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Fig. 2. Effect of Berberis aristata root extract on blood glucose (mM/L). NC: normal control; NE: normal rats administered BA extract; DC: diabetic control; DE: dia- betic rats administered BA extract; DG: diabetic rats administered glybenclamide; error bars shows standard error mean between groups; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control).

Figure 2 Effect of Berberis aristata root extract on blood glucose (mM/L). NC: normal control; NE: normal rats administered BA extract; DC: diabetic control; DE: dia- betic rats administered BA extract; DG: diabetic rats administered glybenclamide; error bars shows standard error mean between groups; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control).

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Fig. 1. Dose optimization through oral glucose tolerance test (OGTT), glucose (mM/L). NC: normal control; DE1: diabetic rats administered BA extract (250 mg/kg bw); DE2: diabetic rats administered BA extract (500 mg/kg bw); DC: diabetic con- trol; DG: diabetic rats administered glybenclamide.
Fig. 1. Dose optimization through oral glucose tolerance test (OGTT), glucose (mM/L). NC: normal control; DE1: diabetic rats administered BA extract (250 mg/kg bw); DE2: diabetic rats administered BA extract (500 mg/kg bw); DC: diabetic con- trol; DG: diabetic rats administered glybenclamide.
Values are given as mean+S.D. for five determinations in each group: serum glutamic pyruvic transaminase/alanine amino transferase (SGPT/ALT): U/L; serum glutamic oxaloacetic transaminase/aspartate amino transferase (SGOT/AST): U/L; blood urea nitrogen (BUN): mM/L; serum protein: mg/dL; white blood cell counts (WBC): (m/mm3); red blood cell counts (RBC): (M/mm+?); hemoglobin (Hb): mg/dL; mean corpuscular volume (MCV): fl; heamatocrit (HCT): %. Effect of Berberis aristata root extract on hematological and biochemical parameters to assess toxicity. Table 1
Values are given as mean+S.D. for five determinations in each group: serum glutamic pyruvic transaminase/alanine amino transferase (SGPT/ALT): U/L; serum glutamic oxaloacetic transaminase/aspartate amino transferase (SGOT/AST): U/L; blood urea nitrogen (BUN): mM/L; serum protein: mg/dL; white blood cell counts (WBC): (m/mm3); red blood cell counts (RBC): (M/mm+?); hemoglobin (Hb): mg/dL; mean corpuscular volume (MCV): fl; heamatocrit (HCT): %. Effect of Berberis aristata root extract on hematological and biochemical parameters to assess toxicity. Table 1
Values are given as mean+S.D. for five rats in each group; S.E.M.: standard error mean between groups; CD =critical difference significant at p <0.05; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control). Effect of Berberis aristata root extract on day 21 on enzymes involved in glucose metabolism and glycogen content
Values are given as mean+S.D. for five rats in each group; S.E.M.: standard error mean between groups; CD =critical difference significant at p <0.05; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control). Effect of Berberis aristata root extract on day 21 on enzymes involved in glucose metabolism and glycogen content
Values are given as mean 4 t §.D. for five rats in each group; S.E.M.: standard error mean among groups; CD =critical difference significant at p <0.05; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control). Units of enzymes are: catalase activity (CAT, 14M H202 decomposed/min/g liver), superoxide dismutase activity (SOD, Units/min/g liver), glutathione reductase (GR, NADPH oxidized/min/g liver) activity and glutathione peroxidase (GPx, #M NADPH oxidized/min/g liver), GSH content (nM DTNB conjugated/mg protein), hepatic protein oxidation (nm protein carbonyl content/g liver) and lipid peroxidation (nM MDA/g liver). Effect of Berberis aristata root extract on hepatic antioxidant enzymes and oxidative stress markers. Table 2
Values are given as mean 4 t §.D. for five rats in each group; S.E.M.: standard error mean among groups; CD =critical difference significant at p <0.05; ‘a’ represents the significant change as compared to NC (Normal Vehicle Control) and ‘b’ represents the significant change as compared to DC (Diabetic Vehicle Control). Units of enzymes are: catalase activity (CAT, 14M H202 decomposed/min/g liver), superoxide dismutase activity (SOD, Units/min/g liver), glutathione reductase (GR, NADPH oxidized/min/g liver) activity and glutathione peroxidase (GPx, #M NADPH oxidized/min/g liver), GSH content (nM DTNB conjugated/mg protein), hepatic protein oxidation (nm protein carbonyl content/g liver) and lipid peroxidation (nM MDA/g liver). Effect of Berberis aristata root extract on hepatic antioxidant enzymes and oxidative stress markers. Table 2
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PharmacologyEthnobotanyPlant BiologyMedicineOral Hypoglycemic AgentsDiabetic Rat
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