Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
238
8.1
Adenovirus
541
18.5
Adenovirus + Maraba virus
1
0
Adenovirus + Modified vaccinia Ankara virus (MVA)
11
0.4
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.3
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.2
Bifidobacterium longum
1
0
CRISPR-Cas9
12
0.4
E. coli
2
0.1
Flavivirus
8
0.3
Gene gun
5
0.2
Herpes simplex virus
99
3.4
Human Rhinovirus (RG-HRV16)
1
0
Lactococcus lactis
7
0.2
Lentivirus
278
9.5
Lipofection
119
4.1
Listeria monocytogenes
31
1.1
Live Attenuated Salmonella
1
0
Measles virus
14
0.5
Modified Vaccinia Ankara virus (MVA)
12
0.4
mRNA Electroporation
6
0.2
Naked/Plasmid DNA
452
15.4
Naked/Plasmid DNA + Adenovirus
4
0.1
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + RNA transfer
1
0
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
3
0.1
Newcastle disease virus
1
0
Non-viral
1
0
PiggyBacTM (PB) Transposon
1
0
Poliovirus
5
0.2
Poxvirus
71
2.4
Poxvirus + Vaccinia virus
40
1.4
Retrovirus
514
17.5
Retrovirus + Lentivirus
2
0.1
RNA transfer
51
1.7
RNA transfer + Naked/Plasmid DNA
1
0
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.3
Salmonella typhimurium
4
0.1
Semliki forest virus
2
0.1
Sendai virus
4
0.1
Shigella dysenteriae
1
0
Simian virus
2
0.1
siRNA
5
0.2
Sleeping Beauty transposon
12
0.4
Streptococcus mutans
1
0
Vaccinia virus
133
4.5
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
6
0.2
Vibrio cholerae
1
0
Unknown
184
6.3
Total
2930