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Outline

Title
Abstract
Figures
Introduction
Leuco Crystal Violet Method
Catalytic Reduction Method
Procedure
Field Validation Results
Techniques of Iodate Analysis
Observed Results
Ferrozine Method for Total Iron
Thiocyanate Method for Total Iron
Recommendations for Further Work
Observations and Results
Iron Fortified Flour Test Kit Protocol Validation
Techniques of Iodide Analysis
Analysis
Experimental Methods
Discussion of Results
Conclusions and Recommendations
Phenanthroline Method for Ferrous Iron
Analytical Methods for Ferrous Iron
Phenanthroline Method for Total Iron
Dimethylglyoxime Method for Ferrous Iron
Isonitrosobenzoylmethane Method for Ferrous Iron
Analytical Methods for Ferric Iron
Thiocyanate Method for Ferric Iron
Salicylaldoxime Method for Ferric Iron
Analytical Methods for Ferrous and Ferric Iron
Materials
Results
Conclusion
Recommendations
Methods
References

Field tests for iodide, iodate, and iron: phase 2, final report

Profile image of Levente DiosadyLevente Diosady

1998

Abstract
sparkles

AI

This report discusses phase 2 of field tests conducted for the determination of iodine, iodate, and iron levels in food fortification programs aimed at combating micronutrient deficiencies in developing countries. The study highlights the development of a liquid-phase colorimetric system for qualitative tests, showing reliable, reproducible results. Laboratory testing in various locations, including India and Zimbabwe, demonstrated significant improvements in measurement accuracy and operational simplicity for effective implementation of food fortification strategies.

Figures (2)

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References (129)

  1. BIBLIOGRAPHY An extensive bibliography on the analysis of iodine and iron is attached.
  2. Ali-Mohamed, A. Y., Jamali, S. G. A. -Potentiometric determination of fluoride and iodide in natural and processed waters of Bahrain using ion-selective electrodes. Water Research 23, 659, 1989.
  3. Anonymous -N Report 5.11990.
  4. Brown, L. -Indispensable iodine. American Health 12, 44, 1993.
  5. Dubravcic, M. -Determination of iodine in natural waters (sodium chloride as a reagent in the catalytic reduction of ceric ions) Analyst 80, 295, 1955.
  6. Fernandez, R.L., Millard, A. V. -A simple matter of salt [book review]. (IDD) Science 254, 133, 1991.
  7. Fischer, P. W. F., IJAbbe, M. R., Giroux, A. -Colorimetric determination of total iodine in foods by iodide-catalyzed reduction of J.A.O.Anal. Chem. 69, 687, 1986.
  8. Gustafson, F.J., Markell, C.G., Simpson, S. M. -Determination of chloride, bromide, and iodide in silver halides by ion exchange and ion interaction chromatography. Analytical Chemistry 57, 621, 1985.
  9. Han, K., Koch, W.F., Pratt, K.W. -Improved procedure for the determination of iodide by ion chromatography with electrochemical detection. Analytical Chemistry 59, 731, 1987.
  10. Hatch, Gary L. -Hypolodous acid, iodine, and iodide determination with teucocrystal violet and N-chlorosuccinimide-succinamide reagents -Analytical Chemistry 56, 2238, 1984.
  11. Joint FAOIWHO Expert Committee on Food Additives -Evaluation of certain food additives and contaminants WHO Tech. Rep. Ser. No. 806, Geneva, Switzerland 1991.
  12. Luther, G. W., 3rd., Swartz, C.B., Ullman, W.J. -Direct determination of iodide in sea water by cathodic stripping square wave voltametry. Analytical Chemistry 60, 1721, 1988.
  13. Markel, H., D. M. Cowie -"When it rains it pours": endemic goiter, iodized salt in goiter therapy. Am. J. Public Health 77, 219,1987.
  14. Maros, L., Kaldy, M., lgaz, S. -Simultaneous determination of bromide and iodide as acetone derivatives by gas chromatography and electron capture detection in natural waters and biological fluids. Analytical Chemistry 61, 733, 1989.
  15. Michlewicz, K. G., Carnahan, J. W. -Determination of aqueous bromide, iodide, and chloride with pneumatic and ultrasonic nebulization into a helium microwave- induced plasma. Analytical Chemistry 58, 3122, 1986.
  16. Mull, D.S., Anderson, J. W., Mull, J. D. -Cow dung, rock salt, and medical innovation in the Hindu Kush of Pakistan: the cultural transformation of neonatal tetanus and iodine deficiency. Social Science & Medicine 30, 91, 1990.
  17. Narasinga Rao, B.S. -Double fortification of salt with iron and iodine to control anaemia and goitre. National Institute of Nutrition, Hyderabad, India 1990.
  18. Raloff, J-Iodized cancer therapy. Iodine may be the key to making some incurable cancers more susceptible to radiation therapy. -Science News 129, 124, 1986.
  19. Rogina, B. & M. Dubravcic -Microdetermination of iodides by arresting the catalytic reduction of ceric ions. Analyst 78, 594, 1953.
  20. Ruo Yuan, Ya-Qin Chai, Dong Liu -Schiff base complexes of cobalt(ll) as neutral carriers for highly selective iodide electrodes. Analytical Chemistry 65, 2572, 1993.
  21. Schmeisser & Brauer ed. -Handbook of Preparative Inorganic Chemistty 2nd Ed., Academic Press, N.Y., 1963.
  22. Scott, W., W. -Standard Methods of Chemical Analysis A manual of Analytical methods and General Reference for the Analytical Chemist and for the Advanced Student, D. Van Nostrand Co., Inc. New York, NY 1939.
  23. Sun Haing Lee., Field, L. R. -Postcolumn fluorescence detection of nitrite, nitrate, thiosulfate, and iodide anions in high-performance liquid chromatography. Analytical Chemistry 56, 2647, 1984.
  24. Tanner, J. T., Barnett, S. A., Mountford, M. K. -Analysis of milk-based infant formula. Phase IV. Iodide, Jinoleic acid, and vitamins D and K: U.S. Food and Drug Administration-Infant Formula Council: collaborative study. J .A. O.A.C. International 76, 1042, 1993.
  25. Tonglet, R. Bourdoux, P., Minga, T. -Efficacy of low oral doses of iodized oil in the control of iodine deficiency in Zaire. New England J. Medicine 326, 236, 1992.Ubom, G. A, Tsuchiya, Y. -Determination of iodide in natural water by ion chromatography. Water Research 22, 1455, 1988.
  26. UNICEF internal paper -Chronology of development of iron and double fortification of salt. UNICEF, New Delhi, India 1989.
  27. Venkatesh Mannar, M. G. -Control of iodine deficiency disorders by iodization of salt: strategy for developing countries. The prevention and control of iodine deficiency disorders. Eds.: Hetzel, B.S., J.T. Dunn & Stanbury J.B., Elsevier 1987.
  28. Venkatesh Mannar, M.G., S.Jayapaf, & Pandav, C.S. -Double fortification of salt with iron and iodine. Proceedings of the Sixth International Nutrition Congress, Seoul 1989.
  29. Verma, K. K., Jam, A., Verma, A. -Determination of iodide by high-performance liquid chromatography after precolumn derivatization. Analytical Chemistry 64, 1484, Weicher, F.J . Organic Analytical Reagents D. Van Nostrand Co., Princeton, N.J., 1976.
  30. Youssef, A.F., El-Shabouri, S. R., Mohamed, F.A. -Colorimetric determination of certain phenothiazine drugs by using morpholine and iodine-potassium iodide reagents. Journal of the Ass. of Off. Analytical Chemists 69, 513, 1986.
  31. 2 IRON Anonymous -Handbook of Preparative Inorganic Chemistty Academic Press, N.Y., 2nd
  32. Anonymous -Merck Index 9th Ed., Merck & Co., Inc. Rahway, N.J. 1976. Anonymous -Use of iron-fortified salt to combat anemia: the Indian experience. Nutrition Review 41, 302, 1983.
  33. Anonymous -Official Methods of Analysis 14th Ed.., AOAC, Arlington, VA, 1984. Anonymous -Standard Methods for the Examination of Water ahd Wastewater -17th Ed. APHA, AWWA, WPCF, 1989.
  34. Anonymous -The Sigma-Aldrich Handbook of Stain, Dyes & Indicators Aldrich Chemical Company 1990.
  35. Asenjo, J. A., Amar, M.., Cartagena, N. -Use of a bovine heme iron concentrate in the fortification of biscuits. J. Food Science 50, 795, 1985.
  36. Ballot, D. E., MacPhail, A. P.., Bothwell, T. H. -Fortification of curry powder with NaFe(111)EDTA in an iron-deficient population: report of a controlled iron- fortification trial. Am. J. Clinical Nutrition 49, 162, 1989. (South Afr.)
  37. Barak, P., Chen, Y. -Determination of FeEDDHA in soils and fertilizers by anion exchange chromatography. Soil Science Society Am. J. 51, 893, 1987.
  38. Beard, J. L. -Iron fortification--rationale and effects. Nutrition Today 21, 17, 1986.
  39. Caldwell, D.H. & R.B. Adams -Colorimetric determination of iron in water with o- phenanthroline. J. Amer. Water Works Ass. 38, 727, 1946.
  40. Capar, S. G. -Determination of copper, iron, and nickel in oils and fats by direct graphite furnace atomic absorption spectrometry: summary of collaborative study. J.A.O. Anal. Chem. 73, 320, 1990.
  41. Chronheim, G. & W. Wink -Determination of divalent iron (by o-nitrosophenol). md. Eng. Chem., Analytical Ed. 14, 447, 1942
  42. Cook, J. D., Reusser, M. E. -Iron fortification: an update. Am. J. Clinical Nutrition 38, 648, 1983.
  43. Crosby, W. H. -Yin, yang and iron. Iron fortification of foods. Nutrition Today 21,14, 1986.
  44. de Ruig, W. G. -Atomic absorption spectrometric determination of calcium, copper, iron, magnesium, manganese, potassium, sodium, and zinc in animal feeding stuffs: inter-laboratory collaborative studies. J.A.O. Anal. Chem. 69, 623, 1986.
  45. Doig, M.T., III, & D.F. Martin -Effect of humic acids on iron analysis in natural waters. Water Res. 5, 689, 1971.
  46. Elrod, V. A., Johnson, K. S., Coale, K. H. -Determination of subnanomolar levels of iron(lI) and total dissolved iron in sea water by flow injection analysis with chemiluminescence detection. Analytical Chemistry 63, 893, 1991.
  47. Fairweather-Tait, S., Southon, S. -Studies of iron:zinc interactions in adult rats and the effect of iron fortification of two commercial infant weaning products on iron and zinc status of weanhing rats. J. Nutrition 119, 599, 1989.
  48. Fortune, W.B. & M.G. Mellon -Determination of iron with o-phenanthroline. Ind. Eng. Chem., Analytical Ed. 10, 60, 1938.
  49. Ghosh, M.M., J.T. O'Connor & R.S. Engelbrecht -Bathophenanthroline method for the determination of ferrous iron. J. Amer. Water Works Ass. 59, 878, 1967.
  50. Gurunath, M.M., Diamond, H.V., & Venkatesh-Mannar, M.G. -Fortification of salt with iron. Proceedings of the Fourth International Symposium on Salt, Houston, Texas. Northern Ohio Geological Society, Cleveland, Ohio 1973.
  51. Hallberg, L., Rossander-Huithin, L., Gramatkovski, E. -Iron fortification of flour with a complex ferric orthophosphate. Am. J. Clinical Nutrition 50, 129, 1989.
  52. Hallberg, L., Brune, M., Rossander, L. -Low bioavailability of carbonyl iron in man: studies on iron fortification of wheat flour. Am. J. Clinical Nutrition 43, 59, 1986.
  53. Hallinan, F.J. -Determination of iron in water. lnd. Eng. Chem., Analytical Ed. 15, 510, 1943.
  54. Hirayama, K., Unohara, N. -Spectrophotometric catalytic determination of an ultratrace amounts of iron(lll) in water based on the oxidation of N,N-dimethyl-p- phenylenediamine by hydrogen peroxide. Analytical Chemistry 60, 2573, 1988.
  55. Hurrehl, R. F., Furniss, D. E., Burn, J. -Iron fortification of infant cereals: a proposal for the use of ferrous fumarate or ferrous succinate. Am. J. Clinical Nutrition 49, 1274, 1989.
  56. Hurrell, R. F., Reddy, M.B., Dassenko, S. A. -Ferrous fumarate fortification of a chocolate drink powder. British J.Nutrition 65, 271, 1991.
  57. Hurrel, R.F. & Cook, J.D. -Strategies for iron fortification of foods. Trends in Food Science and Technology 1990.
  58. Jackson, L.S., Ken, L. -Microencapsulated iron for food fortification. J. Food Science 56,1047, 1991.
  59. Jam, M. -Effect of consumption of iron-fortified salt on iron status in young girls. Human Nutrition 41A,. 174, 1987. WHO Tech. Rep. Ser. No. 806, Geneva, Switzerland 199t
  60. Jonnalangadda, S. B. -Kinetic-potentiometric determination of vanadium(V) and iron(l1). Analytical Chemistry 55, 2253, 1983.
  61. Kolthoff, l.M., T.S. Lee & D.L. Leussing -Equilibrium and kinetic studies on the formation and dissociation of ferroin and ferrin. Analytical Chem. 20, 985, 1948.
  62. Kudo, 0. H., Karatani, H., Nakayama, E. -Automated determination of iron in sea water by chelating resin concentration and chemiluminescence detection. Analytical Chemistry 65, 1524, 1993.
  63. Kulesza, P.J., Brajter, K. Dabek-Zlotorzynska, E. Application of chelate-forming resin and modified glassy carbon electrode for selective determination of iron(lll) by liquid chromatography with electrochemical detection. -Analytical Chemistry 59, 2776, 1987.
  64. Lamparelli, R. D., MacPhail, A.P., Bothwell, T. H. -Curry powder as a vehicle for iron fortification: effects on iron absorption. Am. J. Clinical Nutrition 46 , 335, 1987.
  65. Lau, Oi-Wah, Luk, Shiu-Fai. -Spectrophotometric determination of ascorbic acid in canned fruit juices, cordials, and soft drinks with iron(IlI) and 1,10-phenanthroline as reagents. J.A.O. Anal. Chem. 70, 518, 1987.
  66. Lee, G.F. & W. Stumm -Determination of ferrous iron in the presence of ferric iron using bathophenanthroline. J. Amer. Water Works Ass. 52, 156, 1960.
  67. Lombardi-Boccia, G., Carnovale, E. -In vitro estimation of iron availability from meals and beef: effect of processing and fortification. J. Food Science 44, 1441, 1989.
  68. McMahon J.W. -An acid free bathophenanthroline method for measuring dissolved ferrous iron in lake water. Water Res. 3, 743, 1969.
  69. McMahon J.W. -The influence of light and acid on the measurement of ferrous iron in lake water Limnol. Oceanogr. 12, 437, 1967.
  70. Mehlig, R.P. & R.H. Hulett -Spectrophotometric determination of iron with 0- phenanthroline and with nitro-o-phenanthroline. I nd. Eng .Chem., Analytical Ed. 14,869, 1942.
  71. Morris, R.L. -Determination of iron in water in the presence of heavy metals. Analytical Chem. 25, 1376, 1952.
  72. Moss, M.L. & M.G. Mellon -Color reactions of 1,10-phenanthroline derivatives. lnd. Eng. Chem., Analytical Ed. 14, 931, 1942.
  73. Moss, M.L. & Mellon -Colorimetric determination of iron with 2,2'-bipyridine and with 2,2',2"-tripyridine. md. Eng. Chem., Analytical Ed. 14, 862, 1942.
  74. Nadiger, H.A., Krishnamachari, K.A.V.R., Nadamuni, N., Rao, B.S.N. & Srikantia, S.G. -The use of common salt (sodium chloride) fortified with iron to control anaemia. Results of a preliminary study. British J. Nutrition 43, 45, 1980.
  75. Nagaosa, Y., Kawabe, H., Bond, A. M. -Separation and simultaneous determination of aluminum, iron, and manganese in natural water samples by using high- performance liquid chromatography with spectrophotometric and electrochemical detection. Analytical Chemistry 63, 28, 1991.
  76. Narasinga Rao, B.S. & Vijaya Sarathy, C. -Fortification of common salt with iron. Effect of chemical additives on stability and bioavailability. Am. J. Clinical Nutrition 28, 1395, 1975.
  77. Narasinga Rao, B.S. -Double fortification of salt with iron and iodine to control anaemia and goitre. National Institute of Nutrition, Hyderabad, India 1990.
  78. Obata, Hajime et al. -Automated determination of iron in sea water by chelating resin concentration and chemiluminescence detection. Analytical Chemistry 65, 1524, 1993.
  79. Pizarro, F., Amar, M., Stekel, A. -Determination of iron in stools as a method to monitor consumption of iron-fortified products in infants. Am. J. Clinical Nutrition 45, 484, 1987.
  80. Rainwater, F. H. & L.L. Thatcher -Methods of collection and analysis of water samples. U.S. Geol. Surv. Water Supply Pap. No. 1454, 1960.
  81. Reutz, L.K., A.S. O'Brien & T.L. Davis -Evaluation of three iron methods using factorial experiment. Analytical Chem. 22, 1470, 1950.
  82. Rooze, Henri. -Kinetic-spectrophotometric determination of trace levels of iron. Analytical Chemistry 56, 601, 1984.
  83. Rubio, S., Gomez-Hens, A., Valcarcel, M. -Simultaneous kinetic determination of iron and chromium at the nanogram level. Analytical Chemistry 56, 1417, 1984.
  84. Ryan, J.A. & G.H. Botham -Iron in aluminum alloys: Colorimetric determination using 1,10-phenanthroline. Ibid. 21, 1521 1949.
  85. Salinas, F. J. Sanchez, J. Carlos, G. Diaz, T. -Spectrophotometric determination of iron in wines, foods and minerals with 5,5-dimethyl-1,2,3-cyclohexanetrione 1,2- dioxime 3-thiosemicarbazone. Analytical Chemistry 58, 824, 1986.
  86. Sandell, E. B -Colorimetric Determination of Traces of Metals. Interscience Publishers, Inc., New York, N.Y. 1959.
  87. Schmeisser & Brauer ed. -Handbook of Preparative Inorganic Chemistiy 2nd Ed., Academic Press, N.Y., 1963.
  88. Scott, Wilfred, W. -Standard Methods of Chemical Analysis A manual of Analytical methods and General Reference for the Analytical Chemist and for the Advanced Student, D. Van Nostrand Co., Inc. New York, NY 1939.
  89. Seitz, W.R. & D.M. Hercules -Determination of trace amounts of iron (II) using chemiluminescence analysis. Analytical Chemistry 44: 214, 1972.
  90. Shapiro J. -On the measurement of ferrous iron in natural waters. Limnol. Oceanogr. 11:293, 1966.
  91. Smith, E.G., et al. -Bathophenanthroline (4,7-Diphenyl-1 , I 0-Phenanthroline) for use in iron determination. Analyst 77:418, 1952.
  92. Stekel, A., Olivares, M., Cayazzo, M. -Prevention of iron deficiency by milk fortification. A field trial with a full-fat acidified milk. Am. J. Clinical Nutrition 47:265, 1988.
  93. Stekel, A., Olivares, M, Pizarro, F. -Absorption of fortification iron from milk formulas in infants. Am. J. Clinical Nutrition 43:917, 1986.
  94. - Suzuki, Y., Kuma, K. -Existence of stable Fe(ll) complex in toxic river water and its determination. Water Research 26, 1421, 1992.
  95. UNICEF internal paper -Chronology of development of iron and double fortification of salt. UNICEF, New Delhi, India 1989.
  96. Venkatesh Mannar, M.G., S.Jayapal, & Pandav, C.S. -Double fortification of salt with iron and iodine. Proceedings of the Sixth International Nutrition Congress, Seoul 1989.
  97. Welcher, F.J . Organic Analytical Reagents D. Van Nostrand Co., Princeton, N.J., 1976.
  98. Wikoff, L. R., Moraghan, J. T. -Determination of plant iron, manganese and zinc by wet ashing procedures. J. Sci.Food Agriculture 37, 839, 1986.
  99. Whittaker, P., Vanderveen, J. E. -Effect of EDTA on the bioavailability to rats of fortification iron used in Egyptian balady bread. British J. Nutrition 63, 587, 1990.
  100. Working Group Report -Use of common salt fortified with iron in the control and prevention of anaemia -A collaborative study. Am. J. Clinical Nutrition 35, 1442, 1982.
  101. Yi, Zhen et al. -High-performance liquid chromatographic method for the determination of ultratrace amounts of iron(Il) in aerosols, rainwater, and sea water. Analytical Chemistry. 64, 2826, 1992.
  102. Zak, B. -Bathophenanthroline-Disulfonic acid (4,7-Diphenyl-1 ,1 0-Phenanthroline disulfonic acid) in iron determination. Am. J. Clin. Path 29, 590, 1958.
  103. Zhang, D., Mahoney, A. W. -Iron fortification of process Cheddar cheese. J. Dairy Science 74, 353, 1991.
  104. Zhang, D., Mahoney, A. W. -Effect of iron fortification on quality of Cheddar cheese. 2. Effects of aging and fluorescent light on pilot scale cheeses. J. Dairy Science 73, 2252, 1990.
  105. Zoller, J.M., Wolinsky, I., Paden, C.A., Hoskin, J.C., Lewis, K.C., Lineback, D.R. & McCarthy, R.K. -Fortification of non-staple food items with iron. Food Technology 34,39, 1980.
  106. Ali-Mohamed, A. Y., Jamali, S. C. A. -Potentiometric determination of fluoride and iodide in natural and processed waters of Bahrain using ion-selective electrodes. Water Research 23, 659, 1989.
  107. - Anonymous -Standard Methods For The Examination Of Water And Wastewater 17th Edition, APHA, AWWA, WPCF, 1989
  108. Diosady, L.L., Alberti, J.O, Venkatesh Mannar, M.G. and Stone, T -Stability of Iodine in Iodized Salt Used for Correction of Iodine Deficiency Disorders -Food and Nutrition Bulletin December 1997
  109. Diosady, L.L., Alberti, J.O, Venkatesh Mannar, M.G. and FitzGerrald, S. -Stability of Iodine in Iodized Salt Used for Correction of Iodine Deficiency Disorders II Food and Nutrition Bulletin September 1998.
  110. Dubravcic, M. -Determination of iodine in natural waters (sodium chloride as a reagent in the catalytic reduction of ceric ions) Analyst 80, 295, 1955.
  111. Fischer, P. W. F., L'Abbe, M. R., Giroux, A. -Colorimetric determination of total iodine in foods by iodide-catalyzed reduction of Ce4t J.A.O.Anal. Chem. 69, 687, 1986.
  112. Gustafson, F.J., Markell, C.G., Simpson, S. M. -Determination of chloride, bromide, and iodide in silver halides by ion exchange and ion interaction chromatography. Analytical Chemistry 621, 1985.
  113. Han, K., Koch, W.F., Pratt, K.W. -Improved procedure for the determination of iodide by ion chromatography with electrochemical detection. Analytical Chemistry 59, 731, 1987.
  114. Hatch, Gary L. -Hypoiodous acid, iodine, and iodide determination with leucocrystal References Anonymous -WaterAnalysis Handbook Hach Co. Loveland, Colorado USA 1992.
  115. Diosady, L.L., Alberti, J.O, Venkatesh Mannar, M.G. and Stone, T -Stability of Iodine in Iodized Salt Used for Correction of Iodine Deficiency Disorders -Food and Nutrition Bulletin December 1997
  116. L.L.Diosady, J.O. Alberti, M.G. Venkatesh Mannar, FitzGerrald, S. -Stability of Iodine in Iodized Salt Used for Correction of Iodine Deficiency Disorders II Food and Nutrition Bulletin September 1998.
  117. Hancock,R.G.V. Some aspects of the Analysis of Ancient Artifacts by Neutron Activation, J.IIC-CG 3(2) p 21-27, 1978
  118. Hatch, Gary L. -Hypoiodous acid, iodine, and iodide determination with leucocrystal violet and N-chlorosuccinimide-succinimide reagents -Analytical Chemistry 56, 2238, 1984.
  119. Venkatesh Mannar, M.G. -Control of iodine deficiency disorders by iodization of salt: strategy for developing countries. The prevention and control of iodine deficiency disorders. Eds.: Hetzel, B.S., J.T. Dunn & Stanbury J.B., Elsevier 1987.
  120. Scott, Wilfred, W. Standard Methods Of Chemical Analysis N.Y. D.Van Nostrand Comp. Inc. 1937
  121. Williams, S Ed. -Official Methods Of Analysis of the Association of Official Analytical Chemists 14th Edition; AOAC, Inc. 1984
  122. Kolthoff. 1969. Quantitative Chemical Analysis. 4" edition. New York: The Macmillan Company.
  123. Kolthoff. 1952. Textbook of Quantitative Inorganic Analysis. 3'd edition. New York: The Macmillan Company.
  124. Laitinen, H. A. 1960. Chemical Analysis. New York: McGriII-Hill, Inc.
  125. Mellon, J., W. Mellon's Modern Inorganic Chemistry. London: Longmans, Green and Co.
  126. Sandell, E. B.. 1959. Colorimetric Determination of Traces of Metals vol. III. New York: lnterscience publishes.
  127. Scott, W. 193'). Standard Methods of Chemical Analysis. 5" edition. N. Y.: D. Van Norstrand Company.
  128. Skoog, West, Weller. 1988. Fundamental ofAnatytical Chemistry. Fort Worth: Saunders College Publishing.
  129. Snell, C.T., Snell, F.D. 1949. Colorimetric Methods of Analysis vol. II. 3'd edition. New York: D. Van. Norstrand Campany.

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