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Emini surface accessibility prediction for the accessible region.

Table 4 Emini surface accessibility prediction for the accessible region.

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4 All are weak bonds. Disulfide bonds prediction by DiANNA1.1. Table 1
4 All are weak bonds. Disulfide bonds prediction by DiANNA1.1. Table 1
List of Bepipred linear epitope predicted via IEDB analysis resource.
List of Bepipred linear epitope predicted via IEDB analysis resource.
The Kolaskar and Tongaonkar method for the prediction of antigenicity. Table 3
The Kolaskar and Tongaonkar method for the prediction of antigenicity. Table 3
Fig. 2. (a) Vaccine assemblage by M-protein. The 3D structure of designed vaccine is shown. (b) Graphical view of constructed vaccine. All epitopes are represented in different colors. All linkers, 50 s ribosomal protein and histadine tag are also shown in different colors. (c) represents the presence of different epitopes on the surface of M-protein. Yellow highlighted area represents the B-cell epitopes present on M- protein surface. CTL epitopes are highlighted in blue color and HTL epitopes are indicated in orange color.
Fig. 2. (a) Vaccine assemblage by M-protein. The 3D structure of designed vaccine is shown. (b) Graphical view of constructed vaccine. All epitopes are represented in different colors. All linkers, 50 s ribosomal protein and histadine tag are also shown in different colors. (c) represents the presence of different epitopes on the surface of M-protein. Yellow highlighted area represents the B-cell epitopes present on M- protein surface. CTL epitopes are highlighted in blue color and HTL epitopes are indicated in orange color.
Fig. 3. Docked complex of vaccine construct and TLR-3.
Fig. 3. Docked complex of vaccine construct and TLR-3.
Fig. 4. The results of molecular dynamic simulation study of vaccine construct and TLR-3 docked complex. (a) MNA mobility, (b) deformability, (c) B-factor, (d) Eigon values, (e) variance (red color indicates individual variances and green color indicated cumulative variances), (f) co-variance map (correlated (red), uncorrelated (white), or anti-correlated (blue) motions) and (g) elastic network (darker grey regions indicate more stiffer regions).
Fig. 4. The results of molecular dynamic simulation study of vaccine construct and TLR-3 docked complex. (a) MNA mobility, (b) deformability, (c) B-factor, (d) Eigon values, (e) variance (red color indicates individual variances and green color indicated cumulative variances), (f) co-variance map (correlated (red), uncorrelated (white), or anti-correlated (blue) motions) and (g) elastic network (darker grey regions indicate more stiffer regions).
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VirologyMedicinePublic health systems and services researchDynamic Simulations
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