Giovanna Finzi

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Papers by Giovanna Finzi

Colonic carcinoma with a pancreatic acinar cell differentiation. A case report

Virchows Archiv, 2009

A case of a colonic carcinoma showing a pancreatic acinar cell differentiation is described for t... more

Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy

Cell Stem Cell, 2015

Highlights d IGFBP3 peripheral levels are increased in T1D and diabetic enteropathy (DE) d IGFBP3... more Highlights d IGFBP3 peripheral levels are increased in T1D and diabetic enteropathy (DE) d IGFBP3 disrupts CoSCs via a TMEM219-dependent/ caspase-mediated mechanism d Treatment of T1D restores appropriate IGFBP3 peripheral levels and improves DE d The ecto-TMEM219 recombinant protein quenches peripheral IGFBP3 and preserves CoSCs

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Modelling evaluation of EU road traffic emission strategies

by Giovanna Finzi and Marialuisa Volta

Proceedings of the 16th IFAC World Congress, 2005, 2005

... is considered one of the most significant pollutant with respect to its potential impact on h... more

Nonlinear set membership forecast of urban ozone peaks

by Giovanna Finzi and Marialuisa Volta

Proceedings of the 16th IFAC World Congress, 2005, 2005

A methodology for the evaluation of re-analyzed PM10 concentration fields: a case study over the PO Valley

by Giovanna Finzi and Marialuisa Volta

Air Quality, Atmosphere & Health, 2014

Evaluation of urban pollution abatement strategies by a photochemical dispersion model

International Journal of Environment and Pollution, 2000

ABSTRACT High ozone levels are regularly reached during the summer period in Italian urban areas,... more ABSTRACT High ozone levels are regularly reached during the summer period in Italian urban areas, indicating the need for a careful design of primary pollutants emission reduction strategies. In this perspective, the CALGRID-CALMET modelling system has been applied to the Milano metropolitan area and its suburbs, a very industrialised and populated region in the Po Valley. A simulation domain of 100 x 100 km² has been considered and a summer period, characterised by high photochemical activity, has been selected. Hourly emissions have been derived by spatially and temporally disaggregated national inventories data, while standard upper-air and ground based meteorological data have been used as inputs to the CALMET pre-processor. The modelling system has been applied for the evaluation and comparison of different emission control strategies. Since the main source of pollutants in the area is actually traffic, the impact of cleaner fuels and cleaner cars has been investigated.

The Influence of Deep Convection Phenomena on Trajectories Computed by Long-Range Transport Models

Air Pollution Modeling and Its Application IX, 1992

Integrating Saharan dust forecasts into a regional chemical transport model: a case study over Northern Italy

by Giovanna Finzi and Marialuisa Volta

The Science of the total environment, Jan 15, 2012

The Po Valley in Northern Italy is frequently affected by high PM10 concentrations, where both na... more The Po Valley in Northern Italy is frequently affected by high PM10 concentrations, where both natural and anthropogenic sources play a significant role. To improve air pollution modeling, 3D dust fields, produced by means of the DREAM dust forecasts, were integrated as boundary conditions into the mesoscale 3D deterministic Transport Chemical Aerosol Model (TCAM). A case study of the TCAM and DREAM integration was implemented over Northern Italy for the period May 15-June 30, 2007. First, the Saharan dust impact on PM10 concentration was analyzed for eleven remote PM10 sites with the lowest level of air pollution. These remote sites are the most sensitive to Saharan dust intrusions into Northern Italy, because of the absence of intensive industrial pollution. At these remote sites, the observed maxima in PM10 concentration during dust events is evidence of dust aerosol near the surface in Northern Italy. Comparisons between modeled PM10 concentrations and measurements at 230 PM10 s...

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Aneuploidy, centrosome alteration and securin overexpression as features of pituitary somatotroph and lactotroph adenomas

by Giovanna Finzi and Carlo Capella

Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, 2005

To verify the presence of numerical chromosomal aberrations (NCAs) in different types of pituitar... more To verify the presence of numerical chromosomal aberrations (NCAs) in different types of pituitary adenomas (PAs) and to investigate 2 of the mechanisms that are possibly related to aneuploidies in PAs: securin overexpression and centrosome alterations. Twenty-one PAs of different types were analyzed with interphase fluorescence in situ hybridization (FISH) on paraffin sections with centromeric probes for chromosomes 2, 3, 8, 11 and 12. In all cases, the immunohistochemical expression of securin was evaluated and the number of cells with abnormal nuclear shape recorded. The ultrastructural study of centrosomes was performed in a subset of 12 tumors. At interphase FISH analysis, growth hormone (GH)-cell and prolactin (PRL)-cell PAs showed multiple chromosome gains and a low frequency of chromosome losses, suggesting a hyperdiploid chromosome assessment. In contrast, in the other types of PAs a lower frequency of NCAs was observed. In addition, when compared to other types of PAs, GH-...

Seasonal Evaluation of EU Road Traffic Emission Abatement Strategies on Photochemical Pollution in Northern Italy

by Giovanna Finzi and Marialuisa Volta

Air Pollution Modeling and Its Application XVII, 2006

... Neftel, A., Spirig, C., Prévôt, A., Furger, M., Stuz, J., Vogel, B., Hjorth, J., 2002, Sensit... more

Sulphur deposition on the Italian area: A trajectory model study

Il Nuovo Cimento C, 1995

ABSTRACT

COMBINED USE OF SPACEBORNE OBSERVATIONS OF NO2 AND REGIONAL CTM MODEL FOR AIR QUALITY MONITORING IN NORTHERN ITALY

The use of space-borne measurements of trace gas constituents for air quality monitoring is consi... more The use of space-borne measurements of trace gas constituents for air quality monitoring is considerably increased during the past decade. This is due mainly to the new generation sensors able to observe large areas with good temporal resolution and due to new assimilation techniques that allow a synergetic use of information from satellite and from Chemical Transport Models (CTM). In

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The RIAT project: a multi-objective nonlinear optimization approach to design effective air quality control policies

Secondary atmospheric pollution originates through nonlinear chemical-physical processes involvin... more Secondary atmospheric pollution originates through nonlinear chemical-physical processes involving precursor emissions (VOC -volatile organic compounds, NOxnitrogen oxides, NH3 -ammonia, pPM -primary particulate matter and SOx -sulfur oxides). Exposure to secondary atmospheric pollution can lead to detrimental effects on human health and ecosystems, and so decision makers need support in developing plans to improve air quality, acting in terms of precursor emission reductions. This task is really challenging due to nonlinearities bringing to formation and accumulation of secondary pollution. It is even more difficult when considering at the same time air quality improvement and cost of implementation policies. In the literature the following methodologies, based on Integrated Assessment Modeling, are available to support the design of effective policies: (a) scenario analysis (Thunis et al., 2007), (b) cost-benefit analysis (Rabl et al., 2005) (c) cost-effectiveness analysis (Carslon et al., 2004) and (d) multi-objective analysis (Carnevale et al. 2008, Carnevale et al. 2009).

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COST 728: Enhancing Mesoscale Meteorological Modelling Capabilities for Air Pollution and Dispersion Applications Working Group 3: Mesoscale models for air pollution and dispersion applications Review of the capabilities of selected MetM and CTMs for air pollution and dispersion applications

by Giovanna Finzi and Marialuisa Volta

Long-term meteorological mesoscale RAMS simulations over Northern Italy for air quality assessments

Exceeding the air quality standards set by the European Union for ground-level concentrations of ... more Exceeding the air quality standards set by the European Union for ground-level concentrations of ozone and PM has significant impact on human health and vegetation. This is a well-known problem in Northern Italy, where high anthropogenic emissions and frequent stagnant meteorological conditions bring to very high concentrations of PM in winter and of ozone in summer. Another peculiarity of the Northern Italy domain is the fact that the non-attainment of secondary pollution standards is not restricted to urban areas but often occurs away from cities, at mesoscale. For this reason, in a scenario analysis framework, it is necessary to evaluate emission control strategies considering accurate deterministic simulations performed with complex modeling systems. Meteorological models are an important part of the deterministic modeling systems. The meteorological variables rule pollutants advection, diffusion, wet deposition, chemical reactions and therefore need to be adequately simulated. Within an HPC-EUROPE (Pan-European Research Infrastructure on High Performance Computing) cooperation project the meteorological conditions over Northern Italy were simulated using RAMS4.4 in parallel mode for the year 2004, creating a database for further air quality assessments. First results of the study and comparisons between modeled and measured meteorological parameters are presented and discussed in the paper.

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RIAT+ methodology

1.02 SENSITIVITY ANALYSIS OF OZONE LONG TERM SIMULATIONS TO GRID RESOLUTION

by Marco Bedogni and Giovanna Finzi

Emission reduction strategies to control tropospheric ozone: a multi-objective optimization approach

by Giovanna Finzi and Marialuisa Volta

To control tropospheric ozone Environmental Authorities need to develop air quality plans, implem... more To control tropospheric ozone Environmental Authorities need to develop air quality plans, implementing emission reduction control strategies. This is a challenging task, mainly due to nonlinear processes that bring to ozone formation and accumulation, forced by precursor emissions and solar radiation. This is even more difficult when considering, at the same time, effectiveness and costs of alternative environmental policies. In this study a multi-objective mathematical problem is proposed, considering air quality and cost objectives. Air quality objective is formalized as source-receptor model identified processing simulations of a complex photochemical modelling system. Cost objective is formalized identifying cost functions linking technology cost to emission reduction. The proposed methodology has been applied to a complex domain in Northern Italy, including Milan metropolitan area, a region characterized by high ozone levels during summer season.

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SCENARIO ANALYSIS AND OPTIMIZATION APPROACH IN AIR QUALITY PLANNING: A CASE STUDY IN NORTHERN ITALY

by Giovanna Finzi and Marialuisa Volta

Metodi di analisi multivariata per lo studio della composizione delle precipitazioni in alcune stazioni dell'Italia settentrionale", collana" Contributi ENEL alla Conoscenza di Problematiche Ambientali

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