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*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E2—Age-related change in prevalence of wheeze (current, episodic viral, and multiple trigger) in entire cohort, presented as OR for different age groups*

Table 6 *Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E2—Age-related change in prevalence of wheeze (current, episodic viral, and multiple trigger) in entire cohort, presented as OR for different age groups*

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Table E1—Response rates for questionnaire surveys “ After the age of 5 years, the address database was not updated, thus we did not have valid addresses for all children and not all 8,700 children were contacted at different surveys . Questionnaire only for a subsample, for those who were aged | year in 1998 and had replied to the questionnaire in 1998 “ Response rate A: number of participants who replied/ number of participants who were contacted at the respective survey (for instance for the 2010 survey: 2,544/7,642) A Response rate B: number of participants who replied/ number of originally sampled children (for instance for the 2010 survey: 2,544/8,700).
Table E1—Response rates for questionnaire surveys “ After the age of 5 years, the address database was not updated, thus we did not have valid addresses for all children and not all 8,700 children were contacted at different surveys . Questionnaire only for a subsample, for those who were aged | year in 1998 and had replied to the questionnaire in 1998 “ Response rate A: number of participants who replied/ number of participants who were contacted at the respective survey (for instance for the 2010 survey: 2,544/7,642) A Response rate B: number of participants who replied/ number of originally sampled children (for instance for the 2010 survey: 2,544/8,700).
“ Age at the end of education is >16 years ° The categories cover the following Townsend Deprivation Index intervals: more affluent [-6.222, -2.635], affluent [-2.615, -0.707], average [-0.705, 1.859], deprived [1.861, 5.147], more deprived [5.160, 11.072] TABLE 1—Characteristics of the study population aged 1 year (N=4,102)
“ Age at the end of education is >16 years ° The categories cover the following Townsend Deprivation Index intervals: more affluent [-6.222, -2.635], affluent [-2.615, -0.707], average [-0.705, 1.859], deprived [1.861, 5.147], more deprived [5.160, 11.072] TABLE 1—Characteristics of the study population aged 1 year (N=4,102)
TABLE 2—Original questions about wheezing characteristics analysed in this study
TABLE 2—Original questions about wheezing characteristics analysed in this study
2b) Relative prevalence: proportion of children with certain features of wheeze among wheezers N, number of children who returned the questionnaire at the respective age Percentages are calculated based on those who responded to the respective questions All wheeze features refer to the past 12 months
2b) Relative prevalence: proportion of children with certain features of wheeze among wheezers N, number of children who returned the questionnaire at the respective age Percentages are calculated based on those who responded to the respective questions All wheeze features refer to the past 12 months
Table E3—Age-related change in prevalence of wheeze with triggers in entire cohort, presented as OR for different age groups*
Table E3—Age-related change in prevalence of wheeze with triggers in entire cohort, presented as OR for different age groups*
Table E4—Age-related change in prevalence of indicators of wheeze severity in entire cohort, presented as OF for different age groups* *Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of chang prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. “ Frequent wheeze (>4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath “Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze OR, odds ratio (GEE, generalised estimating equations, analysis)
Table E4—Age-related change in prevalence of indicators of wheeze severity in entire cohort, presented as OF for different age groups* *Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of chang prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. “ Frequent wheeze (>4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath “Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze OR, odds ratio (GEE, generalised estimating equations, analysis)
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E5—Age-related change in prevalence of wheeze phenotypes (episodic viral and multiple trigger) among children with current wheeze, presented as OR, for different ace coroups*
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E5—Age-related change in prevalence of wheeze phenotypes (episodic viral and multiple trigger) among children with current wheeze, presented as OR, for different ace coroups*
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E6—Age-related change in prevalence of wheeze with triggers among children with current wheeze presented as OR, for different age groups*
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of change in prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. OR, odds ratio (GEE, generalised estimating equations, analysis) Table E6—Age-related change in prevalence of wheeze with triggers among children with current wheeze presented as OR, for different age groups*
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of chang¢ prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. “ Frequent wheeze (>4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath “Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze OR, odds ratio (GEE, generalised estimating equations, analysis)
*Age-related change: test for the significance of change in prevalence with age for each of the symptoms, calculated with GEE and presented as odds ratio of chang¢ prevalence per age group with respective p-values, accounting for repeated nature of measurements and clustered data. Baseline group: 5-6-year-old children. All symptoms refer to the past 12 months. “ Frequent wheeze (>4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath “Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze OR, odds ratio (GEE, generalised estimating equations, analysis)
Frequent wheeze (=4 wheeze attacks in past 12 months) ’Wheeze always causing shortness of breath Sleep disturbed due to wheeze (>1/week) ' At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months.
Frequent wheeze (=4 wheeze attacks in past 12 months) ’Wheeze always causing shortness of breath Sleep disturbed due to wheeze (>1/week) ' At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months.
Table E9—Unweighted and weighted prevalence of wheeze, episodic viral and multiple trigger wheeze, wheeze with different triggers, and ind of severe wheeze among children with any current wheeze (relative prevalence) “ Frequent wheeze (=4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath © Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months. %(CI), unweighted prevalence with confidence intervals; Now, number of children with current wheeze at respective age
Table E9—Unweighted and weighted prevalence of wheeze, episodic viral and multiple trigger wheeze, wheeze with different triggers, and ind of severe wheeze among children with any current wheeze (relative prevalence) “ Frequent wheeze (=4 wheeze attacks in past 12 months) > Wheeze always causing shortness of breath © Sleep disturbed due to wheeze (>1/week) 4 At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months. %(CI), unweighted prevalence with confidence intervals; Now, number of children with current wheeze at respective age
Sensitivity analysis in the 2010 survey (1,821 children aged 14-17 years) in entire cohort “ Difference between parent- and self-reported symptoms calculated with unpaired (two-sample) t-test > Frequent wheeze (>4 wheeze attacks in past 12 months) “ Wheeze always causing shortness of breath 4 Sleep disturbed due to wheeze (>1/week) * At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months.
Sensitivity analysis in the 2010 survey (1,821 children aged 14-17 years) in entire cohort “ Difference between parent- and self-reported symptoms calculated with unpaired (two-sample) t-test > Frequent wheeze (>4 wheeze attacks in past 12 months) “ Wheeze always causing shortness of breath 4 Sleep disturbed due to wheeze (>1/week) * At least moderate disturbance of daily activities due to wheeze All wheezing characteristics refer to the past 12 months.
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Pediatric PulmonologyPaediatrics and reproductive medicine
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