FORMULATION AND EVALUATION OF DICLOFENAC ORODISPERSIBLE TABLETS

2011

Aim: Acelofenac is nonsteroidal drug with bitter taste. So orodispersible tablet of the acelofenac was formulated for the patient compliance. Method: In the formulation of the orodispersible tablet two superdisintegrants Acdisol and crospovidone was used and different sweetening agent and flavouring agent such as Sodium Saccharine, vannilin, menthol to mask the taste. Results: In the study orodispersible tablet evaluated for hardness, disintegration time, in vitro dissolution time and % drug content. Results indicated that the formulation A-4 exhibited maximum release (100%), minimum disintegration time (23 sec.) and optimum hardness (3.6 Kg) with effective taste masking. Stability study also conducted which show formulation was stable as it is kept at different temperature and different humidity condition Conclusion: The approach using different superdisintegrants and sweetening agent and flavouring agent for formulate a stable orodispersible formulation which could be beneficial f...

Journal of Applied Pharmaceutical Science, 2015

The present study was aimed to formulate, develop and evaluate the fast dissolving tablets of diclofenac sodium, used for the treatment of arthritis, inflammation, pain. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method using crospovidone and sodium starch glycolate as superdisintegrants in concentrations of 5.3%, 6.6% and 8% w/w and in combination. In this work microcrystalline cellulose and mannitol are investigated as diluents. Prepared powder mixtures were evaluated for drug excipient compatibility with FTIR spectroscopy and DSC analysis. Prepared formulations are evaluated for In vitro dissolution, disintegration dispersion and wetting time. Formulation FCS6 prepared with combination of crospovidone and sodium starch glycolate at weight ratio of 6.6 and 2.3% showed better results compare with control. Post compression parameters like hardness (3.4 kg/cm 2) and friability (0.31%) are at good acceptable levels in accordance with official compendia. FCS6 showed improved dissolution (99.8 %) and dispersion (75 seconds) profiles compared to control. The FTIR and DSC showed no interaction between the drug and excipients. The optimized formula FCS6 showed good drug release characteristics with acceptable mouth feel and fast dissolving properties.

Marmara Pharmaceutical Journal, 2017

Diclofenac a phenylacetic acid derivative has long been used as an anti-inflammatory and analgesic drug to treat certain conditions however its sustained release formulation with immediate release loading dose is desirable. The rationale of the current work was to develop and evaluate bilayer tablets with diclofenac potassium as orodispersible layer and diclofenac sodium as sustained release core. The diclofenac sodium core was prepared by wet granulation method while the orodispersible outer layer was prepared by direct compression method using super disintegrant sodium starch glycolate. The powder blends were then evaluated for both pre-compressional and post compressional properties. The physical parameters of both powders and tablets were in accordance with the compendial standards. The orodispersible portion disintegrated in less than 30sec releasing diclofenac potassium as the loading dose while the core was able to sustain the release of diclofenac sodium up to 10hrs in simulated intestinal fluid (pH 6.8). The kinetic data revealed that the release pattern was best fitted into Korsmeyer-Peppas model with non-fickian release. The outer orodispersible layer of diclofenac potassium and sustained release inner core of diclofenac sodium in a single tablet was successfully formulated while sodium starch glycolate showed to have good super disintegrant properties.

Indian Journal of Pharmaceutical Sciences, 2008

Setty, et al.: Fast Dispersible Aceclofenac Tablets Aceclofenac, a non-steroidal antiinfl ammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has been studied. Disintegration time and dissolution parameters (t 50% and t 80%) decreased with increase in the level of croscarmellose sodium. Where as, disintegration time and dissolution parameters increased with increase in the level of sodium starch glycolate in tablets. However, the disintegration time values did not refl ect in the dissolution parameter values of crospovidone tablets and release was dependent on the aggregate size in the dissolution medium. Stability studies indicated that tablets containing superdisintegrants were sensitive to high humidity conditions. It is concluded that fast-dispersible aceclofenac tablets could be prepared by direct compression using superdisintegrants.

IJPSM, 2021

Oral drug delivery is the largest and the oldest segment of the total drug delivery market. It is the fastest growing and most preferred route for drug administration. In oral drug delivery, the sustained release (SR) tablets maintains the desired drug concentration for prolong period of time, reduced 'see-saw' fluctuation, reduced total dose, improved efficiency in treatment. But many patients like paediatric, geriatric and also patients may have difficulty in swallowing (Dysphagia) find it difficult to swallow tablets and thus do not comply with prescription. This problem is overcome by formulating and developing modified disintegrating sustained release tablets. In this case, first microspheres of the drug are formulated by using any suitable technique. And then optimized microspheres formulation is further formulated in to the fast disintegrating tablets (FDT) by using superdisintegrants. So that after taking such a tablets, the tablet only disintegrates into the mouth then microspheres are separated and ingestion of such microspheres starts releasing drug for prolonged period of time. This concept fulfills both the advantages of sustained release and fast disintegrating tablets.

International journal of pharmaceutical chemistry and analysis, 2024

Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been prepared" Corn silk " powder with various 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In-vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes. The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.

2017

The aim of this study was to formulate and characterization of dispersible tablet (Aceclofenac). Aceclofenac is a phenylacetic acid belongs to the group of non-steroidal anti-inflammatory drug (NSAID). It causes by inhibition of COX-2 and prostaglandin E2(PGE2) synthesis in blood mononuclear and polymorphonuclear cells.It used as anti-rheumatic, anti-inflammatory (both acute and chronic),analgesic (effective pain killer in lower backache, dental or gynecological pain) and antipyretic. In present study, disintegrants(crospovidone and sodium starch glycolate) with are used. Evaluation of different batches of tablets by thickness, weigh variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro drug release. Quantitative analyzes of aceclofenac by UV-Spectrophotometry, High Performance Liqud Chromatography (HPLC) and Mass Spectroscopy. Three formulation patterns were used for in-vitro drug release study.

The objective of the present investigation was to design suitable Immediate release tablet formulation of Aceclofenac by using cross carmellose sodium as super-disintegrant in four different concentrations i.e., 0, 4, 6, 8% w/w of tablet weight by two granulation methods i.e., Wet and melt granulation methods. The objective of the research was to compare the two granulation methods i.e., wet and melt granulation methods. Melt granulation provides an advantageous method of granulation which results in a tablet dosage form showing immediate and fast release of drug. The main scope of this research work was to compare pre-compression, post-compression and in Vitro drug release properties of the tablets prepared by two granulation methods. Aceclofenac is an analgesic belonging to the class of NSAIDs. Four formulations (F W , F 1 , F 2 , and F 3) of IR tablets were prepared by wet granulation method and four formulations of melt granulation (F M , F 4 , F 5 , and F 6) were prepared. All the formulations were evaluated for their pre and post compression properties and also the in Vitro dissolution tests were carried out. It was found that the melt granulation formulations showed faster and immediate release compared to that of wet granulation method. Among all the formulations F 6 formulation containing 8% CCS showed the faster drug release. Also the best formulations of both the granulation methods i.e., F 3 and F 6 were compared.

International Journal of Pharmaceutical Sciences and Nanotechnology, 2013

Traditionally experimental methods in the pharmaceutical formulation development involve significant amount of time and efforts to get an optimized dosage form. It is very much desirable as per industrial perspective to obtain suitable, optimized and stable formulation with minimum amount of time and effort. The purpose of this study was to study the synergic effect of natural disintegrants and central composite design in optimization of diclofenac sodium orodispersible tablets. In this study, central composite design was applied to study the effect of natural disintegrant as independent variables i.e. seed mucilage of Plantago ovata, and seed mucilage of Ocimum basilicum. Diclofenac sodium orodispersible tablets were prepared by direct compression method on Cadmech single punch machine using flat 8-mm punches and characterized for the dependent variables like disintegration time and cumulative percent drug released after 25 minutes. Optimization study by multiple regression analys...