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Spatial arrangement of sialic acid residues on an N-linked glycoprotein. A typical oligosaccharide, which includes a conserved pentasaccharide core, is shown. Greater degrees of mannosyl-branching, concomitant with increased sialylation, are also possible. might compete for binding to receptors in the host. This observa- tion occurs as a result of the polydisperse nature of the polymer. Concerns have also been raised about introducing into the body a synthetic polymer that does not appear to be completely biode- gradable. This is despite the observation that mono- and di-car- boxylated metabolites of PEG are detected in bile; these metabolites are generated by cytochrome P450 oxidation via a mechanism that is analogous to that acting on more chemically inert polyethylene to generate ketone and aldehyde groups [6].

Figure 1 Spatial arrangement of sialic acid residues on an N-linked glycoprotein. A typical oligosaccharide, which includes a conserved pentasaccharide core, is shown. Greater degrees of mannosyl-branching, concomitant with increased sialylation, are also possible. might compete for binding to receptors in the host. This observa- tion occurs as a result of the polydisperse nature of the polymer. Concerns have also been raised about introducing into the body a synthetic polymer that does not appear to be completely biode- gradable. This is despite the observation that mono- and di-car- boxylated metabolites of PEG are detected in bile; these metabolites are generated by cytochrome P450 oxidation via a mechanism that is analogous to that acting on more chemically inert polyethylene to generate ketone and aldehyde groups [6].

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FIGURE 2 The structure and linkages of some common, natural derivatives of sialic acid. Sialic acids can be linked with galactose by either an a-(2,3) or a-(2,6) linkage, whereas the sialic acid residues in PSA molecules interact with each other through an a-(2,8) linkage.
FIGURE 2 The structure and linkages of some common, natural derivatives of sialic acid. Sialic acids can be linked with galactose by either an a-(2,3) or a-(2,6) linkage, whereas the sialic acid residues in PSA molecules interact with each other through an a-(2,8) linkage.
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