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Clinicopathological comparison between placenta accreta, increta, and percreta Table 2

Table 2 Clinicopathological comparison between placenta accreta, increta, and percreta Table 2

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* Statistically significant. Clinicopathological characteristics in cases of creta vs. non-creta Table |
* Statistically significant. Clinicopathological characteristics in cases of creta vs. non-creta Table |
Fig. 2. Remodeled vessels in a case of placenta increta, located very close to serosal surface (A. H&E, B. Cytokeratin staining; original magnification x40). significantly higher percentage of multinuclea ted interstitial tro- phoblasts were found in cases with accreta (Table 2). The max- imal depth of interstitial trophoblastic infiltration in the myometrium in creta cases was significantly creta cases (3.57 + 2.02 mm increta vs. 2.63 4 trols, P=0.009, see Table 1). However, trophoblasts were seen in the outer one-half o higher than non- t 1.36 mm incon- again, interstitial f the myometrium only in increta and percreta cases. Also, within subgroups of creta, the maximal depth of IT invasion was not significantly different (Table 2).
Fig. 2. Remodeled vessels in a case of placenta increta, located very close to serosal surface (A. H&E, B. Cytokeratin staining; original magnification x40). significantly higher percentage of multinuclea ted interstitial tro- phoblasts were found in cases with accreta (Table 2). The max- imal depth of interstitial trophoblastic infiltration in the myometrium in creta cases was significantly creta cases (3.57 + 2.02 mm increta vs. 2.63 4 trols, P=0.009, see Table 1). However, trophoblasts were seen in the outer one-half o higher than non- t 1.36 mm incon- again, interstitial f the myometrium only in increta and percreta cases. Also, within subgroups of creta, the maximal depth of IT invasion was not significantly different (Table 2).
Fig. 1. Remodeled vessels (A, B: complete; C, D: incomplete; original magnification x 100) compared to non-remodeled vessels (E, F; original magnificatio x200). The trophoblasts were highlighted by cytokeratin (AE1/AE3) staining.
Fig. 1. Remodeled vessels (A, B: complete; C, D: incomplete; original magnification x 100) compared to non-remodeled vessels (E, F; original magnificatio x200). The trophoblasts were highlighted by cytokeratin (AE1/AE3) staining.
Fig. 3. Confluent sheet of interstitial trophoblasts infiltrating the myometrium in a case of placenta increta (A. H&E, B. Cytokeratin staining; original mag- nification x40). The basic histopathology of placenta creta is the absence of decidua basalis, with direct attachment of chorionic villi to the myometrium [1]. While the pathogenesis of defective decidu- alization remains unknown, previous instrumentation is thought to play a role. This is supported by the conditions associated with placenta creta, including advanced maternal age, high gravidity, previous uterine instrumentation (curet- tage and c-section), uterine structural defects, placenta previa, and ectopic implantation [13,22,23]. In our study, previous history of abortion and c-section, two or more previous curet- tages, and placenta previa were significantly associated with placenta creta. History of previous c-section was identified in 71.1% of cases with placenta creta, which was similar to a recently published study [24]. Overall, the prevalence of
Fig. 3. Confluent sheet of interstitial trophoblasts infiltrating the myometrium in a case of placenta increta (A. H&E, B. Cytokeratin staining; original mag- nification x40). The basic histopathology of placenta creta is the absence of decidua basalis, with direct attachment of chorionic villi to the myometrium [1]. While the pathogenesis of defective decidu- alization remains unknown, previous instrumentation is thought to play a role. This is supported by the conditions associated with placenta creta, including advanced maternal age, high gravidity, previous uterine instrumentation (curet- tage and c-section), uterine structural defects, placenta previa, and ectopic implantation [13,22,23]. In our study, previous history of abortion and c-section, two or more previous curet- tages, and placenta previa were significantly associated with placenta creta. History of previous c-section was identified in 71.1% of cases with placenta creta, which was similar to a recently published study [24]. Overall, the prevalence of
Fig. 4. Ki-67 staining in a case of percreta at 13 weeks gestation. The positive Ki-67 immunoreactivity was mainly seen in trophoblastic columns (A. H&E staining B. Cytokeratin staining, C. Ki-67 staining; original magnification x40).
Fig. 4. Ki-67 staining in a case of percreta at 13 weeks gestation. The positive Ki-67 immunoreactivity was mainly seen in trophoblastic columns (A. H&E staining B. Cytokeratin staining, C. Ki-67 staining; original magnification x40).
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placenta accretaPaediatrics and reproductive medicine
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