sahil kumar

Indian Institute of Technology Delhi, Computer Science and Engineering, Undergraduate

Followers

Following

Public Views

Interests

Uploads

Papers by sahil kumar

RehabFork: An Interactive Game-assisted Upper Limb Stroke Rehabilitation System

2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020

In this paper, we present the design and development of a game-assisted stroke rehabilitation sys... more In this paper, we present the design and development of a game-assisted stroke rehabilitation system RehabFork that allows a user to train their upper-limb to perform certain functions related to the task of eating. The task of eating is divided into several components: (i) grasping the eating utensils such as a fork and knife; (ii) lifting the eating utensils; (iii) using the eating utensils to cut a piece of food; (iv) transferring the food to the mouth; and (v) chewing the food. The RehabFork supports the user through sub-tasks (i)–(iii). The hardware components of RehabFork consist of an instrumented fork and knife, and a 3D printed pressure pad, that measure and communicate information on user performance to a gaming environment to render an integrated rehabilitation system. The gaming environment consists of an interactive game that utilizes sensory data as well as user information about the severity of their disability and current level of progress to adjust the difficulty levels of the game to maintain user motivation. Information pertaining to the user, including performance data, is stored and can be shared with care providers for ongoing oversight.

Breast cancer survival and its prognostic factors in the United Arab Emirates: A retrospective study

PLOS ONE, 2021

Background Data on breast cancer survival and its prognostic factors are lacking in the United Ar... more Background Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been studied widely in western populations but are very limited in this region. This study is the first to report breast cancer survival and investigate prognostic factors associated with its survival in the UAE. Methods This is a retrospective cohort study involving 988 patients who were diagnosed and histologically confirmed with breast cancer between January 2008 and December 2012 at Tawam hospital, Al Ain, UAE. Patient were followed from the date of initial diagnosis until the date of death from any cause, lost-to-follow up or the end of December 2018. The primary outcome is overall survival (OS). The Kaplan-Meier method was used to estimate the survival curve along with the 2- and 5-year survivals. Different group of patients categorized according to prognostic factors were compared using the log-rank test. Multiple Cox...

Download

Prioritization of Wheel Materials Using MCDM Techniques (TOPSIS) for Automobile Wheels

Lecture Notes in Mechanical Engineering, 2021

Download

Optimization of Material Removal Rate of WEDM Process on Mild Steel Using Molybdenum Wire

International Journal of Advanced Engineering, Management and Science, 2017

For any manufacturing process and, particularly, in process related to WEDM the correct selection... more For any manufacturing process and, particularly, in process related to WEDM the correct selection of process parameters is one of the most important aspects to be taken into consideration. WEDM is capable of machining geometrically complex shapes or hard material components, such as composites, carbides, heat treated tool steels, super alloys, ceramics and heat resistant steels etc. These hard material components are widely used in die and mold making industries, aerospace, aeronautics and nuclear industries. This study discusses the influence of process parameters like current, Pulse on time, Pulse off Time and Voltage on the performance parameters such as material removal rate. The experiment has been conducted on Mild Steel work piece using brass wire, because Mild Steel has various industrial applications in manufacturing of frame of motorcycles, dies, automobile chassis, base of boilers and cook wares etc. The experimental layout is based on Taguchi L16 orthogonal array. Further, the analysis of variance [ANOVA] is used to analyze the results obtained from Taguchi method. The analysis of results obtained for material removal rate indicate that current and pulse on time has the highest impact on material removal rate. As the current and pulse on time increases, the material removal rate also increases. Pulse off time and voltage has no significant effect on material removal rate.

Download

I Vitro a Thelmi Tic Activity O Aqueous a D Etha Ol Extracts of Mimusops Ele Gi LI . Bark

The anthelmintic activity of ethanolic and aqueous extracts of Mimusops elengi Linn. was studied ... more The anthelmintic activity of ethanolic and aqueous extracts of Mimusops elengi Linn. was studied against adult earthworm Eisenia foetida (redworm).the ethanolic and aqueous extract prepared by hot and cold extraction respectively. Albendazole was used as the standard drug. The anthelmintic activity was carried out to study the effect of plant extract on Adult earthworm Eisenia foetida (redworm), and noted down the paralysis time (Vermifuse), and death time (Vermicidal). It was found that both ethanolic and aqueous extract of bark of Mimusops elengi Linn. Found to have significant anthelmintic action against adult earthworm Eisenia foetida (redworm) at the dose of 4 mg/ml or more (0 mg/ml); which may be due the presence of glycoside, carbohydrates, tannins, saponins in the extract. Thus it can be concluded that the bark of Mimusops elengi Linn. can be used as anthelmintic agent.

Download

Recent advancesin the development of novel drug delivery systems for the prophylaxis of malaria

International Journal of Advances in Pharmaceutical Sciences, 2018

The present review high-lights the advancement in nanoparticles formulations for the prophylaxis ... more The present review high-lights the advancement in nanoparticles formulations for the prophylaxis of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metal like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulation have improved the targeted drug delivey of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and lumefantrine etc.

Download

Techniques & data: field sample with insects

Synthesis and Evaluation of Novel Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) Agonists for the Treatment of Diabetes

A series of novel thiazolidinedione derivatives as peroxisome proliferator activated receptor-gam... more A series of novel thiazolidinedione derivatives as peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists bearing different fatty acid esters and amides as substituents in the positions 3 and 4 of the benzylidene moiety have been designed, synthesized and tested as potential antihyperglycemic agents. The compounds containing stearic acid (A1TU, A2TU, A3TU, A2TS and A3TS) exhibited the maximum activity (64.7-70.3 % BG reduction) among all the synthesized compounds. The capric acid containing compounds (D2TU and D3TU) showed the minimum activity (28.8-36.3 % BG reduction) with exception of D1TU and D1TS which exhibited 57.2 % and 48.7 % of BG reduction respectively. Compounds containing myristic acid (B1TU, B2TU, B3TU, B1TS and B3TS) and palmitic acid (C1TU, C2TU, C3TU, C2TS and C3TS) were found to be less active than stearic acid derivatives but more active than capric acid derivatives. Keywords: PPAR-γ, thiazolidinedione, fatty acids, antihyperglycemic activity Cite ...

Review: Current development on catalytic synthesis and pharmacological applications of 1,4-dihydropyridines

Dihydropyridines (1,4-DHPs) are recognized as one of the most versatile pharmacophores present as... more Dihydropyridines (1,4-DHPs) are recognized as one of the most versatile pharmacophores present as central core in many pharmaceuticals. Low yield and harsh reaction conditions prompted the researchers for the development of new environmental- friendly methods for the synthesis of 1,4-DHPs. This review explored the development of various green chemistry approaches using new catalysts developed for constructing novel 1,4-dihydropyridine and its derivatives. The present review also encompasses the synthesis of some novel 1, 4-DHPs derivatives with novel pharmacological actions. We have restricted our review of synthesis and pharmacological actions of 1,4-DHPs from 2006 onwards.

Properties of Bio-Concrete

Concrete plays a major role in the construction industry. For a durable structure, good quality c... more Concrete plays a major role in the construction industry. For a durable structure, good quality concrete must be used. A SelfHealing Concrete for the Future which says a common soil bacterium was used to induce calcite precipitation which is highly desirable because the mineral precipitation induced as a result of microbial activities is pollution free and natural. The workability test of the bacterial concrete resulted in 90mm of slump value. We have found out that the compressive strength of the bacterial concrete with 10% and 20% of addition of bacillus sphaericus as 13.07% and 13.75 % respectively. Same way we have found out that the split tensile strength of the bacterial concrete with 10% and 20% of addition of bacillus sphaericus as 3.15% and 7.25% respectively. We have also casted a beam of size 500mm x 100mm x 100mm with 20% addition of bacillus sphaericus and made some tiny cracks by giving little load and the observation of the healing process of the crack is going on.

The Missing Antimatter

Objectives: To determine if inhaled nitrous oxide with oxygen (NOS) is superior to oral sedation ... more Objectives: To determine if inhaled nitrous oxide with oxygen (NOS) is superior to oral sedation for pain management during in-office hysteroscopic sterilization. Methods: This double blinded randomized controlled trial enrolled women undergoing in-office hysteroscopic sterilization. The intervention group received NOS titrated to a maximum 70%:30% NO:O2 mixture and placebo pills 30 minutes prior to the procedure. The control group received inhaled O2 during the procedure and 5/325mg hydrocodone/acetaminophen and 1mg lorazepam 30 minutes prior to the procedure. The primary outcome was maximum procedural pain, assessed on a 100mm Visual Analogue Scale (VAS) 3 minutes post iv procedure. A sample size of 30 women per treatment arm was required to detect a clinically significant pain difference of 20mm on the VAS. Results: 72 women, 36 per study arm, were randomized in order to account for unsuccessful bilateral coil placement and drop out after randomization. Two women in the study group and 6 in the control group were excluded due to unsuccessful bilateral coil placement. Mean age of participants was 34.1 ± 5.7 years and mean BMI was 30.1 ± 6.6 kg/m 2. Mean maximum procedural pain scores were 22.8 ± 27.6 mm and 54.5 ± 32.7 mm for study and control groups, respectively (p < 0.001). Most study participants (97%) stated NOS should be offered for gynecologic office procedures and 86% would pay extra for NOS if it were not a covered benefit. Conclusions: NOS significantly decreased pain with in-office hysteroscopic sterilization compared to PO sedation. Given its safety and favorable side effect profile, routine availability of NOS should be considered for in-office hysteroscopic sterilization.

Download

Shivering Due to Repeat Dose of Tranexamic Acid: A Peculiar Case Series

Tranexamic acid (TXA) is a well-tolerated hemostatic agent that has been in clinical use for near... more Tranexamic acid (TXA) is a well-tolerated hemostatic agent that has been in clinical use for nearly 60 years. In this report, we describe for the first time 10 patients who experienced adverse reactions to repeat dose of TXA, which were not seen with the first dose. Shivering was found to be the most common adverse reaction. In half of the cases, shivering was associated with low-grade fever. On dechallenge and subsequent administration of steroids and antihistaminic agents, the reactions were controlled. On assessment with the World Health Organization–Uppsala Monitoring Centre scale, the causality was ascertained to be “Probable”.There is no clear postulated mechanism for shivering with TXA. We have postulated that hypersensitivity, fever, and shivering in these patients may be interlinked. In the light of this report, the physicians should take into account that repeated challenge with TXA may lead to adverse reactions in some patients and withdrawing the drug in such patients ma...

Neural Topic Modeling to Understand Breast Cancer Peer-to-peer Online Information Seeking at Diagnosis

2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI), 2021

Topic modeling is a valuable method that enhances researchers’ ability to interpret information. ... more Topic modeling is a valuable method that enhances researchers’ ability to interpret information. Our research is the first to investigate neural topic modeling (NTM) methods for healthcare content analysis and topic discovery. We evaluated two NTM models to understand online information-seeking right after being diagnosed with breast cancer. Based on the achieved topic coherence and qualitative analysis on the topics discovered by each method, the NTM models work better than the traditional Latent Dirichlet Allocation (LDA) method when evaluated using the topic coherence score. The qualitative analysis shows that NTM models can find specific content-relevant topics, whereas LDA finds the general topics. Based on the results, we discover the main topics of online peerto-peer information seeking after the diagnosis of breast cancer, which included treatment and medication for different breast cancer types, symptom management after radiation treatments, insurance coverage of pathology, and family decision-making and support.

A Higher-Level Security Scheme for Key Access on Cloud Computing

IEEE Access, 2021

In this work, we construct a key access management scheme that seamlessly transitions any hierarc... more In this work, we construct a key access management scheme that seamlessly transitions any hierarchical-like access policy to the digital medium. The proposed scheme allows any public cloud system to be used as a private cloud. We consider the data owner an entity consisting of several organization units. We provide a secure method for each user of this entity to access the public cloud from both inside and outside the company's network. The idea of our key access control scheme, which is based on Shamir's secret sharing algorithm and polynomial interpolation method, is suitable especially for hierarchical organizational structures. It offers a secure, flexible, and hierarchical key access mechanism for organizations utilizing mission-critical data. It also minimizes concerns about moving mission-critical data to the public cloud and ensures that only users with sufficient approvals from the same or higher privileged users can access the key by making use of the topological ordering of a directed graph, including self-loop. Main overheads such as public and private storage needs are reduced to a tolerable level, and the key derivation is computationally efficient. From a security perspective, our scheme is both resistant to collaboration attacks and provides key indistinguishability security. Since the key does not need to be held anywhere, the problem of a data breach based on key disclosure risk is also eliminated.

Download

The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models

Biomolecules, 2021

Adult stem cells (ASCs) are the undifferentiated cells that possess self-renewal and differentiat... more Adult stem cells (ASCs) are the undifferentiated cells that possess self-renewal and differentiation abilities. They are present in all major organ systems of the body and are uniquely reserved there during development for tissue maintenance during homeostasis, injury, and infection. They do so by promptly modulating the dynamics of proliferation, differentiation, survival, and migration. Any imbalance in these processes may result in regeneration failure or developing cancer. Hence, the dynamics of these various behaviors of ASCs need to always be precisely controlled. Several genetic and epigenetic factors have been demonstrated to be involved in tightly regulating the proliferation, differentiation, and self-renewal of ASCs. Understanding these mechanisms is of great importance, given the role of stem cells in regenerative medicine. Investigations on various animal models have played a significant part in enriching our knowledge and giving In Vivo in-sight into such ASCs regulato...

Download

A highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative elicits high titers of neutralizing antibodies

The Receptor Binding Domain of SARS-CoV-2 is the primary target of neutralizing antibodies. We fu... more The Receptor Binding Domain of SARS-CoV-2 is the primary target of neutralizing antibodies. We fused our previously described, highly thermotolerant glycan engineered monomeric RBD to a heterologous non-immunogenic trimerization domain derived from cartilage matrix protein. The protein was expressed at a good yield of ∼80-100 mg/liter in Expi293 cells, as well as in both CHO and HEK293 stable cell lines. The designed trimeric RBD was observed to form homogeneous disulfide-linked trimers. When lyophilized, the trimer possessed remarkable functional stability to transient thermal stress of upto 100 °C and was stable to long term storage of over 4 weeks at 37 °C. Two immunizations with an AddaVax adjuvanted formulation elicited antibodies with high endpoint neutralizing titers against replicative virus with geometric mean titers of ∼1114 and 1940 in guinea pigs and mice respectively. In pseudoviral assays, corresponding titers were ∼3600 and ∼16050, while the corresponding value for hu...

Download

Anti-DENV and Anti-Dengue Vector Activity of Some Heterocyclic Scaffolds

Mini-Reviews in Medicinal Chemistry, 2020

Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries wi... more Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries with an annual estimated above 390 million incidences of infection all around the world. During the period 1996-2015, a considerable increase in the number of dengue cases (more than 500%) was reported in India. Information about dengue disease burden, its prevalence, incidence and geographic distribution is critical in planning appropriate control measures against dengue fever. Till date, no specific treatment for dengue fever is available in any system of medicine, which can be accepted globally. Therefore, safe, cost-effective, and efficacious agents possessing anti-viral potential against dengue virus are needed to be searched in order to fight the dengue infection globally. The aim of the present review is to systematically revise the published research work available concerning the development and evaluation of some heterocyclic scaffolds in the management of dengue.

Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine

International Journal of Drug Delivery, Oct 6, 2017

The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphos... more The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphosphazene has been used in the synthesis of polyphosphazene-linked conjugates of Lumifantrine. These polymer-linked Conjugates have been synthesized and characterized by modern analytical techniques. The in-vitro drug release of Lumifantrine drug conjugates: p-Amino benzoic acid ester substituted polyphosphazene drug conjugate (15) and Glycine methyl ester substituted polyphosphazene drug conjugate (21) have been found to be 6.00 % and 5.96% (pH 1.2), 88.52% and 79.86% (pH7.4), respectively. These drugs conjugate may prove an effective delivery system for the treatment of malaria.

Download

Clinical Benefits of Switching from Original Infliximab to its Biosimilar (CT-P13) as a Potential TNF-α Inhibitor

Journal of Exploratory Research in Pharmacology, 2020

Tumor necrosis factor-alpha (TNF-α) is implicated in the process of various autoimmune and inflam... more Tumor necrosis factor-alpha (TNF-α) is implicated in the process of various autoimmune and inflammatory diseases through binding to its receptor, the tumor necrosis factor receptor. Nowadays, monoclonal anti-TNF-α antibody is used for the treatment of these diseases because it can neutralize TNF-α to block the relevant signaling responsible for the pathogenesis of these diseases. Currently, such antibody-based therapies have been demonstrated to be effective in controlling rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis. Infliximab is the first monoclonal antibody for the treatment of rheumatoid arthritis and has been approved for the intervention of other autoimmune and inflammatory diseases in the clinic. Although infliximab is considered highly efficacious, more so than common medications such as methotrexate and calcipotriol, its potential disadvantages, including loss of response in some patients, drug-related adverse events and particularly high cost, have motivated chemists and researchers to shift towards its biosimilar, CT-P13. CT-P13 has a better tolerance and much less cost, attracting more attention. Here, we summarize the clinical findings of CT-P13 from clinical trials in various diseases.

Download

An information-theoretic graph-based approach for feature selection

Sādhanā, 2019

Feature selection is a critical research problem in data science. The need for feature selection ... more Feature selection is a critical research problem in data science. The need for feature selection has become more critical with the advent of high-dimensional data sets especially related to text, image and microarray data. In this paper, a graph-theoretic approach with step-by-step visualization is proposed in the context of supervised feature selection. Mutual information criterion is used to evaluate the relevance of the features with respect to the class. A graph-based representation of the input data set, named as feature information map (FIM) is created, highlighting the vertices representing the less informative features. Amongst the more informative features, the inter-feature similarity is measured to draw edges between features having high similarity. At the end, minimal vertex cover is applied on the connected vertices to identify a subset of features potentially having less similarity among each other. Results of the experiments conducted with standard data sets show that the proposed method gives better results than the competing algorithms for most of the data sets. The proposed algorithm also has a novel contribution of rendering a visualization of features in terms of relevance and redundancy.

Download

sahil kumar

Uploads

Papers by sahil kumar

Log In