Papers by JOSE CARLOS PARRAGA SAAVEDRA
Shermak MA, Saavedra JM, Jackson TL: Effect of yoghurt on symptoms and kinetics of hydrogen production in lactose-malabsorbing children
American Journal of Clinical Nutrition
Journal of Dairy Science, 1995
Dairy products containing live bacteria that possess lactase activity are used for dietary manage... more Dairy products containing live bacteria that possess lactase activity are used for dietary management of lactose maldigestion. The efficacy of acidophilus milk and the effect of consuming unfermented milk that had been inoculated with yogurt bacteria have not been examined in children. We compared scores for breath H2 excretion and symptoms of 20 lactose-maldigesting children following ingestion of 250 ml of uninoculated milk with two identical milks inoculated with 10 10 cells of Lactobacillus acidophi/us or with a commercial yogurt starter culture containing lOS cells of Lactobacillus lactis and 10 10 cells of Streptococcus thermophilus. Nine of 10 subjects who were symptomatic following ingestion of uninoculated milk experienced a reduction in symptoms following ingestion of milk inoculated with L acidophilus, without a decline in H2 excretion. Five of 6 subjects who were symptomatic following uninoculated milk had decreased symptoms and a significant reduction in H2 excretion following milk inoculated with the yogurt culture. For lactose-maldigestlng children, milks inoculated with L acidophi-Ius or with a yogurt culture were as-
Growth and Tolerance of Term Infants Fed Formula With Probiotic Lactobacillus reuteri
Clinical pediatrics, Jan 10, 2015
Lactobacillus reuteri has been studied for its safety and beneficial effects in infants. This stu... more Lactobacillus reuteri has been studied for its safety and beneficial effects in infants. This study assessed growth of infants fed a partially hydrolyzed whey formula with L reuteri. Healthy term infants were randomized to 1 of 2 formulas (partially hydrolyzed whey formula with (PRO) or without (CON) L reuteri from 14 to 112 days of age. Anthropometric measures were assessed at 14, 28, 56, 84, and 112 days of age. Tolerance records were completed 2 days prior to each visit. A total of 122 subjects completed study per protocol (60 PRO, 62 CON). No differences were seen in daily weight gain, length, or head circumference. Overall, between groups, there were no significant differences in formula intake, stool frequency, color, consistency, flatulence, frequency of spit-up/vomiting, mood, sleep, or incidence of adverse events. Infants fed probiotic formula had similar growth to infants fed control formula. Both formulas were well tolerated.
Longitudinal growth during the first 2 years of life in children born to HIV-infected mothers in Malawi, Africa
Pediatric AIDS and HIV infection, 1996
To evaluate the longitudinal growth patterns of infants born to HIV-infected and uninfected mothe... more To evaluate the longitudinal growth patterns of infants born to HIV-infected and uninfected mothers in Malawi, Africa, 92 HIV-infected infants, 270 uninfected infants born to HIV-infected mothers, and 686 infants born to uninfected mothers between birth and 24 months of life were studied. Weight and length were evaluated longitudinally utilizing generalized estimating equations. HIV-infected children were compared with uninfected children born to HIV-infected and uninfected mothers, and to United States National Center for Health Statistics (NCHS) growth standards. Median weight and length-for-age of seronegative infants born to either seronegative or seropositive mothers approximated the NCHS median from birth to approximately 4 months of age. Median weight and length of HIV-infected infants deviated from the NCHS median at an earlier age, and the deviation was more pronounced than was observed for uninfected infants. Mean growth curves constructed by generalized estimating equatio...
[Probiotics, immunity and pediatric health]
Gaceta médica de México, 2011
Early bacterial stimulation of gut associated immune cells is essential for the development and m... more Early bacterial stimulation of gut associated immune cells is essential for the development and maturation of the infant's immune response. This "microbial experience" has been affected due to a decrease in vaginal births (which are the first source of bacterial exposure for an infant), the substitution of breast feeding, in favor of almost sterile formulas, an increase use of antibiotics, and an increasingly "cleaner" environment. Increased hygienic measures and pasteurization perpetuate this decreased microbe-host interaction. These changes in environmental and gut microbiota are associated with an altered and inadequate development of immune response, with related health implications. The inadequate host response to infectious diseases, as well as the epidemic of immune related chronic conditions (such as allergy) can be explained in great measure by these changes. The consumption of certain probiotics (specific dietary bacteria that provide a benefit to t...
Evaluation of hypoallergenicity of a new, amino Acid-based formula
Clinical pediatrics, 2015
The American Academy of Pediatrics (AAP) defined a formula as hypoallergenic if it ensures with 9... more The American Academy of Pediatrics (AAP) defined a formula as hypoallergenic if it ensures with 95% confidence that 90% of infants with confirmed cow's milk allergy (CMA) will not react with defined symptoms under double-blind, placebo-controlled conditions. This study's objective was to determine whether a new amino acid-based formula (AAF) meets the AAP hypoallergenicity criteria. Methods. Children with CMA were randomized to double-blind placebo-controlled food challenges (DBPCFC) with a new AAF and a commercial AAF in crossover fashion followed by an at-home open challenge with the new AAF. Allergic reactions were assessed using a scoring system. Results. Thirty-three subjects completed DBPCFCs with both formulas without acute allergic reactions. The lower bound 95% confidence interval for hypoallergenicity was 91.3%. No unusual stool patterns, allergic symptoms, or signs of intolerance were reported during the open challenge. . The new AAF meets AAP hypoallergenicity cr...
The use of high-fat, low-carbohydrate diets for advancement of enteral feedings in children with short bowel syndrome
TOPICS IN CLINICAL NUTRITION, 1995
ABSTRACT Low-fat diets frequently recommended for managing short bowel syndrome (SBS) may preclud... more ABSTRACT Low-fat diets frequently recommended for managing short bowel syndrome (SBS) may preclude enteral feeding advancement. We report using low-carbohydrate (CHO), high-fat diets with medium chain triglycerides (MCT) to transition SBS patients from parenteral to enteral nutrition. Thirteen SBS patients (7 months to 7 years old, 7% to 60% residual bowel length) initially received protein hydrolysate drip feedings. When severe CHO malabsorption precluded feeding advancement, caloric density was increased with MCT to provide 56.6 +/- 7.3% of calories as fat and 32 +/- 4.8% as CHO. Patients reached 50% of requirements enterally by 16 +/- 14 months. Seven patients reached full requirements by 27 +/- 20 months. In this population, high-fat diets successfully accelerated the transition to complete enteral nutrition. (C) 1995 Aspen Publishers, Inc.
Journal of Obesity, 2012
Childhood obesity is currently one of the most prevailing and challenging public health issues am... more Childhood obesity is currently one of the most prevailing and challenging public health issues among industrialized countries and of international priority. The global prevalence of obesity poses such a serious concern that the World Health Organization (WHO) has described it as a “global epidemic.” Recent literature suggests that the genesis of the problem occurs in the first years of life as feeding patterns, dietary habits, and parental feeding practices are established. Obesity prevention evidence points to specific dietary factors, such as the promotion of breastfeeding and appropriate introduction of nutritious complementary foods, but also calls for attention to parental feeding practices, awareness of appropriate responses to infant hunger and satiety cues, physical activity/inactivity behaviors, infant sleep duration, and family meals. Interventions that begin at birth, targeting multiple factors related to healthy growth, have not been adequately studied. Due to the overwh...
Proceedings of the 1st ACM International Conference on Multimedia Retrieval, ICMR'11, 2011
Since 3D models are becoming more popular, the need for effective methods capable of retrieving 3... more Since 3D models are becoming more popular, the need for effective methods capable of retrieving 3D models are becoming crucial. Current methods require an example 3D model as query. However, in many cases, such a query is not easy to get. An alternative is using a hand-draw sketch as query. We present a structure-based local approach (STELA) for retrieving 3D models using a rough sketch as query. It consists of four steps: get an abstract image, detect keyshapes, compute a local descriptor, and match local descriptors. We represent a 3D model by means of suggestive contours. Our proposal includes an additional step aiming at reducing the number of models that will be compared by our local approach. The proposed method is invariant to position, scale, and rotation changes as well. We evaluate our method using the first-tier precision and compare it with a current global approach (HELO). Our results show an increasing in precision for many classes of 3D models.
SHREC'12 track: Sketch-based 3D shape retrieval
Eurographics Workshop on 3D Object Retrieval, EG 3DOR, 2012
British Journal of Nutrition, 2003
Fructo-oligosaccharides (FOS) may have potential benefits, since they exhibit many soluble dietar... more Fructo-oligosaccharides (FOS) may have potential benefits, since they exhibit many soluble dietary fibre-like properties. Foods currently available for weaning infants are generally low in fibre content and lack these potential benefits. Data documenting tolerance of FOS in weaning foods are greatly lacking. Our present objective was to evaluate the tolerance and gastrointestinal effects of FOS-supplemented infant cereal used as a daily addition to the diet of healthy infants. Healthy infants were randomly assigned to receive either 0·75 g FOS per serving of cereal or placebo for 28 d. The primary outcome of interest was gastrointestinal tolerance, which was assessed by daily parental reporting of functional variables for 28 d, including stool patterns and signs and symptoms of gastrointestinal tolerance. Secondary outcomes were also measured including: cereal intake (g cereal and g FOS/d), stool pH, changes in anthropometric measurements and adverse events. The study population inc...
Sketch-based image retrieval using keyshapes
Multimedia Tools and Applications, 2013
Although sketch based image retrieval (SBIR) is still a young research area, there are many appli... more Although sketch based image retrieval (SBIR) is still a young research area, there are many applications capable of exploiting this retrieval paradigm, such as web searching and pattern detection. ...
The Journal of Pediatrics, 2013
Introduction: Atopic dermatitis (AD) is a complex inflammatory disease of the skin that has a sig... more Introduction: Atopic dermatitis (AD) is a complex inflammatory disease of the skin that has a significant impact on the well-being of patients and their families. The prevalence of AD has increased in developing countries and regions, including the Middle East. Despite similarities in the presentation of the disease, there is a lack of consistent management and treatment guidelines for AD. The objective of this survey was to develop further insight into the management patterns of AD from dermatologists, pediatricians, and primary care/family medicine physicians in the Middle Eastern nations of Egypt, Lebanon, the United Arab Emirates, and Saudi Arabia. Methods: The survey was composed of 47 closedended, multiple-choice questions. These questions assessed physician and patient characteristics and treatment familiarity and approach. Results: A total of 400 physicians, including 200 dermatologists, 100 pediatricians, and 100 primary care physicians, participated in the survey. The findings provide insight into the management of AD by physician specialty within the region. A diverse array of management approaches was observed for both referral patterns and treatments for AD in the Middle East. Conclusion: The diversity of management tactics highlights the lack of a standard approach for the management of AD throughout the Middle East.
Journal of Pediatric Gastroenterology and Nutrition, 2002
Journal of Pediatric Gastroenterology and Nutrition, 2005
Background: Although IgA endomysial antibodies (EMA) and tissue transglutaminase (TG) are sensiti... more Background: Although IgA endomysial antibodies (EMA) and tissue transglutaminase (TG) are sensitive and specific serologic tests for the diagnosis of celiac disease, there is limited information on the association of the magnitude of antibody level with the severity of the histological abnormalities of the intestine. Purpose: To determine if EMA and TG titers correlate with the severity of histological changes in patients with celiac disease. Methods: We identified 148 children from our laboratory database that had EMA, TG and intestinal biopsies performed. IgA EMA was determined by indirect immunofluorescence with results expressed as a dilutional titer with positivity determined at 1:5. IgA TG was determined by an enzyme linked human immunosorbent ELISA assay with results expressed in standardized units. A modified Marsh histological grading system was used to describe the duodenal biopsies: Type 0 normal, I increased intraepithelial lymphocytes (IEL), II hyperplastic crypts, IIIa partial villus atrophy, IIIb subtotal villus atrophy, IIIc total villous atrophy. Results: Mean values for EMA (Table ) and TG (Table ) progressively increased with increasing Marsh score. There was considerable variability in EMA and TG levels for each Marsh grade, so that an individual level could not be utilized to predict histological severity. The data show that as a group, increasing severity of the histological lesion in celiac disease was associated with increased levels of both IgA EMA and TG antibodies.
40 Resolution of TPN Associated Cholestasis Following Discontinuation of Parenteral Protein
Journal of Pediatric Gastroenterology & Nutrition, 1996
Gastroenterology Clinics of North America, 2012
Early acquisition and maintenance of a healthy intestinal microbiota is critical to the longterm ... more Early acquisition and maintenance of a healthy intestinal microbiota is critical to the longterm health of the host; and the mechanisms through which this occurs are beginning to be elucidated. Factors that lead to alterations in microbial composition during infancy are associated with inadequate and inappropriate host immune responses, which lead to the development of disease. A greater understanding of these factors and of these mechanisms will unlock potential strategies to modulate the acquisition and maintenance of a human microbiota that maintains and promotes health. These strategies will be critical in battling the epidemic of noncommunicable immunerelated diseases encountered in the modern world.
Life-Threatenting Ceftriaxone-Induced Immune Hemolytic Anemia in a Child with Crohn’s Disease
Clinical Pediatrics, 2004
Page 1. http://cpj.sagepub.com/ Clinical Pediatrics http://cpj.sagepub.com/content/ 43/2/175 The ... more Page 1. http://cpj.sagepub.com/ Clinical Pediatrics http://cpj.sagepub.com/content/ 43/2/175 The online version of this article can be found at: DOI: 10.1177/ 000992280404300207 2004 43: 175 CLIN PEDIATR Lynn E. Mattis, Jose ...
Annals of Nutrition and Metabolism, 2013
The latest exhaustive survey of dietary patterns in infants from the Feeding Infants and Toddlers... more The latest exhaustive survey of dietary patterns in infants from the Feeding Infants and Toddlers Study (FITS) in North America documents and quantifies current trends in infant feeding. These include higher than generally recommended energy, protein, and saturated fat intakes. The majority of infants are bottle fed at some point in their first year of life, and their weaning diet often includes low intakes of fruits and vegetables, with high starchy, rather than green or yellow, vegetables. Early introduction of solids, use of cow's milk prior to 1 year of age, and high juice intake in the first 2 years - all less desirable diet practices - are improving, but are still prevalent. More preschoolers are likely to get sweets or sweetened beverages than a serving of fruit or a vegetable on a given day. These food intake patterns mimic the adult American diet and are associated with an increased risk of obesity in childhood and later life. But more importantly, these patterns appear...
Poder discriminatorio de las acciones finales de voleibol en etapas de formación / Discriminatory... more Poder discriminatorio de las acciones finales de voleibol en etapas de formación / Discriminatory power of final game actions volleyball in formative stages.
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Papers by JOSE CARLOS PARRAGA SAAVEDRA