitus is one of the oldest diseases known to mankind and yet with the tremendous scientific advances witnessed in this century, medical science cannot claim that it knows all that needs to be known about this disease, including its management. This is the main reason for the persistent interest all over the world to explore alternative remedies from the so-called "alternative systems" of medicine. It is the fact that diabetes can it be cured and it has never been reported that someone had recovered totally from diabetes. The rapidly increasing incidence of diabetes mellitus is becoming a serious threat to mankind health in all parts of the world. Plants have been the major source of drugs in medicine and other ancient systems in the world. Herbals are a traditional medicine or folk medicine practice based on the use of plants and plant extracts. This review presents the profiles of plants with hypoglycaemic properties, reported in the literature. The profiles p...
The use of herbal products has increased attention in both in recent years for treatment as medic... more The use of herbal products has increased attention in both in recent years for treatment as medical therapy in developed & developing countries. Elaeocarpus ganitrus roxb. (rudraksha) is a broad leaved tree, belonging to the family Elaeocarpeaceae has found in tropical and subtropical areas. It has great a place in indigenous system of medicine like Ayurveda, Siddha and Unani. Ancient time rudraksha is used for the treatment of various ailments like stress, anxiety, depression, neuralgia and epilepsy, migraine, asthma, hypertension, arthritis and liver diseases. According to the ayurvedic medicinal system, putting on rudraksha can have positive effects on heart and nerves. Research revealed that aqueous extract of leaves contains glycosides and ethanolic extract of leaves contains gallic acid, ellagic acid & quercetin. This plant reported to display various biological activities l ike antihypertensive, anti-depressant, anti-inflammatory, anti-microbial, analgesic, anti-diabetic and ...
Herbal Sources of Anti-Inflammatory Potential: A Review
Inflammation is usually regarded as a pathological state. It is a physiological response of the l... more Inflammation is usually regarded as a pathological state. It is a physiological response of the living tissue to injury, provided the injury is not of such a degree as to cause necrosis or loss of viability. Inflammation is characterized by redness, pain and swelling. There are many drugs available for inflammation like Non-steroidal anti-inflammatory drug (NSAID). But these drugs have many adverse effects like peptic ulceration, Na+ and water retention, raised transaminases, mental confusion, etc. While the drugs obtained from plant source (herbal drug) have fewer side effect. The main aim of this review to summarize the herbal plants used in inflammation.
International Journal of Research in Pharmaceutical Sciences, 2021
Ashwagandha, also known as Indian winter cherry, belonging to the Withania Somnifera Linn. (Solan... more Ashwagandha, also known as Indian winter cherry, belonging to the Withania Somnifera Linn. (Solanaceae) family, (commonly available as Churna). Africa, the Mediterranean, and India are all home to this species. It is 30-50cm high and mainly found in the drier parts of India. Since it raises haemoglobin (red blood count) and hair melanin. Withania Somnifera is known as "Rasayana," which means "strong rejuvenator" in Ayurvedic jargon. In ethnomedicine, it is a well-known health food and herbal tonic that is used to treat cardiovascular diseases. It can be used as a single herb or as part of polyherbal or herbo-mineral formulations for humans. It is traditionally used to treat various diseases such as inflammation, asthma, dyspepsia, hypertension, rheumatism, tumor, anxiety, hemopoietic, antimicrobial, depression, immunomodulation, antiulcer, hepatoprotective activities, Alzheimer’s, Parkinson’s disease, rejuvenating properties and syphilis. It has wide variety of ...
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Antimicrobial activity of ethanolic, methanolic and hot aqueous extract of Punica granatum peel
The main objective of the study is to evaluate anti bacterial activity of Punica granatum pericar... more The main objective of the study is to evaluate anti bacterial activity of Punica granatum pericarp (peel) extracts (hot aqueous, methanolic and ethanolic) against E. coli and P. aeruginosa , using Zone of Inhibition (ZOI) and Minimum Inhibitory Concentration (MIC) method. Hot aqueous, methanolic and ethanolic extracts of P. granatum pericap showed an average inhibitory zone diameter of 21.5, 22.5 and 23mm respectively which indicates that et hanolic extract showed best result having ZOI greater than that of the standard antibiotic Tetracycline (20.1m m) against E. coli while hot aqueous, methanolic and ethanolic extra cts of P. granatum pericap showed an average inhibitory zone diameter of 21, 23.5 and 25.5mm respectively which indicates that ethanolic extract showed best r esult having ZOI greater than that of the standard antibiotic Te tracycline (22.5 mm) against P. aeruginosa . P. granatum peel has MIC of 0.312 µg/ml against E. coli and 0.421 µg/ml against P. aeruginosa . Data r...
In vitro anti-inflammatory activity of hydroalcoholic extract of Asparagus racemosus roots
Asparagus racemosus commonly known as Shatavari belonging to family Liliaceae. In India, it is fo... more Asparagus racemosus commonly known as Shatavari belonging to family Liliaceae. In India, it is found in Himalaya’s up to an altitude of 1300-1400m and all tropical part. Its various uses are galactogogue, tonic, diuretic, rheumatism, inflammation, nervine disorder etc. The aim of study is to evaluate anti-inflammatory activity of hydroalcoholic extract of Asparagus racemosus (ARHE) roots by using human red blood cell membrane stabilisation (HRBC) method and protein denaturation method. The inhibition of hypotonicity induced HRBC membrane lysis and denaturation of protein was taken as a measure of the anti inflammatory activity. The percentage of membrane stabilisation and protein denaturation for hydroalcoholic extracts and Diclofenac sodium were done at different concentrations. The maximum membrane stabilization and denaturation of protein of A. racemosus extracts was found to be 76.63 % at a dose of 1600 μg/ml and 545.91 at a dose of 2000 μg/ml respectively.
The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(co... more The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(covid-19), has spread quickly from the initially known cases in china in December 2019 to nations round the globe. On March 10,2020, the world health organization reported that there have been 113,702 affirmed instances of corona virus -19 round the globe, additionaly to 4,012 passing. Due to this worldwide well being emergency analysts are handling build up a corona virus immunization. Protected and compelling immunizations are going to be a game changer: yet for years to return we should always wearing covers, genuinely separating and staying faraway from swarms. Being inoculated doesn't imply that we will laugh in the face of any potential risk and put ourselves as well as other people in danger, especially in light of the very fact that it is as yet not satisfactory what proportions the antibodies can ensure against sickness also as against contamination and transmission. Vaccine f...
Anti-inflammatory agents of herbal origin: An overview
Inflammation is a pathological state characterized by redness, pain and swelling which is probabl... more Inflammation is a pathological state characterized by redness, pain and swelling which is probably the result of leucocyte infiltration. Various agents such as Non-steroidal anti-inflammatory drug (NSAID’s) have potent anti-inflammatory activity that are accompanied by various adverse effects like peptic ulceration, increase Na+ and water retention, raised transaminases, mental confusion, etc. Contrary to that the drugs obtained from plant source (herbal drug) have fewer side effects. The main objective of this review is to abridge the herbal plants used in inflammation and to seek their anti-inflammatory potential.
A Comprehensive Review on Hepatoprotective Herbal Agents
Herbal drugs are conventionally used in various parts of the world to alleviate different disease... more Herbal drugs are conventionally used in various parts of the world to alleviate different diseases. Many herbs have been proven to be efficient as hepatoprotective agents while many more are claimed to be hepatoprotective but be deficient in any such scientific substantiation to support such claims. The therapeutic values were tested against a few chemicals-induced subclinical levels of liver damages in rodents. Liver diseases are a major worldwide health problem, with high endemicity in developing countries. They are mainly caused by chemicals and some drugs when taken in very high doses. Liver is a vital organ play a major role in metabolism and excretion from the body. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity. There are several chemicals have been known to induce hepatotoxicity by producing reactive species which cause exhaustion in tissue thiol, lipid peroxidation, plasma membrane damage like carbonte...
Herbal Sources of Antidepressant Potential: A Review
The history of herbal medicines is as old as human civilization. The documents revealed that plan... more The history of herbal medicines is as old as human civilization. The documents revealed that plants were used medicinally in China, India, Egypt and Greece long before the beginning of the Christian era. The human being appears to be afflicted with more diseases than any other animal’s species. They sought to alleviate their sufferings from injury and disease by taking advantage of plant growing around them. Depression is such a common mental disorder, which affects the personal and social relations of a person. There are variety of neuro chemical theories proposed and number of synthetic antidepressant drugs are available now a days, however their effectiveness does not come up the entire range of population suffering from this disorder. Moreover the side effects and the drug interactions are major restrictions in their clinical applications. Unlike, synthetic medications, herbal medicines are widely used across the globe due to their wide applicability and therapeutic efficacy ass...
Sodium valproate and tomato extract have been studied in different experimental models of epileps... more Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These groups were treated with pentylenetetrazol (45 mg/kg on days 8, 10, and 12 and 70 mg/kg on day 14 day, i.p.); sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol; lycopene (2 mg/kg, p.o.) + sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol; and lycopene (4 mg/kg, p.o.) + sodium valproate (200 mg/kg, p.o.) + pentylenetetrazol, for 14 days, respectively. After treatment, the animals were observed for 30 minutes for behavioral analysis. Subsequently, the animals were sacrificed, and their brain was removed for the biochemical estimations of thiobarbituric acid reactive substances, catalase, su...
Uploads
Papers by Praveen Dixit