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All Journal Jurnal Ilmiah Manuntung Jurnal Ilmu Kesehatan Heart Science Journal Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Fransiska Anggreni Sihotang
Laboratorium Fisiologi Fakultas Kedokteran Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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SKRINING THALASEMIA-BETA MINOR PADA MAHASISWA FAKULTAS KEDOKTERAN Sihotang, Fransiska Anggreni; Siagian, Loly Rotua Dharmanita; Ngo, Novia Fransiska; Kalalo, Lily Pertiwi
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (713.562 KB)

Abstract

Thalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values ??with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding.
The RELATIONSHIP BETWEEN TYPES OF PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX WITH THE DEGREE OF THROMBOCYTOPENIA IN MALARIA PATIENTS AT RSUD RATU AJI PUTRI BOTUNG PENAJAM PASER UTARA Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Ilmu Kesehatan Vol 9 No 1 (2021): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v9i1.2218

Abstract

Malaria is a tropical infectious disease with high morbidity and mortality rates. In malaria, various kinds of haematological complications can arise, one of which is thrombocytopenia. Thrombocytopenia is most commonly encountered during acute malaria infection with varying degrees observed in both Plasmodium falciparum and Plasmodium vivax infections. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients at the Ratu Aji Putri Botung Penajam Paser Utara Hospital. This research is an observasional analytic study with cross sectional method. The data was taken by using purposive sampling method from the medical records of malaria patients hospitalized in Ratu Aji Putri Botung Penajam Paser Utara Hospital in the period of January 2013 - August 2018. Data analysis used the Chi-square test. Of the 310 malaria patients who were study subjects, 60,3% (n = 187) were infected with Plasmodium falciparum and 39,7% (n = 123) were infected with Plasmodium vivax. Most of the research subjects were male (95,8%) who were dominated by adults (56,5%). As many as 90% of malaria patients experienced thrombocytopenia with mild, moderate, and severe thrombocytopenia respectively 29,4% ; 56,6% ; 14,0%. Severe thrombocytopenia was more common in falciparum malaria patients (16,4%). The statistical test result for the type of Plasmodium with the degree of thrombocytopenia were p = 0,139. It was concluded that there was no relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients.
Pengaruh SSRIs Untuk Meningkatkan Independensi Fungsional Pada Pasien Depresi Pasca Stroke: Effect of SSRIs to Improve Functional Independence in Post-Stroke Depression Patients Winda Puspita Salim; Yetty Octavia Hutahaean; Fransiska Anggreni Sihotang
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.280

Abstract

Post-stroke depression has a negative impact on the functional independence of patients carrying out daily activities. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that are recommended as the first-line therapy for post-stroke depression because of their favorable tolerability profile. This literature review is intended to present a new insight about the effect of SSRIs in increasing the functional independence in patients with post-stroke depression. We applied a qualitative research design using two notable databases: PubMed and Google Scholar. Only references written in English were used in this paper. We also limited the publication year of journals from 2010 to 2020. From the results of journal searches, we found around 52.984 journals. However only 5 were included that met the inclusion criteria which were: (1), Randomized Controlled Trial (RCT) that tested the benefits of SSRIs treatment in post-stroke depression patients compared to other antidepressants or other treatment modalities; and (2) provided with the outcome measure of functional independence. In conclusion, we believe that SSRIs have an effect on improving functional independence in post-stroke depression patients. SSRIs have also been shown to have positive effects with various combinations of non-pharmacological therapeutic modalities as their support.
Hubungan Jenis Plasmodium falciparum dan Plasmodium vivax dengan Kejadian Anemia pada Pasien Malaria di RSUD Ratu Aji Putri Botung Penajam Paser Utara: Relationship between Plasmodium falciparum and Plasmodium vivax Types with the Incidence of Anemia in Malaria Patients at Ratu Aji Putri Botung Hospital, Penajam Paser Utara Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.283

Abstract

Malaria is a disease caused by Plasmodium infection that is still a health problem in the tropical area including Indonesia. Penajam Paser Utara is the only district with a high level of malaria endemicity outside eastern of Indonesia which is located at the Province of East Kalimantan. Malaria can cause various complications including haematological abnormalities. Haematological abnormalities that are often found in both falciparum malaria and vivax malaria is anaemia. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients at Ratu Aji Putri Botung, Penajam Paser Utara hospital. This research is an observational analytic study with cross sectional method. The data was obtained from medical records of hospitalized malaria patients at Ratu Aji Putri Botung Penajam Paser Utara hospital in the period of January 2013 – August 2018 by purposive sampling method. The data were analyzed using the Chi-square test. The subjects of the study were 310 malaria patients consisting of 60,3% (n=187) patients infected with Plasmodium falciparum and 39,7% (n=123) patients infected with Plasmodium vivax. The majority of research subjects were male (95,8%) and were in the 26 – 40 years age group (56,5%). Anaemia was found in 49% of malaria patients dominated by vivax malaria patients (52%). Statistical test result between types of Plasmodium with the incidence of anaemia was p = 0,391. It was concluded that there was no association between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients.
Hubungan Lama Penggunaan Amlodipine dengan Derajat Keluhan Mata Kering pada Pasien Hipertensi: Relationship of duration of use of Amlodipine with Severity of Dry Eye Symptoms in Hypertensive Patients Fadillah Hana Hafifah; Nur Khoma Fatmawati; Fransiska Anggreni Sihotang; Siti Khotimah
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i4.435

Abstract

Mata kering merupakan penyakit pada permukaan mata yang dapat mempengaruhi kualitas hidup. Beberapa penelitian melaporkan hubungan penggunaan amlodipine dengan kejadian mata kering. Namun, penelitian mengenai faktor lama penggunaan amlodipine dengan derajat keluhan mata kering masih kurang. Oleh karena itu, penelitian ini dilakukan untuk mengetahui hubungan lama penggunaan amlodipine dengan derajat keluhan mata kering pada pasien hipertensi. Penelitian ini bersifat analitik observasional dengan pendekatan cross sectional yang dilakukan pada bulan Desember 2020. Data diperoleh dari 30 pasien berusia antara 41-65 tahun yang diambil dengan teknik purposive sampling di Klinik Mitra Keluarga Samarinda. Penelitian ini menggunakan lembar rekam medik dan kuesioner Ocular Surface Disease Index. Hasil penelitian ini didapatkan lama penggunaan amlodipine dan derajat keluhan mata kering memiliki hubungan yang bermakna (p = 0,005) dengan kekuatan korelasi sedang (r = 0,496) dengan uji Spearman. Berdasarkan hasil penelitian ini disimpulkan bahwa ada hubungan antara lama penggunaan amlodipine dengan derajat keluhan mata kering, yaitu semakin lama menggunakan obat amlodipine maka derajat keluhan mata kering semakin berat.
SKRINING THALASEMIA-BETA MINOR PADA MAHASISWA FAKULTAS KEDOKTERAN Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian; Novia Fransiska Ngo; Lily Pertiwi Kalalo
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.214

Abstract

Thalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values ​​with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding.
Multimodality imaging in evaluation of cardiac masses Sihotang, Fransiska Anggreni; Handari, Saskia Dyah
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.8

Abstract

Cardiac masses are infrequently encountered in routine cardiology practice but often pose as a diagnostic challenge. Cardiac masses can be categorised as either neoplastic (benign and malignant) or non-neoplastic, and as either primary or secondary. The prognosis is contingent upon the identification of the mass, as treatment choices vary significantly. Histopathology remains the most dependable approach for diagnosing any cardiac tumour. Nevertheless, given its invasive characteristics, cardiac imaging plays a crucial role in diagnosing cardiac masses. The emergence of new imaging tools necessitates a multimodality strategy to assess intracardiac masses. This approach is crucial for non-invasive evaluation before considering surgical planning or oncological treatment. This article aims to compare the different imaging techniques, particularly echocardiography, cardiovascular magnetic resonance, cardiac computed tomography, and nuclear imaging, in terms of their clinical applications in the evaluation of cardiac masses and to determine distinctive features on these modalities for the most prevalent intracardiac masses.
Co-Authors Doni Suryadi Doni Suryadi Fadillah Hana Hafifah Handari, Saskia Dyah Kalalo, Lily Pertiwi Lily Pertiwi Kalalo Loly Rotua Dharmanita Siagian Mudinillah, Adam Novia Fransiska Ngo Nur Khoma Fatmawati Siagian, Loly Rotua Dharmanita Siti Khotimah Vera Madonna Lumban Toruan Winda Puspita Salim Yetty Octavia Hutahaean