Papers by Prashant Tandale
Graphene oxide based multifunctional nano composite for cancer theranostics: Present clinical and regulatory breakthroughs
THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022)
International Journal of Applied Pharmaceutics, May 7, 2025
Objective: This study aimed to develop graphene oxide (GO) nanoparticles (NPs) loaded with Querce... more Objective: This study aimed to develop graphene oxide (GO) nanoparticles (NPs) loaded with Quercetin (QUE) for oncological applications, enhancing therapeutic efficacy while minimizing adverse effects. Methods: QUE-GO NPs were synthesized using Tween 80 and probe sonication, with optimization achieved through a Box-Behnken Design (BBD) that considered parameters including GO weight, surfactant volume, and sonication time. Results: The optimized batch 14 achieved an Entrapment Efficiency (EE) of 92.5±0.7%, with a particle size of 86.9±0.46 nm and a Polydispersity Index (PDI) of 0.158±0.001, indicating good stability. Drug release studies showed 88.60±2.3% release over 8 h (n = 3). Cytotoxicity assays in MCF-7 breast cancer and HEK293 noncancerous cells revealed enhanced cytotoxicity against MCF-7 cells (IC50: 126.20 µg/ml) (p<0.001) compared to pure QUE's (MW: 302.24 g/mol) IC50 of 175.89 µg/ml (p<0.05). The safety profile was observed for HEK 293 cells (IC50: 1009.40 µg/ml). Conclusion: These findings support QUE-GO NPs as a promising nanocarrier for targeted cancer therapy. A favourable safety profile was observed.
Biochemistry and Biophysics Reports, 2021
Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical char... more Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from 2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical characteristics that can be used as drug carrier vehicle and as a diagnostic in the field of nanomedicine. Scientists from various fields are aggressively working for the development of single platform that can sense, can produce a microscopic image and even be used to deliver a therapeutic agent. QDs are the fluorescent nano dots with which the possibilities of the drug delivery to a targeted site and its biomedical imaging can be explored. This review is mainly focused on the different process of synthesis of QDs, their application especially in the areas of malignancies and as a theranostic tool. The attempt is to consolidate the data available for the use of QDs in the biomedical applications.
Biochemistry and Biophysics Reports (Elsevier B.V.) , 2021
Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical char... more Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from 2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical characteristics that can be used as drug carrier vehicle and as a diagnostic in the field of nanomedicine. Scientists from various fields are aggressively working for the development of single platform that can sense, can produce a microscopic image and even be used to deliver a therapeutic agent. QDs are the fluorescent nano dots with which the possibilities of the drug delivery to a targeted site and its biomedical imaging can be explored. This review is mainly focused on the different process of synthesis of QDs, their application especially in the areas of malignancies and as a theranostic tool. The attempt is to consolidate the data available for the use of QDs in the biomedical applications.
International Journal of Applied Pharmaceutics, Sep 7, 2021
In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdiscip... more In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, and chemistry. The present work aims to cover the optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots (QDs). Articles were reviewed in English literature reporting the pharmaceutical and bio-pharmaceutical aspects of QDs which were indexed in Scopus, web of science, google scholar and PubMed without applying the year of publication criterion. One significant value of utilizing nanotechnology is that one can alter and control the properties in a genuinely unsurprising way to address explicit applications' issues. In science and biomedicine, the usage of functional nanomaterials has been broadly investigated and has become one of the quick-moving and stimulating research directions. Different types of nanomaterial (silicon nanowires, QDs, carbon nanotubes, nanoparticles of gold/silver) were extensively utilized for biological purposes. Nanomedicine shows numerous advantages in the natural characteristics of targeted drug delivery and therapeutics. For instance, protection of drugs against degradation, improvement in the drug's stability, prolonged circulation time, deceased side effects, and enhanced distribution in tissues. The present review article deals with the quantum dots, their optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots. The review also discusses various biomedical applications of QDs. The QDs-based bio-nanotechnology will always be in the growing list of unique applications, with progress being made in specialized nanoparticle development, the detection of elegant conjugation methods, and the discovery of new targeting ligands.
International Journal of Applied Pharmaceutics
In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdiscip... more In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, and chemistry. The present work aims to cover the optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots (QDs). Articles were reviewed in English literature reporting the pharmaceutical and bio-pharmaceutical aspects of QDs which were indexed in Scopus, web of science, google scholar and PubMed without applying the year of publication criterion. One significant value of utilizing nanotechnology is that one can alter and control the properties in a genuinely unsurprising way to address explicit applications' issues. In science and biomedicine, the usage of functional nanomaterials has been broadly investigated and has become one of the quick-moving and stimulating research d...
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Papers by Prashant Tandale