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Table 3 The experiment layout was obtained in accordance with the 2-level full-factorial Central Composite Design with 8 cube points, | axial points, 4 center points, and 2 center points in axial, resulting in a total of 20 runs. a was chosen as | to make design fac center. Table 3.2 below contains the experimental layout used. Analysis of Variance Table E. Lay out of Experiment for RSM